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1. 发明申请

US20100133489A1 Photoinduced phase separation of gold in two-component nanoparticles to form nanoprisms 审中-公开
标题翻译：双组分纳米颗粒中金的光诱导相分离形成纳米棱镜
公开(公告)号：US20100133489A1
公开(公告)日：2010-06-03
申请号：US11715562
申请日：2007-03-08
申请人： Chad A. Mirkin , Gabriella Metraux , Rongchao Jin
发明人： Chad A. Mirkin , Gabriella Metraux , Rongchao Jin
IPC分类号： F21V9/04 , B05D3/06
CPC分类号： B22F1/0018 , B22F1/025 , B22F2001/0037 , B22F2998/10 , B22F2999/00 , B82Y30/00 , B22F9/24 , B22F1/0081 , B22F2202/11
摘要： Nanoprisms containing silver and gold are disclosed. The nanoprisms exhibit the properties of pure silver nanoprisms, but are less susceptible to silver modification or reaction by a surrounding environment than pure silver nanoprisms due to the presence of the gold. The gold surface of the nanoprisms can be further modified, using known gold-modification techniques.
摘要翻译：公开了含有银和金的纳米棱镜。纳米棱镜表现出纯银纳米棱镜的性质，但由于金的存在，它们比纯银纳米棱镜更不易受银改性或周围环境的反应。可以使用已知的金改性技术进一步修饰纳米棱镜的金表面。

2. 发明授权

US07611562B2 Triangular nanoframes and method of making same 失效
标题翻译：三角形纳米框架及其制作方法
公开(公告)号：US07611562B2
公开(公告)日：2009-11-03
申请号：US11786172
申请日：2007-04-11
申请人： Chad A. Mirkin , Gabriella Metraux , Yunwei Cao , Rongchao Jin
发明人： Chad A. Mirkin , Gabriella Metraux , Yunwei Cao , Rongchao Jin
IPC分类号： B22F9/16
CPC分类号： C22F1/14 , B22F1/0022 , B22F1/0088 , B22F9/24 , B22F2001/0029 , B22F2001/0037 , B22F2998/00 , B22F2999/00 , B82Y30/00 , C22C5/06 , Y10S977/773 , Y10S977/81 , Y10S977/888 , B22F1/0007
摘要： The present invention provides nanoprisms etched to generate triangular framework structures. These triangular nanoframes possess no strong surface plasmon bands in the ultraviolet or visible regions of the optical spectrum. By adding a mild reducing agent, metal ions remaining in solution can be reduced, resulting in metal plating and reformation of nanoprisms. The extent of the backfilling process can be controlled, allowing the formation of novel nanoprisms with nanopores. This back-filling process is accompanied by a regeneration of the surface plasmon bands in the UV-visible spectrum.
摘要翻译：本发明提供蚀刻以产生三角形框架结构的纳米棱镜。这些三角形纳米框架在光谱的紫外或可见光区域中没有强表面等离子体谱带。通过添加温和的还原剂，可以减少残留在溶液中的金属离子，导致金属电镀和纳米棱镜的改性。可以控制回填工艺的程度，允许用纳米孔形成新的纳米棱镜。这种回填过程伴随着紫外 - 可见光谱中的表面等离子体激元带的再生。

3. 发明申请

US20080164239A1 Triangular nanoframes and method of making same 失效
标题翻译：三角形纳米框架及其制作方法
公开(公告)号：US20080164239A1
公开(公告)日：2008-07-10
申请号：US11786172
申请日：2007-04-11
申请人： Chad A. Mirkin , Gabriella Metraux , YunWei Charles Cao , Rongchao Jin
发明人： Chad A. Mirkin , Gabriella Metraux , YunWei Charles Cao , Rongchao Jin
IPC分类号： C23F1/00
CPC分类号： C22F1/14 , B22F1/0022 , B22F1/0088 , B22F9/24 , B22F2001/0029 , B22F2001/0037 , B22F2998/00 , B22F2999/00 , B82Y30/00 , C22C5/06 , Y10S977/773 , Y10S977/81 , Y10S977/888 , B22F1/0007
摘要： The present invention provides nanoprisms etched to generate triangular framework structures. These triangular nanoframes possess no strong surface plasmon bands in the ultraviolet or visible regions of the optical spectrum. By adding a mild reducing agent, metal ions remaining in solution can be reduced, resulting in metal plating and reformation of nanoprisms. The extent of the backfilling process can be controlled, allowing the formation of novel nanoprisms with nanopores. This back-filling process is accompanied by a regeneration of the surface plasmon bands in the UV-visible spectrum.
摘要翻译：本发明提供蚀刻以产生三角形框架结构的纳米棱镜。这些三角形纳米框架在光谱的紫外或可见光区域中没有强表面等离子体谱带。通过添加温和的还原剂，可以减少残留在溶液中的金属离子，导致金属电镀和纳米棱镜的改性。可以控制回填过程的程度，允许用纳米孔形成新的纳米棱镜。这种回填过程伴随着紫外 - 可见光谱中的表面等离子体激元带的再生。

4. 发明申请

US20050188789A1 Methods of controlling nanoparticle growth 失效
标题翻译：控制纳米颗粒生长的方法
公开(公告)号：US20050188789A1
公开(公告)日：2005-09-01
申请号：US10817754
申请日：2004-04-02
申请人： Chad Mirkin , Gabriella Metraux , Rongchao Jin , YunWei Cao
发明人： Chad Mirkin , Gabriella Metraux , Rongchao Jin , YunWei Cao
IPC分类号： B22F1/00 , B22F9/24
CPC分类号： B22F1/0014 , B22F1/0018 , B22F1/0022 , B22F9/24 , B22F2001/0037 , B22F2998/00 , B22F2999/00 , B82Y30/00 , B22F2202/11
摘要： The invention provides new types of plasmon-driven growth mechanism for silver nanostructures involving the fusion of triangular nanoprisms. This mechanism, which is plasmon excitation-driven and highly cooperative, produces bimodal particle size distributions. In these methods, the growth process can be selectively switched between bimodal and unimodal distributions using dual beam illumination of the nanoparticles. This type of cooperative photo-control over nanostructure growth enables synthesis of monodisperse nanoprisms with a preselected edge length in the 30-120 nm range simply by using one beam to turn off bimodal growth and the other (varied over the 450-700 nm range) for controlling particle size.
摘要翻译：本发明提供了涉及三角形纳米棱镜融合的银纳米结构的新型等离子激元驱动生长机制。这种机制是等离子体激发驱动和高度协作的，产生双峰粒度分布。在这些方法中，生长过程可以使用纳米颗粒的双光束照射在双峰和单峰分布之间有选择地转换。这种类型的纳米结构生长的协同光控制可以简单地通过使用一个光束来关闭双峰生长而另一个（在450-700nm范围内变化）来合成具有30-120nm范围内的预选边缘长度的单分散纳米棱镜，用于控制粒度。

5. 发明申请

US20070056659A1 TRIANGULAR NANOFRAMES AND METHOD OF MAKING SAME 失效
标题翻译：三角形纳米粒子及其制备方法
公开(公告)号：US20070056659A1
公开(公告)日：2007-03-15
申请号：US10801976
申请日：2004-03-15
申请人： Chad Mirkin , Gabriella Metraux , YunWei Cao , Rongchao Jin
发明人： Chad Mirkin , Gabriella Metraux , YunWei Cao , Rongchao Jin
IPC分类号： C22C5/00 , B22F9/16
CPC分类号： C22F1/14 , B22F1/0022 , B22F1/0088 , B22F9/24 , B22F2001/0029 , B22F2001/0037 , B22F2998/00 , B22F2999/00 , B82Y30/00 , C22C5/06 , Y10S977/773 , Y10S977/81 , Y10S977/888 , B22F1/0007
摘要： The present invention provides nanoprisms etched to generate triangular framework structures. These triangular nanoframes possess no strong surface plasmon bands in the ultraviolet or visible regions of the optical spectrum. By adding a mild reducing agent, metal ions remaining in solution can be reduced, resulting in metal plating and reformation of nanoprisms. The extent of the backfilling process can be controlled, allowing the formation of novel nanoprisms with nanopores. This back-filling process is accompanied by a regeneration of the surface plasmon bands in the UV-visible spectrum.
摘要翻译：本发明提供蚀刻以产生三角形框架结构的纳米棱镜。这些三角形纳米框架在光谱的紫外或可见光区域中没有强表面等离子体谱带。通过添加温和的还原剂，可以减少残留在溶液中的金属离子，导致金属电镀和纳米棱镜的改性。可以控制回填过程的程度，允许用纳米孔形成新的纳米棱镜。这种回填过程伴随着紫外 - 可见光谱中的表面等离子体激元带的再生。

6. 发明授权

US07985539B2 Nanoparticle probes with raman spectroscopic fingerprints for analyte detection 有权
标题翻译：具有拉曼光谱指纹的纳米粒子探针用于分析物检测
公开(公告)号：US07985539B2
公开(公告)日：2011-07-26
申请号：US10431341
申请日：2003-05-07
申请人： Chad A. Mirkin , Yunwei Cao , Rongchao Jin
发明人： Chad A. Mirkin , Yunwei Cao , Rongchao Jin
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/587 , C12Q1/6816 , G01N33/54373 , G01N33/583 , Y02A50/54 , C12Q2565/632 , C12Q2565/519 , C12Q2537/125
摘要： The invention encompasses reagents comprising particles with at least one Raman dye and a specific binding members bound thereto and methods of using such reagents. The invention also encompasses reagents of a specific binding member and two or more different Raman dyes and methods for using such reagents. New types of particle probes having a specific binding member bound thereto are described. These reagents are used in a novel detection strategy that utilizes the catalytic properties of the Au nanoparticles to generate a silver coating that can behave as a surface-enhanced Raman scattering (SERS) promoter for the dye-labeled particles that have been captured by target and an underlying chip in microarray format. The strategy provides the high sensitivity and high selectivity attributes of grey-scale scanometric detection but provides a route to multiplexing and ratioing capabilities since a very large number of probes can be designed based upon the concept of using a Raman tag as a spectroscopic fingerprint in detection. These spectra are used as fingerprints to differentiate oligonucleotide or other targets in one solution. This method has been used to distinguish six dissimilar DNA targets with six Raman labeled nanoparticle probes, and also two RNA targets with single nucleotide polymorphisms (SNPs).
摘要翻译：本发明包括含有至少一种拉曼染料和与其结合的特异性结合成员的颗粒的试剂和使用这些试剂的方法。本发明还包括特异性结合成员和两种或更多种不同拉曼染料的试剂和使用这些试剂的方法。描述具有与其结合的特异性结合成员的新型粒子探针。这些试剂用于一种新的检测策略，其利用Au纳米粒子的催化性能产生可以作为被目标捕获的染料标记的颗粒的表面增强拉曼散射（SERS）启动子的银涂层，微芯片格式的底层芯片。该策略提供了灰度扫描测量检测的高灵敏度和高选择性属性，但是提供了多路复用和比较能力的途径，因为可以基于在检测中使用拉曼标签作为光谱指纹的概念来设计非常大量的探针。这些光谱用作指纹以在一种溶液中区分寡核苷酸或其他靶标。该方法已被用于区分六个不同的DNA靶标与六个拉曼标记的纳米颗粒探针，以及两个具有单核苷酸多态性（SNPs）的RNA靶标。

7. 发明授权

US07033415B2 Methods of controlling nanoparticle growth 失效
标题翻译：控制纳米颗粒生长的方法
公开(公告)号：US07033415B2
公开(公告)日：2006-04-25
申请号：US10817754
申请日：2004-04-02
申请人： Chad A. Mirkin , Gabriella S. Métraux , Rongchao Jin , YunWei Charles Cao
发明人： Chad A. Mirkin , Gabriella S. Métraux , Rongchao Jin , YunWei Charles Cao
IPC分类号： C22C5/06 , B22F1/00
CPC分类号： B22F1/0014 , B22F1/0018 , B22F1/0022 , B22F9/24 , B22F2001/0037 , B22F2998/00 , B22F2999/00 , B82Y30/00 , B22F2202/11
摘要： The invention provides new types of plasmon-driven growth mechanism for silver nanostructures involving the fusion of triangular nanoprisms. This mechanism, which is plasmon excitation-driven and highly cooperative, produces bimodal particle size distributions. In these methods, the growth process can be selectively switched between bimodal and unimodal distributions using dual beam illumination of the nanoparticles. This type of cooperative photo-control over nanostructure growth enables synthesis of monodisperse nanoprisms with a preselected edge length in the 30–120 nm range simply by using one beam to turn off bimodal growth and the other (varied over the 450–700 nm range) for controlling particle size.
摘要翻译：本发明提供了涉及三角形纳米棱镜融合的银纳米结构的新型等离子激元驱动生长机制。这种机制是等离子体激发驱动和高度协作的，产生双峰粒度分布。在这些方法中，生长过程可以使用纳米颗粒的双光束照射在双峰和单峰分布之间有选择地转换。这种类型的纳米结构生长的协同光控制可以简单地通过使用一个光束来关闭双峰生长而另一个（在450-700nm范围内变化）来合成具有30-120nm范围内的预选边缘长度的单分散纳米棱镜，用于控制粒度。

8. 发明申请

US20090308202A1 METHODS OF MAKING NANOPRISMS 失效
标题翻译：制备纳米材料的方法
公开(公告)号：US20090308202A1
公开(公告)日：2009-12-17
申请号：US11499024
申请日：2006-08-04
申请人： Rongchao Jin , Yunwei Cao , Chad A. Mirkin
发明人： Rongchao Jin , Yunwei Cao , Chad A. Mirkin
IPC分类号： B22F9/16
CPC分类号： B82Y30/00 , B22F1/0018 , B22F9/24 , B22F2001/0037 , B22F2999/00 , C22C5/06 , Y10S977/773 , Y10S977/81 , B22F2202/11
摘要： The invention is a novel photo-induced method for converting large quantities of silver nanospheres into nanoprisms, the nanoprisms formed by this method and applications in which the nanoprisms are useful. Significantly, this light driven process results in a colloid with a unique set of optical properties that directly relate to the nanoprism shape of the particles. Theoretical calculations coupled with experimental observations allow for the assignment of the nanoprism plasmon bands and the first identification of two distinct quadrupole plasmon resonances for a nanoparticle. Finally, unlike the spherical particles from which they derive and which Rayleigh light scatter in the blue, these nanoprisms exhibit-scattering in the red, permitting multicolor diagnostic labels based not only on nanoparticle composition and size but also on shape.
摘要翻译：本发明是一种用于将大量银纳米球转化为纳米棱镜的新型光诱导方法，该方法形成的纳米棱镜以及纳米棱镜可用的应用。重要的是，这种光驱过程导致具有与粒子的纳米棱镜形状直接相关的独特的光学性质的胶体。与实验观察结合的理论计算允许分配纳米棱镜等离子体激元带并且对于纳米颗粒首次鉴定两种不同的四极等离子体共振。最后，不同于它们衍生的球形颗粒和蓝色的瑞利光散射，这些纳米棱镜在红色中表现出散射，允许多色诊断标签不仅基于纳米颗粒的组成和尺寸，而且基于形状。

9. 发明授权

US07238472B2 Non-alloying core shell nanoparticles 有权
标题翻译：非合金核壳纳米粒子
公开(公告)号：US07238472B2
公开(公告)日：2007-07-03
申请号：US10034451
申请日：2001-12-28
申请人： Chad A. Mirkin , Yun-Wei Cao , Rongchao Jin
发明人： Chad A. Mirkin , Yun-Wei Cao , Rongchao Jin
IPC分类号： C12Q1/68 , C07H21/02 , B82B1/00 , B82B3/00
CPC分类号： B22F1/0062 , A61K47/6923 , B22F1/0059 , B22F1/025 , B22F9/24 , B22F2998/00 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C01B19/007 , C01G7/00 , C01G11/02 , C01G49/08 , C01P2002/82 , C01P2004/04 , C01P2004/64 , C01P2004/84 , C01P2006/42 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834 , G01N33/543 , G01N33/5434 , G01N33/54393 , G01N33/553 , G01N33/588 , H01F1/0054 , H01L29/127 , Y10S977/704 , Y10S977/722 , Y10S977/773 , Y10S977/81 , Y10T428/12014 , C12Q2563/155 , B22F1/0018
摘要： The present invention relates composite core/shell nanoparticles and a two-step method for their preparation. The present invention further relates to biomolecule-core/shell nanoparticle conjugates and methods for their preparation. The invention also relates to methods of detection of biomolecules comprising the biomolecule or specific binding substance-core/shell nanoparticle conjugates.
摘要翻译：本发明涉及复合核/壳纳米颗粒和两步法的制备方法。本发明还涉及生物分子 - 核/壳纳米颗粒缀合物及其制备方法。本发明还涉及检测包含生物分子或特异性结合物质 - 核/壳纳米颗粒共轭物的生物分子的方法。

10. 发明授权

US07648595B2 Methods of making nanoprisms 失效
标题翻译：制作纳米棱镜的方法
公开(公告)号：US07648595B2
公开(公告)日：2010-01-19
申请号：US11499024
申请日：2006-08-04
申请人： Rongchao Jin , Yunwei Cao , Chad A. Mirkin
发明人： Rongchao Jin , Yunwei Cao , Chad A. Mirkin
IPC分类号： B22F9/00
CPC分类号： B82Y30/00 , B22F1/0018 , B22F9/24 , B22F2001/0037 , B22F2999/00 , C22C5/06 , Y10S977/773 , Y10S977/81 , B22F2202/11
摘要： The invention is a novel photo-induced method for converting large quantities of silver nanospheres into nanoprisms, the nanoprisms formed by this method and applications in which the nanoprisms are useful. Significantly, this light driven process results in a colloid with a unique set of optical properties that directly relate to the nanoprism shape of the particles. Theoretical calculations coupled with experimental observations allow for the assignment of the nanoprism plasmon bands and the first identification of two distinct quadrupole plasmon resonances for a nanoparticle. Finally, unlike the spherical particles from which they derive and which Rayleigh light scatter in the blue, these nanoprisms exhibit scattering in the red, permitting multicolor diagnostic labels based not only on nanoparticle composition and size but also on shape.
摘要翻译：本发明是一种用于将大量银纳米球转化为纳米棱镜的新型光诱导方法，该方法形成的纳米棱镜以及纳米棱镜可用的应用。重要的是，这种光驱过程导致具有与粒子的纳米棱镜形状直接相关的独特的光学性质的胶体。与实验观察结合的理论计算允许分配纳米棱镜等离子体激元带并且对于纳米颗粒首次鉴定两种不同的四极等离子体共振。最后，不同于它们衍生的球形颗粒和蓝色的瑞利光散射，这些纳米棱镜在红色中表现出散射，允许多色诊断标签不仅基于纳米颗粒的组成和尺寸，而且基于形状。

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