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1. 发明授权

US09566583B2 Thermal uniformity for thermal cycler instrumentation using dynamic control 有权
标题翻译：热循环仪器的热均匀性采用动态控制
公开(公告)号：US09566583B2
公开(公告)日：2017-02-14
申请号：US13082888
申请日：2011-04-08
申请人： Thomas Conner , Chee Kiong Lim , Michael Pallas , Chee Wee Ching
发明人： Thomas Conner , Chee Kiong Lim , Michael Pallas , Chee Wee Ching
IPC分类号： C12Q3/00 , C12M1/40 , B01L7/00
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/1822 , B01L2300/1894
摘要： A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.
摘要翻译：提供了一种用于提高热不均匀性的聚合酶链反应（PCR）的方法。该方法包括通过第一传感器测量样品块的第一样品块扇区的第一温度，并通过第二传感器测量与第一样品块相邻的样品块的第二样品块扇区的第二温度样品块部门。该方法还包括通过热电控制器计算第一温度和第二温度之间的温度差，并且由热电控制器通过使用一个或多个温度控制器来调节基于温差的第一样品块扇区的第一温度更多热电冷却器。一个或多个热电冷却器被配置为通过调节从热电控制器输出的功率来加热或冷却第一样品块扇区。

2. 发明申请

US20060001955A1 Methods, software, and apparatus for focusing an optical system using computer image analysis 失效
标题翻译：使用计算机图像分析聚焦光学系统的方法，软件和装置
公开(公告)号：US20060001955A1
公开(公告)日：2006-01-05
申请号：US10881868
申请日：2004-06-30
申请人： Patrick Kinney , Howard King , Michael Pallas , Mark Naley
发明人： Patrick Kinney , Howard King , Michael Pallas , Mark Naley
IPC分类号： G02B21/26
CPC分类号： G02B21/244 , G02B7/38
摘要： Methods, software, and apparatus for focusing an image in biological instrument are disclosed. Focusing elements are moved to various focus positions within a focus element travel range, and sample images are captured at the various focus positions. The sample images are resolved into subregions and an optimal focus position is determined based on the image intensity statistical dispersions within the identified subregions.
摘要翻译：公开了用于将图像聚焦在生物仪器中的方法，软件和装置。将聚焦元件移动到聚焦元件行进范围内的各个焦点位置，并且在各个焦点位置捕获采样图像。样本图像被分解成次区域，并且基于所识别的子区域内的图像强度统计分散来确定最佳焦点位置。

3. 发明授权

US09322055B2 System and method for determining copies-per-unit-volume using PCR and flow control of droplets 有权
标题翻译：使用PCR和液滴的流量控制来确定每单位体积份数的系统和方法
公开(公告)号：US09322055B2
公开(公告)日：2016-04-26
申请号：US14009304
申请日：2012-03-30
申请人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
发明人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/158 , C12Q2600/178 , G01N21/6486 , C12Q2537/16 , C12Q2563/143 , C12Q2563/159 , C12Q2565/626
摘要： Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample. Estimating the number of copies-per-unit-volume is based on the number of discrete processed sample portions determined to contain the at least one target nucleic acid therein.
摘要翻译：提供了用于定量样品中靶核酸的方法和系统。该方法包括形成多个离散的样本部分。多个离散样品部分中的每一个包含样品的一部分和反应混合物。该方法还包括放大多个离散样本部分以形成多个离散处理的样本部分。至少一个离散加工的样品部分含有核酸扩增反应产物。从所述多个离散处理样品部分中的至少一个检测荧光信号以确定所述至少一种靶核酸的存在。该方法还包括确定多个多个离散处理的样本部分的相应体积，以及估计样品中至少一个靶核酸的每单位体积的拷贝数。估计每单位体积的拷贝数是基于确定为在其中含有至少一种靶核酸的离散加工样品部分的数量。

4. 发明申请

US20110275055A1 THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL 有权
标题翻译：使用动态控制的热循环仪器的热均匀性
公开(公告)号：US20110275055A1
公开(公告)日：2011-11-10
申请号：US13082888
申请日：2011-04-08
申请人： Thomas CONNER , Chee Kiong Lim , Michael Pallas , Chee Wee Ching
发明人： Thomas CONNER , Chee Kiong Lim , Michael Pallas , Chee Wee Ching
IPC分类号： C12Q3/00 , C12M1/40
CPC分类号： B01L7/52 , B01L2200/147 , B01L2300/1822 , B01L2300/1894
摘要： A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.
摘要翻译：提供了一种用于提高热不均匀性的聚合酶链反应（PCR）的方法。该方法包括通过第一传感器测量样品块的第一样品块扇区的第一温度，并通过第二传感器测量与第一样品块相邻的样品块的第二样品块扇区的第二温度样品块部门。该方法还包括通过热电控制器计算第一温度和第二温度之间的温度差，并且由热电控制器通过使用一个或多个温度控制器来调节基于温差的第一样品块扇区的第一温度更多热电冷却器。一个或多个热电冷却器被配置为通过调节从热电控制器输出的功率来加热或冷却第一样品块扇区。

5. 发明申请

US20060051876A1 System and apparatus for sequential processing of analytes 有权
公开(公告)号：US20060051876A1
公开(公告)日：2006-03-09
申请号：US11207443
申请日：2005-08-18
申请人： John Bridgham , Kevin Corcoran , George Golda , Michael Pallas , Sydney Brenner
发明人： John Bridgham , Kevin Corcoran , George Golda , Michael Pallas , Sydney Brenner
IPC分类号： G01N33/50
CPC分类号： G01N21/253 , B01J2219/00274 , B01L3/5027 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2200/10 , B01L2300/0877 , B01L2400/0403 , B01L2400/0475 , B01L2400/0622 , B01L2400/0644 , G01N2015/144 , G01N2015/1452 , G01N2035/00158 , Y10S435/81 , Y10T436/13 , Y10T436/143333
摘要： An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside of a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.

6. 发明申请

US20140248623A1 System and Method for Determining Copies-per-Unit-Volume Using PCR and Flow Control of Droplets 有权
标题翻译：使用PCR和流量控制液滴确定每单位体积份数的系统和方法
公开(公告)号：US20140248623A1
公开(公告)日：2014-09-04
申请号：US14009304
申请日：2012-03-30
申请人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
发明人： Gordon A. Janaway , Mark Andersen , Kornelija Zgonc , Michael Pallas , Marcin Sikora , Casey McFarland , Ferrier N. Le , Haopeng Wang , Jian Gong , Gothami Padmabandu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/158 , C12Q2600/178 , G01N21/6486 , C12Q2537/16 , C12Q2563/143 , C12Q2563/159 , C12Q2565/626
摘要： Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample. Estimating the number of copies-per-unit-volume is based on the number of discrete processed sample portions determined to contain the at least one target nucleic acid therein.
摘要翻译：提供了用于定量样品中靶核酸的方法和系统。该方法包括形成多个离散的样本部分。多个离散样品部分中的每一个包含样品的一部分和反应混合物。该方法还包括放大多个离散样本部分以形成多个离散处理的样本部分。至少一个离散加工的样品部分含有核酸扩增反应产物。从所述多个离散处理样品部分中的至少一个检测荧光信号以确定所述至少一种靶核酸的存在。该方法还包括确定多个多个离散处理的样本部分的相应体积，以及估计样品中至少一个靶核酸的每单位体积的拷贝数。估计每单位体积的拷贝数是基于确定为在其中含有至少一种靶核酸的离散加工样品部分的数量。

7. 发明申请

US20130054988A1 INTEGRATED CIRCUIT DEVICE, SIGNAL PROCESSING SYSTEM AND METHOD FOR MANAGING POWER RESOURCES OF A SIGNAL PROCESSING SYSTEM 审中-公开
标题翻译：集成电路装置，信号处理系统及信号处理系统功率资源管理方法
公开(公告)号：US20130054988A1
公开(公告)日：2013-02-28
申请号：US13643358
申请日：2010-05-18
申请人： Vladimir Litovtchenko , Frank Donner , Michael Pallas
发明人： Vladimir Litovtchenko , Frank Donner , Michael Pallas
IPC分类号： G06F1/26
CPC分类号： G06F1/3203
摘要： An integrated circuit device comprises a power resource management module for managing at least one power resource of a signal processing system. The power resource management module comprises an input for receiving an indication of an intended state change for the signal processing system. The power resource management module is arranged to calculate at least one power resource load prediction for implementing the indicated system state change in response to receiving the indication of an intended state change. The power resource management module comprises an output connectable to the at least one power resource of the signal processing system for configuring the at least one power resource to fulfill the at least one power resource load prediction.
摘要翻译：集成电路装置包括用于管理信号处理系统的至少一个电力资源的电力资源管理模块。电力资源管理模块包括用于接收信号处理系统的预期状态改变的指示的输入。功率资源管理模块被布置成响应于接收到预期状态改变的指示而计算用于实现所指示的系统状态改变的至少一个功率资源负载预测。电力资源管理模块包括可连接到信号处理系统的至少一个电力资源的输出，用于配置至少一个电力资源以实现至少一个电力资源负荷预测。

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