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    • 2. 发明申请
    • SEMICONDUCTOR EMBEDDED RESISTOR GENERATION
    • 半导体嵌入式电阻发生器
    • US20100197106A1
    • 2010-08-05
    • US12364764
    • 2009-02-03
    • Choongryul RyouSeunghwan LeeJun YuanVictor ChanManfred EllerNam Sung KimNarasimhulu KanikeSrikanth Balaji Samavedam
    • Choongryul RyouSeunghwan LeeJun YuanVictor ChanManfred EllerNam Sung KimNarasimhulu KanikeSrikanth Balaji Samavedam
    • H01L21/76G06F17/50
    • H01L27/0629H01L23/5256H01L28/20H01L2924/0002H01L2924/00
    • A method for generating an embedded resistor in a semiconductor device and related computer-readable storage medium are provided, the method and program steps of the medium including forming a shallow trench isolation (STI) region in a substrate; forming a pad oxide on the STI region and substrate; depositing a silicon layer on the pad oxide; forming a photo-resist mask on a portion of the silicon layer disposed substantially above the STI region.; etching the silicon layer to yield a polyconductor (PC) disposed substantially above the STI region; oxidizing the PC; depositing at least one of an oxide material or a metal gate material on the oxidized surface; depositing a silicon layer on the at least one oxide material or metal gate material; depositing additional silicon on a portion of the silicon layer disposed substantially above the STI region; patterning a transistor gate with a photo-resist mask disposed on another portion of the silicon layer disposed substantially away from the STI region; and etching the silicon layer to yield at least one transistor structure disposed substantially away from the STI region and at least one resistor structure disposed substantially above the STI region.
    • 提供了一种用于在半导体器件和相关的计算机可读存储介质中产生嵌入式电阻器的方法,所述介质的方法和程序步骤包括在衬底中形成浅沟槽隔离(STI)区域; 在STI区和衬底上形成衬垫氧化物; 在衬垫氧化物上沉积硅层; 在基本上位于STI区域上方的硅层的一部分上形成光刻胶掩模; 蚀刻硅层以产生基本上位于STI区域上方的多导体(PC); 氧化PC; 在氧化表面上沉积氧化物材料或金属栅极材料中的至少一种; 在所述至少一种氧化物材料或金属栅极材料上沉积硅层; 在基本上位于STI区域上方的硅层的一部分上沉积附加的硅; 图案化具有设置在基本上远离STI区域设置在硅层的另一部分上的光致抗蚀剂掩模的晶体管栅极; 并且蚀刻所述硅层以产生基本上远离所述STI区域布置的至少一个晶体管结构以及基本上设置在所述STI区域上的至少一个电阻器结构。
    • 7. 发明授权
    • Bioconjugates of synthetic apelin polypeptides
    • 合成apelin多肽的生物缀合物
    • US09340582B2
    • 2016-05-17
    • US14336290
    • 2014-07-21
    • Jun YuanFrederic ZecriPhilipp GroscheHongjuan ZhaoEric PetersShari Lynn CaplanChanggang Lou
    • Jun YuanFrederic ZecriPhilipp GroscheHongjuan ZhaoEric PetersShari Lynn CaplanChanggang Lou
    • C07K14/47C07K7/08A61K47/48A61K45/06A61K38/10C07K16/00A61K39/395
    • A61K38/10A61K38/00A61K45/06A61K47/542A61K47/643A61K47/68A61K47/6811C07K14/47C07K14/765C07K2319/30C07K2319/31
    • The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    • 本发明提供包含式I'(SEQ ID NO:1)的合成多肽的生物缀合物或其酰胺,其酯或其盐,其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,X 8,X 9 ,X10,X11,X12和X13在本文中定义并且半衰期延长部分,其中肽和半衰期延长部分任选地经由连接体共价连接或融合。 多肽是APJ受体的激动剂。 本发明还涉及本发明的生物缀合物的制备方法及其治疗用途,例如治疗或预防急性失代偿性心力衰竭(ADHF),慢性心力衰竭,肺动脉高压,心房颤动,布鲁加达综合征,室性心动过速,动脉粥样硬化 ,高血压,再狭窄,缺血性心血管疾病,心肌病,心脏纤维化,心律失常,保水,糖尿病(包括妊娠糖尿病),肥胖,外周动脉疾病,脑血管意外,短暂性脑缺血发作,创伤性脑损伤,肌萎缩性侧索硬化,烧伤( 包括晒伤)和先兆子痫。 本发明还提供药理活性剂和药物组合物的组合。