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1. 发明授权

US06606992B1 Systems and methods for aerosolizing pharmaceutical formulations 有权
标题翻译：雾化药物制剂的系统和方法
公开(公告)号：US06606992B1
公开(公告)日：2003-08-19
申请号：US09583312
申请日：2000-05-30
申请人： Carlos Schuler , Steve Paboojian , Derrick J. Tuttle , Adrian E. Smith , Dennis R. Rasmussen , Aneesh Bakshi , Andrew Clark , Brian R. S. Ward , William W. Alston, Jr. , Kevin S. Nason
发明人： Carlos Schuler , Steve Paboojian , Derrick J. Tuttle , Adrian E. Smith , Dennis R. Rasmussen , Aneesh Bakshi , Andrew Clark , Brian R. S. Ward , William W. Alston, Jr. , Kevin S. Nason
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M15/002 , A61M15/0036 , A61M15/0051 , A61M15/0068 , A61M15/0083 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M16/0493 , A61M16/0495 , A61M16/0866 , A61M16/206 , A61M16/208 , A61M2202/064
摘要： Systems and methods are provided for aerosolizing a pharmaceutical formulation. According to one method, respiratory gases are prevented from flowing to the lungs when attempting to inhale. Then, respiratory gases are abruptly permitted to flow to the lungs. The flow of respiratory gases may then be used to extract a pharmaceutical formulation from a receptacle and to place the pharmaceutical formulation within the flow of respiratory gases to form an aerosol.
摘要翻译：提供了用于雾化药物制剂的系统和方法。根据一种方法，当试图吸气时，防止呼吸气体流向肺部。然后，呼吸道气体突然被允许流向肺部。呼吸气体的流动然后可用于从容器中提取药物制剂并将药物制剂置于呼吸气体流中以形成气溶胶。

2. 发明申请

US20050016533A1 Systems and methods for aerosolizing pharmaceutical formulations 审中-公开
标题翻译：雾化药物制剂的系统和方法
公开(公告)号：US20050016533A1
公开(公告)日：2005-01-27
申请号：US10601127
申请日：2003-06-19
申请人： Carlos Schuler , Steve Paboojian , Derrick Tuttle , Adrian Smith , Dennis Rasmussen , Aneesh Bakshi , Andrew Clark , Brian Ward , William Alston , Kevin Nason
发明人： Carlos Schuler , Steve Paboojian , Derrick Tuttle , Adrian Smith , Dennis Rasmussen , Aneesh Bakshi , Andrew Clark , Brian Ward , William Alston , Kevin Nason
IPC分类号： A61M15/00 , A61M16/20 , A61M16/00
CPC分类号： A61M15/0028 , A61M15/002 , A61M15/0036 , A61M15/0051 , A61M15/0068 , A61M15/0083 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M16/0493 , A61M16/0495 , A61M16/0866 , A61M16/206 , A61M16/208 , A61M2202/064
摘要： Systems and methods are provided for aerosolizing a pharmaceutical formulation. According to one method, respiratory gases are prevented from flowing to the lungs when attempting to inhale. Then, respiratory gases are abruptly permitted to flow to the lungs. The flow of respiratory gases may then be used to extract a pharmaceutical formulation from a receptacle and to place the pharmaceutical formulation within the flow of respiratory gases to form an aerosol.
摘要翻译：提供了用于雾化药物制剂的系统和方法。根据一种方法，当试图吸气时，防止呼吸气体流向肺部。然后，呼吸道气体突然被允许流向肺部。呼吸气体的流动然后可用于从容器中提取药物制剂并将药物制剂置于呼吸气体流中以形成气溶胶。

3. 发明授权

US08408200B2 Flow resistance modulated aerosolized active agent delivery 失效
标题翻译：阻流调制气雾剂活性剂输送
公开(公告)号：US08408200B2
公开(公告)日：2013-04-02
申请号：US09414384
申请日：1999-10-07
申请人： Andrew Clark , Carlos Schuler , Steve Paboojian
发明人： Andrew Clark , Carlos Schuler , Steve Paboojian
IPC分类号： A61M16/00 , A61M15/00 , A62B9/02
CPC分类号： A61M15/00 , A61M2016/0021 , A61M2202/064
摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.
摘要翻译：本发明涉及用于将活性剂制剂递送到人类患者的肺的方法和装置。活性剂制剂可以是干粉形式，它可以是雾化的，或者它可以与推进剂混合。活性剂制剂以低吸入流速在初始时期递送给患者，以提高活性剂的生物利用度。

4. 发明授权

US06679256B2 Systems and methods for extracting powders from receptacles 失效
标题翻译：从容器中提取粉末的系统和方法
公开(公告)号：US06679256B2
公开(公告)日：2004-01-20
申请号：US09731368
申请日：2000-12-06
申请人： Frank W. Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
发明人： Frank W. Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
IPC分类号： A61M1500
CPC分类号： B05B11/062 , A61M11/001 , A61M15/002 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M2202/064 , A61M2205/073 , B05B7/1413 , B65D75/366 , B65D2575/362
摘要： A method for aerosolizing a powder utilizes a receptacle having a cavity containing a powder. An access end of an extraction tube is inserted into the cavity, and an inlet opening is formed in the receptacle. A pressurized gas is flowed through the inlet opening, through the cavity and through the extraction tube to move the powder in the cavity into the extraction tube where the powder is entrained in the gas to form an aerosol.
摘要翻译：用于雾化粉末的方法利用具有包含粉末的空腔的容器。抽吸管的入口端插入空腔中，并且在容器中形成入口。加压气体通过入口开口流过空腔并通过抽出管，将空腔中的粉末移动到提取管中，将粉末夹带在气体中形成气溶胶。

5. 发明申请

US20050056275A1 Systems and methods for powder from receptacles 审中-公开
标题翻译：从容器的粉末的系统和方法
公开(公告)号：US20050056275A1
公开(公告)日：2005-03-17
申请号：US10727077
申请日：2003-12-02
申请人： Frank Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
发明人： Frank Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
IPC分类号： A61M13/00 , A61M15/00 , B05B7/14 , B05B11/06 , B65D75/36 , A61M11/00 , A61M16/00
CPC分类号： B05B11/062 , A61M11/001 , A61M15/002 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M2202/064 , A61M2205/073 , B05B7/1413 , B65D75/366 , B65D2575/362
摘要： A method for aerosolizing a powder utilizes a receptacle having a cavity containing a powder. An access end of an extraction tube is inserted into the cavity, and an inlet opening is formed in the receptacle. A pressurized gas is flowed through the inlet opening, through the cavity and through the extraction tube to move the powder in the cavity into the extraction tube where the powder is entrained in the gas to form an aerosol.
摘要翻译：用于雾化粉末的方法利用具有包含粉末的空腔的容器。抽吸管的入口端插入空腔中，并且在容器中形成入口。加压气体通过入口开口流过空腔并通过抽出管，将空腔中的粉末移动到提取管中，将粉末夹带在气体中形成气溶胶。

6. 发明授权

US06257233B1 Dry powder dispersing apparatus and methods for their use 有权
标题翻译：干粉分散装置及其使用方法
公开(公告)号：US06257233B1
公开(公告)日：2001-07-10
申请号：US09312434
申请日：1999-05-14
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.
摘要翻译：本发明提供了用于使粉末状药物雾化的各种装置和方法。在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。包括支架组件以接收容器并将容器连接到雾化机构。第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。

7. 发明授权

US06901929B2 Dry powder dispersing apparatus and methods for their use 失效
标题翻译：干粉分散装置及其使用方法
公开(公告)号：US06901929B2
公开(公告)日：2005-06-07
申请号：US10327633
申请日：2002-12-19
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
IPC分类号： A61K31/505 , A61M15/00 , B05B11/06 , C07D239/70 , C07D487/12
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.
摘要翻译：本发明提供了用于使粉末状药物雾化的各种装置和方法。在一个示例性实施例中，一种装置包括加压缸和可在气缸内滑动以对气体加压的活塞。手柄联接到活塞并且可以在延伸位置和原始位置之间移动以对气体加压。包括雾化机构，并且被配置为使来自气缸的加压气体保持在容器内的粉末状药物雾化。包括支架组件以接收容器并将容器连接到雾化机构。第一和第二互锁可操作地与托架组件接合以防止容器与雾化机构的联接。第一互锁被释放以允许滑架在手柄移动到延伸位置时移动。如果容器仅部分地插入到滑架组件中，则第二互锁保持接合。

8. 发明授权

US06546929B2 Dry powder dispersing apparatus and methods for their use 失效
公开(公告)号：US06546929B2
公开(公告)日：2003-04-15
申请号：US09873946
申请日：2001-06-04
申请人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
发明人： John D. Burr , Adrian E. Smith , Randy K. Hall , Herman Snyder , Carlos Schuler , George S. Axford , Charles Ray
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0086 , A61M2202/064 , A61M2205/07 , A61M2205/073 , B05B11/062
摘要： The invention provides various apparatus and methods for aerosolizing a powdered medicament. In one exemplary embodiment, an apparatus includes a pressurization cylinder, and a piston which is slidable within the cylinder to pressurize a gas. A handle is coupled to the piston and is movable between an extended position and a home position to pressurize the gas. An aerosolizing mechanism is included and is configured to aerosolize a powdered medicament that is held within a receptacle with pressurized gas from the cylinder. A carriage assembly is included to receive the receptacle and to couple the receptacle to the aerosolizing mechanism. A first and a second interlock are operably engageable with the carriage assembly to prevent coupling of the receptacle with the aerosolization mechanism. The first interlock is released to allow movement of the carriage upon movement of the handle to the extended position. The second interlock remains engaged if the receptacle is only partially inserted into the carriage assembly.

9. 发明申请

US20050051162A1 Increased dosage metered dose inhaler 有权
标题翻译：增加剂量计量剂量吸入器
公开(公告)号：US20050051162A1
公开(公告)日：2005-03-10
申请号：US10698025
申请日：2003-10-30
申请人： Carlos Schuler , Andrew Clark , Kevin Walsh , William Alston
发明人： Carlos Schuler , Andrew Clark , Kevin Walsh , William Alston
IPC分类号： A61M15/00 , B65D83/14 , A61M11/00
CPC分类号： B65D83/54 , A61M15/009
摘要： An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.
摘要翻译：雾化装置包括容纳药物制剂的容器，药物制剂包含活性剂和推进剂。雾化装置还包括与容器连通的计量室，计量室适于容纳计量量的药物制剂，阀，以允许计量量的药物制剂在计量室内从计量腔室释放时，阀门为以及当药物制剂从计量室释放时向计量室中的药物制剂施加压力的加压器。在一个版本中，计量室的尺寸设定为使得至少2mg，优选至少5mg的活性剂被雾化以在吸入期间输送给使用者。

10. 发明授权

US06668827B2 Systems devices and methods for opening receptacles having a powder to be fluidized 失效
公开(公告)号：US06668827B2
公开(公告)日：2003-12-30
申请号：US09853173
申请日：2001-05-09
申请人： Carlos Schuler , Bill Alston , Derrick Tuttle , Dennis Rasmussen , Stephen R. Deming
发明人： Carlos Schuler , Bill Alston , Derrick Tuttle , Dennis Rasmussen , Stephen R. Deming
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M15/0036 , A61M15/0038 , A61M2202/064 , B67B7/30 , Y10T408/03 , Y10T408/895 , Y10T408/896 , Y10T408/909 , Y10T408/9097
摘要： A method for forming at least one opening in a receptacle comprises the steps of providing a receptacle having a cover with an exterior surface and an interior surface covering a cavity. A cutting mechanism is also provided having at least one blade. The cover is pierced with the blade, and the blade is moved through the cover to cut a portion of the cover and create an opening in the cover to provide access into the cavity. Further, the cut portion curls on top of the exterior surface as the opening is created.

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