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    • 4. 发明申请
    • COMPOUND USED TO PREVENT DISEASES CAUSED BY AQUAPORIN DEFICIENCY
    • 化合物用于预防由阿曲康宁缺乏引起的疾病
    • US20120129929A1
    • 2012-05-24
    • US13162038
    • 2011-06-16
    • Chi-Feng Hung
    • Chi-Feng Hung
    • A61K31/215A61P17/02A61K31/185C07C69/76C07C63/44
    • A61K31/215A61K31/19C07J63/008
    • A compound used to prevent diseases caused by aquaporin deficiency, which is 18β-Glycyrrhetinic acid derivative. Said compound can not only prevent diseases caused aquaporin deficiency, but be able to prevent aquaporin (AQP) production and enhance skin function. Since AQPs have many advantages in skin cells, e.g. promoting water and glycerine molecular transportation, increasing skin elasticity and cuticle moisture, increasing the cell proliferation and cell migration, aquaporin can promote skin bather function and wound cicatrization. Therefore, said compound can be applied potentially as a medicinal cosmetic in skin medicine cosmetology, or as a new medical composition to treat diseases caused by AQP abnormality, such as urine concentration defect, wound healing slow down, corneal re-epithelialization slow down and etc.
    • 一种用于预防由水通道蛋白缺乏引起的疾病的化合物,其为甘草次酸衍生物。 所述化合物不仅可以预防导致水通道蛋白缺乏症的疾病,而且可以防止水通道蛋白(AQP)产生和增强皮肤功能。 因为AQP在皮肤细胞中具有许多优点,例如 促进水和甘油分子运输,增加皮肤弹性和角质层水分,增加细胞增殖和细胞迁移,水通道蛋白可促进皮肤沐浴功能和伤口瘢痕形成。 因此,所述化合物可以作为皮肤医学美容中的药用化妆品,或作为治疗由AQP异常引起的疾病如尿液缺乏,伤口愈合减缓,角膜上皮化减慢等的新药物组合物 。