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1. 发明申请

US20120165658A1 SYSTEM, ARTICLE OF MANUFACTURE, AND METHOD FOR CHARACTERIZING A MEDICAL DEVICE AND/OR ONE OR MORE SENSORS MOUNTED THEREON 审中-公开
标题翻译：系统，制造品和用于表征医疗装置和/或一个或更多传感器的方法
公开(公告)号：US20120165658A1
公开(公告)日：2012-06-28
申请号：US12979663
申请日：2010-12-28
申请人： Jiazheng Shi , Valtino X. Afonso , Dennis J. Morgan , Jeffrey A. Schweitzer
发明人： Jiazheng Shi , Valtino X. Afonso , Dennis J. Morgan , Jeffrey A. Schweitzer
IPC分类号： A61B5/05
CPC分类号： A61B5/6852 , A61B5/06
摘要： Systems and methods for characterizing a medical device and/or the sensors thereof are provided. A system comprises an electronic control unit (ECU) configured to acquire first and second configurations of the device. The ECU is configured to process the configurations to calculate an index used to characterize the device and/or the sensors thereof. An article of manufacture comprises a computer-readable storage medium having a computer program encoded thereon for characterizing the device and/or the sensor thereof. The program includes code for acquiring first and second configurations of the device, and processing them together to calculate an index used to characterize the device and/or the sensors thereof. A method for characterizing the device and/or the sensors thereof comprises providing an ECU, acquiring, by the ECU, first and second configurations of the device, and processing them together to calculate an index used to characterize the device and/or the sensors thereof.
摘要翻译：提供了用于表征医疗装置和/或其传感器的系统和方法。系统包括被配置为获取设备的第一和第二配置的电子控制单元（ECU）。 ECU被配置为处理配置以计算用于表征设备和/或其传感器的索引。一种制品包括其上编码有用于表征该装置和/或其传感器的计算机程序的计算机可读存储介质。该程序包括用于获取设备的第一和第二配置的代码，并将它们一起处理以计算用于表征设备和/或其传感器的索引。用于表征设备和/或其传感器的方法包括提供ECU，由ECU获取设备的第一和第二配置，并一起处理它们，以计算用于表征设备和/或其传感器的索引。

2. 发明授权

US09186081B2 System and method for diagnosing arrhythmias and directing catheter therapies 有权
标题翻译：用于诊断心律失常并引导导管治疗的系统和方法
公开(公告)号：US09186081B2
公开(公告)日：2015-11-17
申请号：US13977147
申请日：2011-12-20
申请人： Valtino X. Afonso , Jiazheng Shi , Steven J. Kim , D. Curtis Deno , Dennis J. Morgan
发明人： Valtino X. Afonso , Jiazheng Shi , Steven J. Kim , D. Curtis Deno , Dennis J. Morgan
IPC分类号： A61B5/042 , A61B5/044 , A61B5/06 , A61B5/00 , A61B5/053 , A61B18/14 , A61B19/00 , A61B18/00
CPC分类号： A61B5/0422 , A61B5/0044 , A61B5/04017 , A61B5/044 , A61B5/0452 , A61B5/0538 , A61B5/065 , A61B5/066 , A61B5/068 , A61B5/4836 , A61B5/6852 , A61B5/6855 , A61B18/1492 , A61B34/20 , A61B34/25 , A61B2018/00577 , A61B2018/00839 , A61B2562/043 , A61B2576/023
摘要： An efficient system for diagnosing arrhythmias and directing catheter therapies may allow for measuring, classifying, analyzing, and mapping spatial electrophysiological (EP) patterns within a body. The efficient system may further guide arrhythmia therapy and update maps as treatment is delivered. The efficient system may use a medical device having a high density of sensors with a known spatial configuration for collecting EP data and positioning data. Further, the efficient system may also use an electronic control system (ECU) for computing and providing the user with a variety of metrics, derivative metrics, high definition (HD) maps, HD composite maps, and general visual aids for association with a geometrical anatomical model shown on a display device.
摘要翻译：用于诊断心律失常和引导导管治疗的有效系统可以允许测量，分类，分析和映射身体内的空间电生理（EP）模式。有效的系统可以进一步指导心律失常治疗并且随着治疗的进行更新地图。有效的系统可以使用具有已知空间配置的高密度传感器的医疗装置来收集EP数据和定位数据。此外，有效系统还可以使用电子控制系统（ECU）来计算并向用户提供各种度量，导数度量，高清（HD）地图，高清复合地图和用于与几何学解剖模型显示在显示设备上。

3. 发明申请

US20130274582A1 System and Method for Diagnosing Arrhythmias and Directing Catheter Therapies 有权
标题翻译：用于诊断心律失常和导向导管治疗的系统和方法
公开(公告)号：US20130274582A1
公开(公告)日：2013-10-17
申请号：US13977147
申请日：2011-12-20
申请人： Valtino X. Afonso , Jiazheng Shi , Steven J. Kim , D. Curtis Deno , Dennis J. Morgan
发明人： Valtino X. Afonso , Jiazheng Shi , Steven J. Kim , D. Curtis Deno , Dennis J. Morgan
IPC分类号： A61B5/042 , A61B5/06 , A61B5/044 , A61B5/00
CPC分类号： A61B5/0422 , A61B5/0044 , A61B5/04017 , A61B5/044 , A61B5/0452 , A61B5/0538 , A61B5/065 , A61B5/066 , A61B5/068 , A61B5/4836 , A61B5/6852 , A61B5/6855 , A61B18/1492 , A61B34/20 , A61B34/25 , A61B2018/00577 , A61B2018/00839 , A61B2562/043 , A61B2576/023
摘要： An efficient system for diagnosing arrhythmias and directing catheter therapies may allow for measuring, classifying, analyzing, and mapping spatial electrophysiological (EP) patterns within a body. The efficient system may further guide arrhythmia therapy and update maps as treatment is delivered. The efficient system may use a medical device having a high density of sensors with a known spatial configuration for collecting EP data and positioning data. Further, the efficient system may also use an electronic control system (ECU) for computing and providing the user with a variety of metrics, derivative metrics, high definition (HD) maps, HD composite maps, and general visual aids for association with a geometrical anatomical model shown on a display device.
摘要翻译：用于诊断心律失常和引导导管治疗的有效系统可以允许测量，分类，分析和映射身体内的空间电生理（EP）模式。有效的系统可以进一步指导心律失常治疗并且随着治疗的进行更新地图。有效的系统可以使用具有已知空间配置的高密度传感器的医疗装置来收集EP数据和定位数据。此外，有效系统还可以使用电子控制系统（ECU）来计算并向用户提供各种度量，导数度量，高清（HD）地图，高清复合地图和用于与几何学解剖模型显示在显示设备上。

4. 发明授权

US08038625B2 System and method for three-dimensional mapping of electrophysiology information 有权
标题翻译：电生理信息三维映射的系统和方法
公开(公告)号：US08038625B2
公开(公告)日：2011-10-18
申请号：US11227006
申请日：2005-09-15
申请人： Valtino X. Afonso , Kedar Ravindra Belhe , Jeffrey A. Schweitzer
发明人： Valtino X. Afonso , Kedar Ravindra Belhe , Jeffrey A. Schweitzer
IPC分类号： A61B5/02 , A61B5/05
CPC分类号： A61B5/0422 , A61B5/04012 , A61B5/044 , A61B5/0452
摘要： An electrophysiology apparatus is used to measure electrical activity occurring in a heart of a patient and to visualize the electrical activity and/or information related to the electrical activity. A three-dimensional map of the electrical activity and/or the information related to the electrical activity is created. Exemplary maps include a time difference between action potentials at a roving electrode and a reference electrode, the peak-to-peak timing of action potentials at the roving electrode, the peak negative voltage of action potentials at the roving electrode, complex fractionated electrogram information, a dominant frequency of an electrogram signal, a maximum peak amplitude at the dominant frequency, a ratio of energy in one band of the frequency-domain to the energy in a second band of the frequency-domain, a low-frequency or high-frequency passband of interest, a frequency with the maximum energy in a passband, a number of peaks within a passband, an energy, power, and/or area in each peak, a ratio of energy and/or area in each peak to that in another passband, and a width of each peak in a spectrum. Colors, shades of colors, and/or grayscales are assigned to values of the parameters and colors corresponding to the parameters for the electrograms sampled by the electrodes are updated on the three-dimensional model.
摘要翻译：电生理学装置用于测量在患者心脏中发生的电活动并且可视化与电活动有关的电活动和/或信息。创建电活动的三维图和/或与电活动相关的信息。示例性地图包括粗纱电极上的动作电位和参考电极之间的时间差，粗纱动作电位的峰 - 峰定时，粗纱动作电位的峰值负电压，复分数电描记图信息，电描记信号的主要频率，主频率的最大峰值幅度，频域的一个频带中的能量与频域的第二频带中的能量的比率，低频或高频通带的通带，通带中的最大能量的频率，通带内的峰值数，每个峰中的能量，功率和/或面积，每个峰中的能量和/或面积与另一峰中的峰的比率通带和频谱中每个峰的宽度。将颜色，色调和/或灰度等级分配给参数的值，并且对应于由电极采集的电描记图的参数对应的颜色在三维模型上更新。

5. 发明申请

US20120029504A1 SYSTEM AND METHOD FOR PRESENTING INFORMATION REPRESENTATIVE OF LESION FORMATION IN TISSUE DURING AN ABLATION PROCEDURE 有权
标题翻译：系统和方法，用于在消除程序期间呈现组织中的组织形成信息表示
公开(公告)号：US20120029504A1
公开(公告)日：2012-02-02
申请号：US12964910
申请日：2010-12-10
申请人： Valtino X. Afonso , Lubomir V. Dragnev , Sarah E. Cumming , Yitzhak I. Shai , Saurav Paul
发明人： Valtino X. Afonso , Lubomir V. Dragnev , Sarah E. Cumming , Yitzhak I. Shai , Saurav Paul
IPC分类号： A61B18/14 , A61B18/12
CPC分类号： A61B18/1492 , A61B5/0402 , A61B5/042 , A61B5/7203 , A61B18/1233 , A61B18/14 , A61B18/24 , A61B34/25 , A61B2017/00128 , A61B2017/00199 , A61B2018/00178 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00648 , A61B2018/00702 , A61B2018/00714 , A61B2018/00738 , A61B2018/00779 , A61B2018/00875 , A61B2018/00892 , A61B2018/0212 , A61B2018/0262 , A61B2034/104 , A61B2034/2046 , A61B2034/2051 , A61B2034/2072 , A61B2034/301 , A61B2090/065 , A61B2218/002 , A61N7/022
摘要： A method and system for presenting information representative of lesion formation is provided. The system comprises an electronic control unit (ECU). The ECU is configured to acquire a value for an ablation description parameter and/or a position signal metric, wherein the value corresponds to a location in the tissue. The ECU is further configured to evaluate the value, assign it a visual indicator of a visualization scheme associated with the parameter/metric corresponding to the value, and generate a marker comprising the visual indicator such that the marker is indicative of the acquired value. The method comprises acquiring a value for the parameter/metric, and evaluating the value. The method further includes assigning a visual indicator of a visualization scheme associated with the parameter/metric corresponding to the value, and generating a marker comprising the visual indicator.
摘要翻译：提供了表示病变形成信息的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取消融描述参数和/或位置信号度量的值，其中该值对应于组织中的位置。 ECU还被配置为评估该值，为其分配与该值对应的参数/度量相关联的可视化方案的视觉指示符，并且生成包括视觉指示符的标记，使得该标记指示所获取的值。该方法包括获取参数/度量的值并评估该值。该方法还包括分配与该值对应的参数/度量相关联的可视化方案的视觉指示符，以及生成包括视觉指示符的标记。

6. 发明授权

US09095264B2 Method and system for identifying cardiac arrhythmia driver sites 有权
标题翻译：识别心律失常司机场所的方法和系统
公开(公告)号：US09095264B2
公开(公告)日：2015-08-04
申请号：US13678764
申请日：2012-11-16
申请人： Kyungmoo Ryu , Valtino X. Afonso
发明人： Kyungmoo Ryu , Valtino X. Afonso
IPC分类号： A61B5/044 , A61B5/0452 , A61B5/046 , A61N1/362
CPC分类号： A61B5/0452 , A61B5/046 , A61N1/3624
摘要： A method of identifying potential driver sites for cardiac arrhythmias includes acquiring a plurality of electrograms from a plurality of locations on at least a portion of a patient's heart. Using the acquired electrograms, at least one electrical activity map is generated. Desirable electrical activity maps include complex fractionated electrogram standard deviation and mean maps, dominant frequency maps, peak-to-peak voltage maps, and activation sequence maps. Using one or more of these maps (e.g., by analyzing one or more electrogram morphological characteristics represented by these maps), at least one potential driver site can be detected.
摘要翻译：识别用于心律失常的潜在驾驶员位置的方法包括从患者心脏的至少一部分上的多个位置获取多个电描记图。使用所获取的电描记图，生成至少一个电活动图。期望的电活动图包括复杂的分级电描记图标准偏差和平均图，主要频率图，峰 - 峰电压图和激活序列图。使用这些图中的一个或多个（例如，通过分析由这些图表示的一个或多个电描记图形态特征），可以检测至少一个潜在的驾驶员位置。

7. 发明申请

US20120089038A1 Method and system for identifying cardiac arrhythmia driver sites 有权
标题翻译：识别心律失常司机场所的方法和系统
公开(公告)号：US20120089038A1
公开(公告)日：2012-04-12
申请号：US12923769
申请日：2010-10-07
申请人： Kyungmoo Ryu , Valtino X. Afonso
发明人： Kyungmoo Ryu , Valtino X. Afonso
IPC分类号： A61B5/0452 , A61N1/365
CPC分类号： A61B5/0452 , A61B5/046 , A61N1/3624
摘要： A method of identifying potential driver sites for cardiac arrhythmias includes acquiring a plurality of electrograms from a plurality of locations on at least a portion of a patient's heart. Using the acquired electrograms, at least one electrical activity map is generated. Desirable electrical activity maps include complex fractionated electrogram standard deviation and mean maps, dominant frequency maps, peak-to-peak voltage maps, and activation sequence maps. Using one or more of these maps (e.g., by analyzing one or more electrogram morphological characteristics represented by these maps), at least one potential driver site can be detected.
摘要翻译：识别用于心律失常的潜在驾驶员位置的方法包括从患者心脏的至少一部分上的多个位置获取多个电描记图。使用所获取的电描记图，生成至少一个电活动图。期望的电活动图包括复杂的分级电描记图标准偏差和平均图，主要频率图，峰 - 峰电压图和激活序列图。使用这些图中的一个或多个（例如，通过分析由这些图表示的一个或多个电描记图形态特征），可以检测至少一个潜在的驾驶员位置。

8. 发明授权

US09204927B2 System and method for presenting information representative of lesion formation in tissue during an ablation procedure 有权
标题翻译：用于在消融过程中呈现代表组织中病变形成的信息的系统和方法
公开(公告)号：US09204927B2
公开(公告)日：2015-12-08
申请号：US12964910
申请日：2010-12-10
申请人： Valtino X. Afonso , Lubomir V. Dragnev , Yitzhak I. Shai , Saurav Paul
发明人： Valtino X. Afonso , Lubomir V. Dragnev , Sarah E. Cumming , Yitzhak I. Shai , Saurav Paul
IPC分类号： A61B18/10 , A61B18/14 , A61B5/0402 , A61B5/042 , A61B18/12 , A61B18/24 , A61B19/00 , A61B17/00 , A61B18/00 , A61B18/02 , A61N7/02 , A61B5/00
CPC分类号： A61B18/1492 , A61B5/0402 , A61B5/042 , A61B5/7203 , A61B18/1233 , A61B18/14 , A61B18/24 , A61B34/25 , A61B2017/00128 , A61B2017/00199 , A61B2018/00178 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00648 , A61B2018/00702 , A61B2018/00714 , A61B2018/00738 , A61B2018/00779 , A61B2018/00875 , A61B2018/00892 , A61B2018/0212 , A61B2018/0262 , A61B2034/104 , A61B2034/2046 , A61B2034/2051 , A61B2034/2072 , A61B2034/301 , A61B2090/065 , A61B2218/002 , A61N7/022
摘要： A method and system for presenting information representative of lesion formation is provided. The system comprises an electronic control unit (ECU). The ECU is configured to acquire a value for an ablation description parameter and/or a position signal metric, wherein the value corresponds to a location in the tissue. The ECU is further configured to evaluate the value, assign it a visual indicator of a visualization scheme associated with the parameter/metric corresponding to the value, and generate a marker comprising the visual indicator such that the marker is indicative of the acquired value. The method comprises acquiring a value for the parameter/metric, and evaluating the value. The method further includes assigning a visual indicator of a visualization scheme associated with the parameter/metric corresponding to the value, and generating a marker comprising the visual indicator.
摘要翻译：提供了表示病变形成信息的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取消融描述参数和/或位置信号度量的值，其中该值对应于组织中的位置。 ECU还被配置为评估该值，为其分配与该值对应的参数/度量相关联的可视化方案的视觉指示符，并且生成包括视觉指示符的标记，使得该标记指示所获取的值。该方法包括获取参数/度量的值并评估该值。该方法还包括分配与该值对应的参数/度量相关联的可视化方案的视觉指示符，以及生成包括视觉指示符的标记。

9. 发明授权

US08340766B2 Method and system for identifying cardiac arrhythmia driver sites 有权
公开(公告)号：US08340766B2
公开(公告)日：2012-12-25
申请号：US12923769
申请日：2010-10-07
申请人： Kyungmoo Ryu , Valtino X. Afonso
发明人： Kyungmoo Ryu , Valtino X. Afonso
IPC分类号： A61N1/365
CPC分类号： A61B5/0452 , A61B5/046 , A61N1/3624
摘要： A method of identifying potential driver sites for cardiac arrhythmias includes acquiring a plurality of electrograms from a plurality of locations on at least a portion of a patient's heart. Using the acquired electrograms, at least one electrical activity map is generated. Desirable electrical activity maps include complex fractionated electrogram standard deviation and mean maps, dominant frequency maps, peak-to-peak voltage maps, and activation sequence maps. Using one or more of these maps (e.g., by analyzing one or more electrogram morphological characteristics represented by these maps), at least one potential driver site can be detected.

10. 发明申请

US20110144657A1 SYSTEMS AND METHODS FOR DETERMINING THE LIKELIHOOD OF ENDOCARDIAL BAROTRAUMA IN TISSUE DURING ABLATION 有权
标题翻译：系统和方法，用于确定髋关节置换术中组织内BAROTRAUMA
公开(公告)号：US20110144657A1
公开(公告)日：2011-06-16
申请号：US12964956
申请日：2010-12-10
申请人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Rohan Lathia , Harry A. Puryear , Valtino X. Afonso , Saurav Paul
发明人： Jeffrey M. Fish , Israel A. Byrd , Lynn E. Clark , Jeremy D. Dando , Christopher J. Geurkink , Rohan Lathia , Harry A. Puryear , Valtino X. Afonso , Saurav Paul
IPC分类号： A61B19/00 , A61B5/053
CPC分类号： A61B18/1492 , A61B5/036 , A61B5/0538 , A61B2017/00026 , A61B2017/00119 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875 , A61B2034/105 , A61B2034/2051 , A61B2034/2053 , A61B2034/301 , A61B2090/372
摘要： A method and system for determining a likelihood of barotrauma occurring in tissue during the formation of a lesion therein is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire at least one value of at least one component of a complex impedance between an electrode and the tissue. The ECU is further configured to calculate an index responsive to the at least one value of the at least one complex impedance component. The index is indicative of a likelihood of barotrauma occurring in the tissue. The method comprises acquiring at least one value of at least one component of a complex impedance between an electrode and the tissue. The method further comprises calculating an index responsive to the at least one value of the at least one complex impedance component. The calculating index is indicative of a likelihood of barotrauma occurring in the tissue.
摘要翻译：提供了一种用于确定在其中形成病变期间在组织中发生的气压伤的可能性的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取电极和组织之间的复阻抗的至少一个分量的至少一个值。 ECU还被配置为响应于至少一个复阻抗分量的至少一个值来计算索引。该指数表示在组织中发生气压伤的可能性。该方法包括获取电极和组织之间的复阻抗的至少一个分量的至少一个值。该方法还包括响应于至少一个复阻抗分量的至少一个值来计算索引。计算指标表示在组织中发生气压伤的可能性。

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