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1. 发明授权

US07344890B2 Method for discriminating platelets from red blood cells 有权
标题翻译：鉴别血小板与红细胞的方法
公开(公告)号：US07344890B2
公开(公告)日：2008-03-18
申请号：US11270859
申请日：2005-11-09
申请人： Carlos A. Perez , Lidice L. Lopez , Mark A. Wells , Joaquin Ibanez , Eileen Landrum , Roberto Del Valle , Santiago Galvez
发明人： Carlos A. Perez , Lidice L. Lopez , Mark A. Wells , Joaquin Ibanez , Eileen Landrum , Roberto Del Valle , Santiago Galvez
IPC分类号： G01N33/48
CPC分类号： G01N33/80 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/25125
摘要： A method for discriminating and quantifying platelets within an analyzed blood sample involves initially diluting the blood sample with a ghosting reagent that causes a change in the index of refraction of the red blood cells. Owing to the change in the index of refraction, light scattered from the ghosted red blood cells will be substantially reduced relative to light scattered from platelets. This results in locations of platelets within a scatterplot of the analyzed blood sample to fall within a region distinguishable from those containing normal red blood cells, fragmented red blood cells, and microcytic red blood cells.
摘要翻译：在分析的血液样品中鉴别和定量血小板的方法包括首先用引起红细胞折射率变化的重影试剂稀释血液样品。由于折射率的变化，相对于从血小板散射的光，从重影的红细胞散射的光将显着降低。这导致血小板在分析的血液样品的散点图内的位置落入与含有正常红细胞，碎片红细胞和微红细胞的区域区分开的区域内。

2. 发明授权

US07208319B2 Method of measurement of nucleated red blood cells 有权
标题翻译：有核红细胞测量方法
公开(公告)号：US07208319B2
公开(公告)日：2007-04-24
申请号：US11338229
申请日：2006-01-24
申请人： Lidice L. Lopez , Carlos A. Perez , Mark A. Wells , Diana B. Careaga , Ziling Huo , Cheng Qian , Nancy J. Torke
发明人： Lidice L. Lopez , Carlos A. Perez , Mark A. Wells , Diana B. Careaga , Ziling Huo , Cheng Qian , Nancy J. Torke
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N33/80 , G01N15/1031 , G01N15/12 , G01N15/1459 , G01N33/5094 , G01N2015/0073 , G01N2015/008 , G01N2015/1037 , G01N2015/1062 , G01N2015/1486 , Y10T436/101666 , Y10T436/25125
摘要： Methods are provided for measurement of nucleated red blood cells in a blood sample. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells, subsequently analyzing nucleated red blood cells in a flow cell by axial light loss, DC impedance, and medium angle light scatter measurements; by axial light loss, low angle light scatter, and medium angle light scatter measurements; or by axial light loss, DC impedance, low angle light scatter, and medium angle light scatter measurements; and then differentiating nucleated red blood cells from other cell types by using measured signals and/or functions thereof.
摘要翻译：提供了用于测量血液样品中有核红细胞的方法。所述方法包括将血液细胞样品暴露于试剂系统以裂解成熟红细胞，随后通过轴向光损失，DC阻抗和中等角度光散射测量分析流动池中的有核红细胞; 通过轴向光损失，低角度光散射和中等角度光散射测量; 或通过轴向光损失，直流阻抗，低角度光散射和中等角度光散射测量; 然后通过使用测量的信号和/或功能将有核红细胞与其它细胞类型区分开来。

3. 发明授权

US07008792B2 Method of measurement of nucleated red blood cells 有权
标题翻译：有核红细胞测量方法
公开(公告)号：US07008792B2
公开(公告)日：2006-03-07
申请号：US11048086
申请日：2005-02-01
申请人： Lidice L. Lopez , Carlos A. Perez , Mark A. Wells , Diana B. Careaga , Ziling Huo , Cheng Qian
发明人： Lidice L. Lopez , Carlos A. Perez , Mark A. Wells , Diana B. Careaga , Ziling Huo , Cheng Qian
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N15/12 , G01N15/1031 , G01N15/1459 , G01N33/5094 , G01N33/80 , G01N2015/0073 , G01N2015/008 , G01N2015/1037 , G01N2015/1062 , G01N2015/1486 , Y10T436/101666 , Y10T436/25125
摘要： Methods are provided for measurement of nucleated red blood cells. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells, subsequently analyzing nucleated red blood cells in a flow cell by axial light loss, low angle light scatter and DC impedance measurements, or two selected measurements thereof; and then differentiating nucleated red blood cells from other cell types by using measured signals and/or functions thereof.
摘要翻译：提供了用于测量有核红细胞的方法。所述方法包括将血液细胞样品暴露于试剂系统以裂解成熟的红细胞，随后通过轴向光损失，低角度光散射和DC阻抗测量或其两个选定的测量来分析流动池中的有核红细胞; 然后通过使用测量的信号和/或功能将有核红细胞与其它细胞类型区分开来。

4. 发明授权

US07390662B2 Method and apparatus for performing platelet measurement 失效
标题翻译：用于进行血小板测量的方法和装置
公开(公告)号：US07390662B2
公开(公告)日：2008-06-24
申请号：US11270865
申请日：2005-11-09
申请人： John S. Riley , Jose Cano , Valentin Quesada , Maritza Lavernia , Mark A. Wells , Eileen Landrum , Carlos A. Perez , Christophe Godefroy
发明人： John S. Riley , Jose Cano , Valentin Quesada , Maritza Lavernia , Mark A. Wells , Eileen Landrum , Carlos A. Perez , Christophe Godefroy
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N1/12 , G01N15/1459 , G01N2015/0084 , G01N2015/1037 , G01N2015/129 , Y10T436/10 , Y10T436/101666 , Y10T436/107497
摘要： The present invention relates to a hematology instrument system that discriminates platelets from red blood cells, debris and other particles within a blood sample. The instrument system uses an optical trigger and collects data at optical sensor locations relative to a flow cell-illuminating laser beam's optical axis. An axial sensor measures axial light loss due to a particle in the flow cell's illumination aperture. In addition, the instrument system can include an RF unit generates electrical parameters, such as DC and RF parameters, within the flow cell. Blood specimens can be prepared with and without a sphering agent.
摘要翻译：本发明涉及一种血液学仪器系统，其将血小板与血液样本中的红细胞，碎片和其它颗粒区分开。仪器系统使用光学触发器，并相对于流动池照明激光束的光轴在光学传感器位置收集数据。轴向传感器测量由于流动池的照明孔径中的颗粒引起的轴向光损失。此外，仪器系统可以包括RF单元在流动池内产生电参数，例如DC和RF参数。血液标本可以在有和没有球形剂的情况下制备。

5. 发明授权

US08339585B2 Transducer module 有权
标题翻译：传感器模块
公开(公告)号：US08339585B2
公开(公告)日：2012-12-25
申请号：US13312832
申请日：2011-12-06
申请人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
发明人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
IPC分类号： G01N33/48 , G01N21/00
CPC分类号： G01N21/532 , G01N15/1459 , G01N15/147 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084
摘要： Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss. The presented methods for analyzing a blood sample generally include aspirating a whole blood sample into a blood analysis instrument, preparing the blood sample for analysis, passing the blood sample through a flow cell in a transducer system, and measuring axial light loss, multiple angles of light scatter, DC impedance and/or RF conductivity.
摘要翻译：用于血液分析仪器的传感器模块和用于分析血液样本的方法。所呈现的换能器模块通常包括光源，聚焦对准系统，流动池和光散射检测系统。流动池内的电极允许测量通过流动池中的细胞询问区的细胞的DC阻抗和RF电导率。通过细胞询问区的细胞的光散射通过光散射检测系统测量。光散射检测系统测量高中值光散射，较低中角度光散射，低角度光散射和轴向光损失的光散射参数。提出的分析血液样本的方法通常包括将全血样品吸入血液分析仪器，准备用于分析的血液样品，使血液样品通过换能器系统中的流动池，并测量轴向光损失，多个角度光散射，DC阻抗和/或RF电导率。

6. 发明授权

US08094299B2 Transducer module 有权
公开(公告)号：US08094299B2
公开(公告)日：2012-01-10
申请号：US12178817
申请日：2008-07-24
申请人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
发明人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
IPC分类号： G01N21/01
CPC分类号： G01N21/532 , G01N15/1459 , G01N15/147 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084
摘要： Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss. The presented methods for analyzing a blood sample generally include aspirating a whole blood sample into a blood analysis instrument, preparing the blood sample for analysis, passing the blood sample through a flow cell in a transducer system, and measuring axial light loss, multiple angles of light scatter, DC impedance and/or RF conductivity.

7. 发明申请

US20100020308A1 Transducer Module 有权
标题翻译：传感器模块
公开(公告)号：US20100020308A1
公开(公告)日：2010-01-28
申请号：US12178817
申请日：2008-07-24
申请人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
发明人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
IPC分类号： G01N33/48 , G01B11/00
CPC分类号： G01N21/532 , G01N15/1459 , G01N15/147 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084
摘要： Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss. The presented methods for analyzing a blood sample generally include aspirating a whole blood sample into a blood analysis instrument, preparing the blood sample for analysis, passing the blood sample through a flow cell in a transducer system, and measuring axial light loss, multiple angles of light scatter, DC impedance and/or RF conductivity.
摘要翻译：用于血液分析仪器的传感器模块和用于分析血液样本的方法。所呈现的换能器模块通常包括光源，聚焦对准系统，流动池和光散射检测系统。流动池内的电极允许测量通过流动池中的细胞询问区的细胞的DC阻抗和RF电导率。通过细胞询问区的细胞的光散射通过光散射检测系统测量。光散射检测系统测量高中值光散射，较低中角度光散射，低角度光散射和轴向光损失的光散射参数。提出的分析血液样本的方法通常包括将全血样品吸入血液分析仪器，制备用于分析的血液样品，使血液样品通过换能器系统中的流动池，并测量轴向光损失，多个角度光散射，DC阻抗和/或RF电导率。

8. 发明申请

US20120075630A1 Transducer Module 有权
标题翻译：传感器模块
公开(公告)号：US20120075630A1
公开(公告)日：2012-03-29
申请号：US13312832
申请日：2011-12-06
申请人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
发明人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
IPC分类号： G01N21/84
CPC分类号： G01N21/532 , G01N15/1459 , G01N15/147 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084
摘要： Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss. The presented methods for analyzing a blood sample generally include aspirating a whole blood sample into a blood analysis instrument, preparing the blood sample for analysis, passing the blood sample through a flow cell in a transducer system, and measuring axial light loss, multiple angles of light scatter, DC impedance and/or RF conductivity.
摘要翻译：用于血液分析仪器的传感器模块和用于分析血液样本的方法。所呈现的换能器模块通常包括光源，聚焦对准系统，流动池和光散射检测系统。流动池内的电极允许测量通过流动池中的细胞询问区的细胞的DC阻抗和RF电导率。通过细胞询问区的细胞的光散射通过光散射检测系统测量。光散射检测系统测量高中值光散射，较低中角度光散射，低角度光散射和轴向光损失的光散射参数。提出的分析血液样本的方法通常包括将全血样品吸入血液分析仪器，准备用于分析的血液样品，使血液样品通过换能器系统中的流动池，并测量轴向光损失，多个角度光散射，DC阻抗和/或RF电导率。

9. 发明授权

US08189187B2 Monolithic optical flow cells and method of manufacture 有权
标题翻译：单片光流池及其制造方法
公开(公告)号：US08189187B2
公开(公告)日：2012-05-29
申请号：US12617897
申请日：2009-11-13
申请人： Marshall Donnie Graham , William Gerry Graham , James P. Clarkin , Mark A. Wells , Jose M. Cano , Carlos Alberto Arboleda , Armando Jose Sanchez
发明人： Marshall Donnie Graham , William Gerry Graham , James P. Clarkin , Mark A. Wells , Jose M. Cano , Carlos Alberto Arboleda , Armando Jose Sanchez
IPC分类号： G01N1/10
CPC分类号： G01N15/1436 , C03B23/04 , C03B23/047 , C03B23/0476 , C03B23/057 , G01N15/1459 , G01N2015/1037 , G01N2015/1486 , Y02P40/57
摘要： An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells). Manufactured from a monolithic transparent material, the improved flow cell has an internal flow channel of polygonal transverse cross-section through which prepared samples can be metered and an external envelope suited to acquisition of optical parameters from formed bodies in such samples. Preferably, such flow cell is formed by a glass-drawing process in which a relatively large glass preform having a rectilinear internal channel of a desired polygonal cross-sectional shape is heated and drawn to achieve a desired cross-sectional area of reduced size. Also disclosed are preferred methods for differentiating formed bodies using the flow cell of the invention.
摘要翻译：改进的光学流通池，适用于流式细胞仪，用于分化成形体（例如血细胞）。从单片透明材料制造，改进的流动池具有多边形横截面的内部流动通道，通过该内部流动通道，可以对准备的样品进行计量，并且外部包络适合于从这些样品中的成形体获取光学参数。优选地，这样的流动池通过玻璃拉制工艺形成，其中将具有所需多边形横截面形状的具有直线内部通道的相对较大的玻璃预制件加热和拉伸以达到所需的减小尺寸的横截面面积。还公开了使用本发明的流动池来区分成形体的优选方法。

10. 发明申请

US20210183174A1 METHOD AND SYSTEM FOR BATTERY MANAGEMENT FOR MOBILE GEOFENCING DEVICES 有权
公开(公告)号：US20210183174A1
公开(公告)日：2021-06-17
申请号：US17119112
申请日：2020-12-11
申请人： Mark A. Wells , Ezra T. Peachey , Jorma A. Seppanen
发明人： Mark A. Wells , Ezra T. Peachey , Jorma A. Seppanen
IPC分类号： G07C5/00 , G06F1/26 , G07C5/08 , H04L29/08 , G01K3/00
摘要： A method and system for battery management for a mobile geofence apparatus. Location information for a vehicle, temperature information for the vehicle and battery information for the internal battery on the mobile geofence apparatus is automatically, continuously and periodically collected and sent during a connection interval in real-time to an external network server network device via communications network for tracking the vehicle in real-time. The battery information is displayed on the mobile geofence apparatus for a viewer and is also sent to an external server network device for display to a viewer. Internal battery usage is automatically managed internally on the mobile geofence apparatus using the collected location, battery and temperature information. The internal battery on the mobile geofence apparatus can also be automatically managed externally via the external server network device using the collected location, battery and temperature information. The connection interval is adjusted automatically and dynamically by mobile geofence apparatus itself or by the external network server to save battery life on the internal battery when the vehicle is in extreme hot or cold weather conditions and during times when the vehicle is an area with poor network connectivity or coverage.

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