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1. 发明授权

US09420989B2 Apparatus, method and computer program product for calculating the speed of ultrasound in at least two tissue types 有权
标题翻译：用于计算至少两种组织类型的超声速度的装置，方法和计算机程序产品
公开(公告)号：US09420989B2
公开(公告)日：2016-08-23
申请号：US14002270
申请日：2012-02-27
申请人： Charles Mougenot , Gosta Jakob Ehnholm , Iipo Asko Julius Koskela , Max Oskar Köhler
发明人： Charles Mougenot , Gosta Jakob Ehnholm , Iipo Asko Julius Koskela , Max Oskar Köhler
IPC分类号： A61B8/00 , A61B8/08 , A61B5/107 , A61N7/02 , G01H5/00 , A61B5/055 , A61B6/00 , A61N7/00
CPC分类号： A61B8/08 , A61B5/055 , A61B5/1075 , A61B6/50 , A61B6/5247 , A61B8/0825 , A61B8/0858 , A61B8/406 , A61B8/4494 , A61B8/585 , A61B2562/0204 , A61B2562/046 , A61N7/02 , A61N2007/0078 , A61N2007/0095 , G01H5/00 , G06F19/00
摘要： A medical apparatus including an ultrasound transmitter and receiver system for acquiring ultrasound data descriptive of the speed of ultrasound along at least two paths. The medical apparatus further includes a medical imaging system for acquiring medical image data and a memory containing instructions that causes the processor to acquire the medical image data. The instructions further cause the processor to acquire the ultrasound data. The instructions further cause the processor to segment the medical image data into at least two tissue types. The instructions further causes the processor to determine at least two distances corresponding to the at least two paths in the subject. The instructions further cause the processor to calculate the speed of ultrasound in the at least two tissue types.
摘要翻译：一种包括超声波发射器和接收器系统的医疗装置，用于获取描述沿着至少两条路径的超声速度的超声数据。医疗装置还包括用于获取医学图像数据的医学成像系统和包含使处理器获取医学图像数据的指令的存储器。该指令还使得处理器获取超声数据。指令还使处理器将医学图像数据分割成至少两种组织类型。所述指令还使得所述处理器确定与所述对象中的所述至少两条路径相对应的至少两个距离。所述指令还使得所述处理器计算所述至少两种组织类型中的超声波的速度。

2. 发明申请

US20130338485A1 CALCULATING THE SPEED OF ULTRASOUND IN AT LEAST TWO TISSUE TYPES 有权
标题翻译：以最小二组织计算超声波速度
公开(公告)号：US20130338485A1
公开(公告)日：2013-12-19
申请号：US14002270
申请日：2012-02-27
申请人： Charles Mougenot , Gosta Jakob Ehnholm , Iipo Asko Julius Koskela , Max Oskar Köhler
发明人： Charles Mougenot , Gosta Jakob Ehnholm , Iipo Asko Julius Koskela , Max Oskar Köhler
IPC分类号： A61B8/08
CPC分类号： A61B8/08 , A61B5/055 , A61B5/1075 , A61B6/50 , A61B6/5247 , A61B8/0825 , A61B8/0858 , A61B8/406 , A61B8/4494 , A61B8/585 , A61B2562/0204 , A61B2562/046 , A61N7/02 , A61N2007/0078 , A61N2007/0095 , G01H5/00 , G06F19/00
摘要： A medical apparatus (400) comprising an ultrasound transmitter (444, 602) and receiver (446, 604) system (600) for acquiring ultrasound data (476) descriptive of the speed of ultrasound (304, 306) along at least two paths (606, 1114). The medical apparatus further comprises a medical imaging system (402) for acquiring medical image data (468) and a memory (464) containing instructions (490, 492, 494, 496, 498, 500, 502, 504) that causes the processor to acquire (100, 200) the medical image data. The instructions further cause the processor to acquire (102, 202) the ultrasound data. The instructions further cause the processor to segment (104, 204) the medical image data into at least two tissue types (434, 436, 610, 612, 708, 710). The instructions further causes the processor to determine (106, 206) at least two distances corresponding to the at least two paths in the subject. The instructions further cause the processor to calculate (108, 208) the speed of ultrasound in the at least two tissue types.
摘要翻译：一种包括超声波发射器（444,602）和接收器（446,604）系统（600）的医疗设备（400），该系统（600）用于采集描述沿着至少两条路径的超声波（304,306）的速度的超声波数据（476） 606，1114）。医疗设备还包括用于获取医学图像数据（468）的医疗成像系统（402）和包含指令（490,492,494,496,498,500,2005,504）的存储器（464），所述指令使处理器获取（100,200）医学图像数据。该指令还使处理器获取超声数据（102,202）。指令还使处理器将医学图像数据（104,204）分割为至少两种组织类型（434,436,610,612,708,710）。指令还使得处理器确定（106,206）与被摄体中的至少两条路径相对应的至少两个距离。该指令还使得处理器在至少两种组织类型中计算（108,208）超声波的速度。

3. 发明授权

US09669240B2 Therapy system for depositing energy 有权
公开(公告)号：US09669240B2
公开(公告)日：2017-06-06
申请号：US13061985
申请日：2009-09-04
申请人： Max Oskar Köhler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
发明人： Max Oskar Köhler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
IPC分类号： A61N7/02 , A61B18/14 , A61B18/18 , A61B17/00 , A61B90/00
CPC分类号： A61N7/02 , A61B18/14 , A61B18/18 , A61B2017/00084 , A61B2017/00194 , A61B2018/183 , A61B2090/374
摘要： A therapy system includes a therapy module to perform successive deposits of energy in a target zone. The therapy system further includes a control module configured to, prior to deposits of energy, produce an a priori estimate of the induced heating. A thermometry module is configured to measure temperature in a measurement field. The induced heating may be derived based on a tissue model from the settings of a therapy module. The therapy module includes a high-intensity focused ultrasound transmitter. A magnetic resonance examination system configured for thermometry is employed as the thermometry module.

4. 发明授权

US08496587B2 Therapy system for depositing energy 有权
标题翻译：放电能量治疗系统
公开(公告)号：US08496587B2
公开(公告)日：2013-07-30
申请号：US13061566
申请日：2009-09-03
申请人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
发明人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B18/18 , A61B2017/00084 , A61B2090/374
摘要： A therapy system includes a therapy module, e.g., a high-intensity-focused ultrasound transmitter, to perform successive deposits of energy in a target zone. The successive deposits being separated by a cool down period. The therapy system further includes a thermometry module, e.g. by a magnetic resonance examination system, configured for thermometry to measure temperature in a measurement field. A control module regulates the cool down period in dependence of the measured off-focus maximum temperature during the energy deposit preceding the cool down period.
摘要翻译：治疗系统包括治疗模块，例如高强度聚焦超声波发射器，以在目标区域中执行能量的连续沉积。连续的沉积物被冷却时间隔开。治疗系统还包括温度测量模块，例如，通过磁共振检查系统，被配置为用于在测量场中测量温度的温度测量。控制模块根据在冷却时段之前的能量存储期间测量的离焦最大温度来调节冷却时间。

5. 发明授权

US08867811B2 MR imaging guided therapy 有权
标题翻译： MR成像指导治疗
公开(公告)号：US08867811B2
公开(公告)日：2014-10-21
申请号：US13321557
申请日：2010-05-27
申请人： Balasundara Raju , Ajay Anand , Gosta Jakob Ehnholm
发明人： Balasundara Raju , Ajay Anand , Gosta Jakob Ehnholm
IPC分类号： G06K9/00 , A61B6/00 , A61N7/02 , A61B17/00 , A61B19/00
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2090/374
摘要： A therapeutic system, comprising: a MR imaging unit arranged to acquire MR signals from a patient in an examination volume, and a thermal treatment unit for depositing thermal energy within tissue of the patient. The system is arranged for: initiating a thermal treatment by heating the tissue at a focus within the examination volume selectively acquiring MR signals from a first image plane, including the focus, reconstructing a thermographic MR image from the MR signals acquired from the first image plane, computing a baseline thermographic MR image from a temperature distribution within at least one second image plane, moving the focus to a new position within the examination volume, changing the position and/or orientation of the first image plane corresponding to the new position of the focus, repeating the acquiring and reconstructing steps, wherein the baseline thermographic MR image is used for thermographic image reconstruction in a subsequent reconstructing step.
摘要翻译：一种治疗系统，包括：MR成像单元，其布置成在检查体积中从患者获取MR信号;以及热治疗单元，用于在患者的组织内沉积热能。该系统被布置为：通过在检查体积内的焦点处加热组织来开始热处理，其选择性地从包括焦点的第一图像平面获取MR信号，从从第一图像平面获取的MR信号重构热成像MR图像从至少一个第二图像平面内的温度分布计算基线热成像MR图像，将焦点移动到检查体积内的新位置，改变对应于第一图像的新位置的第一图像平面的位置和/或取向聚焦，重复获取和重建步骤，其中基线热成像MR图像用于随后重建步骤中的热成像图像重建。

6. 发明申请

US20120172708A1 MR IMAGING GUIDED THERAPHY 有权
标题翻译：成像指南
公开(公告)号：US20120172708A1
公开(公告)日：2012-07-05
申请号：US13321238
申请日：2010-06-02
申请人： Ajay Anand , Gosta Jakob Ehnholm , Balasundara Iyyavu Raju
发明人： Ajay Anand , Gosta Jakob Ehnholm , Balasundara Iyyavu Raju
IPC分类号： A61N7/00 , A61B8/00 , A61B5/055
CPC分类号： A61N7/02 , A61B8/5223 , A61B2017/00084 , A61B2090/374 , A61B2090/378 , A61N2007/0008 , A61N2007/0078
摘要： The invention relates to a therapeutic system which comprises an ultrasound therapy unit (1, 518) arranged to insonify at least a portion of a body (2, 508) of a patient with high intensity ultrasound and a MR imaging unit (3, 500) arranged to acquire MR signals from the portion of the body (2, 508) and to reconstruct a thermographic MR image from the MR signals. It is an object of the invention to enable MR guided high intensity focused ultrasound (HIFU) treatment, in which temperature values within critical anatomic regions containing fat can be monitored. The invention proposes that the therapeutic system further comprises an ultrasound diagnostic unit (5, 518) which is arranged to acquire ultrasound signals from the portion of the body (2, 508) and to derive at least one local temperature value from the ultrasound signals.
摘要翻译：本发明涉及一种包括超声治疗单元（1,518）的治疗系统，所述超声治疗单元布置成使具有高强度超声的患者的身体（2,508）的至少一部分和MR成像单元（3,5500）布置成从身体（2,508）的部分获取MR信号，并且从MR信号重构热成像MR图像。本发明的一个目的是实现MR引导的高强度聚焦超声（HIFU）治疗，其中可以监测含有脂肪的关键解剖区域内的温度值。本发明提出，治疗系统还包括超声诊断单元（5,518），其被布置成从身体的部分（2,508）获取超声信号，并且从超声信号导出至少一个局部温度值。

7. 发明申请

US20110152730A1 THERAPY SYSTEM FOR DEPOSITING ENERGY 有权
标题翻译：用于放电能量的治疗系统
公开(公告)号：US20110152730A1
公开(公告)日：2011-06-23
申请号：US13061566
申请日：2009-09-03
申请人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
发明人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B18/18 , A61B2017/00084 , A61B2090/374
摘要： A therapy system comprising a therapy module, e.g. a high-intensity- focused ultrasound transmitter, to perform successive deposits of energy in a target zone, the successive deposits being separated by a cool down period. The therapy system being provided with a thermometry module, e.g. by a magnetic resonance examination system configured for thermometry to measure temperature in a measurement field. A control module regulates the cool down period in dependence of the measured off-focus maximum temperature during the energy deposit preceding the cool down period.
摘要翻译：一种治疗系统，包括治疗模块，例如，高强度聚焦超声波发射器，以在目标区域中执行能量的连续沉积，所述连续的沉积物被冷却时段隔开。治疗系统设置有温度测量模块，例如。通过配置用于在测量场中测量温度的温度测量的磁共振检查系统。控制模块根据在冷却时段之前的能量存储期间测量的离焦最大温度来调节冷却时间。

8. 发明授权

US07777490B2 RF antenna with integrated electronics 有权
标题翻译：集成电路的射频天线
公开(公告)号：US07777490B2
公开(公告)日：2010-08-17
申请号：US12089053
申请日：2006-10-10
申请人： Paulus Cornelius Hendrikus Adrianus Haans , Marc Paul Saes , Gosta Jakob Ehnholm
发明人： Paulus Cornelius Hendrikus Adrianus Haans , Marc Paul Saes , Gosta Jakob Ehnholm
IPC分类号： G01V3/00
CPC分类号： G01R33/54 , G01R33/3621 , G01R33/3692
摘要： A radio frequency antenna comprising a resonant pickup circuit (102) arranged to pick up a magnetic resonance signal, an analog-to-digital converter (105) arranged to convert the magnetic resonance signal to digital data, and a frequency converter arranged to convert a primary band of frequencies of the digital data. By upshifting the frequency of the transmitted bit-stream, it is possible to RF-trap the transmission channel (109) by simple high-pass filtering techniques. In case the transmitted bit pattern has frequency components that approach the resonance frequency, an encoding technique like Manchester encoding can be used to eliminate unwanted signals.
摘要翻译：一种射频天线，包括布置成拾取磁共振信号的谐振拾取电路（102），被配置为将磁共振信号转换为数字数据的模数转换器（105），以及频率转换器，数字数据的主频带。通过升高发送的比特流的频率，可以通过简单的高通滤波技术对传输信道（109）进行RF捕获。在发送的位模式具有接近谐振频率的频率分量的情况下，可以使用诸如曼彻斯特编码的编码技术来消除不需要的信号。

9. 发明申请

US20090121717A1 RF ANTENNA WITH INTEGRATED ELECTRONICS 有权
标题翻译：射频天线与集成电子
公开(公告)号：US20090121717A1
公开(公告)日：2009-05-14
申请号：US12089053
申请日：2006-10-10
申请人： Paulus Cornelius Hendrikus Adrianus Haans , Marc Paul Saes , Gosta Jakob Ehnholm
发明人： Paulus Cornelius Hendrikus Adrianus Haans , Marc Paul Saes , Gosta Jakob Ehnholm
IPC分类号： G01R33/48 , G01R33/36
CPC分类号： G01R33/54 , G01R33/3621 , G01R33/3692
摘要： A radio frequency antenna comprising a resonant pickup circuit (102) arranged to pick up a magnetic resonance signal, an analog-to-digital converter (105) arranged to convert the magnetic resonance signal to digital data, and a frequency converter arranged to convert a primary band of frequencies of the digital data. By upshifting the frequency of the transmitted bit-stream, it is possible to RF-trap the transmission channel (109) by simple high-pass filtering techniques. In case the transmitted bit pattern has frequency components that approach the resonance frequency, an encoding technique like Manchester encoding can be used to eliminate unwanted signals.
摘要翻译：一种射频天线，包括布置成拾取磁共振信号的谐振拾取电路（102），被配置为将磁共振信号转换为数字数据的模数转换器（105），以及频率转换器，数字数据的主频带。通过升高发送的比特流的频率，可以通过简单的高通滤波技术对传输信道（109）进行RF捕获。在发送的位模式具有接近谐振频率的频率分量的情况下，可以使用诸如曼彻斯特编码的编码技术来消除不需要的信号。

10. 发明授权

US10058717B2 High intensity focused ultrasound transducer optimization 有权
公开(公告)号：US10058717B2
公开(公告)日：2018-08-28
申请号：US13515519
申请日：2010-12-07
申请人： Emil G. Radulescu , Gosta Jakob Ehnholm , Ramon Q. Erkamp , I. A. Julius Koskela , Shunmugavelu D. Sokka , Erkki T. Vahala , Max Oskar Kohler
发明人： Emil G. Radulescu , Gosta Jakob Ehnholm , Ramon Q. Erkamp , I. A. Julius Koskela , Shunmugavelu D. Sokka , Erkki T. Vahala , Max Oskar Kohler
IPC分类号： A61N7/02 , G06F17/10 , A61B5/055 , A61N7/00 , A61B34/10 , A61B90/00
CPC分类号： A61N7/02 , A61B2034/104 , A61B2034/105 , A61B2090/374 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095
摘要： When planning magnetic resonance (MR) guided high intensity focused ultrasonic (HIFU) therapy, HIFU transducer element parameters are optimized as a function of 3D MR data describing a size, shape, and position of a region of interest (ROI) (146) and any obstructions (144) between the HIFU transducer elements and the ROI (146). Transducer element phases and amplitudes are adjusted to maximize HIFU radiation delivery to the ROI (146) while minimizing delivery to the obstruction (144). Additionally or alternatively, transducer elements are selectively deactivated if the obstruction (144) is positioned between the ROI (146) and a given transducer element.

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