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1. 发明申请

US20200338328A1 PYRAMIDAL MICRONEEDLES WITH ENHANCED DRUG LOADING CAPACITY AND METHOD FOR MANUFACTURING 审中-公开
公开(公告)号：US20200338328A1
公开(公告)日：2020-10-29
申请号：US16500139
申请日：2017-05-10
申请人： Chee Yen LIM
发明人： Chee Yen LIM
IPC分类号： A61M37/00 , A61K9/00
摘要： The present invention provides a solution to increase the drug loading capacity and drug delivery precision of dissolving microneedles. These solutions include: (a) increasing the base of the microneedle cavities without substantially changing the microneedle's height and geometry, (b) use of drug suspension and sedimentation of drug by centrifugation, and (c) a specific centrifugation order for filling drug and matrix material. In the first preferred embodiment, a microneedle master mould comprising a plurality of pyramidal microneedles (5100), wherein each of the pyramidal microneedles further comprising a chamfered base (5200) which extends to and adjoins with its neighbouring chamfered bases is provided. In the second preferred embodiment, a method of making dissolving microneedles is provided, comprising (a) providing a microneedle template comprising a plurality of pyramidal microneedle cavities, wherein each of the pyramidal microneedle cavities further comprising a chamfered base which extends to and adjoins with its neighbouring chamfered bases; (b) loading a drug suspension in the substrate cavity on the microneedle template; (c) centrifuging the microneedle template which is loaded with a drug suspension, (d) loading a matrix material solution in the substrate cavity on the microneedle template; (d) centrifuging the microneedle template loaded with the drug suspension and the matrix material solution; and (e) drying the centrifuged microneedle template in a controlled environment.

2. 发明申请

US20180021556A1 PAINLESS DRUG IMPLANTER 审中-公开
公开(公告)号：US20180021556A1
公开(公告)日：2018-01-25
申请号：US15547550
申请日：2015-02-13
申请人： Chee Yen LIM
发明人： Chee Yen LIM , Yong Wei CHIA , Wei Siong LEE
IPC分类号： A61M37/00 , A61M5/31
CPC分类号： A61M37/0069 , A61M5/158 , A61M5/3134 , A61M5/3148 , A61M37/0015
摘要： The present invention relates to a drug implant device which delivers a drug load to the body painlessly. The present invention achieves the painless drug implantation by adopting two principles: (1) rapid perpendicular insertion of fine cannula is painless and that (2) pain is incurred only when the occupied volume caused by the implant process is increased. Therefore, instead of inserting a cannula and injection a volume of drug, which increases the occupied volume of the injection process due to additional volume of the drug, the present invention retracts the cannula in order to dispose the drug into the body. The retraction of cannula does not increase the occupied volume therefore incurs no pain. In the preferred embodiment, the drug implant device (100) comprises a cannula (300) with a bevelled tip, a drug load (320) and an inner rod (340), wherein the drug load (320) and the inner rod (340) are slidably disposed within the cannula (300), and that the drug load (320) is disposed at the bevelled end of the cannula (300) and that the inner rod (340) is disposed adjacent to the drug load (320).

3. 发明授权

US09007075B2 Contactless conductivity detector 有权
标题翻译：非接触式电导检测器
公开(公告)号：US09007075B2
公开(公告)日：2015-04-14
申请号：US13057922
申请日：2009-08-07
申请人： Kambiz Ansari Mahabadi , Isabel Rodriguez Fernandez , Chee Yen Lim
发明人： Kambiz Ansari Mahabadi , Isabel Rodriguez Fernandez , Chee Yen Lim
IPC分类号： G01R27/26 , G01N27/447
CPC分类号： G01N27/4473 , G01N27/44791
摘要： The contactless conductivity detector in one embodiment includes a microfluidic chip having a channel (102) thereon and four detection electrodes: first and second emitting electrodes (100a, 101a), and first and second receiving electrodes (100b, 101b). The channel (102) is defined by channel walls. The first emitting electrode (100a) and the first receiving electrode (100b) are adjacent a first channel wall, and the second emitting electrode (101a) and the second receiving electrode (101b) are adjacent a second channel wall, the second channel wall being opposite the first channel wall.
摘要翻译：一个实施例中的非接触电导检测器包括其上具有通道（102）的微流体芯片和四个检测电极：第一和第二发射电极（100a，101a）以及第一和第二接收电极（100b，101b）。通道（102）由通道壁限定。第一发光电极（100a）和第一接收电极（100b）与第一通道壁相邻，第二发光电极（101a）和第二接收电极（101b）相邻于第二通道壁，第二通道壁为在第一个通道墙对面。

4. 发明申请

US20140296796A1 PLASTIC MICRONEEDLE STRIP 审中-公开
标题翻译：塑料麦克风条
公开(公告)号：US20140296796A1
公开(公告)日：2014-10-02
申请号：US14351899
申请日：2011-11-02
申请人： Chee Yen Lim
发明人： Chee Yen Lim
IPC分类号： A61M37/00 , B29C33/38
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , B29C33/3842 , B29C45/0081 , Y10T29/49826
摘要： The present invention relates to plastic microneedle strips (10) that are used in transdermal drug delivery for increasing the drug delivery rate through the skin These microneedle strips (10) are mass produced singly or in a cluster (100) via precision injection moulding process, and may be assembled to form microneedle arrays subsequently. The individual microneedle strips can further broken into individual microneedles for other medical applications. The making of the mould (200) for precision injection moulding process is also provided.
摘要翻译：本发明涉及用于透皮药物递送的塑料微针条（10），用于增加通过皮肤的药物输送速率。这些微针条（10）通过精密注射成型工艺单独大量生产或在簇（100）中批量生产，并且可以组装以随后形成微针阵列。单独的微针条可以进一步分成单独的微针以用于其他医疗应用。还提供了用于精密注射成型工艺的模具（200）的制造。

5. 发明授权

US08695101B2 Data privacy engine 失效
标题翻译：数据隐私引擎
公开(公告)号：US08695101B2
公开(公告)日：2014-04-08
申请号：US13442474
申请日：2012-04-09
申请人： Rima Bajaj , Hyman D. Chantz , David A. Chapin , Amy E. Creswick , Eduardo M. Da Silva , Alison L. Graham , Chee Yen Lim , Adam C. Nelson , Nicholas J. Norris , Gregory J. Riche , Varun Sharma , Nevenko Zunic
发明人： Rima Bajaj , Hyman D. Chantz , David A. Chapin , Amy E. Creswick , Eduardo M. Da Silva , Alison L. Graham , Chee Yen Lim , Adam C. Nelson , Nicholas J. Norris , Gregory J. Riche , Varun Sharma , Nevenko Zunic
IPC分类号： G06F7/04
CPC分类号： G06Q10/00
摘要： A computer hardware-implemented method, system, and/or computer program product determines an applicability of a data privacy regulation when transmitting data used with an enterprise project. A data privacy regulation describes regulatory restrictions on data being transmitted from a first geopolitical entity to a second geopolitical entity. A set of categorized data is used by an enterprise project, and the data privacy regulation establishes limitations on a transmission of at least one category of data, from the set of categorized data, from the first geopolitical entity to the second geopolitical entity. A first set of binary data and a second set of binary data are processed to determine if transmission of said at least one category of data from the first geopolitical entity to the second geopolitical entity is regulated by the data privacy regulation.
摘要翻译：计算机硬件实现的方法，系统和/或计算机程序产品在传输与企业项目一起使用的数据时确定数据隐私规则的适用性。数据隐私法规描述了从第一个地缘政治实体向第二个地缘政治实体传输的数据的监管限制。企业项目使用一组分类数据，数据隐私法规规定了从一组分类数据，从第一个地缘政治实体到第二个地缘政治实体的至少一类数据的传输的限制。第一组二进制数据和第二组二进制数据被处理以确定是否通过数据隐私调节来规定来自第一地缘政治实体的所述至少一类数据的数据传输到第二地缘政治实体。

6. 发明授权

US08583225B2 System and method for detecting skin penetration 有权
标题翻译：用于检测皮肤渗透的系统和方法
公开(公告)号：US08583225B2
公开(公告)日：2013-11-12
申请号：US12675031
申请日：2007-08-24
申请人： Chee Yen Lim , Szu Cheng Lai
发明人： Chee Yen Lim , Szu Cheng Lai
IPC分类号： A61B5/053
CPC分类号： A61M5/46 , A61B5/0531 , A61B5/150022 , A61B5/150954 , A61B5/150984 , A61B5/415 , A61B5/418 , A61B5/685 , A61M37/0015
摘要： A system and method for detecting skin penetration. The system comprises an invasive component for penetrating the skin; a dummy electrode for making contact with the surface of the skin; at least one penetrating electrode disposed in the invasive component; and a Wheatstone bridge circuit; wherein a resistance across the dummy electrode and the penetrating electrode constitutes one of the resistive legs of the Wheatstone bridge circuit and skin penetration of the invasive component is detected based on a differential output voltage from the Wheatstone bridge circuit.
摘要翻译：用于检测皮肤渗透的系统和方法。该系统包括用于穿透皮肤的侵入性组件; 用于与皮肤表面接触的虚拟电极; 设置在所述侵入性成分中的至少一个穿透电极; 和惠斯登电桥电路; 其中穿过所述虚拟电极和所述穿透电极的电阻构成所述惠斯通电桥电路的电阻支路之一，并且基于所述惠斯通电桥电路的差分输出电压来检测所述侵入性部件的皮肤穿透。

7. 发明申请

US20100305516A1 Methods and moulds for use in fabricating side-ported microneedles 失效
标题翻译：用于制造侧端微针的方法和模具
公开(公告)号：US20100305516A1
公开(公告)日：2010-12-02
申请号：US10592559
申请日：2004-03-12
申请人： Yuan Xu , Minghua Wang , Mei Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan
发明人： Yuan Xu , Minghua Wang , Mei Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan
IPC分类号： A61M5/00 , B22C9/22 , B29C33/42 , C25D1/00
CPC分类号： B29C33/0061 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C33/301 , B29C33/3857 , B29C33/40 , B29C33/424 , B29C33/56 , B29C59/026 , B29C2791/001 , B29C2793/0009 , B29L2031/756 , B29L2031/759 , B81B2201/055 , B81C99/009 , C25D1/02 , Y10T29/49885 , Y10T29/4998 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986 , Y10T29/49988
摘要： Side-ported microneedles are produced from a suitably shaped microneedle mould (40). A microneedle mould base (32) is made with a number of microneedle mould recesses (30) in it. One surface of the microneedle mould base (32) is coated with a seed layer (34). The microneedle mould base (32) contains two microneedle mould sheets (24, 26), which are separated to gain access to an internal surface of one of the microneedle mould sheets (24, 26). Side-port forming channels (38) are formed on one of the internal surfaces, intersecting with the recesses (30) within the relevant microneedle mould sheet (24). The two microneedle mould sheets (24, 26) are placed back together and joined together as a unitary microneedle mould (40). The microneedles are formed in the recesses (30) by depositing a microneedle layer (44) therein and on the surface with the seed layer (34). The microneedle layer (44) fails to deposit at side-port forming holes (42) where the side-port forming channels (38) intersect the recesses (30), which result in side-ports (46) in the moulded microneedles (52).
摘要翻译：由适当形状的微针模具（40）制造侧端微针。微针模具基座（32）在其中形成有许多微针模具凹槽（30）。微针模具基座（32）的一个表面涂覆有种子层（34）。微针模具基座（32）包含两个微针模具片（24,26），它们分开以进入其中一个微针模板（24,26）的内表面。侧孔形成通道（38）形成在与相关微针模板（24）内的凹部（30）相交的一个内表面上。将两个微针模具片（24,26）放置在一起并作为整体式微针模具（40）连接在一起。通过在其中放置微针层（44）并在种子层（34）的表面上，在凹部（30）中形成微针。该微针层（44）不能沉积在侧孔形成通道（42）处，其中侧孔形成通道（38）与凹槽（30）相交，这导致模制微针（52）中的侧端口（46））。

8. 发明授权

US07497980B2 Microneedles and microneedle fabrication 失效
标题翻译：微针和微针制造
公开(公告)号：US07497980B2
公开(公告)日：2009-03-03
申请号：US10505035
申请日：2003-11-10
申请人： Yuan Xu , Mei Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan
发明人： Yuan Xu , Mei Ma Chen , Zhongli Li , Chee Yen Lim , Pei Ying Joyce Tan
IPC分类号： B29C33/42
CPC分类号： B81C1/00111 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29C33/3878 , B29C33/42 , B29C45/00 , B29C2045/0094 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C2201/034
摘要： A master mould is made by wire cutting a plate in two or more directions to provide a base with an array of master mould needles protruding therefrom. The size and shape of the master mould needles can readily be varied by varying the angles of upward and downward cuts in the two or more directions. The master mould is used to make a secondary mould by hot embossing a secondary mould plate onto the master mould. This forms through-holes in the secondary mould. The secondary mould is plated with a layer of metal, which forms a microneedle array.
摘要翻译：主模具通过在两个或更多个方向上对板进行线切割来制造，以提供具有从其突出的主模具针阵列的基座。通过改变在两个或更多个方向上的向上和向下切割的角度，可以容易地改变主模具针的尺寸和形状。主模具用于通过将二次模板热压在主模上来制造二次模具。这在二次模具中形成通孔。二次模具镀有一层金属，形成微针阵列。

9. 发明申请

US20150265198A1 PLASTIC BLOOD LANCET 审中-公开
标题翻译：塑料血液网
公开(公告)号：US20150265198A1
公开(公告)日：2015-09-24
申请号：US14437283
申请日：2012-11-05
申请人： Chee Yen LIM
发明人： Chee Yen Lim
IPC分类号： A61B5/151 , A61B5/15
CPC分类号： A61B5/15101 , A61B5/150022 , A61B5/150282 , A61B5/150297 , A61B5/150312 , A61B5/150412 , A61B5/150503 , A61B5/150564 , A61B5/150618 , A61B5/150717 , A61B5/15105 , A61B5/15142
摘要： The present invention provides a surgically invasive pointed article for skin penetration and capillary whole blood extraction whose penetration ability can be disabled after use by deforming the tips. The present invention is made by injection moulding a plastic needle 35 having an anchoring means 45 using a first material, followed by another injection moulding process to over-mould a first body segment 20 and second body segment 30 using a second material to encase the plastic needle 35 thereby anchoring the plastic needle 35 to prevent further movement of the plastic needle 35. The encasing of the second material provide a barrier isolating the plastic needle 35 from the ambient to protect the tips 50 from damage and once sterilized, to conserve the sterile conditions till point of use. The barrier formed by a second over-moulding process comprises a detachable cap 20 and a body 30. The present invention is normally used for blood sampling applications but can also be used for applications such as vaccination or skin allergy testing, and transdermal/intradermal drug delivery.
摘要翻译：本发明提供了一种用于皮肤渗透和毛细血管全血提取的外科手术侵入性尖端物品，其使用后的穿透能力可通过使尖端变形而被禁用。本发明通过使用第一材料注射成型具有锚定装置45的塑料针35，然后通过另一种注射成型工艺来模制第一主体部分20和第二主体部分30，使用第二材料来包住塑料针35，从而锚定塑料针35以防止塑料针35的进一步移动。第二材料的包封提供了将塑料针35与环境隔离的障碍物，以保护尖端50不被损坏并一旦被灭菌，以保存无菌使用条件。通过第二过度成型方法形成的阻挡层包括可拆卸盖20和主体30.本发明通常用于血液取样应用，但也可用于例如疫苗接种或皮肤过敏测试，以及透皮/皮内药物交货。

10. 发明申请

US20120160691A1 CONTACTLESS CONDUCTIVITY DETECTOR 审中-公开
标题翻译：无连接电导率检测器
公开(公告)号：US20120160691A1
公开(公告)日：2012-06-28
申请号：US13311315
申请日：2011-12-05
申请人： Kambiz Ansari Mahabadi , Isabel Rodriguez Fernandez , Chee Yen Lim , Jasmine Shu Ying Yuen
发明人： Kambiz Ansari Mahabadi , Isabel Rodriguez Fernandez , Chee Yen Lim , Jasmine Shu Ying Yuen
IPC分类号： G01N27/447 , B81B1/00
CPC分类号： G01N27/4473 , G01N27/44791
摘要： A portable electrophoretic contactless conductivity detection (C4D) system for analysis on a microfluidic chip houses in one embodiment a fluidic compartment for receiving the microfluidic chip, and four detection electrodes: first and second emitting electrodes, and first and second receiving electrodes. The first emitting electrode and the first receiving electrode are adjacent to a first channel wall of the microfluidic chip, and the second emitting electrode and the second receiving electrode are adjacent to a second channel wall, where the second channel wall is opposite to the first channel wall. In an embodiment, the electrodes are provided as portions of a removable cartridge cell.
摘要翻译：在一个实施例中，用于在微流体芯片上分析的便携式电泳非接触电导检测系统（C4D）用于接收微流体芯片的流体隔室和四个检测电极：第一和第二发射电极以及第一和第二接收电极。第一发射电极和第一接收电极与微流体芯片的第一通道壁相邻，并且第二发射电极和第二接收电极邻近第二通道壁，其中第二通道壁与第一通道相对壁。在一个实施例中，电极被提供为可移除盒式电池的部分。

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