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1. 发明授权

US07838036B2 Method and apparatus for isolating and purifying nucleic acid using a single surface 有权
公开(公告)号：US07838036B2
公开(公告)日：2010-11-23
申请号：US12716695
申请日：2010-03-03
申请人： Chang-eun Yoo , Sung-young Jeong , Young-rok Kim
发明人： Chang-eun Yoo , Sung-young Jeong , Young-rok Kim
IPC分类号： A61K9/14 , A61K9/16 , C12Q1/68 , C07H21/04 , C12Q1/70
CPC分类号： B01J20/28009 , B01D15/1807 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , C08F20/02 , C08F26/06 , C12N1/066 , C12N13/00
摘要： Provided is a method of isolating nucleic acid from cells using a single surface, wherein a compound represented by Formula 1 is bound to the surface. Also provided are an apparatus for isolation of nucleic acids, and a bead for isolating nucleic acids.

2. 发明授权

US07718371B2 Method and apparatus for isolating and purifying nucleic acid using a single surface 有权
标题翻译：使用单个表面分离和纯化核酸的方法和设备
公开(公告)号：US07718371B2
公开(公告)日：2010-05-18
申请号：US11693259
申请日：2007-03-29
申请人： Chang eun Yoo , Sung-young Jeong , Young-rok Kim
发明人： Chang eun Yoo , Sung-young Jeong , Young-rok Kim
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/53 , C07H21/04 , B01L3/00 , G01N15/06 , A61K9/14
CPC分类号： B01J20/28009 , B01D15/1807 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , C08F20/02 , C08F26/06 , C12N1/066 , C12N13/00
摘要： Provided is a method of isolating nucleic acid from cells using a single surface, wherein a compound represented by Formula 1 is bound to the surface. Also provided are an apparatus for isolation of nucleic acids, and a bead for isolating nucleic acids.
摘要翻译：提供了使用单个表面从细胞中分离核酸的方法，其中由式1表示的化合物结合到表面。还提供了用于分离核酸的装置和用于分离核酸的珠粒。

3. 发明授权

US07989197B2 Microfluidic device including a microchannel with a hydrophobic porous polymer bonded to walls thereof and to a magnetic bead, and methods of making and using the device 有权
标题翻译：微流体装置包括具有与其壁连接的疏水多孔聚合物的微通道和磁珠，以及制造和使用该装置的方法
公开(公告)号：US07989197B2
公开(公告)日：2011-08-02
申请号：US11675840
申请日：2007-02-16
申请人： Chang-eun Yoo , Jong-myeon Park , Sung-young Jeong
发明人： Chang-eun Yoo , Jong-myeon Park , Sung-young Jeong
IPC分类号： C12M1/34
CPC分类号： C12M47/06 , B01L3/502761 , B01L7/52 , B01L2200/0631 , B01L2200/0668 , B01L2200/10 , B01L2300/069 , B01L2300/087 , B01L2300/165 , B01L2300/18 , B01L2400/043 , C12M23/16
摘要： This invention provides a microfluidic device comprising an inlet and an outlet which are connected with each other through a microchannel, wherein a polymerized hydrophobic porous polymer is bonded to magnetic beads and to the walls of the microchannel. The invention is further directed to methods of making and using the microfluidic device.
摘要翻译：本发明提供了一种微流体装置，其包括通过微通道彼此连接的入口和出口，其中聚合的疏水性多孔聚合物结合到磁珠和微通道的壁上。本发明进一步涉及制造和使用微流体装置的方法。

4. 发明授权

US07402390B2 Method of isolating nucleic acid using material positively charged at first pH and containing amino group and carboxyl group 有权
标题翻译：使用在第一个pH下带正电并含有氨基和羧基的物质分离核酸的方法
公开(公告)号：US07402390B2
公开(公告)日：2008-07-22
申请号：US11317949
申请日：2005-12-23
申请人： Kyu-youn Hwang , Joon-ho Kim , Chang-eun Yoo , Hun-joo Lee , Hee-kyun Lim , Sung-young Jeong , Jeo-young Shim
发明人： Kyu-youn Hwang , Joon-ho Kim , Chang-eun Yoo , Hun-joo Lee , Hee-kyun Lim , Sung-young Jeong , Jeo-young Shim
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/00
CPC分类号： C12N15/1006 , B01D15/361 , B01D15/364 , B01J20/3285 , B01J43/00 , C12Q1/6806 , C12Q2527/119 , C12Q2523/308
摘要： A method of isolating nucleic acid from a sample containing nucleic acid is provided. The method includes contacting the sample with a bifunctional material that contains an amino group and a carboxyl group and is positively charged at a first pH to allow binding of the nucleic acid to the bifunctional material; and extracting the nucleic acid at a second pH higher than the first pH from the complex.
摘要翻译：提供了从含有核酸的样品中分离核酸的方法。该方法包括使样品与含有氨基和羧基的双官能材料接触并在第一pH下带正电荷以允许核酸与双功能材料的结合; 以及从所述络合物中提取比所述第一pH高的第二pH的所述核酸。

5. 发明申请

US20060154284A1 Method of isolating nucleic acid using material positively charged at first pH and containing amino group and carboxyl group 有权
标题翻译：使用在第一个pH下带正电并含有氨基和羧基的物质分离核酸的方法
公开(公告)号：US20060154284A1
公开(公告)日：2006-07-13
申请号：US11317949
申请日：2005-12-23
申请人： Kyu-youn Hwang , Joon-ho Kim , Chang-eun Yoo , Hun-joo Lee , Hee-kyun Lim , Sung-young Jeong , Jeo-young Shim
发明人： Kyu-youn Hwang , Joon-ho Kim , Chang-eun Yoo , Hun-joo Lee , Hee-kyun Lim , Sung-young Jeong , Jeo-young Shim
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12N15/1006 , B01D15/361 , B01D15/364 , B01J20/3285 , B01J43/00 , C12Q1/6806 , C12Q2527/119 , C12Q2523/308
摘要： A method of isolating nucleic acid from a sample containing nucleic acid is provided. The method includes contacting the sample with a bifunctional material that contains an amino group and a carboxyl group and is positively charged at a first pH to allow binding of the nucleic acid to the bifunctional material; and extracting the nucleic acid at a second pH higher than the first pH from the complex.
摘要翻译：提供了从含有核酸的样品中分离核酸的方法。该方法包括使样品与含有氨基和羧基的双官能材料接触并在第一pH下带正电荷以允许核酸与双功能材料的结合; 以及从所述络合物中提取比所述第一pH高的第二pH的所述核酸。

6. 发明授权

US07858042B2 Microfluidic chip and method of fabricating the same 有权
标题翻译：微流控芯片及其制造方法
公开(公告)号：US07858042B2
公开(公告)日：2010-12-28
申请号：US11934811
申请日：2007-11-05
申请人： Kyu-youn Hwang , Joon-ho Kim , Chin-sung Park , Sung-young Jeong
发明人： Kyu-youn Hwang , Joon-ho Kim , Chin-sung Park , Sung-young Jeong
IPC分类号： B01N3/00
CPC分类号： B01L3/502707 , B01L3/502753 , B01L2200/12 , B01L2300/16 , Y10T428/14
摘要： Provided are a microfluidic chip and a method of fabricating the same. The microfluidic chip includes: a lower substrate; an upper substrate formed of a silicone resin, wherein the lower substrate and the upper substrate, bonded together, provide a channel through which a fluid can flow and a chamber to receive the fluid; and an organic thin film formed on the upper surface of the lower substrate except for portions on which the lower substrate and the upper substrate are attached to each other.
摘要翻译：提供了一种微流控芯片及其制造方法。微流体芯片包括：下基板; 由硅树脂形成的上基板，其中所述下基板和所述上基板接合在一起，提供流体可以流过的通道和容纳所述流体的室; 以及形成在下基板的上表面上的有机薄膜，除了下基板和上基板彼此附接的部分之外。

7. 发明授权

US07837943B2 Device and method for pre-treating and injecting liquid specimen 有权
标题翻译：预处理和注射液体样品的装置和方法
公开(公告)号：US07837943B2
公开(公告)日：2010-11-23
申请号：US11484068
申请日：2006-07-11
申请人： Sung-young Jeong , Hun-joo Lee
发明人： Sung-young Jeong , Hun-joo Lee
IPC分类号： A61M5/19 , A61M5/315
CPC分类号： G01N1/14 , G01N1/405
摘要： A device for pre-treating and injecting a liquid specimen includes a first syringe including an open top first tube including a first hole in the bottom and protrusions, a second syringe including an open top second tube including a second hole in the bottom and an inner diameter greater than an outer diameter of the first tube, a second piston movable along an inner wall of the second tube and including a third hole and a communication channel providing fluid communication between the first hole and the third hole, and a joint portion attachable to and detachable from a top of the second tube and including an opening corresponding to a transverse cross-section of the first tube and grooves corresponding to the shape of the protrusions such that the first tube passes through the joint portion when the protrusions are matched with the grooves.
摘要翻译：一种用于预处理和注射液体试样的装置包括：第一注射器，其包括开口顶部第一管，其包括底部中的第一孔和突起;第二注射器，其包括开口顶部第二管，其包括底部中的第二孔，直径大于第一管的外径，第二活塞可沿着第二管的内壁移动并且包括第三孔和提供第一孔和第三孔之间的流体连通的连通通道，以及连接部分，其可附接到并且可从第二管的顶部拆卸并且包括对应于第一管的横截面的开口和对应于突起的形状的槽，使得当突起与第二管匹配时，第一管穿过接合部凹槽

8. 发明申请

US20110129481A1 Antibody specifically binding to c-Met and methods of use 有权
标题翻译：抗体特异性结合c-Met和使用方法
公开(公告)号：US20110129481A1
公开(公告)日：2011-06-02
申请号：US12807191
申请日：2010-08-30
申请人： Kwang Ho Cheong , Sung-young Jeong , Sang-hyun Paek
发明人： Kwang Ho Cheong , Sung-young Jeong , Sang-hyun Paek
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/12 , G01N33/53 , A61P35/00 , C12N5/10 , C12N1/19
CPC分类号： G01N33/57407 , C07K16/2863 , C07K2317/33 , G01N33/57492
摘要： Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.
摘要翻译：本文公开了与c-Met蛋白，杂交瘤细胞系以及包含抗体的组合特异性结合的抗体。还公开了制备和使用抗体和组合物的方法。

9. 发明授权

US07919278B2 Method of amplifying nucleic acid from a cell using a nonplanar solid substrate 有权
标题翻译：使用非平面固体底物从细胞中扩增核酸的方法
公开(公告)号：US07919278B2
公开(公告)日：2011-04-05
申请号：US11841107
申请日：2007-08-20
申请人： Sung-young Jeong , Kyu-youn Hwang , Joon-ho Kim , Jung-im Han , Hun-joo Lee
发明人： Sung-young Jeong , Kyu-youn Hwang , Joon-ho Kim , Jung-im Han , Hun-joo Lee
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12N15/1006 , B01L7/52 , B01L2300/0636 , C12N2533/30 , C12Q1/6806
摘要： Provided is a method of amplifying nucleic acid from a comprising: contacting a cell-containing sample with a nonplanar solid substrate in a liquid medium having a pH range of 3.0-6.0 to attach the cell to the solid substrate; washing the nonplanar solid substrate to remove materials that are not attached thereto; and performing PCR using the nucleic acid from the cell attached to the nonplanar solid substrate as a template sample to amplify nucleic acid from the cell, wherein the contacting, washing and PCR processes are performed in a single vessel.
摘要翻译：本发明提供一种扩增来自a的核酸的方法，其特征在于：在pH范围为3.0-6.0的液体介质中使含细胞的样品与非平面固体基质接触，以将该细胞附着在固体基质上; 洗涤非平面固体基质以除去未附着于其上的材料; 以及使用来自附着在所述非平面固体底物上的细胞的核酸作为模板样品进行PCR以扩增来自所述细胞的核酸，其中所述接触，洗涤和PCR过程在单个容器中进行。

10. 发明授权

US07851151B2 HNF-1α gene including novel single-nucleotide polymorphism, protein encoded by the HNF-1α gene, and polynucleotide, microarray, kit, and method for diagnosis of MODY3 失效
标题翻译： HNF-1α基因包括新型单核苷酸多态性，HNF-1α基因编码的蛋白质，多核苷酸，微阵列，试剂盒和MODY3诊断方法
公开(公告)号：US07851151B2
公开(公告)日：2010-12-14
申请号：US11049806
申请日：2005-02-03
申请人： Sung-young Jeong , Jin-soon Hwang
发明人： Sung-young Jeong , Jin-soon Hwang
IPC分类号： C07H21/04 , C12Q1/68 , C12M1/34
CPC分类号： C07H21/04 , C07K14/4702 , C12Q1/6883 , C12Q2600/156
摘要： Provided are a HNF-1 α gene including a novel single-nucleotide polymorphism and a protein encoded by the HNF-1 α gene, a polynucleotide associated with MODY3 diabetes based on the HNF-1 α gene, a microarray and a diagnostic kit including the polynucleotide, and a method for diagnosis of MODY3 diabetes.
摘要翻译：提供了HNF-1α基因，其包括新颖的单核苷酸多态性和由HNF-1α基因编码的蛋白质，与基于HNF-1α基因的MODY3糖尿病相关的多核苷酸，微阵列和诊断试剂盒，包括多核苷酸，以及MODY3糖尿病诊断方法。

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