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1. 发明申请

US20100329927A1 Pipelining Assembly For A Blood Analyzing Instrument 审中-公开
标题翻译：血液分析仪器用流通装置
公开(公告)号：US20100329927A1
公开(公告)日：2010-12-30
申请号：US12492270
申请日：2009-06-26
申请人： Carlos A. Perez , Jose M. Cano , Joe C. Schorsch , Viviana A. Vargas
发明人： Carlos A. Perez , Jose M. Cano , Joe C. Schorsch , Viviana A. Vargas
IPC分类号： G01N33/48 , G01N1/28
CPC分类号： G01N35/0092 , G01N35/085 , G01N35/1004 , G01N35/1097 , G01N2035/00326 , G01N2035/0093 , Y10T436/11 , Y10T436/2575
摘要： A pipelining assembly for use in a blood analyzing instrument, methods for performing parallel pipelining functions, and methods for processing a plurality of prepared blood samples through a blood analyzing instrument. The pipelining assembly presented generally includes a first sample preparation chamber, a first queuing chamber in fluid communication with the first sample preparation chamber, and a first control valve between the first sample preparation chamber and the first queuing chamber. The pipelining assembly further includes a second sample preparation chamber, a second queuing chamber in fluid communication with the second sample preparation chamber, and a second control valve between the second sample preparation chamber and the second queuing chamber. An analysis chamber is provided to receive first and second prepared blood samples from the in first and second queuing chambers. The presented methods include steps for repeated processing of prepared blood samples through the blood analyzing instrument.
摘要翻译：用于血液分析仪器的流水线组件，用于执行平行流水线功能的方法，以及通过血液分析仪器处理多个准备的血液样本的方法。流水线组件通常包括第一样品制备室，与第一样品制备室流体连通的第一排队室，以及在第一样品制备室和第一排队室之间的第一控制阀。流水线组件还包括第二样品制备室，与第二样品制备室流体连通的第二排列室，以及在第二样品制备室和第二排列室之间的第二控制阀。提供分析室以从第一和第二排队室接收第一和第二准备的血液样本。所提出的方法包括通过血液分析仪器重复处理制备的血液样品的步骤。

2. 发明授权

US08916384B2 Pipelining assembly for a blood analyzing instrument 有权
标题翻译：用于血液分析仪器的流水线组件
公开(公告)号：US08916384B2
公开(公告)日：2014-12-23
申请号：US13443581
申请日：2012-04-10
申请人： Carlos A. Perez , Jose M. Cano , Joe C. Schorsch , Viviana A. Vargas
发明人： Carlos A. Perez , Jose M. Cano , Joe C. Schorsch , Viviana A. Vargas
IPC分类号： G01N35/00 , C12Q1/02 , G01N35/08 , G01N35/10
CPC分类号： G01N35/0092 , G01N35/085 , G01N35/1004 , G01N35/1097 , G01N2035/00326 , G01N2035/0093 , Y10T436/11 , Y10T436/2575
摘要： A pipelining assembly for use in a blood analyzing instrument, methods for performing parallel pipelining functions, and methods for processing a plurality of prepared blood samples through a blood analyzing instrument. The pipelining assembly presented generally includes a first sample preparation chamber, a first queuing chamber in fluid communication with the first sample preparation chamber, and a first control valve between the first sample preparation chamber and the first queuing chamber. The pipelining assembly further includes a second sample preparation chamber, a second queuing chamber in fluid communication with the second sample preparation chamber, and a second control valve between the second sample preparation chamber and the second queuing chamber. An analysis chamber is provided to receive first and second prepared blood samples from the in first and second queuing chambers. The presented methods include steps for repeated processing of prepared blood samples through the blood analyzing instrument.
摘要翻译：用于血液分析仪器的流水线组件，用于执行平行流水线功能的方法，以及通过血液分析仪器处理多个准备的血液样本的方法。流水线组件通常包括第一样品制备室，与第一样品制备室流体连通的第一排队室，以及在第一样品制备室和第一排队室之间的第一控制阀。流水线组件还包括第二样品制备室，与第二样品制备室流体连通的第二排列室，以及在第二样品制备室和第二排列室之间的第二控制阀。提供分析室以从第一和第二排队室接收第一和第二准备的血液样本。所提出的方法包括通过血液分析仪器重复处理制备的血液样品的步骤。

3. 发明申请

US20150080015A2 METHOD AND SYSTEM FOR MONITORING A MOBILE STATION PRESENCE IN A SPECIAL AREA 有权
公开(公告)号：US20150080015A2
公开(公告)日：2015-03-19
申请号：US14250517
申请日：2014-04-11
申请人： Carlos A. Perez Lafuente
发明人： Carlos A. Perez Lafuente
IPC分类号： H04W4/02
CPC分类号： H04W4/021 , H04M3/42365 , H04M3/42374 , H04W4/02 , H04W4/50 , H04W8/005 , H04W24/00 , H04W28/18 , H04W48/08 , H04W48/16 , H04W64/00 , H04W64/006
摘要： Method for monitoring the presence of a mobile station in at least one special area, wherein a radio communication defining device transmits one radio distinctive defining signal that define the special area by its coverage, the mobile station processes a signal received in order to determine whether or not it is defining signal and more precisely a distinctive one that defines the special area, the mobile station sends an updating signal to a mobile telephone network, the network routes the updating signal to special operating means that adapt the value of an operating parameter. According to the invention, the special area is associated to the mobile station by transmitting to the mobile station a checking data used by the mobile station for determining whether or not the defining signal received is distinctive defining signal.

4. 发明授权

US08339585B2 Transducer module 有权
标题翻译：传感器模块
公开(公告)号：US08339585B2
公开(公告)日：2012-12-25
申请号：US13312832
申请日：2011-12-06
申请人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
发明人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
IPC分类号： G01N33/48 , G01N21/00
CPC分类号： G01N21/532 , G01N15/1459 , G01N15/147 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084
摘要： Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss. The presented methods for analyzing a blood sample generally include aspirating a whole blood sample into a blood analysis instrument, preparing the blood sample for analysis, passing the blood sample through a flow cell in a transducer system, and measuring axial light loss, multiple angles of light scatter, DC impedance and/or RF conductivity.
摘要翻译：用于血液分析仪器的传感器模块和用于分析血液样本的方法。所呈现的换能器模块通常包括光源，聚焦对准系统，流动池和光散射检测系统。流动池内的电极允许测量通过流动池中的细胞询问区的细胞的DC阻抗和RF电导率。通过细胞询问区的细胞的光散射通过光散射检测系统测量。光散射检测系统测量高中值光散射，较低中角度光散射，低角度光散射和轴向光损失的光散射参数。提出的分析血液样本的方法通常包括将全血样品吸入血液分析仪器，准备用于分析的血液样品，使血液样品通过换能器系统中的流动池，并测量轴向光损失，多个角度光散射，DC阻抗和/或RF电导率。

5. 发明授权

US08094299B2 Transducer module 有权
公开(公告)号：US08094299B2
公开(公告)日：2012-01-10
申请号：US12178817
申请日：2008-07-24
申请人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
发明人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
IPC分类号： G01N21/01
CPC分类号： G01N21/532 , G01N15/1459 , G01N15/147 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084
摘要： Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss. The presented methods for analyzing a blood sample generally include aspirating a whole blood sample into a blood analysis instrument, preparing the blood sample for analysis, passing the blood sample through a flow cell in a transducer system, and measuring axial light loss, multiple angles of light scatter, DC impedance and/or RF conductivity.

6. 发明申请

US20100020308A1 Transducer Module 有权
标题翻译：传感器模块
公开(公告)号：US20100020308A1
公开(公告)日：2010-01-28
申请号：US12178817
申请日：2008-07-24
申请人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
发明人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
IPC分类号： G01N33/48 , G01B11/00
CPC分类号： G01N21/532 , G01N15/1459 , G01N15/147 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084
摘要： Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss. The presented methods for analyzing a blood sample generally include aspirating a whole blood sample into a blood analysis instrument, preparing the blood sample for analysis, passing the blood sample through a flow cell in a transducer system, and measuring axial light loss, multiple angles of light scatter, DC impedance and/or RF conductivity.
摘要翻译：用于血液分析仪器的传感器模块和用于分析血液样本的方法。所呈现的换能器模块通常包括光源，聚焦对准系统，流动池和光散射检测系统。流动池内的电极允许测量通过流动池中的细胞询问区的细胞的DC阻抗和RF电导率。通过细胞询问区的细胞的光散射通过光散射检测系统测量。光散射检测系统测量高中值光散射，较低中角度光散射，低角度光散射和轴向光损失的光散射参数。提出的分析血液样本的方法通常包括将全血样品吸入血液分析仪器，制备用于分析的血液样品，使血液样品通过换能器系统中的流动池，并测量轴向光损失，多个角度光散射，DC阻抗和/或RF电导率。

7. 发明申请

US20120075630A1 Transducer Module 有权
标题翻译：传感器模块
公开(公告)号：US20120075630A1
公开(公告)日：2012-03-29
申请号：US13312832
申请日：2011-12-06
申请人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
发明人： Mark A. Wells , Carlos A. Perez , Jose M. Cano
IPC分类号： G01N21/84
CPC分类号： G01N21/532 , G01N15/1459 , G01N15/147 , G01N2015/0073 , G01N2015/0076 , G01N2015/008 , G01N2015/0084
摘要： Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss. The presented methods for analyzing a blood sample generally include aspirating a whole blood sample into a blood analysis instrument, preparing the blood sample for analysis, passing the blood sample through a flow cell in a transducer system, and measuring axial light loss, multiple angles of light scatter, DC impedance and/or RF conductivity.
摘要翻译：用于血液分析仪器的传感器模块和用于分析血液样本的方法。所呈现的换能器模块通常包括光源，聚焦对准系统，流动池和光散射检测系统。流动池内的电极允许测量通过流动池中的细胞询问区的细胞的DC阻抗和RF电导率。通过细胞询问区的细胞的光散射通过光散射检测系统测量。光散射检测系统测量高中值光散射，较低中角度光散射，低角度光散射和轴向光损失的光散射参数。提出的分析血液样本的方法通常包括将全血样品吸入血液分析仪器，准备用于分析的血液样品，使血液样品通过换能器系统中的流动池，并测量轴向光损失，多个角度光散射，DC阻抗和/或RF电导率。

8. 发明授权

US07390662B2 Method and apparatus for performing platelet measurement 失效
标题翻译：用于进行血小板测量的方法和装置
公开(公告)号：US07390662B2
公开(公告)日：2008-06-24
申请号：US11270865
申请日：2005-11-09
申请人： John S. Riley , Jose Cano , Valentin Quesada , Maritza Lavernia , Mark A. Wells , Eileen Landrum , Carlos A. Perez , Christophe Godefroy
发明人： John S. Riley , Jose Cano , Valentin Quesada , Maritza Lavernia , Mark A. Wells , Eileen Landrum , Carlos A. Perez , Christophe Godefroy
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N1/12 , G01N15/1459 , G01N2015/0084 , G01N2015/1037 , G01N2015/129 , Y10T436/10 , Y10T436/101666 , Y10T436/107497
摘要： The present invention relates to a hematology instrument system that discriminates platelets from red blood cells, debris and other particles within a blood sample. The instrument system uses an optical trigger and collects data at optical sensor locations relative to a flow cell-illuminating laser beam's optical axis. An axial sensor measures axial light loss due to a particle in the flow cell's illumination aperture. In addition, the instrument system can include an RF unit generates electrical parameters, such as DC and RF parameters, within the flow cell. Blood specimens can be prepared with and without a sphering agent.
摘要翻译：本发明涉及一种血液学仪器系统，其将血小板与血液样本中的红细胞，碎片和其它颗粒区分开。仪器系统使用光学触发器，并相对于流动池照明激光束的光轴在光学传感器位置收集数据。轴向传感器测量由于流动池的照明孔径中的颗粒引起的轴向光损失。此外，仪器系统可以包括RF单元在流动池内产生电参数，例如DC和RF参数。血液标本可以在有和没有球形剂的情况下制备。

9. 发明授权

US07208319B2 Method of measurement of nucleated red blood cells 有权
标题翻译：有核红细胞测量方法
公开(公告)号：US07208319B2
公开(公告)日：2007-04-24
申请号：US11338229
申请日：2006-01-24
申请人： Lidice L. Lopez , Carlos A. Perez , Mark A. Wells , Diana B. Careaga , Ziling Huo , Cheng Qian , Nancy J. Torke
发明人： Lidice L. Lopez , Carlos A. Perez , Mark A. Wells , Diana B. Careaga , Ziling Huo , Cheng Qian , Nancy J. Torke
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N33/80 , G01N15/1031 , G01N15/12 , G01N15/1459 , G01N33/5094 , G01N2015/0073 , G01N2015/008 , G01N2015/1037 , G01N2015/1062 , G01N2015/1486 , Y10T436/101666 , Y10T436/25125
摘要： Methods are provided for measurement of nucleated red blood cells in a blood sample. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells, subsequently analyzing nucleated red blood cells in a flow cell by axial light loss, DC impedance, and medium angle light scatter measurements; by axial light loss, low angle light scatter, and medium angle light scatter measurements; or by axial light loss, DC impedance, low angle light scatter, and medium angle light scatter measurements; and then differentiating nucleated red blood cells from other cell types by using measured signals and/or functions thereof.
摘要翻译：提供了用于测量血液样品中有核红细胞的方法。所述方法包括将血液细胞样品暴露于试剂系统以裂解成熟红细胞，随后通过轴向光损失，DC阻抗和中等角度光散射测量分析流动池中的有核红细胞; 通过轴向光损失，低角度光散射和中等角度光散射测量; 或通过轴向光损失，直流阻抗，低角度光散射和中等角度光散射测量; 然后通过使用测量的信号和/或功能将有核红细胞与其它细胞类型区分开来。

10. 发明授权

US07008792B2 Method of measurement of nucleated red blood cells 有权
标题翻译：有核红细胞测量方法
公开(公告)号：US07008792B2
公开(公告)日：2006-03-07
申请号：US11048086
申请日：2005-02-01
申请人： Lidice L. Lopez , Carlos A. Perez , Mark A. Wells , Diana B. Careaga , Ziling Huo , Cheng Qian
发明人： Lidice L. Lopez , Carlos A. Perez , Mark A. Wells , Diana B. Careaga , Ziling Huo , Cheng Qian
IPC分类号： G01N31/00 , G01N33/48
CPC分类号： G01N15/12 , G01N15/1031 , G01N15/1459 , G01N33/5094 , G01N33/80 , G01N2015/0073 , G01N2015/008 , G01N2015/1037 , G01N2015/1062 , G01N2015/1486 , Y10T436/101666 , Y10T436/25125
摘要： Methods are provided for measurement of nucleated red blood cells. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells, subsequently analyzing nucleated red blood cells in a flow cell by axial light loss, low angle light scatter and DC impedance measurements, or two selected measurements thereof; and then differentiating nucleated red blood cells from other cell types by using measured signals and/or functions thereof.
摘要翻译：提供了用于测量有核红细胞的方法。所述方法包括将血液细胞样品暴露于试剂系统以裂解成熟的红细胞，随后通过轴向光损失，低角度光散射和DC阻抗测量或其两个选定的测量来分析流动池中的有核红细胞; 然后通过使用测量的信号和/或功能将有核红细胞与其它细胞类型区分开来。

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