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1. 发明授权

US5902325A Method and apparatus for detecting cardiac capture 失效
标题翻译：用于检测心脏捕获的方法和装置
公开(公告)号：US5902325A
公开(公告)日：1999-05-11
申请号：US126469
申请日：1998-07-30
申请人： Catherine R. Condie , Daniel J. Baxter , William J. Combs , Daniel J. Greeninger , Karen J. Kleckner , H. Toby Markowitz , John C. Stroebel , John D. Wahlstrand
发明人： Catherine R. Condie , Daniel J. Baxter , William J. Combs , Daniel J. Greeninger , Karen J. Kleckner , H. Toby Markowitz , John C. Stroebel , John D. Wahlstrand
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36521 , A61N1/3712 , A61N1/3714
摘要： A method and apparatus for automatic determination of a pacemaker patient's pacing stimulation threshold. Circuitry is provided in a pacemaker for obtaining a signal reflecting cardiac impedance, which is known to reliably reflect certain aspects of cardiac function. Circuitry is also provided for monitoring the cardiac impedance waveform during a predetermined capture detect window following delivery of stimulating pulses. One or more values are derived which characterize the morphology of the impedance waveform during the capture detect window associated with each stimulation pulse delivered. These values are compared to predetermined control values in order to assess whether a stimulation pulse has achieved cardiac capture. The assessment of whether cardiac capture has been achieved is also based partly upon the conventional sensing of atrial and/or ventricular cardiac signals occurring during the capture detect window. In one embodiment of the invention, the control values against which impedance waveform characterization values are compared are obtained by delivering a series of stimulation pulses having sufficient energy to ensure that capture is achieved, and by monitoring the impedance waveform during delivery of these pulses.
摘要翻译：一种用于自动确定起搏器患者起搏刺激阈值的方法和装置。在起搏器中提供电路以获得反映心脏阻抗的信号，这已知可靠地反映心脏功能的某些方面。还提供电路用于在传送刺激脉冲之后的预定捕获检测窗口期间监测心脏阻抗波形。导出一个或多个值，其表征在与递送的每个刺激脉冲相关联的捕获检测窗口期间阻抗波形的形态。将这些值与预定的控制值进行比较，以便评估刺激脉冲是否已经实现心脏捕获。是否已经实现心脏捕获的评估也部分地基于在捕获检测窗口期间发生的心房和/或心室心脏信号的常规感测。在本发明的一个实施例中，通过递送具有足够能量的一系列刺激脉冲来确定阻抗波形表征值被比较的控制值，以确保实现捕获，并且通过在传送这些脉冲期间监视阻抗波形来获得。

2. 发明授权

US5843137A Capture detection method 失效
标题翻译：捕获检测方法
公开(公告)号：US5843137A
公开(公告)日：1998-12-01
申请号：US784687
申请日：1997-01-22
申请人： Catherine R. Condie , Daniel J. Baxter , William J. Combs , Daniel J. Greeninger , Karen J. Kleckner , H. Toby Markowitz , John C. Stroebel , John D. Wahlstrand
发明人： Catherine R. Condie , Daniel J. Baxter , William J. Combs , Daniel J. Greeninger , Karen J. Kleckner , H. Toby Markowitz , John C. Stroebel , John D. Wahlstrand
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36521 , A61N1/3712 , A61N1/3714
摘要： A method and apparatus for automatic determination of a pacemaker patient's pacing stimulation threshold. Circuitry is provided in a pacemaker for obtaining a signal reflecting cardiac impedance, which is known to reliably reflect certain aspects of cardiac function. Circuitry is also provided for monitoring the cardiac impedance waveform during a predetermined capture detect window following delivery of stimulating pulses. One or more values are derived which characterize the morphology of the impedance waveform during the capture detect window associated with each stimulation pulse delivered. These values are compared to predetermined control values in order to assess whether a stimulation pulse has achieved cardiac capture. The assessment of whether cardiac capture has been achieved is also based partly upon the conventional sensing of atrial and/or ventricular cardiac signals occurring during the capture detect window. In one embodiment of the invention, the control values against which impedance waveform characterization values are compared are obtained by delivering a series of stimulation pulses having sufficient energy to ensure that capture is achieved, and by monitoring the impedance waveform during delivery of these pulses.
摘要翻译：一种用于自动确定起搏器患者起搏刺激阈值的方法和装置。在起搏器中提供电路以获得反映心脏阻抗的信号，这已知可靠地反映心脏功能的某些方面。还提供电路用于在传送刺激脉冲之后的预定捕获检测窗口期间监测心脏阻抗波形。导出一个或多个值，其表征在与递送的每个刺激脉冲相关联的捕获检测窗口期间阻抗波形的形态。将这些值与预定的控制值进行比较，以便评估刺激脉冲是否已经实现心脏捕获。是否已经实现心脏捕获的评估也部分地基于在捕获检测窗口期间发生的心房和/或心室心脏信号的常规感测。在本发明的一个实施例中，通过递送具有足够能量的一系列刺激脉冲来确定阻抗波形表征值被比较的控制值，以确保实现捕获，并且通过在传送这些脉冲期间监视阻抗波形来获得。

3. 发明授权

US5713933A Method and apparatus for automatic pacing threshold determination 失效
标题翻译：用于自动起搏阈值确定的方法和装置
公开(公告)号：US5713933A
公开(公告)日：1998-02-03
申请号：US346815
申请日：1994-11-30
申请人： Catherine R. Condie , Daniel J. Baxter , William J. Combs , Daniel J. Greeninger , Karen J. Kleckner , H. Toby Markowitz , John C. Stroebel , John D. Wahlstrand
发明人： Catherine R. Condie , Daniel J. Baxter , William J. Combs , Daniel J. Greeninger , Karen J. Kleckner , H. Toby Markowitz , John C. Stroebel , John D. Wahlstrand
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/36521 , A61N1/3712 , A61N1/3714
摘要： A method and apparatus for automatic determination of a pacemaker patient's pacing stimulation threshold. Circuitry is provided in a pacemaker for obtaining a signal reflecting cardiac impedance, which is known to reliably reflect certain aspects of cardiac function. Circuitry is also provided for monitoring the cardiac impedance waveform during a predetermined capture detect window following delivery of stimulating pulses. One or more values are derived which characterize the morphology of the impedance waveform during the capture detect window associated with each stimulation pulse delivered. These values are compared to predetermined control values in order to assess whether a stimulation pulse has achieved cardiac capture. The assessment of whether cardiac capture has been achieved is also based partly upon the conventional sensing of atrial and/or ventricular cardiac signals occurring during the capture detect window. In one embodiment of the invention, the control values against which impedance waveform characterization values are compared are obtained by delivering a series of stimulation pulses having sufficient energy to ensure that capture is achieved, and by monitoring the impedance waveform during delivery of these pulses.
摘要翻译：一种用于自动确定起搏器患者起搏刺激阈值的方法和装置。在起搏器中提供电路以获得反映心脏阻抗的信号，这已知可靠地反映心脏功能的某些方面。还提供电路用于在传送刺激脉冲之后的预定捕获检测窗口期间监测心脏阻抗波形。导出一个或多个值，其表征在与递送的每个刺激脉冲相关联的捕获检测窗口期间阻抗波形的形态。将这些值与预定的控制值进行比较，以便评估刺激脉冲是否已经实现心脏捕获。是否已经实现心脏捕获的评估也部分地基于在捕获检测窗口期间发生的心房和/或心室心脏信号的常规感测。在本发明的一个实施例中，通过递送具有足够能量的一系列刺激脉冲来确定阻抗波形表征值被比较的控制值，以确保实现捕获，并且通过在传送这些脉冲期间监视阻抗波形来获得。

4. 发明授权

US06512949B1 Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto 有权
标题翻译：用于测量时变生理条件的植入式医疗装置，特别是水肿并对其进行响应
公开(公告)号：US06512949B1
公开(公告)日：2003-01-28
申请号：US09352179
申请日：1999-07-12
申请人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrand , David L. Thompson , Li Wang
发明人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrand , David L. Thompson , Li Wang
IPC分类号： A61B500
CPC分类号： A61N1/36521 , A61B5/0535 , A61B5/7207 , A61N1/3627
摘要： An impedance monitor for discerning edema through evaluation of respiratory rate. Preferred embodiment includes edema monitor and trigger to initiate diagnostic reporting or corrective action when activated. Recording of Long Term Average and Short Term Average values for secondary edema measure based on DC signal level are described as are methods and apparatus for removing unwanted recurring noise.
摘要翻译：通过评估呼吸频率来辨别水肿的阻抗监测仪。优选实施例包括水肿监测和触发以在被激活时启动诊断报告或纠正动作。长期平均和短期记录基于直流信号电平的次级水肿测量的平均值被描述为用于消除不期望的重复噪声的方法和装置。

5. 发明授权

US08200322B2 Electrogram storage for suspected non-physiological episodes 有权
标题翻译：怀疑非生理发作的电图存储
公开(公告)号：US08200322B2
公开(公告)日：2012-06-12
申请号：US12182687
申请日：2008-07-30
申请人： Kevin T. Ousdigian , Catherine R. Condie , Karen J. Kleckner , Bruce D. Gunderson
发明人： Kevin T. Ousdigian , Catherine R. Condie , Karen J. Kleckner , Bruce D. Gunderson
IPC分类号： A61B5/0468
CPC分类号： A61N1/3702 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/053 , A61B5/0538 , A61B5/7264 , A61B2560/0276 , A61N1/3704 , A61N2001/083
摘要： Techniques for storing electrograms (EGMS) that are associated with sensed episodes or events that may be non-physiological and, instead, associated with a sensing integrity condition are described. In some examples, a device or system identifies suspected non-physiological NSTs, and stores an EGM for the suspected non-physiological NSTs within an episode log. In some examples, a device or system determines whether to store an EGM for a suspected non-physiological episode or event based on whether an impedance integrity criterion has been satisfied. For example, a device or system may store an EGM for a detected short interval if the impedance integrity criterion has been met. In some examples, a device or system determines whether to buffer EGM data based on whether an impedance integrity criterion or other sensing integrity criterion has been met.
摘要翻译：描述了用于存储与可能是非生理感知的事件相关联的电摄影（EGMS）的技术，并且相反地与感测完整性条件相关联的技术。在一些示例中，设备或系统识别疑似非生理NST，并且在发作日志中存储用于可疑非生理NST的EGM。在一些示例中，设备或系统基于是否已经满足阻抗完整性标准来确定是否存储用于可疑非生理事件或事件的EGM。例如，如果已经满足了阻抗完整性标准，则设备或系统可以存储用于检测到的短间隔的EGM。在一些示例中，设备或系统基于是否已经满足阻抗完整性标准或其他感测完整性标准来确定是否缓冲EGM数据。

6. 发明申请

US20090299422A1 ELECTROGRAM STORAGE FOR SUSPECTED NON-PHYSIOLOGICAL EPISODES 有权
标题翻译：电生物存储用于悬浮的非生理性EPISODES
公开(公告)号：US20090299422A1
公开(公告)日：2009-12-03
申请号：US12182687
申请日：2008-07-30
申请人： Kevin T. Ousdigian , Catherine R. Condie , Karen J. Kleckner , Bruce D. Gunderson
发明人： Kevin T. Ousdigian , Catherine R. Condie , Karen J. Kleckner , Bruce D. Gunderson
IPC分类号： A61N1/08 , A61B5/0432
CPC分类号： A61N1/3702 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/053 , A61B5/0538 , A61B5/7264 , A61B2560/0276 , A61N1/3704 , A61N2001/083
摘要： Techniques for storing electrograms (EGMS) that are associated with sensed episodes or events that may be non-physiological and, instead, associated with a sensing integrity condition are described. In some examples, a device or system identifies suspected non-physiological NSTs, and stores an EGM for the suspected non-physiological NSTs within an episode log. In some examples, a device or system determines whether to store an EGM for a suspected non-physiological episode or event based on whether an impedance integrity criterion has been satisfied. For example, a device or system may store an EGM for a detected short interval if the impedance integrity criterion has been met. In some examples, a device or system determines whether to buffer EGM data based on whether an impedance integrity criterion or other sensing integrity criterion has been met.
摘要翻译：描述了用于存储与可能是非生理感知的事件相关联的电摄影（EGMS）的技术，并且相反地与感测完整性条件相关联的技术。在一些示例中，设备或系统识别疑似非生理NST，并且在发作日志中存储用于可疑非生理NST的EGM。在一些示例中，设备或系统基于是否已经满足阻抗完整性标准来确定是否存储用于可疑非生理事件或事件的EGM。例如，如果已经满足了阻抗完整性标准，则设备或系统可以存储用于检测到的短间隔的EGM。在一些示例中，设备或系统基于是否已经满足阻抗完整性标准或其他感测完整性标准来确定是否缓冲EGM数据。

7. 发明授权

US06731983B2 Pacemaker having adaptive arrhythmia detection windows 有权
标题翻译：起搏器具有适应性心律失常检测窗口
公开(公告)号：US06731983B2
公开(公告)日：2004-05-04
申请号：US10082981
申请日：2002-02-25
申请人： James H. Ericksen , Robert A. Betzold , Catherine R. Condie , Jeffrey M. Gillberg , Robert W. Stadler , John C. Stroebel , Troy E. Jackson
发明人： James H. Ericksen , Robert A. Betzold , Catherine R. Condie , Jeffrey M. Gillberg , Robert W. Stadler , John C. Stroebel , Troy E. Jackson
IPC分类号： A61N136
CPC分类号： A61N1/3622 , A61N1/3682
摘要： A device-implemented software system operates a detection window and adjusts PAV as needed after confirming the presence or detection of evidence of an arrhythmia. The detection window is monitored based on a preferred length. If the detection window is shorter than required, intervals are adjusted for a specific pacing rate. Further, the software system provides means for selecting detection over pacing based on an analysis of a preferred length in the presence of evidence of an arrhythmia.
摘要翻译：设备实现的软件系统在确认存在或检测到心律失常的证据之后，根据需要操作检测窗口并调整PAV。基于优选的长度来监视检测窗口。如果检测窗口比要求短，则根据特定的起搏速度对间隔进行调整。此外，软件系统提供了在存在心律失常证据的情况下基于优选长度的分析来选择起搏检测的手段。

8. 发明授权

US07031772B2 Method and apparatus for rate responsive adjustments in an implantable medical device 有权
公开(公告)号：US07031772B2
公开(公告)日：2006-04-18
申请号：US10134560
申请日：2002-04-29
申请人： Catherine R. Condie , John D. Wahlstrand , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon
发明人： Catherine R. Condie , John D. Wahlstrand , Gerald A. Portzline , Yong Kyun Cho , John S. Brandstetter , Luc R. Mongeon
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36521 , G06F19/00 , G06F19/3456 , G16H40/63
摘要： A method and an apparatus for performing rate responsive control in an implantable medical device using a scaling factor. Sensor data is acquired using a sensor operatively coupled with the implantable medical device. At least one setpoint for controlling a rate of therapy is generated, the setpoint being based upon the sensor data. A scaling factor adjustment process is performed for scaling the internal sensor data to correlate the sensor data to the setpoint. The rate of therapy is adjusted based upon the scaling factor adjustment.

9. 发明授权

US5957861A Impedance monitor for discerning edema through evaluation of respiratory rate 失效
标题翻译：阻抗监测仪通过评估呼吸频率进行辨认性水肿
公开(公告)号：US5957861A
公开(公告)日：1999-09-28
申请号：US791206
申请日：1997-01-31
申请人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrandl
发明人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrandl
IPC分类号： A61B5/053 , A61B5/08 , A61N1/362 , A61N1/37 , A61B5/00
CPC分类号： A61B5/4878 , A61B5/0535 , A61B5/0809 , A61N1/3702 , A61N1/3627
摘要： An impedance monitor for discerning edema through evaluation of respiratory rate. Preferred embodiment includes edema monitor and trigger to initiate diagnostic reporting or corrective action when activated. Recording of Long Term Average and Short Term Average values for secondary edema measure based on DC signal level are described as are methods and apparatus for removing unwanted recurring noise.
摘要翻译：通过评估呼吸频率来辨别水肿的阻抗监测仪。优选实施例包括水肿监测和触发以在被激活时启动诊断报告或纠正动作。长期平均和短期记录基于直流信号电平的次级水肿测量的平均值被描述为用于消除不期望的重复噪声的方法和装置。

10. 发明授权

US08229560B2 System and method of using AV conduction timing 有权
标题翻译：使用AV导通定时的系统和方法
公开(公告)号：US08229560B2
公开(公告)日：2012-07-24
申请号：US13078536
申请日：2011-04-01
申请人： Catherine R. Condie
发明人： Catherine R. Condie
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61B5/0468 , A61N1/3682
摘要： In an implantable medical device that provides atrial and ventricular pacing in an atrial-based pacing mode, longer periods of time are permitted for intrinsic AV conduction to occur. By monitoring the patient's AV delay under these circumstances, useful information is obtained that can be correlated to other patient conditions or symptoms.
摘要翻译：在以心房起搏模式提供心房和心室起搏的植入式医疗装置中，允许发生固有AV传导的较长时间段。通过在这些情况下监测患者的AV延迟，获得可以与其他患者状况或症状相关的有用信息。

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