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1. 发明申请

US20080307849A1 Method And Apparatus For Forming Microstructures 审中-公开
标题翻译：用于形成微结构的方法和装置
公开(公告)号：US20080307849A1
公开(公告)日：2008-12-18
申请号：US11791567
申请日：2004-11-26
申请人： Chee Yen Lim , Yuan Xu , Hbaieb Kais , Yuan Ling Christina Tan
发明人： Chee Yen Lim , Yuan Xu , Hbaieb Kais , Yuan Ling Christina Tan
IPC分类号： B26F1/14 , B05D3/12 , C25D5/34 , B05C21/00 , C25D17/00 , B26F1/24
CPC分类号： A61M37/0015 , A61M2037/0053 , B21G1/08 , B21J13/02 , B21K23/00
摘要： A method of micro forming an array of microstructures comprising: advancing a punch having an array of protrusions (620) towards a sheet of material (640) disposed between the punch (620) and a die (630), each protrusion (625) shaped to deform the sheet of material (640) into a corresponding microstructure; providing a holder for holding the sheet of material (640) in place; and punching the sheet of material (640) with the protrusions on the punch (620) to form the array of microstructures on the sheet of material (640).
摘要翻译：一种微观形成微结构阵列的方法，其特征在于，包括：朝向设置在冲头（620）和模具（630）之间的材料片（640）前进具有突起阵列（620）的冲头，每个凸起（625）成形使所述材料片（640）变形成相应的微结构; 提供用于将材料片（640）保持在适当位置的保持器; 以及用所述冲头（620）上的突起冲压所述材料片（640）以在所述材料片（640）上形成所述微结构阵列。

2. 发明申请

US20100305516A1 Methods and moulds for use in fabricating side-ported microneedles 失效
标题翻译：用于制造侧端微针的方法和模具
公开(公告)号：US20100305516A1
公开(公告)日：2010-12-02
申请号：US10592559
申请日：2004-03-12
申请人： Yuan Xu , Minghua Wang , Mei Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan
发明人： Yuan Xu , Minghua Wang , Mei Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan
IPC分类号： A61M5/00 , B22C9/22 , B29C33/42 , C25D1/00
CPC分类号： B29C33/0061 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C33/301 , B29C33/3857 , B29C33/40 , B29C33/424 , B29C33/56 , B29C59/026 , B29C2791/001 , B29C2793/0009 , B29L2031/756 , B29L2031/759 , B81B2201/055 , B81C99/009 , C25D1/02 , Y10T29/49885 , Y10T29/4998 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986 , Y10T29/49988
摘要： Side-ported microneedles are produced from a suitably shaped microneedle mould (40). A microneedle mould base (32) is made with a number of microneedle mould recesses (30) in it. One surface of the microneedle mould base (32) is coated with a seed layer (34). The microneedle mould base (32) contains two microneedle mould sheets (24, 26), which are separated to gain access to an internal surface of one of the microneedle mould sheets (24, 26). Side-port forming channels (38) are formed on one of the internal surfaces, intersecting with the recesses (30) within the relevant microneedle mould sheet (24). The two microneedle mould sheets (24, 26) are placed back together and joined together as a unitary microneedle mould (40). The microneedles are formed in the recesses (30) by depositing a microneedle layer (44) therein and on the surface with the seed layer (34). The microneedle layer (44) fails to deposit at side-port forming holes (42) where the side-port forming channels (38) intersect the recesses (30), which result in side-ports (46) in the moulded microneedles (52).
摘要翻译：由适当形状的微针模具（40）制造侧端微针。微针模具基座（32）在其中形成有许多微针模具凹槽（30）。微针模具基座（32）的一个表面涂覆有种子层（34）。微针模具基座（32）包含两个微针模具片（24,26），它们分开以进入其中一个微针模板（24,26）的内表面。侧孔形成通道（38）形成在与相关微针模板（24）内的凹部（30）相交的一个内表面上。将两个微针模具片（24,26）放置在一起并作为整体式微针模具（40）连接在一起。通过在其中放置微针层（44）并在种子层（34）的表面上，在凹部（30）中形成微针。该微针层（44）不能沉积在侧孔形成通道（42）处，其中侧孔形成通道（38）与凹槽（30）相交，这导致模制微针（52）中的侧端口（46））。

3. 发明授权

US07497980B2 Microneedles and microneedle fabrication 失效
标题翻译：微针和微针制造
公开(公告)号：US07497980B2
公开(公告)日：2009-03-03
申请号：US10505035
申请日：2003-11-10
申请人： Yuan Xu , Mei Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan
发明人： Yuan Xu , Mei Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan
IPC分类号： B29C33/42
CPC分类号： B81C1/00111 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29C33/3878 , B29C33/42 , B29C45/00 , B29C2045/0094 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C2201/034
摘要： A master mould is made by wire cutting a plate in two or more directions to provide a base with an array of master mould needles protruding therefrom. The size and shape of the master mould needles can readily be varied by varying the angles of upward and downward cuts in the two or more directions. The master mould is used to make a secondary mould by hot embossing a secondary mould plate onto the master mould. This forms through-holes in the secondary mould. The secondary mould is plated with a layer of metal, which forms a microneedle array.
摘要翻译：主模具通过在两个或更多个方向上对板进行线切割来制造，以提供具有从其突出的主模具针阵列的基座。通过改变在两个或更多个方向上的向上和向下切割的角度，可以容易地改变主模具针的尺寸和形状。主模具用于通过将二次模板热压在主模上来制造二次模具。这在二次模具中形成通孔。二次模具镀有一层金属，形成微针阵列。

4. 发明授权

US08671544B2 Methods and moulds for use in fabricating side-ported microneedles 失效
标题翻译：用于制造侧端微针的方法和模具
公开(公告)号：US08671544B2
公开(公告)日：2014-03-18
申请号：US10592559
申请日：2004-03-12
申请人： Meí Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan , Minghua Wang
发明人： Yuan Xu , Meí Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan
IPC分类号： B23P25/00 , B28B1/48 , B29C33/00 , B23P17/00
CPC分类号： B29C33/0061 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C33/301 , B29C33/3857 , B29C33/40 , B29C33/424 , B29C33/56 , B29C59/026 , B29C2791/001 , B29C2793/0009 , B29L2031/756 , B29L2031/759 , B81B2201/055 , B81C99/009 , C25D1/02 , Y10T29/49885 , Y10T29/4998 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986 , Y10T29/49988
摘要： A microneedle mold and a method of manufacturing a microneedle mold are provided for use in fabricating microneedles. The method includes providing a microneedle mold base with recesses therein, the recesses corresponding to the microneedles to be fabricated and extending from a first surface of the microneedle mold base; and forming side-port forming holes in the microneedle mold base, the side-port forming holes extend in side surfaces of the recesses within the microneedle mold base at side-port forming positions of the recesses.
摘要翻译：提供微针模具和制造微针模具的方法用于制造微针。该方法包括：在其中设置微针模具基座，其中凹部对应于待制造的微针并从微针模具底座的第一表面延伸; 并且在微针模具基座中形成侧口形成孔，所述侧端口形成孔在所述凹部的侧端口形成位置处在所述微针基座内的凹部的侧面上延伸。

5. 发明授权

US10271781B2 Plastic blood Lancet 有权
公开(公告)号：US10271781B2
公开(公告)日：2019-04-30
申请号：US14437283
申请日：2012-11-05
申请人： Chee Yen Lim
发明人： Chee Yen Lim
IPC分类号： A61B5/00 , A61B5/151 , A61B5/15
摘要： The present invention provides a surgically invasive pointed article for skin penetration and capillary whole blood extraction whose penetration ability can be disabled after use by deforming the tips. The present invention is made by injection molding a plastic needle 35 having an anchoring means 45 using a first material, followed by another injection molding process to over-mold a first body segment 20 and second body segment 30 using a second material to encase the plastic needle 35 thereby anchoring the plastic needle 35 to prevent further movement of the plastic needle 35. The encasing of the second material provide a barrier isolating the plastic needle 35 from the ambient to protect the tips 50 from damage and once sterilized, to conserve the sterile conditions till point of use. The barrier formed by a second over-molding process comprises a detachable cap 20 and a body 30. The present invention is normally used for blood sampling applications but can also be used for applications such as vaccination or skin allergy testing, and transdermal/intradermal drug delivery.

6. 发明申请

US20140243867A1 SURGICALLY INVASIVE POINTED ARTICLES FOR SKIN PENETRATION AND METHODS FOR THEIR PREPARATION 审中-公开
标题翻译：用于皮肤渗透的有意义的入侵物品及其制备方法
公开(公告)号：US20140243867A1
公开(公告)日：2014-08-28
申请号：US14351894
申请日：2011-11-02
申请人： Chee Yen Lim
发明人： Chee Yen Lim
IPC分类号： A61B5/151 , B29C45/14
CPC分类号： A61B5/15134 , A61B5/150022 , A61B5/150282 , A61B5/150427 , A61B5/150511 , A61B5/150587 , A61B5/150618 , A61B5/150717 , A61B5/150923 , A61B5/15117 , A61B5/15186 , A61M5/3202 , B29C45/14
摘要： A surgically invasive pointed article for skin penetration and its fabrication method are presented. The present invention comprises a protruding sharp end portion and a body portion, the protruding sharp end portion comprising at least one penetration tip that can be disabled after use. The tip disablement after use is an effective safety measure in eradicating accidental injuries and re-use. The tip disablement can be carried out manually by the user or automatically if the article is used with a custom-made tip-disabling applicator. The skin penetration device can be used as a lancet for blood sampling, a needle for immunization and skin allergy testing, or a skin breaching device for transdermal drug delivery. The second aspect of the invention is a method for preparing the surgically invasive pointed article for skin penetration. The preparation method includes injection mould the articles into at least two body segments, the first body segment comprising at least one protruding end for skin penetration, and the second body segment being hollow forming a handle for handling purpose or an adaptor for fitting into an applicator. The third aspect of the invention is an over-moulding process for packaging purposes, wherein the articles moulded with a first material mentioned above are over-moulded with a second softer and cheaper material to form various additional functional parts.
摘要翻译：介绍了一种用于皮肤穿透的手术侵入性尖端物品及其制造方法。本发明包括突出的尖端部分和主体部分，突出的尖端部分包括至少一个穿透尖端，该穿透尖端在使用后可被禁用。使用后的提示禁用是消除意外伤害和重复使用的有效安全措施。尖端禁用可以由用户手动执行，或者如果物品与定制的尖头禁用施放器一起使用，则可自动进行。皮肤穿透装置可以用作血液取样的刺血针，用于免疫的针和皮肤过敏测试，或用于透皮药物递送的皮肤破裂装置。本发明的第二方面是用于制备用于皮肤穿透的外科手术侵入性尖端物品的方法。该制备方法包括将制品注射成至少两个主体部分，第一主体部分包括用于皮肤穿透的至少一个突出端，并且第二主体部分是中空的，形成用于处理目的的手柄或用于装配到施加器中的适配器。本发明的第三方面是用于包装目的的过度成型方法，其中用上述第一种材料模制的制品用第二较软和便宜的材料进行超模塑以形成各种附加的功能部件。

7. 发明申请

US20150265198A1 PLASTIC BLOOD LANCET 审中-公开
标题翻译：塑料血液网
公开(公告)号：US20150265198A1
公开(公告)日：2015-09-24
申请号：US14437283
申请日：2012-11-05
申请人： Chee Yen LIM
发明人： Chee Yen Lim
IPC分类号： A61B5/151 , A61B5/15
CPC分类号： A61B5/15101 , A61B5/150022 , A61B5/150282 , A61B5/150297 , A61B5/150312 , A61B5/150412 , A61B5/150503 , A61B5/150564 , A61B5/150618 , A61B5/150717 , A61B5/15105 , A61B5/15142
摘要： The present invention provides a surgically invasive pointed article for skin penetration and capillary whole blood extraction whose penetration ability can be disabled after use by deforming the tips. The present invention is made by injection moulding a plastic needle 35 having an anchoring means 45 using a first material, followed by another injection moulding process to over-mould a first body segment 20 and second body segment 30 using a second material to encase the plastic needle 35 thereby anchoring the plastic needle 35 to prevent further movement of the plastic needle 35. The encasing of the second material provide a barrier isolating the plastic needle 35 from the ambient to protect the tips 50 from damage and once sterilized, to conserve the sterile conditions till point of use. The barrier formed by a second over-moulding process comprises a detachable cap 20 and a body 30. The present invention is normally used for blood sampling applications but can also be used for applications such as vaccination or skin allergy testing, and transdermal/intradermal drug delivery.
摘要翻译：本发明提供了一种用于皮肤渗透和毛细血管全血提取的外科手术侵入性尖端物品，其使用后的穿透能力可通过使尖端变形而被禁用。本发明通过使用第一材料注射成型具有锚定装置45的塑料针35，然后通过另一种注射成型工艺来模制第一主体部分20和第二主体部分30，使用第二材料来包住塑料针35，从而锚定塑料针35以防止塑料针35的进一步移动。第二材料的包封提供了将塑料针35与环境隔离的障碍物，以保护尖端50不被损坏并一旦被灭菌，以保存无菌使用条件。通过第二过度成型方法形成的阻挡层包括可拆卸盖20和主体30.本发明通常用于血液取样应用，但也可用于例如疫苗接种或皮肤过敏测试，以及透皮/皮内药物交货。

8. 发明申请

US20120160691A1 CONTACTLESS CONDUCTIVITY DETECTOR 审中-公开
标题翻译：无连接电导率检测器
公开(公告)号：US20120160691A1
公开(公告)日：2012-06-28
申请号：US13311315
申请日：2011-12-05
申请人： Kambiz Ansari Mahabadi , Isabel Rodriguez Fernandez , Chee Yen Lim , Jasmine Shu Ying Yuen
发明人： Kambiz Ansari Mahabadi , Isabel Rodriguez Fernandez , Chee Yen Lim , Jasmine Shu Ying Yuen
IPC分类号： G01N27/447 , B81B1/00
CPC分类号： G01N27/4473 , G01N27/44791
摘要： A portable electrophoretic contactless conductivity detection (C4D) system for analysis on a microfluidic chip houses in one embodiment a fluidic compartment for receiving the microfluidic chip, and four detection electrodes: first and second emitting electrodes, and first and second receiving electrodes. The first emitting electrode and the first receiving electrode are adjacent to a first channel wall of the microfluidic chip, and the second emitting electrode and the second receiving electrode are adjacent to a second channel wall, where the second channel wall is opposite to the first channel wall. In an embodiment, the electrodes are provided as portions of a removable cartridge cell.
摘要翻译：在一个实施例中，用于在微流体芯片上分析的便携式电泳非接触电导检测系统（C4D）用于接收微流体芯片的流体隔室和四个检测电极：第一和第二发射电极以及第一和第二接收电极。第一发射电极和第一接收电极与微流体芯片的第一通道壁相邻，并且第二发射电极和第二接收电极邻近第二通道壁，其中第二通道壁与第一通道相对壁。在一个实施例中，电极被提供为可移除盒式电池的部分。

9. 发明申请

US20110140721A1 CONTACTLESS CONDUCTIVITY DETECTOR 有权
标题翻译：无连接电导率检测器
公开(公告)号：US20110140721A1
公开(公告)日：2011-06-16
申请号：US13057922
申请日：2009-08-07
申请人： Kambiz Ansari Mahabadi , Isabel Rodriguez Fernandez , Chee Yen Lim
发明人： Kambiz Ansari Mahabadi , Isabel Rodriguez Fernandez , Chee Yen Lim
IPC分类号： G01R27/26
CPC分类号： G01N27/4473 , G01N27/44791
摘要： The contactless conductivity detector in one embodiment includes a microfluidic chip having a channel (102) thereon and four detection electrodes: first and second emitting electrodes (100a, 101a), and first and second receiving electrodes (100b, 101b). The channel (102) is defined by channel walls. The first emitting electrode (100a) and the first receiving electrode (100b) are adjacent a first channel wall, and the second emitting electrode (101a) and the second receiving electrode (101b) are adjacent a second channel wall, the second channel wall being opposite the first channel wall.
摘要翻译：一个实施例中的非接触电导检测器包括其上具有通道（102）的微流体芯片和四个检测电极：第一和第二发射电极（100a，101a）以及第一和第二接收电极（100b，101b）。通道（102）由通道壁限定。第一发光电极（100a）和第一接收电极（100b）与第一通道壁相邻，第二发光电极（101a）和第二接收电极（101b）相邻于第二通道壁，第二通道壁为在第一个通道墙对面。

10. 发明申请

US20090326415A1 MICRONEEDLES AND METHODS FOR FABRICATING MICRONEEDLES 审中-公开
标题翻译：麦克风和制备麦克风的方法
公开(公告)号：US20090326415A1
公开(公告)日：2009-12-31
申请号：US12439142
申请日：2006-08-28
申请人： Chee Yen Lim
发明人： Chee Yen Lim
IPC分类号： A61B5/15 , B29C33/40 , B29C45/00 , A61M5/00
CPC分类号： A61B5/151 , A61B5/14514 , A61B5/150022 , A61B5/150236 , A61B5/150244 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C33/3878
摘要： A plastic microneedle comprising: a body portion tapering from a larger end of the body portion towards a tip portion of the body portion; at least one side port; and a lumen extending from the larger end of the body portion and within the body portion of the microneedle, wherein the side port extends into the lumen such that the side port and the lumen are in fluid communication with each other.
摘要翻译：一种塑料微针，包括：主体部分，其从所述主体部分的较大端朝向所述主体部分的尖端部分渐缩; 至少一个侧端口; 以及从所述主体部分的较大端部延伸并且在所述微针的主体部分内延伸的内腔，其中所述侧部端口延伸到所述内腔中，使得所述侧端口和所述内腔彼此流体连通。

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