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1. 发明授权

US06994827B2 Parallel semicontinuous or continuous reactors 有权
公开(公告)号：US06994827B2
公开(公告)日：2006-02-07
申请号：US09873176
申请日：2001-06-01
申请人： Adam Safir , Ralph Nielsen , Thomas H. McWaid , Richard Tiede , Lynn Van Erden
发明人： Adam Safir , Ralph Nielsen , Thomas H. McWaid , Richard Tiede , Lynn Van Erden
IPC分类号： G01N33/00 , B01N3/02 , B01N3/00 , B01J10/00 , B32B27/04
CPC分类号： B01F7/167 , B01F7/00258 , B01F7/00266 , B01F7/00291 , B01F7/00416 , B01F7/00575 , B01F15/00207 , B01F2215/0037 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00335 , B01J2219/00337 , B01J2219/00342 , B01J2219/00353 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00689 , B01J2219/00698 , B01J2219/00722 , C40B40/14 , C40B60/14 , G01N35/1079
摘要： Parallel semi-continuous or continuous reactors are disclosed. The parallel reactors preferably comprise four or more reaction vessels. The reaction vessels are preferably small volume reaction vessels, preferably pressure reaction vessels, and/or preferably integral with a common reactor block. The reaction vessels can comprise shaft-driven stirrers. At least two, preferably at least three or at least four liquid feed lines can provide selective fluid communication between each of the reaction vessels and one or more liquid reagent sources. Additional features, suitable in connection with parallel reactors or with single reaction vessels are also disclosed.

2. 发明授权

US07041257B2 Microfabricated two-pin liquid sample dispensing system 有权
公开(公告)号：US07041257B2
公开(公告)日：2006-05-09
申请号：US10027171
申请日：2001-12-21
申请人： John Gilbert , John Harley
发明人： John Gilbert , John Harley
IPC分类号： B01L3/02 , B01N3/00 , G01N15/06 , G01N1/10 , G01N1/04
CPC分类号： B01L3/0244 , B01L3/0248 , B01L2200/143 , B01L2200/147 , B01L2400/0439 , G01N2035/1037 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： A two-pin liquid sample dispensing system is provided. The two-pin dispensing system comprises a pair of separately movable pins for holding a droplet of liquid therebetween. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The pins acquire and hold a droplet of the liquid sample in the sample acquisition region formed in the space between the tips and apply the droplet to a selected sample handing system. The distance between the tips is variable to accommodate different liquid samples having varying physical properties and to vary the volume of the acquired droplet.

3. 发明授权

US07892843B2 Nickel crucible for melting analytical sample, method of preparing analytical sample and method of analysis 有权
标题翻译：用于熔化分析样品的镍坩埚，制备分析样品的方法和分析方法
公开(公告)号：US07892843B2
公开(公告)日：2011-02-22
申请号：US12278889
申请日：2007-02-15
申请人： Masahiro Sakaguchi , Mitsuru Yamaguchi , Tomio Takahashi , Kouichi Takemoto
发明人： Masahiro Sakaguchi , Mitsuru Yamaguchi , Tomio Takahashi , Kouichi Takemoto
IPC分类号： G01N33/20 , B01N3/00 , G01N1/22
CPC分类号： G01N1/44 , B01L3/04 , B01L2300/12 , Y10T436/25875
摘要： A nickel crucible used for melting an analytical sample in the pretreatment of the analytical sample, characterized in that the purity of the nickel crucible is 99.9999 wt % or higher. Also provided is a method of analysis, comprising melting a sample by the use of the nickel crucible for melting having a purity of 99.9999 wt % or higher, and analyzing the melt to thereby obtain an analytical result in which the respective lower limits of determination of Mn, Al, Si, Mg, Pb, Fe, Co, Ti, Cu, Cr, Zr, Mo, and W are Mn: 5 wtppm, Al: 10 wtppm, Si: 10 wtppm, Mg: 5 wtppm, Pb: 5 wtppm, Fe: 5 wtppm, Co: 5 wtppm, Ti: 20 wtppm, Cu: 20 wtppm, Cr: 10 wtppm, Zr: 5 wtppm, Mo: 2 wtppm, and W: 10 wtppm. In light of the recent analytical technology demanded of fast and accurate measurement of high purity materials, high purity analysis is attained through inhibition of mixing of impurities from the crucible.
摘要翻译：用于在分析样品的预处理中熔化分析样品的镍坩埚，其特征在于，所述镍坩埚的纯度为99.9999重量％以上。还提供了一种分析方法，包括通过使用纯度为99.9999重量％以上的熔融用镍坩埚来熔解样品，分析熔融物，得到分析结果，其中， Mn，Al，Si，Mg，Pb，Fe，Co，Ti，Cu，Cr，Zr，Mo和W分别为Mn：5重量ppm，Al：10重量ppm，Si：10重量ppm，Mg：5重量ppm，Pb：5 重量ppm，Fe：5重量ppm，Co：5重量ppm，Ti：20重量ppm，Cu：20重量ppm，Cr：10重量ppm，Zr：5重量ppm，Mo：2重量ppm，W：10重量ppm。鉴于最近需要快速准确地测量高纯度材料的分析技术，通过抑制来自坩埚的杂质的混合来获得高纯度分析。

4. 发明授权

US07858042B2 Microfluidic chip and method of fabricating the same 有权
标题翻译：微流控芯片及其制造方法
公开(公告)号：US07858042B2
公开(公告)日：2010-12-28
申请号：US11934811
申请日：2007-11-05
申请人： Kyu-youn Hwang , Joon-ho Kim , Chin-sung Park , Sung-young Jeong
发明人： Kyu-youn Hwang , Joon-ho Kim , Chin-sung Park , Sung-young Jeong
IPC分类号： B01N3/00
CPC分类号： B01L3/502707 , B01L3/502753 , B01L2200/12 , B01L2300/16 , Y10T428/14
摘要： Provided are a microfluidic chip and a method of fabricating the same. The microfluidic chip includes: a lower substrate; an upper substrate formed of a silicone resin, wherein the lower substrate and the upper substrate, bonded together, provide a channel through which a fluid can flow and a chamber to receive the fluid; and an organic thin film formed on the upper surface of the lower substrate except for portions on which the lower substrate and the upper substrate are attached to each other.
摘要翻译：提供了一种微流控芯片及其制造方法。微流体芯片包括：下基板; 由硅树脂形成的上基板，其中所述下基板和所述上基板接合在一起，提供流体可以流过的通道和容纳所述流体的室; 以及形成在下基板的上表面上的有机薄膜，除了下基板和上基板彼此附接的部分之外。

5. 发明授权

US07749444B2 Microfluidic device, method for testing reagent and system for testing reagent 失效
标题翻译：微流控装置，试剂检测方法及试剂检测系统
公开(公告)号：US07749444B2
公开(公告)日：2010-07-06
申请号：US11024592
申请日：2004-12-29
申请人： Masayuki Yamada , Takeshi Matsumoto , Yasuhiro Sando , Kusunoki Higashino
发明人： Masayuki Yamada , Takeshi Matsumoto , Yasuhiro Sando , Kusunoki Higashino
IPC分类号： B01N3/00
CPC分类号： B01L3/50273 , B01L3/502715 , B01L7/525 , B01L2200/0673 , B01L2200/141 , B01L2300/0645 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2400/0439 , B01L2400/0481 , B01L2400/0487 , F04B43/046 , F04B53/1077
摘要： A microfluidic device for performing a test on the reagent includes a fill port formed on the chip to inject the reagent into at least one of the channels, one or more heating portions for performing a test on the reagent injected into the channel, and a micropump. An inside of the micropump and a vicinity of the channel connecting to an inlet and an outlet of the micropump are filled with a drive solution that is driven by the micropump, a gas is sealed between the reagent and the drive solution in the channel to prevent the reagent from contacting the drive solution directly, and the micropump directly drives the drive solution in the forward and backward directions, so that the reagent is repeatedly moved to the test portions through the gas in an indirect manner or is repeatedly passed through the test portions through the gas.
摘要翻译：用于对试剂进行试验的微流体装置包括形成在芯片上的填充口，用于将试剂注入到至少一个通道中，一个或多个用于对注入通道的试剂进行测试的加热部分，以及微型泵。微型泵的内部和连接到微型泵的入口和出口的通道的附近填充有由微型泵驱动的驱动溶液，气体被密封在试剂和通道中的驱动溶液之间，以防止试剂直接接触驱动溶液，微泵直接驱动驱动溶液的前后方向，使试剂以间接的方式重复地通过气体移动到试验部分，或重复通过试验部分通过气体。

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