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1. 发明授权

US09420989B2 Apparatus, method and computer program product for calculating the speed of ultrasound in at least two tissue types 有权
标题翻译：用于计算至少两种组织类型的超声速度的装置，方法和计算机程序产品
公开(公告)号：US09420989B2
公开(公告)日：2016-08-23
申请号：US14002270
申请日：2012-02-27
申请人： Charles Mougenot , Gosta Jakob Ehnholm , Iipo Asko Julius Koskela , Max Oskar Köhler
发明人： Charles Mougenot , Gosta Jakob Ehnholm , Iipo Asko Julius Koskela , Max Oskar Köhler
IPC分类号： A61B8/00 , A61B8/08 , A61B5/107 , A61N7/02 , G01H5/00 , A61B5/055 , A61B6/00 , A61N7/00
CPC分类号： A61B8/08 , A61B5/055 , A61B5/1075 , A61B6/50 , A61B6/5247 , A61B8/0825 , A61B8/0858 , A61B8/406 , A61B8/4494 , A61B8/585 , A61B2562/0204 , A61B2562/046 , A61N7/02 , A61N2007/0078 , A61N2007/0095 , G01H5/00 , G06F19/00
摘要： A medical apparatus including an ultrasound transmitter and receiver system for acquiring ultrasound data descriptive of the speed of ultrasound along at least two paths. The medical apparatus further includes a medical imaging system for acquiring medical image data and a memory containing instructions that causes the processor to acquire the medical image data. The instructions further cause the processor to acquire the ultrasound data. The instructions further cause the processor to segment the medical image data into at least two tissue types. The instructions further causes the processor to determine at least two distances corresponding to the at least two paths in the subject. The instructions further cause the processor to calculate the speed of ultrasound in the at least two tissue types.
摘要翻译：一种包括超声波发射器和接收器系统的医疗装置，用于获取描述沿着至少两条路径的超声速度的超声数据。医疗装置还包括用于获取医学图像数据的医学成像系统和包含使处理器获取医学图像数据的指令的存储器。该指令还使得处理器获取超声数据。指令还使处理器将医学图像数据分割成至少两种组织类型。所述指令还使得所述处理器确定与所述对象中的所述至少两条路径相对应的至少两个距离。所述指令还使得所述处理器计算所述至少两种组织类型中的超声波的速度。

2. 发明申请

US20130338485A1 CALCULATING THE SPEED OF ULTRASOUND IN AT LEAST TWO TISSUE TYPES 有权
标题翻译：以最小二组织计算超声波速度
公开(公告)号：US20130338485A1
公开(公告)日：2013-12-19
申请号：US14002270
申请日：2012-02-27
申请人： Charles Mougenot , Gosta Jakob Ehnholm , Iipo Asko Julius Koskela , Max Oskar Köhler
发明人： Charles Mougenot , Gosta Jakob Ehnholm , Iipo Asko Julius Koskela , Max Oskar Köhler
IPC分类号： A61B8/08
CPC分类号： A61B8/08 , A61B5/055 , A61B5/1075 , A61B6/50 , A61B6/5247 , A61B8/0825 , A61B8/0858 , A61B8/406 , A61B8/4494 , A61B8/585 , A61B2562/0204 , A61B2562/046 , A61N7/02 , A61N2007/0078 , A61N2007/0095 , G01H5/00 , G06F19/00
摘要： A medical apparatus (400) comprising an ultrasound transmitter (444, 602) and receiver (446, 604) system (600) for acquiring ultrasound data (476) descriptive of the speed of ultrasound (304, 306) along at least two paths (606, 1114). The medical apparatus further comprises a medical imaging system (402) for acquiring medical image data (468) and a memory (464) containing instructions (490, 492, 494, 496, 498, 500, 502, 504) that causes the processor to acquire (100, 200) the medical image data. The instructions further cause the processor to acquire (102, 202) the ultrasound data. The instructions further cause the processor to segment (104, 204) the medical image data into at least two tissue types (434, 436, 610, 612, 708, 710). The instructions further causes the processor to determine (106, 206) at least two distances corresponding to the at least two paths in the subject. The instructions further cause the processor to calculate (108, 208) the speed of ultrasound in the at least two tissue types.
摘要翻译：一种包括超声波发射器（444,602）和接收器（446,604）系统（600）的医疗设备（400），该系统（600）用于采集描述沿着至少两条路径的超声波（304,306）的速度的超声波数据（476） 606，1114）。医疗设备还包括用于获取医学图像数据（468）的医疗成像系统（402）和包含指令（490,492,494,496,498,500,2005,504）的存储器（464），所述指令使处理器获取（100,200）医学图像数据。该指令还使处理器获取超声数据（102,202）。指令还使处理器将医学图像数据（104,204）分割为至少两种组织类型（434,436,610,612,708,710）。指令还使得处理器确定（106,206）与被摄体中的至少两条路径相对应的至少两个距离。该指令还使得处理器在至少两种组织类型中计算（108,208）超声波的速度。

3. 发明授权

US09669240B2 Therapy system for depositing energy 有权
公开(公告)号：US09669240B2
公开(公告)日：2017-06-06
申请号：US13061985
申请日：2009-09-04
申请人： Max Oskar Köhler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
发明人： Max Oskar Köhler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
IPC分类号： A61N7/02 , A61B18/14 , A61B18/18 , A61B17/00 , A61B90/00
CPC分类号： A61N7/02 , A61B18/14 , A61B18/18 , A61B2017/00084 , A61B2017/00194 , A61B2018/183 , A61B2090/374
摘要： A therapy system includes a therapy module to perform successive deposits of energy in a target zone. The therapy system further includes a control module configured to, prior to deposits of energy, produce an a priori estimate of the induced heating. A thermometry module is configured to measure temperature in a measurement field. The induced heating may be derived based on a tissue model from the settings of a therapy module. The therapy module includes a high-intensity focused ultrasound transmitter. A magnetic resonance examination system configured for thermometry is employed as the thermometry module.

4. 发明申请

US20140350539A1 THERAPEUTIC APPARATUS FOR SONICATING A MOVING TARGET 审中-公开
标题翻译：用于指示移动目标的治疗设备
公开(公告)号：US20140350539A1
公开(公告)日：2014-11-27
申请号：US14345259
申请日：2012-08-27
申请人： Charles Mougenot , Max Oskar Köhler
发明人： Charles Mougenot , Max Oskar Köhler
IPC分类号： A61B18/04
CPC分类号： A61B18/04 , A61B8/44 , A61B8/4477 , A61B8/585 , A61B90/00 , A61B2018/00642 , A61B2018/00791 , A61B2090/374 , A61B2090/378 , A61N7/02 , A61N2007/0091 , A61N2007/0095
摘要： A therapeutic apparatus (300, 400, 500) comprising a high intensity focused ultrasound system (302) comprising an ultrasound transducer (306). The ultrasound transducer has an electronically adjustable focus (318). The high intensity focused ultrasound system has a beam deflection zone (322, 608, 704, 1010). The intensity of ultrasound at the electronically adjustable focus divided by the acoustic power emitted is above a predetermined threshold (606, 1008) within the beam deflection zone. The therapeutic apparatus further comprises a processor (328) for controlling the therapeutic apparatus. Execution of machine executable instructions (350, 352, 354) causes the processor to: receive (102, 202) real time medical data (342, 424, 506) descriptive of the location of a moving target (320, 802); adjust (104, 204) the electronically adjustable focus to target the moving target using the real time medical data; and sonicate (106, 206) the moving target when the moving target is within the beam deflection zone.
摘要翻译：一种包括超声换能器（306）的高强度聚焦超声系统（302）的治疗仪（300,400,500）。超声换能器具有电子调节焦距（318）。高强度聚焦超声系统具有光束偏转区域（322,608,704,1010）。在电子可调焦点处的超声波强度除以发射的声功率高于光束偏转区域内的预定阈值（606,1008）。治疗装置还包括用于控制治疗装置的处理器（328）。机器可执行指令（350,352,354）的执行使处理器：接收（102,202）描述移动目标（320,802）的位置的实时医学数据（342,424,506）; 使用实时医学数据调整（104,204）电子可调聚焦以对准移动目标; 并且当所述移动目标在所述光束偏转区域内时，将所述移动目标超声处理（106,206）。

5. 发明授权

US09986916B2 Catheter comprising capacitive micromachined ultrasonic transducers with an adjustable focus 有权
公开(公告)号：US09986916B2
公开(公告)日：2018-06-05
申请号：US13885791
申请日：2011-11-15
申请人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
发明人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
IPC分类号： A61B8/08 , A61B8/12 , A61B5/01 , A61N7/02 , B06B1/02 , A61B5/055 , A61B5/00 , A61B6/03 , A61B6/00 , A61B5/06 , A61B6/12 , A61B8/00 , A61B18/00 , A61N7/00 , A61B90/00
CPC分类号： A61B5/015 , A61B5/055 , A61B5/064 , A61B5/4836 , A61B6/03 , A61B6/12 , A61B6/4057 , A61B8/0841 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/54 , A61B8/58 , A61B2018/00023 , A61B2090/064 , A61B2090/374 , A61B2562/028 , A61N7/022 , A61N2007/0095 , B06B1/0292 , G06F19/00
摘要： A catheter (700, 800, 1206) includes a shaft with distal (808, 906, 1004, 208) and proximal ends (1006). The distal end comprises at least one array of capacitive micromachined ultrasound transducers (308, 402, 404, 500, 512, 600, 604, 802, 008) with an adjustable focus for controllably heating a target zone (806, 1014, 1210). A connector (1012) at the proximal end supplies the at least one array of capacitive micromachined ultrasound transducers with electrical power and controls the adjustable focus.

6. 发明申请

US20130338484A1 ACCELERATED MR THERMOMETRY MAPPING INVOLVING AN IMAGE RATIO CONSTRAINED RECONSTRUCTION 有权
标题翻译：涉及图像比例限制重建的加速MR热敏图
公开(公告)号：US20130338484A1
公开(公告)日：2013-12-19
申请号：US14001941
申请日：2012-02-03
申请人： Feng Huang , Max Oskar Köhler , Jukka Iimari Tanttu , Wei Lin
发明人： Feng Huang , Max Oskar Köhler , Jukka Iimari Tanttu , Wei Lin
IPC分类号： G01R33/56 , A61N5/06 , A61B18/02 , A61N7/02 , A61N5/00
CPC分类号： G01R33/56 , A61B18/02 , A61N5/00 , A61N5/0625 , A61N7/02 , G01R33/4804 , G01R33/4814 , G01R33/561 , G01R33/5611
摘要： A medical apparatus (300, 400, 500, 600) comprising a magnetic resonance imaging system (301). The medical apparatus further comprises a memory (330) containing instructions (350, 352, 354, 456, 458, 460) for execution by a processor (324). Execution of the instructions cause the processor to acquire (102, 202) baseline magnetic resonance data (332) and reconstruct (104, 204) a first image (334) using the baseline magnetic resonance data. Execution of the instructions further cause the processor acquire (106, 212) undersampled magnetic resonance data (336), which is undersampled in k-space in comparison to the baseline magnetic resonance data. Execution of the instructions further cause the processor reconstruct (108, 214) a second image (338) using the undersampled magnetic resonance data and the first image. The second image is reconstructed using an image ratio constrained reconstruction algorithm (354) and to calculate (110, 216) a temperature map (340) using the second image.
摘要翻译：一种包括磁共振成像系统（301）的医疗设备（300,400,500,600）。医疗设备还包括一个包含用于由处理器（324）执行的指令（350,352,354,458,458,460）的存储器（330）。执行指令使得处理器使用基线磁共振数据获取（102,202）基线磁共振数据（332）并重建（104,204）第一图像（334）。与基线磁共振数据相比，执行指令还使得处理器获取（106,212）欠采样的磁共振数据（336），其在k空间中被欠采样。执行指令还使得处理器使用欠采样的磁共振数据和第一图像来重建（108,214）第二图像（338）。使用图像比例约束重构算法（354）重建第二图像，并使用第二图像计算（110,216）温度图（340）。

7. 发明授权

US09360544B2 Accelerated MR thermometry mapping involving an image ratio constrained reconstruction 有权
标题翻译：涉及图像比例约束重建的加速MR测温映射
公开(公告)号：US09360544B2
公开(公告)日：2016-06-07
申请号：US14001941
申请日：2012-02-03
申请人： Feng Huang , Max Oskar Köhler , Jukka Iimari Tanttu , Wei Lin
发明人： Feng Huang , Max Oskar Köhler , Jukka Iimari Tanttu , Wei Lin
IPC分类号： A61B5/055 , G01R33/56 , G01R33/48 , A61B18/02 , A61N5/00 , A61N5/06 , A61N7/02 , G01R33/561
CPC分类号： G01R33/56 , A61B18/02 , A61N5/00 , A61N5/0625 , A61N7/02 , G01R33/4804 , G01R33/4814 , G01R33/561 , G01R33/5611
摘要： A medical apparatus (300, 400, 500, 600) includes a magnetic resonance imaging system (301). The medical apparatus further includes a memory (330) containing instructions (350, 352, 354, 456, 458, 460) for execution by a processor (324). Execution of the instructions causes the processor to acquire (102, 202) baseline magnetic resonance data (332) and reconstruct (104, 204) a first image (334) using the baseline magnetic resonance data. Execution of the instructions further causes the processor acquire (106, 212) undersampled magnetic resonance data (336), which is undersampled in k- space in comparison to the baseline magnetic resonance data. Execution of the instructions further causes the processor reconstruct (108, 214) a second image (338) using the undersampled magnetic resonance data and the first image. The second image is reconstructed using an image ratio constrained reconstruction algorithm (354). A temperature map (340) is calculated (110, 216) using the second image.
摘要翻译：医疗装置（300,400,500,600）包括磁共振成像系统（301）。医疗设备还包括一个包含用于由处理器（324）执行的指令（350,352,354,456,458,460）的存储器（330）。执行指令使得处理器使用基线磁共振数据获取（102,202）基线磁共振数据（332）并重建（104,204）第一图像（334）。执行指令还使得处理器获取与基线磁共振数据相比在k空间中欠采样的欠采样磁共振数据（106,212）。执行指令还使得处理器使用欠采样的磁共振数据和第一图像来重建（108,214）第二图像（338）。使用图像比例约束重建算法重构第二图像（354）。使用第二图像计算温度图（340）（110,216）。

8. 发明申请

US20140005521A1 CATHETER COMPRISING CAPACITIVE MICROMACHINED ULTRASONIC TRANSDUCERS WITH AN ADJUSTABLE FOCUS 有权
标题翻译：包含具有可调焦点的电容式微超声波超声波传感器的导管
公开(公告)号：US20140005521A1
公开(公告)日：2014-01-02
申请号：US13885791
申请日：2011-11-15
申请人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
发明人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
IPC分类号： A61N7/02 , A61B5/055 , A61B5/01 , A61B6/00 , A61B8/12 , A61B8/00 , A61B5/00 , A61B6/03
CPC分类号： A61B5/015 , A61B5/055 , A61B5/064 , A61B5/4836 , A61B6/03 , A61B6/12 , A61B6/4057 , A61B8/0841 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/54 , A61B8/58 , A61B2018/00023 , A61B2090/064 , A61B2090/374 , A61B2562/028 , A61N7/022 , A61N2007/0095 , B06B1/0292 , G06F19/00
摘要： A catheter (700, 800, 1206) comprising: a shaft with distal (808, 906, 1004, 208) and proximal ends (1006),wherein the distal end comprises at least one array of capacitive micromachined ultrasound transducers (308, 402, 404, 500, 512, 600, 604, 802, 008) with an adjustable focus for controllably heating a target zone (806, 1014, 1210); and a connector (1012) at the proximal end for supplying the at least one array of capacitive micromachined ultrasound transducers with electrical power and for controlling the adjustable focus.
摘要翻译：导管（700,800,1206）包括：具有远端（808,906,1004,208）和近端（1006）的轴，其中所述远端包括至少一个电容微加工超声换能器阵列（308,402，具有可调焦点，用于可控制地加热目标区域（806,104,1210）; 以及在所述近端处的用于向所述至少一个电容微加工超声换能器阵列供电并用于控制所述可调焦点的连接器（1012）。

9. 发明授权

US09971003B2 Accelerated magnetic resonance thermometry 有权
公开(公告)号：US09971003B2
公开(公告)日：2018-05-15
申请号：US14005060
申请日：2012-03-02
申请人： Max Oskar Köhler , Erkki Tapani Vahala , Kirsi Ilona Nurmilaukas
发明人： Max Oskar Köhler , Erkki Tapani Vahala , Kirsi Ilona Nurmilaukas
IPC分类号： A61B5/00 , G01R33/48 , A61B5/055 , A61B18/02 , A61B18/12 , A61B18/18 , A61B18/20 , A61B17/00 , A61B18/00 , A61N7/02 , A61N7/00 , A61B90/00
CPC分类号： G01R33/4804 , A61B5/055 , A61B18/02 , A61B18/12 , A61B18/1815 , A61B18/20 , A61B2017/00084 , A61B2018/00791 , A61B2090/374 , A61N7/02 , A61N2007/0065 , G01R33/4808 , G01R33/4814
摘要： A medical apparatus (300, 400, 500, 600) comprising a magnetic resonance imaging system (302). The medical apparatus further comprises a memory (332) storing machine readable instructions (352, 354, 356, 358, 470, 472, 474) for execution by a processor (326). Execution of the instructions causes the processor to acquire (100, 202) spectroscopic magnetic resonance data (334). Execution of the instructions further cause the processor to calculate (102, 204) a calibration thermal map (336) using the spectroscopic magnetic resonance data. Execution of the instructions further causes the processor to acquire (104, 206) baseline magnetic resonance thermometry data (338). Execution of the instructions further causes the processor to repeatedly acquire (106, 212) magnetic resonance thermometry data (340). Execution of the instructions further cause the processor to calculate (108, 214) a temperature map (351) using the magnetic resonance thermometry data, the calibration thermal map, and the baseline magnetic resonance thermometry data.

10. 发明授权

US09336605B2 Medical imaging system, computer-implemented method, and computer program product for identifying a treated region in a medical image 有权
标题翻译：医学成像系统，计算机实现方法和用于识别医学图像中的治疗区域的计算机程序产品
公开(公告)号：US09336605B2
公开(公告)日：2016-05-10
申请号：US13879745
申请日：2011-10-13
申请人： Heikki Juhani Nieminen , Max Oskar Köhler , Marko Tapani Hakkinen
发明人： Heikki Juhani Nieminen , Max Oskar Köhler , Marko Tapani Hakkinen
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0079 , G06T7/11 , G06T2207/10132 , G06T2207/30004
摘要： A medical imaging system (900, 1000, 1100, 1200) for acquiring medical image data (930), the medical imaging system comprising: a tissue treating system (910, 1080, 1180, 1190, 1280, 1290) for treating a target volume (908); a computer system (918) comprising a processor (922), wherein the computer system is adapted for controlling the medical imaging system; and a memory (928) containing machine readable instructions (954, 956, 958, 962, 964, 966, 968, 970, 972, 974). Execution of the instructions cause the processor to: acquire (100, 200, 308) medical image data; reconstruct (102, 202, 310) a medical image (932) using the medical image data; receive (104, 204, 312) an image segmentation seed (600, 934) derived from a treatment plan (936), and identify (106, 210, 314) a treated volume (400, 700, 800) in the medical image by segmenting the medical image in accordance with the image segmentation seed.
摘要翻译：一种用于获取医学图像数据（930）的医学成像系统（900,1000,1100,1200），所述医学成像系统包括：用于治疗目标体积的组织处理系统（910,1080,1180,1190,1280,1290）（908）; 包括处理器（922）的计算机系统（918），其中所述计算机系统适于控制所述医学成像系统; 以及包含机器可读指令（954,956,958,962,964,966,968,970,972,974）的存储器（928）。执行指令使得处理器：获取（100,200,308）医学图像数据; 使用医学图像数据重建（102,202,310）医学图像（932）; 接收（104,204,312）从治疗计划（936）导出的图像分割种子（600,934），并且通过以下方式识别医疗图像中的经处理的体积（400,700,800）：（106,210,314）根据图像分割种子分割医学图像。

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