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1. 发明授权

US10799699B2 Systems and methods for avoiding neural stimulation habituation 有权
公开(公告)号：US10799699B2
公开(公告)日：2020-10-13
申请号：US15943916
申请日：2018-04-03
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/36 , A61N1/372
摘要： An embodiment relates to a method for delivering a vagal stimulation therapy to a vagus nerve, including delivering a neural stimulation signal to non-selectively stimulate both afferent axons and efferent axons in the vagus nerve according to a predetermined schedule for the vagal stimulation therapy, and selecting a value for at least one parameter for the predetermined schedule for the vagal stimulation therapy to control the neural stimulation therapy to avoid physiological habituation to the vagal stimulation therapy. The parameter(s) include at least one parameter selected from the group of parameters consisting of a predetermined therapy duration parameter for a predetermined therapy period, and a predetermined intermittent neural stimulation parameter associated with on/off timing for the intermittent neural stimulation parameter.

2. 发明申请

US20180146863A1 HEART FAILURE MANAGEMENT 审中-公开
公开(公告)号：US20180146863A1
公开(公告)日：2018-05-31
申请号：US15879139
申请日：2018-01-24
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
IPC分类号： A61B5/0205 , A61N1/36 , A61N1/372 , A61B5/0402 , A61B5/00 , A61B5/0488 , A61B5/0215
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61B7/00 , A61B7/04 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.

3. 发明授权

US09924877B2 Heart failure management 有权
公开(公告)号：US09924877B2
公开(公告)日：2018-03-27
申请号：US15608692
申请日：2017-05-30
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Krzysztof Z. Siejko , Marina V. Brockway , Robert J. Sweeney
IPC分类号： A61N1/36 , A61B5/0205 , A61B5/00 , A61B5/0215 , A61B5/0402 , A61B5/0488 , A61N1/372
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.

4. 发明授权

US09339652B2 Neural stimulation system for cardiac fat pads 有权
公开(公告)号：US09339652B2
公开(公告)日：2016-05-17
申请号：US14571809
申请日：2014-12-16
申请人： Cardiac Pacemakers, Inc.
发明人： Julia Moffitt , Imad Libbus
IPC分类号： A61N1/39 , A61N1/36 , A61N1/05 , A61N1/365
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/056 , A61N1/0587 , A61N1/36135 , A61N1/36514 , A61N1/3962 , A61N1/3987
摘要： Various aspects relate to a device which, in various embodiments, comprises a header, a neural stimulator, a detector and a controller. The header includes at least one port to connect to at least one lead, and includes first and second channels for use to provide neural stimulation to first and second neural stimulation sites for a heart. The controller is connected to the detector and the neural stimulator to selectively deliver a therapy based on the feedback signal. A first therapy signal is delivered to the first neural stimulation site to selectively control contractility and a second therapy signal is delivered to the second neural stimulation site to selectively control one of a sinus rate and an AV conduction. Other aspects and embodiments are provided herein.

5. 发明授权

US09186522B2 Neural stimulation systems, devices and methods 有权
标题翻译：神经刺激系统，装置和方法
公开(公告)号：US09186522B2
公开(公告)日：2015-11-17
申请号：US14220939
申请日：2014-03-20
申请人： Cardiac Pacemakers, Inc.
发明人： David J. Ternes , Andrew P. Kramer , Imad Libbus , Jeffrey E. Stahmann
IPC分类号： A61N1/36 , A61N1/39 , A61N1/362
CPC分类号： A61N1/3987 , A61N1/36071 , A61N1/36078 , A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/3962
摘要： Various system embodiments comprise circuitry to determine when an arrhythmia has terminated, and a neural stimulator adapted to temporarily deliver neural stimulation therapy to assist with recovering from the arrhythmia in response to termination of the arrhythmia.
摘要翻译：各种系统实施例包括用于确定心律失常何时终止的电路，以及适于暂时递送神经刺激疗法以帮助响应于心律失常终止从心律失常中恢复的神经刺激器。

6. 发明申请

US20140316487A1 VAGAL NERVE STIMULATOR WITH MODE SWITCHING 审中-公开
标题翻译：带模式切换的VAGAL神经刺激仪
公开(公告)号：US20140316487A1
公开(公告)日：2014-10-23
申请号：US14318785
申请日：2014-06-30
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/36128 , A61M5/1723 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36135 , A61N1/3688
摘要： Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及可植入装置。各种装置实施例包括至少一个端口，以连接至少一个引线，至少电极，刺激电路连接到至少一个端口，并且适于使用至少一个至少一个端口向至少一个神经刺激目标提供至少一个神经刺激治疗一个电极，连接到所述至少一个端口并适于提供感测信号的感测电路，以及连接到所述刺激电路以提供所述至少一个神经刺激治疗的控制器，以及所述感测电路以接收感测到的信号。响应于触发事件，控制器适于在至少两种模式之间切换。本文提供了其它方面和实施例。

7. 发明申请

US20140243932A1 UNIDIRECTIONAL NEURAL STIMULATION SYSTEMS, DEVICES AND METHODS 审中-公开
标题翻译：非线性神经刺激系统，设备和方法
公开(公告)号：US20140243932A1
公开(公告)日：2014-08-28
申请号：US14271779
申请日：2014-05-07
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Avram Scheiner
IPC分类号： A61N1/36
CPC分类号： A61N1/36057 , A61B5/021 , A61B5/024 , A61N1/0551 , A61N1/36114 , A61N1/36135 , A61N1/37217 , A61N1/37282 , A61N1/37288
摘要： An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.
摘要翻译：一个实施方案涉及用于递送单向传入神经刺激治疗的方法。传递测试神经刺激，并监测对测试神经刺激的生理反应。如果测试神经刺激不引起所需的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。如果测试神经刺激确实引起所需的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数确定单向传入神经刺激的至少一个治疗参数。使用至少一个治疗参数递送单向传入神经刺激。

8. 发明申请

US20140207203A1 NEURAL STIMULATION SYSTEMS, DEVICES AND METHODS 审中-公开
标题翻译：神经刺激系统，设备和方法
公开(公告)号：US20140207203A1
公开(公告)日：2014-07-24
申请号：US14220939
申请日：2014-03-20
申请人： Cardiac Pacemakers, Inc.
发明人： David J. Ternes , Andrew P. Kramer , Imad Libbus , Jeffrey E. Stahmann
IPC分类号： A61N1/362 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3987 , A61N1/36071 , A61N1/36078 , A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/3962
摘要： Various system embodiments comprise circuitry to determine when an arrhythmia has terminated, and a neural stimulator adapted to temporarily deliver neural stimulation therapy to assist with recovering from the arrhythmia in response to termination of the arrhythmia.
摘要翻译：各种系统实施例包括用于确定心律失常何时终止的电路，以及适于暂时递送神经刺激疗法以帮助响应于心律失常终止从心律失常中恢复的神经刺激器。

9. 发明申请

US20140194952A1 METHOD AND APPARATUS FOR CONTROLLING AUTONOMIC BALANCE USING NEURAL STIMULATION 审中-公开
标题翻译：使用神经刺激来控制自动平衡的方法和装置
公开(公告)号：US20140194952A1
公开(公告)日：2014-07-10
申请号：US14203782
申请日：2014-03-11
申请人： Cardiac Pacemakers, Inc.
发明人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/36057 , A61N1/36114 , A61N1/36139 , A61N1/3621 , A61N1/3627 , A61N1/36585
摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.
摘要翻译：神经刺激系统感知自主活动，并将神经刺激应用于交感神经和副交感神经以控制自主神经平衡。神经刺激系统能够传递交感神经激励，交感神经抑制，副交感神经激动和副交感神经抑制的神经刺激脉冲。

10. 发明申请

US20140025141A1 METHOD AND APPARATUS FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 审中-公开
标题翻译：用呼吸反馈神经刺激的方法和装置
公开(公告)号：US20140025141A1
公开(公告)日：2014-01-23
申请号：US14041967
申请日：2013-09-30
申请人： Cardiac Pacemakers, Inc.
发明人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

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