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1. 发明授权

US07611872B2 Method for the production of D-pantothenic acid and/or salts thereof via purification by nanofiltration as adjunct for animal feedstuffs 失效
标题翻译：通过纳米过滤作为动物饲料辅助生产D-泛酸和/或其盐的方法
公开(公告)号：US07611872B2
公开(公告)日：2009-11-03
申请号：US10468564
申请日：2002-02-20
申请人： Christine Beck , Hans-Peter Harz , Daniela Klein , Martin Leemann , Markus Lohscheidt , Stefan Bitterlich , Hartwig Voβ
发明人： Christine Beck , Hans-Peter Harz , Daniela Klein , Martin Leemann , Markus Lohscheidt , Stefan Bitterlich , Hartwig Voβ
IPC分类号： C12P13/04
CPC分类号： C12P13/02 , A23K10/12 , A23K20/174
摘要： The invention relates to an improved method for the production of D-pantothenic acid and/or salts thereof and use thereof as adjunct for animal feedstuffs.
摘要翻译：本发明涉及一种生产D-泛酸和/或其盐的改进方法和用作动物饲料的辅助剂。

2. 发明授权

US07727748B2 Method for producing D-pantothenic acid and/or salts thereof via purification by anion exchange as an additive for animal feed 失效
标题翻译：通过阴离子交换作为动物饲料添加剂的纯化生产D-泛酸和/或其盐的方法
公开(公告)号：US07727748B2
公开(公告)日：2010-06-01
申请号：US10468562
申请日：2002-02-20
申请人： Christine Beck , Hans-Peter Harz , Daniela Klein , Martin Leemann , Markus Lohscheidt
发明人： Christine Beck , Hans-Peter Harz , Daniela Klein , Martin Leemann , Markus Lohscheidt
IPC分类号： C12P13/04 , C12P21/02 , B01D15/04 , B01J41/00
CPC分类号： C12P13/02 , A23K10/12 , A23K20/174
摘要： The invention relates to an improved method for producing D-pantothenic acid and/or the salts thereof and to the use thereof as an additive for animal feed.
摘要翻译：本发明涉及一种生产D-泛酸和/或其盐的改进方法及其用作动物饲料添加剂的用途。

3. 发明授权

US07781192B2 Method for producing D-pantothenic acid and/or a salt thereof via purification by cation exchange as additive for animal food 有权
标题翻译：通过阳离子交换纯化生产D-泛酸和/或其盐的方法，作为动物食品的添加剂
公开(公告)号：US07781192B2
公开(公告)日：2010-08-24
申请号：US10468609
申请日：2002-02-20
申请人： Kai-Uwe Baldenius , Christine Beck , Hans-Peter Harz , Markus Lohscheidt , Daniela Klein
发明人： Kai-Uwe Baldenius , Christine Beck , Hans-Peter Harz , Markus Lohscheidt , Daniela Klein
IPC分类号： C12P13/04 , C12P21/02 , B01D15/04 , B01J39/00 , C07C229/08
CPC分类号： A61N1/20 , A61N1/205 , A61N1/326 , C12P13/02
摘要： The invention relates to an improved method for producing D-pantothenic acid and/or the salts thereof and the use of said substance as an additive for animal food.
摘要翻译：本发明涉及一种生产D-泛酸和/或其盐的改进方法以及所述物质作为动物食品添加剂的用途。

4. 发明授权

US07365210B2 Method for the production of chiral imidazolidin-2-ones 失效
标题翻译：制备手性咪唑烷-2-酮的方法
公开(公告)号：US07365210B2
公开(公告)日：2008-04-29
申请号：US10510439
申请日：2003-04-08
申请人： Hansgeorg Ernst , Jürgen Koppenhöfer , Daniela Klein
发明人： Hansgeorg Ernst , Jürgen Koppenhöfer , Daniela Klein
IPC分类号： C07D233/04
CPC分类号： C07D233/00
摘要： The invention relates to a process for preparing chiral imidazolidin-2-ones of the formula I in which R1 is C1-C8-alkyl, cyclohexyl, phenyl, a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto- or CF3-substituted phenyl radical, naphthyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy- or CF3-substituted naphthyl radical, R2 is C1-C8-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a phenyl-C1-C6-alkyl radical which may be substituted by a nitro, C1-C6-alkoxy, methylenedioxy or CF3 radical, and R3 is C1-C12-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, methylenedioxy-, dialkylamino- or CF3-substituted phenyl radical, by reacting a compound of the formula II or the salt thereof in which R1, R2 and R3 have the abovementioned meaning, with urea in the presence of an involatile ammonium salt, wherein the reaction is carried out in the presence of an aprotic polar organic solvent.
摘要翻译：本发明涉及一种制备其中R 1是C 1 -C 8 - 的式I的手性咪唑烷-2-酮的方法，烷基，环己基，苯基，C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 3 - C 6 - 烷氧基 - ，C 1 -C 6 - 烷基巯基或CF 3 - 取代的苯基，萘基或C C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 6 - 烷氧基 - 或CF 3 - 取代的萘基，R 2是C 1 -C 8 - 烷基，C _{和R 3具有上述含义，在非挥发性铵盐存在下用脲进行反应，其中反应在非质子极性有机溶剂的存在下进行。}

5. 发明申请

US20080108113A1 Methods for the Enrichment of Trehalose Using Alumosilicates 审中-公开
标题翻译：使用硅铝酸盐富集海藻糖的方法
公开(公告)号：US20080108113A1
公开(公告)日：2008-05-08
申请号：US10593223
申请日：2005-03-18
申请人： Matthias Boy , Markus Pompejus , Daniela Klein , Martin Volkert , James Reuben Brown
发明人： Matthias Boy , Markus Pompejus , Daniela Klein , Martin Volkert , James Reuben Brown
IPC分类号： C12P19/12 , C07H1/06
CPC分类号： C07H3/04
摘要： The invention relates to a process for enriching trehalose from solutions, in which the enrichment is performed using an adsorbent, in which the adsorbent is an aluminosilicate. Preferably, the aluminosilicate is a zeolite. The invention further relates to the enrichment and purification of trehalose from fermentation broths, in particular as a coupled product of production by fermentation of other products of value.
摘要翻译：本发明涉及从溶液中富集海藻糖的方法，其中使用吸附剂进行富集，其中吸附剂是铝硅酸盐。优选地，硅铝酸盐是沸石。本发明还涉及从发酵液中富集和纯化海藻糖，特别是作为通过其他有价值产物的发酵生产的偶联产物。

6. 发明申请

US20050165078A1 Method for the production of chiral imidazolidin-2-ones 失效
标题翻译：制备手性咪唑烷-2-酮的方法
公开(公告)号：US20050165078A1
公开(公告)日：2005-07-28
申请号：US10510439
申请日：2003-04-08
申请人： Hansgeorg Ernst , Jurgen Koppenhofer , Daniela Klein
发明人： Hansgeorg Ernst , Jurgen Koppenhofer , Daniela Klein
IPC分类号： C07D233/34 , C07B53/00 , C07B61/00 , C07D233/00 , A61K31/4178 , A61K31/4168 , C07D233/04 , C07D47/02
CPC分类号： C07D233/00
摘要： The invention relates to a process for preparing chiral imidazolidin-2-ones of the formula I in which R1 is C1-C8-alkyl, cyclohexyl, phenyl, a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto- or CF3-substituted phenyl radical, naphthyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy- or CF3-substituted naphthyl radical, R2 is C1-C8-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a phenyl-C1-C6-alkyl radical which may be substituted by a nitro, C1-C6-alkoxy, methylenedioxy or CF3 radical, and R3 is C1-C12-alkyl, C2-C8-alkenyl, cyclohexyl, phenyl or a C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, methylenedioxy-, dialkylamino- or CF3-substituted phenyl radical, by reacting a compound of the formula II or the salt thereof in which R1, R2 and R3 have the abovementioned meaning, with urea in the presence of an involatile ammonium salt, wherein the reaction is carried out in the presence of an aprotic polar organic solvent.
摘要翻译：本发明涉及一种制备其中R 1是C 1 -C 8 - 的式I的手性咪唑烷-2-酮的方法，烷基，环己基，苯基，C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 3 - C 6 - 烷氧基 - ，C 1 -C 6 - 烷基巯基或CF 3 - 取代的苯基，萘基或C C 1 -C 6 - 烷基 - ，卤代 - ，硝基 - ，C 1 -C 6 - 烷氧基 - 或CF 3 - 取代的萘基，R 2是C 1 -C 8 - 烷基，C _{和R 3具有上述含义，在非挥发性铵盐存在下用脲进行反应，其中反应在非质子极性有机溶剂的存在下进行。}

7. 发明授权

US08017790B2 Method for producing pyrrolidones from succinates from fermentation broths 有权
标题翻译：从发酵液中由琥珀酸生产吡咯烷酮的方法
公开(公告)号：US08017790B2
公开(公告)日：2011-09-13
申请号：US11722263
申请日：2005-12-17
申请人： Wolfgang Fischer , Daniela Klein , Andreas Künkel , Rolf Pinkos , Edzard Scholten
发明人： Wolfgang Fischer , Daniela Klein , Andreas Künkel , Rolf Pinkos , Edzard Scholten
IPC分类号： C07D207/12
CPC分类号： C07D207/408 , C07D207/267 , Y02P20/582
摘要： The present invention relates to a process for preparing a compound II or a composition comprising the compound II to a composition comprising succinimide and to a composition prepared by the process according to the invention.
摘要翻译：本发明涉及一种制备化合物II或包含化合物II的组合物的方法，所述组合物包含琥珀酰亚胺和通过本发明的方法制备的组合物。

8. 发明申请

US20070122888A1 Method for the production of methionine 有权
标题翻译：生产甲硫氨酸的方法
公开(公告)号：US20070122888A1
公开(公告)日：2007-05-31
申请号：US10583304
申请日：2004-12-17
申请人： Matthias Boy , Daniela Klein , Hartwig Schroder
发明人： Matthias Boy , Daniela Klein , Hartwig Schroder
IPC分类号： C12P13/12 , C07C323/35
CPC分类号： C07C319/28 , C12P13/12 , C07C323/58
摘要： The present invention relates to a process for producing methionine by fermentation, a process for isolating the methionine formed, the methionine-containing biomass produced in isolation, use thereof for producing a feedstuff or feed supplement, and also to the use of the isolated methionine for producing foodstuffs or feedstuffs or food supplements or feed supplements.
摘要翻译：本发明涉及通过发酵生产甲硫氨酸的方法，分离形成的甲硫氨酸的方法，分离产生的含有甲硫氨酸的生物质，用于生产饲料或饲料添加剂的用途，以及将分离的甲硫氨酸用于生产食品或饲料或食品补充剂或饲料添加剂。

9. 发明申请

US20060234333A1 Method for producing carotenoids or their precursors using genetically modified organisms of the blakeslea genus, carotenoids or their precursors produced by said method and use thereof 审中-公开
标题翻译：使用所述方法生产的布鲁氏菌属，类胡萝卜素或其前体的遗传修饰生物来生产类胡萝卜素或其前体的方法及其用途
公开(公告)号：US20060234333A1
公开(公告)日：2006-10-19
申请号：US10541750
申请日：2004-01-09
申请人： Markus Matuschek , Daniela Klein , Thorsten Heinekamp , Andre Schmidt
发明人： Markus Matuschek , Daniela Klein , Thorsten Heinekamp , Andre Schmidt
IPC分类号： C12P23/00 , C12N15/74 , C12N1/14
CPC分类号： C12N15/80 , A23K20/179 , A23L5/00 , A23L5/44 , A23L31/00 , A23L33/105 , C12P23/00
摘要： The invention relates to a method for producing carotenoids or their precursors using genetically modified organisms of the Blakeslea genus. Said method comprises the following steps (i) transformation of at least one of the cells, (ii) optional homokaryotic conversion of the cells obtained in step (i) to produce cells, in which one or more genetic characteristics of the nuclei are all modified in an identical manner and said modification manifests itself in the cells, (iii) selection and reproduction of the genetically modified cell or cells, (iv) cultivation of the genetically modified cells, (v) preparation of the carotenoids produced by the genetically modified cells or the carotenoid precursor produced by said genetically modified cells. The invention also relates to carotenoids or their precursors produced according to said method and to the use thereof.
摘要翻译：本发明涉及使用布鲁氏菌属的转基因生物来生产类胡萝卜素或其前体的方法。所述方法包括以下步骤：（i）至少一个细胞的转化，（ii）步骤（i）中获得的细胞的任选的同源转化以产生其中一个或多个核的遗传特征都被修饰的细胞以相同的方式，并且所述修饰本身在细胞中，（iii）遗传修饰的细胞或细胞的选择和繁殖，（iv）遗传修饰的细胞的培养，（v）由遗传修饰的细胞产生的类胡萝卜素的制备或由所述遗传修饰的细胞产生的类胡萝卜素前体。本发明还涉及根据所述方法生产的类胡萝卜素或其前体及其用途。

10. 发明授权

US06630605B2 Process for the purification of phosphonium salts 失效
公开(公告)号：US06630605B2
公开(公告)日：2003-10-07
申请号：US10161682
申请日：2002-06-05
申请人： Christoph Wegner , Daniela Klein
发明人： Christoph Wegner , Daniela Klein
IPC分类号： C07F954
CPC分类号： C07F9/5428 , C07F9/025 , C07F9/5435
摘要： The invention relates to a process for the purification of phosphonium salts in which a solution of the crude phosphonium salt is passed over a bed of a cation exchange resin in salt form or of an adsorber resin, the resin is washed with a polar protic solvent in the case of the cation exchange resin and with an electrolyte solution and a nonpolar solvent in the case of the adsorber resin, and the phosphonium salt is eluted from the cation exchange resin with an electrolyte solution or from the adsorber resin with a polar solvent.

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