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1. 发明授权

US3972627A Apparatus for investigating fast chemical reactions by optical detection 失效
标题翻译：用于通过光学检测来调查快速化学反应的装置
公开(公告)号：US3972627A
公开(公告)日：1976-08-03
申请号：US487592
申请日：1974-07-11
申请人： Carl-Roland Rabl , Rudolf Rigler , Thomas J. Jovin , Hermann Brundl , Wolfgang Simm
发明人： Carl-Roland Rabl , Rudolf Rigler , Thomas J. Jovin , Hermann Brundl , Wolfgang Simm
IPC分类号： G01N21/03 , G01N21/27 , G01N21/59 , G01N21/64 , G01N21/24
CPC分类号： G01N21/6445 , G01N21/272 , G01N21/645 , G01N2021/0389 , G01N2021/0392 , G01N2021/1738 , G01N2021/6491 , G01N21/0332 , G01N21/59 , G01N2201/1226 , G01N2201/127
摘要： An apparatus for investigating the course of fast chemical reactions, which are initiated in a liquid chemical system under investigation by an external perturbation, e.g. a steep temperature rise (temperature jump). The apparatus comprises first and second light paths conveying a probing light beam and a sense light beam, respectively, and an optical system of extremely high aperture which allows a wide variety of types of measurements, including absorption, fluorescense, fluorescense polarization, and the like with a high signal-to-noise ratio even of small sample concentrations.
摘要翻译：一种用于调查快速化学反应过程的装置，其在通过外部扰动研究的液体化学系统中开始，例如，温度升高（温度上升）。该装置包括分别传送探测光束和感测光束的第一和第二光路以及极高孔径的光学系统，其允许多种类型的测量，包括吸收，荧光，荧光偏振等甚至具有较小的样品浓度的高信噪比。

2. 发明授权

US07534576B2 Method and a device for the evaluation of biopolymer fitness 失效
标题翻译：用于评估生物聚合物适应性的方法和装置
公开(公告)号：US07534576B2
公开(公告)日：2009-05-19
申请号：US11730931
申请日：2007-04-04
申请人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehman
发明人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehman
IPC分类号： G01N33/569
CPC分类号： G01N21/6452 , C12Q1/04 , C12Q1/6827 , G01N21/64 , G01N21/6402 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G02B21/24 , Y10S435/808 , Y10S436/805 , Y10T436/11 , C12Q2565/107 , C12Q2561/113 , C12Q2535/131
摘要： A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 μM, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably ≧1.2 N.A. is employed, the light quantity is limited by a confocally arranged pinhole aperture in the object plane behind the microscope objective, and the measuring compartment is positioned at a distance of between 0 and 1000 μm from the observation objective.
摘要翻译：使用测量时间<= 500ms的激光激发FCS和要分析的分子的短扩散路径来识别一个或少数分子，特别是稀释度为<=1μM的分子的方法，其中测量在通过确定由待分析的分子的发光测量确定的材料特异性参数，优选<=10-14μl的小体积单位。可以优选用于执行根据本发明的方法的装置是本身已知的用于在非常稀释的溶液的小测量室中进行荧光激发的激光聚焦的显微镜光学系统，并且用于在后续测量中对发射的光进行成像通过共焦成像，其中使用具有优选> = 1.2NA的高数值孔径的至少一个光学系统，光量受到在显微镜物镜后面的物平面中的共同排列的针孔的限制，并且测量室位于与观察目标之间的距离为0至1000μm。

3. 发明申请

US20070243525A1 Method and a device for the evaluation of biopolymer fitness 失效
公开(公告)号：US20070243525A1
公开(公告)日：2007-10-18
申请号：US11730931
申请日：2007-04-04
申请人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehmann
发明人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehmann
IPC分类号： C12Q1/02 , C12Q1/70 , G01J3/30
CPC分类号： G01N21/6452 , C12Q1/04 , C12Q1/6827 , G01N21/64 , G01N21/6402 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G02B21/24 , Y10S435/808 , Y10S436/805 , Y10T436/11 , C12Q2565/107 , C12Q2561/113 , C12Q2535/131
摘要： A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 μM, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined. The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably ≧1.2 N.A. is employed, the light quantity is limited by a confocally arranged pinhole aperture in the object plane behind the microscope objective, and the measuring compartment is positioned at a distance of between 0 and 1000 μm from the observation objective.

4. 发明授权

US06582903B1 Method and a device for the evaluation of biopolymer fitness 失效
标题翻译：用于评估生物聚合物适应性的方法和装置
公开(公告)号：US06582903B1
公开(公告)日：2003-06-24
申请号：US09021410
申请日：1998-02-10
申请人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehmann
发明人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehmann
IPC分类号： G01N33543
CPC分类号： G01N21/6402 , G01N21/6428 , G01N21/6458 , G01N2021/6417 , Y10S435/808 , Y10S436/805 , Y10T436/11
摘要： A method for identifying one or a small number of molecules, especially in a dilution of ≦1 &mgr;M, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.
摘要翻译：使用测量时间<= 500ms的激光激发FCS和要分析的分子的短扩散路径来识别一个或少数分子，特别是稀释度为<=1μM的分子的方法，其中测量在通过确定由待分析的分子的发光测量确定的材料特异性参数，优选<=10-14μl的小体积单位。

5. 发明授权

US07241569B2 Method and a device for the evaluation of biopolymer fitness 有权
标题翻译：用于评估生物聚合物适应性的方法和装置
公开(公告)号：US07241569B2
公开(公告)日：2007-07-10
申请号：US10435674
申请日：2003-05-12
申请人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehman
发明人： Rudolf Rigler , Manfred Eigen , Karsten Henco , Ulo Mets , Jerker Widengren , Michael Stuke , Michael Brinkmeyer , Wolfgang Simm , Olaf Lehman
IPC分类号： G01N33/543
CPC分类号： G01N21/6452 , C12Q1/04 , C12Q1/6827 , G01N21/64 , G01N21/6402 , G01N21/6408 , G01N21/6428 , G01N21/6458 , G02B21/24 , Y10S435/808 , Y10S436/805 , Y10T436/11 , C12Q2565/107 , C12Q2561/113 , C12Q2535/131
摘要： A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 μM, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l, by determining material-specific parameters which are determined by luminescence measurements of molecules to be examined.The device which can be preferably used for performing the method according to the invention is a per se known system of microscope optics for laser focusing for fluorescence excitation in a small measuring compartment of a very diluted solution and for imaging the emitted light in the subsequent measurement through confocal imaging wherein at least one system of optics with high numerical aperture of preferably ≧1.2 N.A. is employed, the light quantity is limited by a confocally arranged pinhole aperture in the object plane behind the microscope objective, and the measuring compartment is positioned at a distance of between 0 and 1000 μm from the observation objective.
摘要翻译：使用测量时间<= 500ms的激光激发FCS和要分析的分子的短扩散路径来识别一个或少数分子，特别是稀释度为<=1μM的分子的方法，其中测量在通过确定通过待检测分子的发光测量确定的材料特异性参数，优选<= 10 -14 / 1的小体积单位。可以优选用于执行根据本发明的方法的装置是本身已知的用于在非常稀释的溶液的小测量室中进行荧光激发的激光聚焦的显微镜光学系统，并且用于在后续测量中对发射的光进行成像通过共焦成像，其中使用具有优选> = 1.2NA的高数值孔径的至少一个光学系统，光量受到在显微镜物镜后面的物平面中的共同排列的针孔的限制，并且测量室位于与观察目标之间的距离为0至1000μm。

6. 发明授权

US5430957A Installation and process for the temperature control of chemical and/or biochemical and/or microbiological substances 失效
标题翻译：化学和/或生物化学和/或微生物物质的温度控制的安装和处理
公开(公告)号：US5430957A
公开(公告)日：1995-07-11
申请号：US30046
申请日：1993-03-10
申请人： Manfred Eigen , Wolfgang Simm , Roderich Weise
发明人： Manfred Eigen , Wolfgang Simm , Roderich Weise
IPC分类号： B01L7/00 , B01L7/04 , F26B7/00
CPC分类号： B01L7/5255 , B01L7/52
摘要： A device (10) for tempering substances has a metal block arrangement (12) th at least one zone (32) the temperature of which can be set at a determined mean value, as well as at least another zone (32'). The device (10) has a metallic base plate (31) with a receptacle for the substances, and at least one of its outer surfaces can be brought into thermal contact with the metal block arrangement (12). In addition, a pressure generator (49) generates a pressure that deviates from the ambient pressure between at least one outer surface and the metal block arrangement. The device (10) further has a conveyor (33) that selectively conveys the base plate (31) into one of the zones (32, 32') of the metal block arrangement (12) along a conveying path (44). The pressure generator (49) is capable of generating an overpressure or a depression. In addition, the conveyor (33) has a member (40) that can be brought to bear against the base plate (31), so that a thrust directed mainly along the conveying path (44) can be exerted on the base plate (31).
摘要翻译： PCT No.PCT / DE91 / 00704 Sec。 371日期1993年3月10日 102（e）1993年3月10日PCT 1991年9月6日PCT PCT。公开号WO92 / 04979 用于回火物质的装置（10）具有金属块装置（12），其具有至少一个区域（32），其温度可以被设置为确定的平均值，以及至少另一个区域区域（32'）。装置（10）具有金属基板（31），其具有用于物质的容器，并且其外表面中的至少一个可以与金属块装置（12）热接触。此外，压力发生器（49）产生偏离至少一个外表面和金属块装置之间的环境压力的压力。所述装置（10）还具有一个传送器（33），其沿着输送路径（44）选择性地将基板（31）输送到金属块装置（12）的一个区域（32,32'）中。压力发生器（49）能够产生超压或凹陷。此外，输送机（33）具有能够抵靠基板（31）的构件（40），从而能够沿着输送路径（44）主导的推力施加在基板（31）上）。

7. 发明授权

US5047265A Method of flame-spraying of powdered materials and flame-spraying apparatus for carrying out that method 失效
标题翻译：粉末材料的火焰喷涂方法和实施该方法的火焰喷涂装置
公开(公告)号：US5047265A
公开(公告)日：1991-09-10
申请号：US342341
申请日：1989-04-24
申请人： Wolfgang Simm , Hans-Theo Steine
发明人： Wolfgang Simm , Hans-Theo Steine
IPC分类号： B05B7/20
CPC分类号： B05B7/205
摘要： A method is provided for flame-spraying powdered materials onto a substrate by means of an autogenous flame-spraying apparatus of the type in which a combustion gas-oxidation gas mixture is produced and ignited at the outlet of a burner nozzle with the powdered material conveyed by a carrier gas to the burner nozzle and introduced in the flame at the outlet of the burner nozzle. The working parameters of the flame-spraying apparatus are chosen so as to provide an energy constant P.sub.E which together with the kinetic energy E.sub.k of the particles enables the use of a broad range of flame speeds.
摘要翻译：提供了一种通过自发火焰喷射装置将粉末材料火焰喷射到基材上的方法，其中产生燃烧气体 - 氧化气体混合物并在燃烧器喷嘴的出口处点燃，粉末状材料被输送通过载气向燃烧器喷嘴引入燃烧器喷嘴出口处的火焰中。选择火焰喷涂装置的工作参数以便提供能量常数PE，其与颗粒的动能Ek一起可以使用宽范围的火焰速度。

8. 发明授权

US4594103A Powdered nickel-chromium based material for thermal spraying 失效
标题翻译：用于热喷涂的粉末状镍铬基材料
公开(公告)号：US4594103A
公开(公告)日：1986-06-10
申请号：US713402
申请日：1985-02-21
申请人： Wolfgang Simm , Hans-Theo Steine
发明人： Wolfgang Simm , Hans-Theo Steine
IPC分类号： C22C19/05 , B23K35/30 , C23C4/06 , C22C38/40
CPC分类号： B23K35/304 , C23C4/067
摘要： The material according to the present invention comprises a self-flowing alloy containing particularly from 18 to 35% by weight of chromium as well as fractions of boron and silicon in a ratio of 3:4. The alloy also contains from 0.1 to 25.0% by weight of iron, except for the range from 1.5 to 6. The layers obtained by means of said material exhibit a very high resistance to temperatures, particularly also to corrosion and oxidation.
摘要翻译： PCT No.PCT / CH84 / 00101 Sec。 371日期1985年2月21日 102（e）1985年2月21日PCT PCT。1984年6月20日PCT公布。公开号WO85 / 00127 日本1985年1月17日。根据本发明的材料包括自流动合金，其特别地含有18至35重量％的铬以及比例为3:4的硼和硅的部分。该合金还含有0.1至25.0重量％的铁，除了1.5至6的范围内。通过所述材料获得的层表现出非常高的耐温性，特别是对腐蚀和氧化。

9. 发明授权

US4317540A Safety burner for projecting molten metal powders 失效
标题翻译：用于投射熔融金属粉末的安全燃烧器
公开(公告)号：US4317540A
公开(公告)日：1982-03-02
申请号：US177759
申请日：1979-11-29
申请人： Wolfgang Simm , Hans-Theo Steine , Daniel Audemars
发明人： Wolfgang Simm , Hans-Theo Steine , Daniel Audemars
IPC分类号： B05B7/20 , B05B7/24
CPC分类号： B05B7/206
摘要： A safety burner for spraying metal powder in the molten state is provided comprising a burner body and a powder supply device formed of a carrier part firmly connected to the burner body and having an intermediate part removably attached to the carrier part, the intermediate part having means for detachably coupling a powder container thereto and also having a powder shutoff device cooperably associated therewith, the intermediate part and the carrier part being arranged one to the other such that the intermediate part can be removed from the carrier part only when the powder shutoff device is closed. The burner also includes gas flow conduits within it for conveying combustible gas and an oxidizing gas and powder-carrier gas therethrough. The burner body contains a first combustible gas-oxidizing gas injector and a second powder-carrier gas injector, the first injector being coupled to the combustible gas-oxidizing gas conduit and the second injector being coupled to the powder-carrier gas conduit. A gas-shutoff device is provided coupled to the gas-flow conduits.
摘要翻译：提供一种用于喷射处于熔融状态的金属粉末的安全燃烧器，其包括燃烧器主体和粉末供给装置，所述燃烧器主体和由与所述燃烧器主体牢固连接的承载部分形成的粉末供给装置，并且具有可移除地附接到所述承载部分的中间部分，为了将粉末容器可拆卸地连接到其上并且还具有与其配合的粉末关闭装置，所述中间部分和所述载体部分一个地布置成使得仅当所述粉末切断装置是关闭。燃烧器还包括其内的气体流动管道，用于输送可燃气体和通过其中的氧化气体和粉末载体气体。燃烧器主体包含第一可燃气体氧化气体注入器和第二粉末载体气体注入器，第一喷射器联接到可燃气体氧化气体导管，第二喷射器联接到粉末载体气体导管。提供了一种联接到气流导管的气体关闭装置。

10. 发明授权

US4011056A Quinary silver alloy 失效
标题翻译：金银合金
公开(公告)号：US4011056A
公开(公告)日：1977-03-08
申请号：US584406
申请日：1975-06-06
申请人： Hans T. Steine , Rene Wasserman , Wolfgang Simm
发明人： Hans T. Steine , Rene Wasserman , Wolfgang Simm
IPC分类号： B23K35/30 , C22C30/02
CPC分类号： C22C30/02 , B23K35/3006 , Y10T428/12896
摘要： A quinary silver alloy containing copper, zinc and tin as essential elements and also including effective amounts of silicon, is provided capable of a variety of uses and having particular utility as a solder or brazing alloy, the alloy having the following composition by weight:35 -- 48% Ag25 -- 35% Zn0.5 -- 3.5% Sn0.01 -- 0.4% Si0 --1% Ni0 --1% Pd0 -- 0.5% Pbalance -- essentially Cu.

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