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1. 发明授权

US6159166A Sensor and method for sensing arterial pulse pressure 失效
标题翻译：用于感测动脉脉压的传感器和方法
公开(公告)号：US6159166A
公开(公告)日：2000-12-12
申请号：US45018
申请日：1998-03-20
申请人： Charles F. Chesney , Dennis J. Morgan , Eugene A. O'Rourke , Michael T. Riggs , Fred Randall Thornton
发明人： Charles F. Chesney , Dennis J. Morgan , Eugene A. O'Rourke , Michael T. Riggs , Fred Randall Thornton
IPC分类号： A61B5/021 , A61B7/00 , A61B7/04 , A61B5/02
CPC分类号： A61B7/00 , A61B5/021 , A61B5/02108 , A61B7/045
摘要： A method and a pulse pressure sensor for sensing an arterial pulse pressure waveform. In one embodiment, the pulse pressure sensor includes a housing, a diaphragm, a piezoelectric device, and a self-contained amplifier. The skin-contact diaphragm is attached across a recess or opening in the housing. The piezoelectric device has a first portion mounted in a fixed relationship to the housing and a second portion displacementally coupled to the diaphragm. The solid-state amplifier has a signal input coupled to the piezoelectric device, wherein the piezoelectric device and amplifier together have a frequency response at least including a range from below approximately 0.1 hertz to above approximately 250 hertz. In one such embodiment, the housing and the skin-contact diaphragm of the sensor are stainless steel. In one such embodiment, the diaphragm has a skin-contact surface with a skin-contact dimension of between approximately 0.4 inch and 0.6 inch. In one embodiment, the sensor includes a solid-state amplifier that includes a high-input-impedance MOSFET input stage having an input resistance high enough to provide a frequency response that extends below approximately 0.1 hertz.
摘要翻译：一种用于感测动脉脉压波形的方法和脉搏压力传感器。在一个实施例中，脉冲压力传感器包括外壳，隔膜，压电装置和独立放大器。皮肤接触隔膜穿过外壳中的凹槽或开口。压电装置具有以与壳体成固定关系的方式安装的第一部分和与隔膜成一体的第二部分。固态放大器具有耦合到压电器件的信号输入，其中压电器件和放大器一起具有频率响应，至少包括从低于约0.1赫兹到大约250赫兹的范围。在一个这样的实施例中，传感器的外壳和皮肤接触隔膜是不锈钢。在一个这样的实施例中，隔膜具有皮肤接触表面，皮肤接触尺寸在大约0.4英寸和0.6英寸之间。在一个实施例中，传感器包括固态放大器，其包括高输入阻抗MOSFET输入级，其具有足够高的输入电阻以提供延伸到大约0.1赫兹以下的频率响应。

2. 发明授权

US6132383A Apparatus for holding and positioning an arterial pulse pressure sensor 失效
标题翻译：用于保持和定位动脉脉压传感器的装置
公开(公告)号：US6132383A
公开(公告)日：2000-10-17
申请号：US45449
申请日：1998-03-20
申请人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
发明人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
IPC分类号： A61B5/022 , A61B5/02
CPC分类号： A61B5/411 , A61B5/022 , A61B5/6824
摘要： A sensor holding and positioning device. In one embodiment, the device includes a sensor base having two feet, the base forming a raised bridge between the two feet. The bridge has one or more cross members spanning all or part of the space between the two feet. A sensor suspension including a sensor holder and sensor-height-adjustment mechanism is coupled by a pivot-arm axle to the sensor base, such that the sensor suspension is able to rotate in an arc about the long axis of the axle. In one such embodiment, the device further includes a pressure sensor attached to the sensor holder of the sensor suspension. In another such embodiment, the sensor suspension is able to slide back and forth along a line parallel to the long axis of the axle. Another aspect is for positioning the sensor over the radial artery, for example in a human's wrist. Yet another aspect is a pulse-waveform acquisition system. In one embodiment, such a system includes a wrist stabilizer, the stabilizer comprising a first member shaped on a forearm portion to conform to contours of a forearm, shaped on a wrist portion to contours of a wrist, and shaped on a hand portion to the contours of a hand, and forming an angle of approximately 150 degrees between the forearm portion and the hand portion, the stabilizer further including straps for holding the forearm and hand to the stabilizer.
摘要翻译：传感器保持定位装置。在一个实施例中，该装置包括具有两个脚的传感器基座，该基座在两个脚之间形成升高的桥。桥梁具有跨越两脚之间的全部或部分空间的一个或多个横梁。包括传感器保持器和传感器高度调节机构的传感器悬架通过枢转臂轴耦合到传感器基座，使得传感器悬架能够围绕轴的长轴线旋转。在一个这样的实施例中，该装置还包括附接到传感器悬架的传感器保持器的压力传感器。在另一个这样的实施例中，传感器悬架能够沿着与轴的长轴平行的线来回滑动。另一方面是将传感器定位在桡动脉上，例如在人的手腕上。另一方面是脉冲波形采集系统。在一个实施例中，这种系统包括腕部稳定器，该稳定器包括形成在前臂部分上的第一构件，以与前臂成形的轮廓线形成手腕部分的轮廓，并在手部形成手的轮廓，并且在前臂部分和手部分之间形成大约150度的角度，所述稳定器还包括用于将前臂和手保持在稳定器上的带子。

3. 发明授权

US06544188B1 Apparatus and method for holding and positioning an arterial pulse pressure sensor 失效
标题翻译：用于保持和定位动脉脉压传感器的装置和方法
公开(公告)号：US06544188B1
公开(公告)日：2003-04-08
申请号：US09383783
申请日：1999-08-26
申请人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
发明人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
IPC分类号： A61B504
CPC分类号： A61B5/411 , A61B5/022 , A61B5/6824
摘要： A method and a sensor holding and positioning device. In one embodiment, the device includes a sensor base having two feet, the base forming a raised bridge between the two feet. The bridge has one or more cross members spanning all or part of the space between the two feet. A sensor suspension including a sensor holder and sensor-height-adjustment mechanism is coupled by a pivot-arm axle to the sensor base, such that the sensor suspension is able to rotate in an arc about the long axis of the axle. In one such embodiment, the device further includes a pressure sensor attached to the sensor holder of the sensor suspension. In another such embodiment, the sensor suspension is able to slide back and forth along a line parallel to the long axis of the axle. Another aspect is a method for positioning a sensor over the radial artery, for example in a human's wrist. Yet another aspect is a pulse-waveform acquisition system. In one embodiment, such a system includes a wrist stabilizer, the stabilizer comprising a first member shaped on a forearm portion to conform to contours of a forearm, shaped on a wrist portion to contours of a wrist, and shaped on a hand portion to the contours of a hand, and forming an angle of approximately 150 degrees between the forearm portion and the hand portion, the stabilizer further including straps for holding the forearm and hand to the stabilizer.
摘要翻译：一种方法和传感器保持定位装置。在一个实施例中，该装置包括具有两个脚的传感器基座，该基座在两个脚之间形成升高的桥。桥梁具有跨越两脚之间的全部或部分空间的一个或多个横梁。包括传感器保持器和传感器高度调节机构的传感器悬架通过枢转臂轴耦合到传感器基座，使得传感器悬架能够围绕轴的长轴线旋转。在一个这样的实施例中，该装置还包括附接到传感器悬架的传感器保持器的压力传感器。在另一个这样的实施例中，传感器悬架能够沿着与轴的长轴平行的线来回滑动。另一方面是用于将传感器定位在桡动脉上的方法，例如在人的手腕中。另一方面是脉冲波形采集系统。在一个实施例中，这种系统包括腕部稳定器，该稳定器包括形成在前臂部分上的第一构件，以与前臂成形的轮廓线形成手腕部分的轮廓，并在手部形成手的轮廓，并且在前臂部分和手部分之间形成大约150度的角度，所述稳定器还包括用于将前臂和手保持在稳定器上的带子。

4. 发明授权

US09186081B2 System and method for diagnosing arrhythmias and directing catheter therapies 有权
标题翻译：用于诊断心律失常并引导导管治疗的系统和方法
公开(公告)号：US09186081B2
公开(公告)日：2015-11-17
申请号：US13977147
申请日：2011-12-20
申请人： Valtino X. Afonso , Jiazheng Shi , Steven J. Kim , D. Curtis Deno , Dennis J. Morgan
发明人： Valtino X. Afonso , Jiazheng Shi , Steven J. Kim , D. Curtis Deno , Dennis J. Morgan
IPC分类号： A61B5/042 , A61B5/044 , A61B5/06 , A61B5/00 , A61B5/053 , A61B18/14 , A61B19/00 , A61B18/00
CPC分类号： A61B5/0422 , A61B5/0044 , A61B5/04017 , A61B5/044 , A61B5/0452 , A61B5/0538 , A61B5/065 , A61B5/066 , A61B5/068 , A61B5/4836 , A61B5/6852 , A61B5/6855 , A61B18/1492 , A61B34/20 , A61B34/25 , A61B2018/00577 , A61B2018/00839 , A61B2562/043 , A61B2576/023
摘要： An efficient system for diagnosing arrhythmias and directing catheter therapies may allow for measuring, classifying, analyzing, and mapping spatial electrophysiological (EP) patterns within a body. The efficient system may further guide arrhythmia therapy and update maps as treatment is delivered. The efficient system may use a medical device having a high density of sensors with a known spatial configuration for collecting EP data and positioning data. Further, the efficient system may also use an electronic control system (ECU) for computing and providing the user with a variety of metrics, derivative metrics, high definition (HD) maps, HD composite maps, and general visual aids for association with a geometrical anatomical model shown on a display device.
摘要翻译：用于诊断心律失常和引导导管治疗的有效系统可以允许测量，分类，分析和映射身体内的空间电生理（EP）模式。有效的系统可以进一步指导心律失常治疗并且随着治疗的进行更新地图。有效的系统可以使用具有已知空间配置的高密度传感器的医疗装置来收集EP数据和定位数据。此外，有效系统还可以使用电子控制系统（ECU）来计算并向用户提供各种度量，导数度量，高清（HD）地图，高清复合地图和用于与几何学解剖模型显示在显示设备上。

5. 发明授权

US06689069B2 Apparatus and method for blood pressure pulse waveform contour analysis 失效
标题翻译：血压脉搏波形轮廓分析装置及方法
公开(公告)号：US06689069B2
公开(公告)日：2004-02-10
申请号：US10157551
申请日：2002-05-28
申请人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
发明人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
IPC分类号： A61B502
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/7239 , A61B7/00 , A61B7/045 , G06F19/00
摘要： Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the ‘A’ parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.
摘要翻译：本文公开了用于处理动脉血压波形以提取关于心血管系统的状态的临床有用信息的方法和装置。为了获得修改的Windkessel模型的参数，选择受试者的血压波形的舒张部分在多个范围上扫描，并且选择产生数据最佳拟合的范围和最低误差估计。此外，使用多个经验确定的“A”参数的起始值来找到模型数据与实际动脉血压波形数据的最佳拟合。

6. 发明授权

US5151225A Flame retardant composition and method for treating wood 失效
标题翻译：阻燃剂组合物及其处理方法
公开(公告)号：US5151225A
公开(公告)日：1992-09-29
申请号：US588278
申请日：1990-09-26
申请人： James F. Herndon , Dennis J. Morgan
发明人： James F. Herndon , Dennis J. Morgan
IPC分类号： B27K3/02 , B27K3/16 , B27K3/52 , B27K5/00 , C09K21/12
CPC分类号： C09K21/12 , C09D15/00 , C09D5/18 , B27K2240/30 , B27K3/163 , B27K3/166 , B27K3/34 , B27K3/52
摘要： A flame retardant composition and associated method for treating wood and other cellulosic materials is disclosed. The composition, in its preferred embodiment, represents and aqueous solution containing a water soluble amide; an oxy-acid of phosphorous; a metal salt of boron; an oxy-acid of boron and sodium hydroxide and has a pH of about 4.75 to about 5.25.
摘要翻译：公开了一种用于处理木材和其它纤维素材料的阻燃组合物和相关方法。在其优选实施方案中，组合物代表含有水溶性酰胺的水溶液; 磷酸的氧酸; 硼的金属盐; 硼和氢氧化钠的氧酸，并且具有约4.75至约5.25的pH。

7. 发明申请

US20120165658A1 SYSTEM, ARTICLE OF MANUFACTURE, AND METHOD FOR CHARACTERIZING A MEDICAL DEVICE AND/OR ONE OR MORE SENSORS MOUNTED THEREON 审中-公开
标题翻译：系统，制造品和用于表征医疗装置和/或一个或更多传感器的方法
公开(公告)号：US20120165658A1
公开(公告)日：2012-06-28
申请号：US12979663
申请日：2010-12-28
申请人： Jiazheng Shi , Valtino X. Afonso , Dennis J. Morgan , Jeffrey A. Schweitzer
发明人： Jiazheng Shi , Valtino X. Afonso , Dennis J. Morgan , Jeffrey A. Schweitzer
IPC分类号： A61B5/05
CPC分类号： A61B5/6852 , A61B5/06
摘要： Systems and methods for characterizing a medical device and/or the sensors thereof are provided. A system comprises an electronic control unit (ECU) configured to acquire first and second configurations of the device. The ECU is configured to process the configurations to calculate an index used to characterize the device and/or the sensors thereof. An article of manufacture comprises a computer-readable storage medium having a computer program encoded thereon for characterizing the device and/or the sensor thereof. The program includes code for acquiring first and second configurations of the device, and processing them together to calculate an index used to characterize the device and/or the sensors thereof. A method for characterizing the device and/or the sensors thereof comprises providing an ECU, acquiring, by the ECU, first and second configurations of the device, and processing them together to calculate an index used to characterize the device and/or the sensors thereof.
摘要翻译：提供了用于表征医疗装置和/或其传感器的系统和方法。系统包括被配置为获取设备的第一和第二配置的电子控制单元（ECU）。 ECU被配置为处理配置以计算用于表征设备和/或其传感器的索引。一种制品包括其上编码有用于表征该装置和/或其传感器的计算机程序的计算机可读存储介质。该程序包括用于获取设备的第一和第二配置的代码，并将它们一起处理以计算用于表征设备和/或其传感器的索引。用于表征设备和/或其传感器的方法包括提供ECU，由ECU获取设备的第一和第二配置，并一起处理它们，以计算用于表征设备和/或其传感器的索引。

8. 发明授权

US06394958B1 Apparatus and method for blood pressure pulse waveform contour analysis 有权
标题翻译：血压脉搏波形轮廓分析装置及方法
公开(公告)号：US06394958B1
公开(公告)日：2002-05-28
申请号：US09434077
申请日：1999-11-05
申请人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
发明人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
IPC分类号： A61B502
CPC分类号： A61B5/021 , A61B5/02108 , A61B5/7239 , A61B7/00 , A61B7/045 , G06F19/00
摘要： Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the ‘A’ parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.
摘要翻译：本文公开了用于处理动脉血压波形以提取关于心血管系统的状态的临床有用信息的方法和装置。为了获得修改的Windkessel模型的参数，选择受试者的血压波形的舒张部分在多个范围上扫描，并且选择产生数据最佳拟合的范围和最低误差估计。此外，使用“A”参数的多个经验确定的起始值来找到模型数据与实际动脉血压波形数据的最佳拟合。

9. 发明授权

US6017313A Apparatus and method for blood pressure pulse waveform contour analysis 失效
标题翻译：血压脉搏波形轮廓分析装置及方法
公开(公告)号：US6017313A
公开(公告)日：2000-01-25
申请号：US45420
申请日：1998-03-20
申请人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
发明人： Christopher W. Bratteli , Jay N. Cohn , Stanley M. Finkelstein , Dennis J. Morgan
IPC分类号： A61B5/021 , A61B7/00 , A61B7/04 , A61N5/00
CPC分类号： A61B5/021 , A61B5/02108 , A61B7/00 , A61B7/045 , A61B5/7239
摘要： Methods and apparatus for processing an arterial blood pressure waveform to extract clinically useful information on the state of the cardiovascular system are disclosed herein. In order to obtain the parameters of the modified Windkessel model, the diastolic portion of a subject's blood pressure waveform is scanned over a plurality of ranges and the range that produces the best fit of data and lowest error estimates are selected. In addition, multiple empirically determined starting values of the `A` parameters are used to find the best fit of the model data to the actual arterial blood pressure waveform data.
摘要翻译：本文公开了用于处理动脉血压波形以提取关于心血管系统的状态的临床有用信息的方法和装置。为了获得修改的Windkessel模型的参数，选择受试者的血压波形的舒张部分在多个范围上扫描，并且选择产生数据最佳拟合的范围和最低误差估计。此外，使用多个经验确定的“A”参数的起始值来找到模型数据与实际动脉血压波形数据的最佳拟合。

10. 发明申请

US20130274582A1 System and Method for Diagnosing Arrhythmias and Directing Catheter Therapies 有权
标题翻译：用于诊断心律失常和导向导管治疗的系统和方法
公开(公告)号：US20130274582A1
公开(公告)日：2013-10-17
申请号：US13977147
申请日：2011-12-20
申请人： Valtino X. Afonso , Jiazheng Shi , Steven J. Kim , D. Curtis Deno , Dennis J. Morgan
发明人： Valtino X. Afonso , Jiazheng Shi , Steven J. Kim , D. Curtis Deno , Dennis J. Morgan
IPC分类号： A61B5/042 , A61B5/06 , A61B5/044 , A61B5/00
CPC分类号： A61B5/0422 , A61B5/0044 , A61B5/04017 , A61B5/044 , A61B5/0452 , A61B5/0538 , A61B5/065 , A61B5/066 , A61B5/068 , A61B5/4836 , A61B5/6852 , A61B5/6855 , A61B18/1492 , A61B34/20 , A61B34/25 , A61B2018/00577 , A61B2018/00839 , A61B2562/043 , A61B2576/023
摘要： An efficient system for diagnosing arrhythmias and directing catheter therapies may allow for measuring, classifying, analyzing, and mapping spatial electrophysiological (EP) patterns within a body. The efficient system may further guide arrhythmia therapy and update maps as treatment is delivered. The efficient system may use a medical device having a high density of sensors with a known spatial configuration for collecting EP data and positioning data. Further, the efficient system may also use an electronic control system (ECU) for computing and providing the user with a variety of metrics, derivative metrics, high definition (HD) maps, HD composite maps, and general visual aids for association with a geometrical anatomical model shown on a display device.
摘要翻译：用于诊断心律失常和引导导管治疗的有效系统可以允许测量，分类，分析和映射身体内的空间电生理（EP）模式。有效的系统可以进一步指导心律失常治疗并且随着治疗的进行更新地图。有效的系统可以使用具有已知空间配置的高密度传感器的医疗装置来收集EP数据和定位数据。此外，有效系统还可以使用电子控制系统（ECU）来计算并向用户提供各种度量，导数度量，高清（HD）地图，高清复合地图和用于与几何学解剖模型显示在显示设备上。

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