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    • 4. 发明申请
    • NANOFLUIDIC DELIVERY SYSTEM
    • US20150151097A1
    • 2015-06-04
    • US14558503
    • 2014-12-02
    • Biltmore Technologies, Inc.
    • David CarnahanNolan NicholasKyle G. FohrmanHoward BuschThomas T. MorganTroy G. Fohrman
    • A61M37/00B21G1/08
    • A61M5/32A61M5/3295A61M37/0015A61M2037/0023A61M2037/003A61M2037/0053A61M2037/0061B21G1/08
    • Apparatus for subcutaneously delivering a substance to a patient, said apparatus comprising: a carrier comprising a flexible body, wherein said flexible body comprises a reservoir, and further wherein said reservoir contains the substance which is to be delivered to the patient; a nanoneedle assembly comprising: a tubular body having a distal end and a proximal end; a base plate movably mounted intermediate said distal end and said proximal end of said tubular body, said base plate comprising a distal surface and a proximal surface, with a plurality of through-holes extending between said distal surface and said proximal surface of said base plate, said proximal surface of said base plate being in fluid communication with said reservoir; a plurality of nanoneedles, wherein each of said plurality of nanoneedles comprises a distal end, a proximal end, and a lumen extending therebetween, said proximal end of each of said plurality of nanoneedles being mounted to said base plate such that said lumen of each of said plurality of nanoneedles is in fluid communication with said through-holes of said base plate; a fixed guide plate mounted at said distal end of said tubular body, said fixed guide plate comprising a plurality of through-holes extending therethrough, said through-holes of said fixed guide plate being sized to receive said distal ends of said plurality of nanoneedles; and a moveable guide plate disposed intermediate said base plate and said fixed guide plate, said moveable guide plate comprising a plurality of through-holes extending therethrough, said through-holes of said movable guide plate being sized to receive said plurality of nanoneedles, such that said plurality of nanoneedles extend through said through-holes of said movable guide plate; and at least one spring tab for biasing said movable guide plate away from said fixed guide plate; wherein, when said base plate is moved distally, said movable guide plate moves distally, such that said movable guide plate provides lateral support to said nanoneedles, whereby to prevent buckling of said nanoneedles; and wherein when said base plate moves distally, said distal end of each of said plurality of nanoneedles passes through said through-holes of said fixed guide plate into the patient, and further wherein when said distal ends of said plurality of nanoneedles are disposed distally of said fixed guide plate, the substance within said reservoir passes through each of said lumens of said plurality of nanoneedles, whereby to deliver the substance to the patient.
    • 5. 发明申请
    • METHOD FOR PRODUCING A SMALL THIN-WALLED TUBE FROM A MAGNESIUM ALLOY
    • 从镁合金制造小薄壁管的方法
    • US20120125070A1
    • 2012-05-24
    • US13321427
    • 2010-05-19
    • Alois BirgmannMartin BrandeckerMaria KuehleinThomas Waltenberger
    • Alois BirgmannMartin BrandeckerMaria KuehleinThomas Waltenberger
    • B21C1/26B21C3/04B21C3/16
    • B21C1/003A61F2/82A61F2210/0004B21C1/24B21C1/26B21C3/04B21C3/16B21C9/00B21C23/18B21C37/30B21D22/00B21G1/08
    • The invention relates to a method for producing a small thin-walled tube for a medical application or for a medical product, in particular for a stent, wherein a blank of an in particular bioresorbable magnesium alloy is deformed to produce a small tube, after which the small tube is used for medical purposes or from which the medical product, such as a stent, can be made. In order to be able to produce the small tube in one step and with high precision, it is provided according to the invention that a male die (2) with a base body (3) and a mandrel (4) tapered relative to the base body (3) and the blank is provided with a blind hole or an opening, wherein a diameter of the blind hole or the opening of the blank is equal to or greater than an outer diameter of the mandrel (4), after which the blank with inserted mandrel (4) with the male die (2) is pressed forwards at least in part through a female die (5) with a receiving region (6) and a contouring region (7), wherein the contouring region (7) has a free diameter, which is larger than the outer diameter of the mandrel (4), but smaller than an outer diameter of the blank, in order to form the small tube.
    • 本发明涉及一种用于制造用于医疗应用或医疗产品,特别是用于支架的小型薄壁管的方法,其中特定生物可再吸收的镁合金的坯料变形以产生小管,之后 小管用于医疗目的,或者可以从其制造诸如支架的医疗产品。 为了能够在一个步骤中以高精度生产小管,根据本发明提供了一种具有基体(3)和心轴(4)的阳模(2)相对于基部 本体(3)和坯料设置有盲孔或开口,其中盲孔或坯料的开口的直径等于或大于心轴(4)的外径,之后坯料 其中插入的具有阳模(2)的心轴(4)至少部分地通过具有接收区域(6)和轮廓区域(7)的阴模(5)向前挤压,其中轮廓区域(7)具有 自由直径大于心轴(4)的外径,但小于坯料的外径,以便形成小管。
    • 7. 发明授权
    • Method for manufacturing high flow insufflation needle stylet
    • 制造高流量吹气针通针的方法
    • US08028395B2
    • 2011-10-04
    • US11868901
    • 2007-10-08
    • Scott V. TaylorPaul BalschweitMatthew A. Wixey
    • Scott V. TaylorPaul BalschweitMatthew A. Wixey
    • B23P13/04B21C37/06
    • B21G1/08A61B17/3474A61B17/3496A61B2017/00526B21D28/06B21D31/02Y10T29/49995
    • A method for forming a high flow insufflation needle stylet having distal, intermediate and proximal sections includes providing a flat sheet of metal and forming pilot holes in the sheet proximate opposed edges of the sheet. A profile of a flat pattern of the stylet is formed. The flat pattern has a proximal end, a distal end and a pair of substantially longitudinal edges. At least one support tab is positioned between the flat pattern and the sheet. The intermediate and the proximal sections of the stylet are progressively formed into a partial cylindrical shape with the proximal end being open and the longitudinal edges in the intermediate and proximal sections being positioned between about 90° and 180° apart. The distal section is progressively formed into a substantially cylindrical shape having a closed distal end. The stylet is trimmed from the sheet by cutting the at least one support tab.
    • 用于形成具有远端,中间和近端部分的高流量吹入针探针的方法包括提供平坦的金属片并且在片材的相对的边缘附近在片材中形成导向孔。 形成通孔的扁平图案的轮廓。 扁平图案具有近端,远端和一对基本上纵向的边缘。 至少一个支撑片位于平面图案和片材之间。 探针的中间部分和近侧部分逐渐形成为部分圆柱形形状,其中近端是开放的,并且中间部分和近侧部分中的纵向边缘位于约90°和180°之间。 远侧部分逐渐形成为具有封闭的远端的大致圆柱形形状。 通过切割至少一个支撑片来从片材修剪探针。
    • 8. 发明授权
    • Rapid thermal treatment for coloring surgical needles
    • 快速热处理染色手术针
    • US07887746B2
    • 2011-02-15
    • US11956120
    • 2007-12-13
    • Frank Richard Cichocki, Jr.David DemarestGregory HollinEugene D. Reynolds
    • Frank Richard Cichocki, Jr.David DemarestGregory HollinEugene D. Reynolds
    • C21D1/00C21D1/74
    • C21D9/26A61B17/06066A61B90/92A61B2017/00526B21G1/08C21D9/0018C21D9/0056
    • An apparatus for thermally treating and coloring a plurality of curved suture needles. The apparatus includes a conveyer for transferring the plurality of curved suture needles from a source of curved suture needles to a receiver, a housing positioned adjacent the conveyer, the housing having a first end, a second end, and an opening running from the first end to the second end, the opening aligned with the conveyer to enable the plurality of curved suture needles to pass therethrough, a heat source located within the housing for heating the plurality of curved suture needles as the plurality of curved suture needles are transferred by the conveyer from the first end of the housing to the second end of the housing and a system for providing a gas mixture containing a fractional concentration of oxygen to oxidize and colorize the surfaces of the plurality of curved suture needles as the plurality of suture needles pass through the housing. A process for thermally treating and coloring a plurality of curved suture needles to colorize and enhance the stiffness and yield moment of the curved suture needles is also provided.
    • 一种用于热处理和着色多个弯曲缝合针的装置。 该装置包括用于将多个弯曲缝合针从弯曲缝合针的源转移到接收器的输送机,邻近输送机定位的壳体,壳体具有第一端,第二端和从第一端延伸的开口 在第二端,开口与输送机对准,使得多个弯曲的缝合针能够通过,当多个弯曲的缝合针被传送器传送时,位于壳体内的热源用于加热多个弯曲的缝合针 从壳体的第一端到壳体的第二端,以及用于提供含有分数浓度的氧的气体混合物的系统,以便当多个缝合针穿过所述多个缝合针时,多个弯曲缝合针的表面氧化和着色 住房。 还提供了一种用于热处理和着色多个弯曲缝合针以使着色和增强弯曲缝合针的刚度和屈服力矩的方法。