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1. 发明申请

US20050016533A1 Systems and methods for aerosolizing pharmaceutical formulations 审中-公开
标题翻译：雾化药物制剂的系统和方法
公开(公告)号：US20050016533A1
公开(公告)日：2005-01-27
申请号：US10601127
申请日：2003-06-19
申请人： Carlos Schuler , Steve Paboojian , Derrick Tuttle , Adrian Smith , Dennis Rasmussen , Aneesh Bakshi , Andrew Clark , Brian Ward , William Alston , Kevin Nason
发明人： Carlos Schuler , Steve Paboojian , Derrick Tuttle , Adrian Smith , Dennis Rasmussen , Aneesh Bakshi , Andrew Clark , Brian Ward , William Alston , Kevin Nason
IPC分类号： A61M15/00 , A61M16/20 , A61M16/00
CPC分类号： A61M15/0028 , A61M15/002 , A61M15/0036 , A61M15/0051 , A61M15/0068 , A61M15/0083 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M16/0493 , A61M16/0495 , A61M16/0866 , A61M16/206 , A61M16/208 , A61M2202/064
摘要： Systems and methods are provided for aerosolizing a pharmaceutical formulation. According to one method, respiratory gases are prevented from flowing to the lungs when attempting to inhale. Then, respiratory gases are abruptly permitted to flow to the lungs. The flow of respiratory gases may then be used to extract a pharmaceutical formulation from a receptacle and to place the pharmaceutical formulation within the flow of respiratory gases to form an aerosol.
摘要翻译：提供了用于雾化药物制剂的系统和方法。根据一种方法，当试图吸气时，防止呼吸气体流向肺部。然后，呼吸道气体突然被允许流向肺部。呼吸气体的流动然后可用于从容器中提取药物制剂并将药物制剂置于呼吸气体流中以形成气溶胶。

2. 发明授权

US08408200B2 Flow resistance modulated aerosolized active agent delivery 失效
标题翻译：阻流调制气雾剂活性剂输送
公开(公告)号：US08408200B2
公开(公告)日：2013-04-02
申请号：US09414384
申请日：1999-10-07
申请人： Andrew Clark , Carlos Schuler , Steve Paboojian
发明人： Andrew Clark , Carlos Schuler , Steve Paboojian
IPC分类号： A61M16/00 , A61M15/00 , A62B9/02
CPC分类号： A61M15/00 , A61M2016/0021 , A61M2202/064
摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.
摘要翻译：本发明涉及用于将活性剂制剂递送到人类患者的肺的方法和装置。活性剂制剂可以是干粉形式，它可以是雾化的，或者它可以与推进剂混合。活性剂制剂以低吸入流速在初始时期递送给患者，以提高活性剂的生物利用度。

3. 发明授权

US06679256B2 Systems and methods for extracting powders from receptacles 失效
标题翻译：从容器中提取粉末的系统和方法
公开(公告)号：US06679256B2
公开(公告)日：2004-01-20
申请号：US09731368
申请日：2000-12-06
申请人： Frank W. Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
发明人： Frank W. Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
IPC分类号： A61M1500
CPC分类号： B05B11/062 , A61M11/001 , A61M15/002 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M2202/064 , A61M2205/073 , B05B7/1413 , B65D75/366 , B65D2575/362
摘要： A method for aerosolizing a powder utilizes a receptacle having a cavity containing a powder. An access end of an extraction tube is inserted into the cavity, and an inlet opening is formed in the receptacle. A pressurized gas is flowed through the inlet opening, through the cavity and through the extraction tube to move the powder in the cavity into the extraction tube where the powder is entrained in the gas to form an aerosol.
摘要翻译：用于雾化粉末的方法利用具有包含粉末的空腔的容器。抽吸管的入口端插入空腔中，并且在容器中形成入口。加压气体通过入口开口流过空腔并通过抽出管，将空腔中的粉末移动到提取管中，将粉末夹带在气体中形成气溶胶。

4. 发明申请

US20050056275A1 Systems and methods for powder from receptacles 审中-公开
标题翻译：从容器的粉末的系统和方法
公开(公告)号：US20050056275A1
公开(公告)日：2005-03-17
申请号：US10727077
申请日：2003-12-02
申请人： Frank Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
发明人： Frank Ingle , Steve Paboojian , Carlos Schuler , Andrew Clark
IPC分类号： A61M13/00 , A61M15/00 , B05B7/14 , B05B11/06 , B65D75/36 , A61M11/00 , A61M16/00
CPC分类号： B05B11/062 , A61M11/001 , A61M15/002 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M2202/064 , A61M2205/073 , B05B7/1413 , B65D75/366 , B65D2575/362
摘要： A method for aerosolizing a powder utilizes a receptacle having a cavity containing a powder. An access end of an extraction tube is inserted into the cavity, and an inlet opening is formed in the receptacle. A pressurized gas is flowed through the inlet opening, through the cavity and through the extraction tube to move the powder in the cavity into the extraction tube where the powder is entrained in the gas to form an aerosol.
摘要翻译：用于雾化粉末的方法利用具有包含粉末的空腔的容器。抽吸管的入口端插入空腔中，并且在容器中形成入口。加压气体通过入口开口流过空腔并通过抽出管，将空腔中的粉末移动到提取管中，将粉末夹带在气体中形成气溶胶。

5. 发明授权

US06606992B1 Systems and methods for aerosolizing pharmaceutical formulations 有权
标题翻译：雾化药物制剂的系统和方法
公开(公告)号：US06606992B1
公开(公告)日：2003-08-19
申请号：US09583312
申请日：2000-05-30
申请人： Carlos Schuler , Steve Paboojian , Derrick J. Tuttle , Adrian E. Smith , Dennis R. Rasmussen , Aneesh Bakshi , Andrew Clark , Brian R. S. Ward , William W. Alston, Jr. , Kevin S. Nason
发明人： Carlos Schuler , Steve Paboojian , Derrick J. Tuttle , Adrian E. Smith , Dennis R. Rasmussen , Aneesh Bakshi , Andrew Clark , Brian R. S. Ward , William W. Alston, Jr. , Kevin S. Nason
IPC分类号： A61M1500
CPC分类号： A61M15/0028 , A61M15/002 , A61M15/0036 , A61M15/0051 , A61M15/0068 , A61M15/0083 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M16/0493 , A61M16/0495 , A61M16/0866 , A61M16/206 , A61M16/208 , A61M2202/064
摘要： Systems and methods are provided for aerosolizing a pharmaceutical formulation. According to one method, respiratory gases are prevented from flowing to the lungs when attempting to inhale. Then, respiratory gases are abruptly permitted to flow to the lungs. The flow of respiratory gases may then be used to extract a pharmaceutical formulation from a receptacle and to place the pharmaceutical formulation within the flow of respiratory gases to form an aerosol.
摘要翻译：提供了用于雾化药物制剂的系统和方法。根据一种方法，当试图吸气时，防止呼吸气体流向肺部。然后，呼吸道气体突然被允许流向肺部。呼吸气体的流动然后可用于从容器中提取药物制剂并将药物制剂置于呼吸气体流中以形成气溶胶。

6. 发明授权

US10207066B2 Aerosolization apparatus with capsule puncture alignment guide 有权
公开(公告)号：US10207066B2
公开(公告)日：2019-02-19
申请号：US10821624
申请日：2004-04-09
申请人： Michael John Dunkley , Jon David Tuckwell , Edward William Vernon-Harcourt , Mark Glusker , Steve Paboojian
发明人： Michael John Dunkley , Jon David Tuckwell , Edward William Vernon-Harcourt , Mark Glusker , Steve Paboojian
IPC分类号： A61M15/00
摘要： An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule. The alignment guide allows for more consistent puncturing of the capsule and a longer lifetime of the apparatus.

7. 发明申请

US20050000518A1 Aerosolization apparatus with capsule puncture alignment guide 审中-公开
标题翻译：胶囊穿刺对准导管的气雾化装置
公开(公告)号：US20050000518A1
公开(公告)日：2005-01-06
申请号：US10821624
申请日：2004-04-09
申请人： Michael Dunkley , Jon Tuckwell , Edward Vernon-Harcourt , Mark Glusker , Steve Paboojian
发明人： Michael Dunkley , Jon Tuckwell , Edward Vernon-Harcourt , Mark Glusker , Steve Paboojian
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0033 , A61M2202/064
摘要： An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule. The alignment guide allows for more consistent puncturing of the capsule and a longer lifetime of the apparatus.
摘要翻译：雾化装置包括限定具有一个或多个空气入口的室的壳体。该腔室的大小适于接收含有可雾化药物制剂的胶囊。雾化装置还包括在壳体内的穿刺机构。穿刺机构包括对准引导件和穿刺构件，其中对齐引导件包括适于在穿刺构件前进到胶囊中以接触胶囊的表面以在胶囊中形成开口。表面的至少一部分相对于胶囊的纵向轴线倾斜。或者或另外，表面可以包括一个或多个突起。端部与壳体相关联。端部的尺寸和形状被容纳在使用者的嘴或鼻中，使得使用者可以通过端部部分吸入，以吸入通过在胶囊中形成的开口离开胶囊的雾化药物制剂。对准引导件允许胶囊的更一致的穿刺和装置的更长的使用寿命。

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