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1. 发明申请

US20180146863A1 HEART FAILURE MANAGEMENT 审中-公开
公开(公告)号：US20180146863A1
公开(公告)日：2018-05-31
申请号：US15879139
申请日：2018-01-24
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
IPC分类号： A61B5/0205 , A61N1/36 , A61N1/372 , A61B5/0402 , A61B5/00 , A61B5/0488 , A61B5/0215
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61B7/00 , A61B7/04 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.

2. 发明授权

US09924877B2 Heart failure management 有权
公开(公告)号：US09924877B2
公开(公告)日：2018-03-27
申请号：US15608692
申请日：2017-05-30
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
IPC分类号： A61N1/36 , A61B5/0205 , A61B5/00 , A61B5/0215 , A61B5/0402 , A61B5/0488 , A61N1/372
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.

3. 发明授权

US09895074B2 Methodology for automated signal morphology analysis in implantable electrotherapy and diagnostic systems 有权
公开(公告)号：US09895074B2
公开(公告)日：2018-02-20
申请号：US14509790
申请日：2014-10-08
申请人： Cardiac Pacemakers, Inc.
发明人： Matthias Woellenstein , Howard D. Simms, Jr. , Scott T. Mazar , Robert J. Sweeney
IPC分类号： A61B5/04 , A61B5/0452 , A61B5/0432
CPC分类号： A61B5/0432 , A61B5/0452
摘要： Systems and related methods for analyzing data sensed from a device implanted in a patient, such as a cardiac pacing system. The system detects and evaluates electric signals within the patient that share a common event marker. By using algorithms and graphical presentation of the collected signals having common event markers, deviations in signals over time can be identified and evaluated in consideration of taking further action related to the patient and the implanted device. The system can also be used in conjunction with an advanced patient management system that includes a programmer or repeater capable of gathering information from the implanted device and transmitting the data to a host via a communications network for evaluation at a remote location.

4. 发明申请

US20170215809A1 HEART FAILURE EVENT DETECTION USING MULTI-LEVEL CATEGORICAL FUSION 审中-公开
公开(公告)号：US20170215809A1
公开(公告)日：2017-08-03
申请号：US15490226
申请日：2017-04-18
申请人： Cardiac Pacemakers, Inc.
发明人： Yi Zhang , Pramodsingh Hirasingh Thakur , Qi An , Julie A. Thompson , Ramesh Wariar , Robert J. Sweeney
IPC分类号： A61B5/00 , A61B7/00
CPC分类号： A61B5/7275 , A61B5/0205 , A61B5/4842 , A61B5/686 , A61B7/00 , A61B7/04 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Systems and methods for detecting a present, or predicting a future, target physiologic event such as worsening heart failure (HF) are described. A system can comprise a patient information receiver circuit, at least two categorical risk analyzer circuits, and a categorical fusion circuit. The patient information receiver circuit receives physiologic signals and generates signal trends. The categorical risk analyzer circuit receives a category-specific input selected from the signal trends according to an associative physiologic condition indicative or correlative of the target event. The categorical risk analyzer circuit produces a signal trend metric indicating relative change in signal strength over time. The categorical risk analyzer circuit calculates a categorical risk index that indicates likelihood of the patient developing or presenting the associative physiologic condition. The categorical fusion circuit uses the categorical risk indices to generate a composite risk indicator indicating likelihood of the patient developing the target physiologic event.

5. 发明申请

US20160000380A1 SYSTEMS AND METHODS FOR DETECTING MEDICAL TREATMENT 有权
标题翻译：用于检测医疗治疗的系统和方法
公开(公告)号：US20160000380A1
公开(公告)日：2016-01-07
申请号：US14755150
申请日：2015-06-30
申请人： Cardiac Pacemakers, Inc.
发明人： Viktoria A. Averina , Pramodsingh Hirasingh Thakur , Robert J. Sweeney
IPC分类号： A61B5/00 , A61B5/091 , A61B7/04 , A61B5/11 , A61B5/053
CPC分类号： A61B5/7275 , A61B5/0205 , A61B5/0537 , A61B5/091 , A61B5/1116 , A61B5/1118 , A61B5/4839 , A61B5/4848 , A61B5/4857 , A61B7/04 , A61N1/36114 , A61N1/3627 , A61N1/36521 , A61N1/36528 , A61N1/36535 , A61N1/36542 , A61N1/36578 , A61N1/36585 , A61N1/39 , G06F19/00
摘要： Systems and methods are provided for using stored physiologic information about a subject to detect a previous treatment event. Physiologic information can be sensed from a subject using one or more sensors. Using a detection circuit, a change in the sensed physiologic information, such as a change from reference physiologic information, can be used to identify a candidate previous treatment event. An alert or other information about the candidate treatment event can be provided to a patient or clinician. In an example, a candidate treatment event can include a heart failure or diuresis treatment that is identified using information about a change in one or more of a subject's circadian pattern, a subject's thoracic impedance, or a subject's respiration status.
摘要翻译：提供了系统和方法，用于使用存储的关于受试者的生理信息来检测先前的治疗事件。可以使用一个或多个传感器从对象感测生理信息。使用检测电路，可以使用感测到的生理信息（例如从参考生理信息的变化）的变化来识别候选的先前治疗事件。关于候选治疗事件的警报或其他信息可以提供给患者或临床医师。在一个示例中，候选治疗事件可以包括使用关于受试者的昼夜节律模式，受试者的胸部阻抗或受试者的呼吸状态中的一种或多种的变化的信息来识别的心力衰竭或利尿治疗。

6. 发明申请

US20140046200A1 MONITORING OF HEART SOUNDS 有权
标题翻译：心脏监测
公开(公告)号：US20140046200A1
公开(公告)日：2014-02-13
申请号：US14057174
申请日：2013-10-18
申请人： Cardiac Pacemakers, Inc.
发明人： Abhilash Patangay , Jeffrey E. Stahmann , Robert J. Sweeney
IPC分类号： A61B5/025 , A61B5/0205
CPC分类号： A61B5/025 , A61B5/0031 , A61B5/0205 , A61B5/029 , A61B5/0295 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/103 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36542 , A61N1/36578
摘要： This document discusses, among other things, a system comprising an implantable medical device (IMD) including an implantable heart sound sensor circuit configured to produce an electrical heart sound signal representative of a heart sound of a subject and a processor circuit. The processor circuit is coupled to the heart sound sensor circuit and includes a detection circuit, a heart sound feature circuit and a trending circuit. The detection circuit configured to detect a physiologic perturbation and the heart sound feature circuit is configured to identify a heart sound feature in the electrical signal. The processor circuit is configured to trigger the heart sound feature circuit in relation to a detected physiologic perturbation. The trending circuit is configured to trend the heart sound feature in relation to a recurrence of the physiologic perturbation. The processor circuit is configured to declare a change in a physiologic condition of the patient according to the trending.
摘要翻译：本文件尤其涉及一种包括可植入医疗装置（IMD）的系统，该可植入医疗装置（IMD）包括可植入的心音传感器电路，该可植入心音传感器电路被配置为产生代表对象的心脏声音的电心脏心音信号和处理器电路。处理器电路耦合到心脏声音传感器电路，并且包括检测电路，心脏声音特征电路和趋势电路。被配置为检测生理扰动的检测电路和心音特征电路被配置为识别电信号中的心音特征。处理器电路被配置为相对于检测到的生理扰动触发心音特征电路。趋势电路被配置为相对于生理扰动的复发趋向心音特征。处理器电路被配置为根据趋势来声明患者的生理状况的变化。

7. 发明授权

US10548535B2 Method and apparatus for multi-state heart failure decompensation detection 有权
公开(公告)号：US10548535B2
公开(公告)日：2020-02-04
申请号：US14178624
申请日：2014-02-12
申请人： Cardiac Pacemakers, Inc.
发明人： Yi Zhang , Pramodsingh Hirasingh Thakur , Robert J. Sweeney
IPC分类号： A61B5/00
摘要： Devices and methods for detecting events indicative of heart failure (HF) decompensation status are described. An ambulatory medical device can determine the present physiologic state as being either a drift state or a stable state, and applies an algorithm to detect HF decompensation event according to the physiologic state. In some embodiments, the ambulatory medical device uses the present physiologic state to estimate one ore more expected future signal characteristics, and to detect HF decompensation event using the one or more expected futures signal characteristics.

8. 发明授权

US10143385B2 Methods and apparatus for stratifying risk of heart failure decompensation 有权
公开(公告)号：US10143385B2
公开(公告)日：2018-12-04
申请号：US14282353
申请日：2014-05-20
申请人： Cardiac Pacemakers, Inc.
发明人： Robert J. Sweeney , Yi Zhang , Qi An , Pramodsingh Hirasingh Thakur
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/08 , A61B5/145 , A61B5/00 , A61B5/20 , A61B5/024 , A61B5/0245 , G06F19/00
摘要： Devices and methods for identifying patient at elevated risk of developing future heart failure (HF) events, such as events indicative of HF decompensation status, are described. The devices and methods can stratify the risk using sensor signals or signal metrics selected in accordance with patient chronic conditions. A medical device can receive a patient status input including at least a first and a second chronic condition indicators, sense one or more physiologic signals from the patient, and generate a plurality of signal metrics from the physiologic signals when the first chronic condition indicator and the second chronic condition indicator meets respective criterion. One or more patient-specific signal metrics can be selected from a group including the signal metrics selected for both the first and the second chronic conditions. A risk stratification algorithm can use the selected one or more patient-specific signal metrics to compute a composite risk index indicative of the probability of the patient later developing an event indicative of worsening of HF.

9. 发明申请

US20170258337A1 HEART FAILURE MANAGEMENT 审中-公开
公开(公告)号：US20170258337A1
公开(公告)日：2017-09-14
申请号：US15608692
申请日：2017-05-30
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
IPC分类号： A61B5/0205 , A61B5/0215 , A61N1/372 , A61B5/0488 , A61N1/36 , A61B5/00 , A61B5/0402
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.

10. 发明授权

US09662073B2 Heart failure event detection using multi-level categorical fusion 有权
公开(公告)号：US09662073B2
公开(公告)日：2017-05-30
申请号：US14637447
申请日：2015-03-04
申请人： Cardiac Pacemakers, Inc.
发明人： Yi Zhang , Pramodsingh Hirasingh Thakur , Qi An , Julie A. Thompson , Ramesh Wariar , Robert J. Sweeney
IPC分类号： A61B5/00 , A61B5/0205 , G06F19/00
CPC分类号： A61B5/7275 , A61B5/0205 , A61B5/4842 , A61B5/686 , A61B7/00 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Systems and methods for detecting a present, or predicting a future, target physiologic event such as worsening heart failure (HF) are described. A system can comprise a patient information receiver circuit, at least two categorical risk analyzer circuits, and a categorical fusion circuit. The patient information receiver circuit receives physiologic signals and generates signal trends. The categorical risk analyzer circuit receives a category-specific input selected from the signal trends according to an associative physiologic condition indicative or correlative of the target event. The categorical risk analyzer circuit produces a signal trend metric indicating relative change in signal strength over time. The categorical risk analyzer circuit calculates a categorical risk index that indicates likelihood of the patient developing or presenting the associative physiologic condition. The categorical fusion circuit uses the categorical risk indices to generate a composite risk indicator indicating likelihood of the patient developing the target physiologic event.

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