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1. 发明申请

US20030235924A1 Optoelectronic and microfluidic integration for miniaturized spectroscopic devices 有权
公开(公告)号：US20030235924A1
公开(公告)日：2003-12-25
申请号：US10351294
申请日：2003-01-23
申请人： California Institute of Technology , Office of Technology Transfer
发明人： Mark L. Adams , Stephen R. Quake , Axel Scherer
IPC分类号： G01N021/76
CPC分类号： G01N21/6454 , B01L3/502715 , B01L2300/0654
摘要： Techniques for integrating optoelectronic system and microfluidic system. An apparatus for optical analysis includes a detector system and a microfluidic system on the detector system. The apparatus is free from any lens system between the microfluidic system and the detector system. Methods of making such an apparatus and using such an apparatus are also disclosed.

2. 发明申请

US20020144738A1 Microfabricated elastomeric valve and pump systems 有权
公开(公告)号：US20020144738A1
公开(公告)日：2002-10-10
申请号：US09997205
申请日：2001-11-28
申请人： California Institute of Technology
发明人： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake , Jian Liu , Mark L. Adams , Carl L. Hansen
IPC分类号： F15C001/20
CPC分类号： B29C39/02 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B32B2037/1081 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , C12Q1/6874 , F04B43/043 , F15C5/00 , F16K31/126 , F16K99/0001 , F16K99/0015 , F16K99/0026 , F16K99/0046 , F16K99/0051 , F16K99/0055 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/2174 , Y10T137/2224 , Y10T137/7879 , Y10T137/87877 , C12Q2535/125
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

3. 发明申请

US20030148539A1 Micro fabricated fountain pen apparatus and method for ultra high density biological arrays 审中-公开
标题翻译：用于超高密度生物阵列的微型钢笔设备和方法
公开(公告)号：US20030148539A1
公开(公告)日：2003-08-07
申请号：US10288248
申请日：2002-11-04
申请人： California Institute of Technology
发明人： R. Michael van Dam , Stephen R. Quake , Axel Scherer , Matthew O. Reese
IPC分类号： B01L003/02 , G01N001/10
CPC分类号： B01L3/0244 , B01L3/0248 , B01L3/0275 , B01L3/5085 , B01L2200/0642 , B01L2300/0838 , B01L2300/123 , G01N2035/1037 , Y10T436/2575
摘要： A fluid dispensing system for at least biological applications, e.g., oligonucleotides, peptide nucleic acids (nullPNAnull), proteins, polysaccharides, polypeptides, inorganic solutions, microelectromechanical systems (MEMS), optical sensors, and other applications. The dispensing system includes a fluid dispensing apparatus for applying selected fluids in a predetermined manner to form a plurality of spots based upon one or more of the selected fluids on a surface of a substrate. The apparatus comprises an elongated member having at least a tip portion, which extends from the elongated member. The apparatus also has an etched trench extending along a portion of a length of the elongated member to the tip to form an opening defined on the tip portion and coupled to the etched trench. A flexible region is defined within the elongated member to allow the tip to adjust in position upon contact with the surface of the substrate. A fluid is disposed within the etched trench. The fluid is output through the opening on the tip to form more than one spots on the surface of the substrate.
摘要翻译：用于至少生物应用的流体分配系统，例如寡核苷酸，肽核酸（“PNA”），蛋白质，多糖，多肽，无机溶液，微机电系统（MEMS），光学传感器和其它应用。分配系统包括用于以预定方式施加选定流体以形成基于基底表面上的一种或多种所选流体的多个斑点的流体分配装置。该装置包括细长构件，该细长构件至少具有从细长构件延伸的尖端部分。该设备还具有沿着细长构件的长度的一部分延伸到尖端的蚀刻沟槽，以形成限定在尖端部分上并连接到蚀刻沟槽的开口。柔性区域限定在细长构件内，以允许尖端在与基底的表面接触时调节位置。流体被设置在蚀刻沟槽内。流体通过尖端上的开口输出，以在基底表面上形成多于一个点。

4. 发明申请

US20010012640A1 Semiconductor surface lenses and shaped structures 有权
公开(公告)号：US20010012640A1
公开(公告)日：2001-08-09
申请号：US09832413
申请日：2001-04-10
申请人： California Institute of Technology, California non-profit organization
发明人： John O'Brien , Chuan-Cheng Cheng , Axel Scherer , Amnon Yariv , Yong Xu
IPC分类号： H01L021/00
CPC分类号： H01L33/20
摘要： A lens is formed out of semiconductor material. The semiconductor produces light which is coupled to the lens. The lens focuses the light and also minimizes refractive reflection. The lens is formed by a graded aluminum alloy, which is oxidized in a lateral direction. The oxidation changes the effective shape of the device according to the grading.

5. 发明申请

US20030019833A1 Microfabricated elastomeric valve and pump systems 有权
公开(公告)号：US20030019833A1
公开(公告)日：2003-01-30
申请号：US10150895
申请日：2002-05-15
申请人： California Institute of Technology
发明人： Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake
IPC分类号： C23F001/00
CPC分类号： B29C51/00 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B81B5/00 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , B81C2201/034 , C12Q1/6874 , F04B43/043 , F15C1/06 , F15C5/00 , F16K11/20 , F16K13/00 , F16K31/126 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/0491 , Y10T137/0497 , Y10T137/2224 , Y10T137/87249 , Y10T156/10 , Y10T428/24479 , Y10T428/24744 , C12Q2535/125
摘要： A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

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