专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110229913A1 Method for Amplification of Signal in Immunochromatographic Assay and Immunochromatographic Kit Using the Method 审中-公开
公开(公告)号：US20110229913A1
公开(公告)日：2011-09-22
申请号：US13131711
申请日：2008-11-28
申请人： Byeong-Woo Bae , Sung-Dong Lee , Min-Gon Kim , Yong-Beom Shin , Jin-Hee Jang , Ji-Hun Shin
发明人： Byeong-Woo Bae , Sung-Dong Lee , Min-Gon Kim , Yong-Beom Shin , Jin-Hee Jang , Ji-Hun Shin
IPC分类号： G01N33/569 , G01N33/558 , G01N33/566 , C12M1/34 , B82Y99/00
CPC分类号： G01N33/558 , G01N33/585
摘要： The present invention relates to a method for amplifying a signal in an immunochro-matographic assay for high-sensitivity detection of an analyte and an immunochromatographic kit using the method, which amplifies a signal by controlling a flow rate by discrimination between the size of a first indicator and the size of a second indicator. According to an aspect of the present invention, a method for amplifying a signal in an immunochromatographic assay includes: binding a primary conjugate body, which has a first antibody binding specifically to a first epitope of an analyte, a connector, and a first indicator to which the first antibody and the connector are bound, to the analyte; binding the analyte bound to the primary conjugate body to an immobilized second antibody binding specifically to a second epitope of the analyte; and binding a secondary conjugate body, which has a third antibody binding specifically to the connector of the primary conjugate body and a second indicator to which the third antibody is bound, to the connector of the primary conjugate body, wherein the primary conjugate body is disposed nearer to the immobilized second antibody than the secondary conjugate body, and the particle of the second indicator is larger than the particle of the first indicator, so that the secondary conjugate body reaches the immobilized second antibody later than the primary conjugate body. According to another aspect of the present invention, an immunochromatographic kit includes: a sample pad to which a liquid sample containing an analyte is applied; a conjugate pad including a primary conjugate body having a first antibody binding specifically to a first epitope of an analyte, a connector, and a first indicator to which the first antibody and the connector are bound, and a secondary conjugate body having a third antibody binding specifically to the connector of the primary conjugate body and a second indicator to which the third antibody is bound, wherein the primary conjugate body is disposed nearer to an immobilized second antibody than the secondary conjugate body and the second indicator is larger than the first indicator so that the secondary conjugate body reaches the immobilized second antibody later than the primary conjugate body; a membrane including a detection site immobilizing thereto the second antibody binding specifically to a second epitope of the analyte to which the primary conjugate body is bound, and a control site for error detection; and an absorbing pad absorbing the liquid sample by a capillary phenomenon. Thus, the present invention can perform signal amplification without separate mechanical control or artificial step-by-step reaction.

2. 发明授权

US06272277B1 Optical fiber for light amplifier 失效
标题翻译：光放大器用光纤
公开(公告)号：US06272277B1
公开(公告)日：2001-08-07
申请号：US09417056
申请日：1999-10-13
申请人： Jong Heo , Yong-Beom Shin , Se-Ho Park , Sun-tae Jung , Hyoun-soo Kim
发明人： Jong Heo , Yong-Beom Shin , Se-Ho Park , Sun-tae Jung , Hyoun-soo Kim
IPC分类号： G02B600
CPC分类号： C03C13/044 , C03C3/323 , H01S3/06716
摘要： An optical fiber for use in a light amplifier. The optical fiber is formed by doping a gerrnanium-gallium-sulfur (Ge—Ga—S) glass containing less sulfur than a GeS2—Ga2S3 stoichiometric composition line with a rare earth element, and further contains 0.1˜10 atomic % of a halogen element base on the Ge—Ga—S glass. By using optical fiber, clustering of praseodymium (Pr+3) ions can be suppressed even when the concentration of added Pr+3 is high, thereby improving light amplification efficiency.
摘要翻译：一种用于光放大器的光纤。光纤通过将含有比GeS2-Ga2S3化学计量组成线少的硫的锗 - 镓 - 硫（Ge-Ga-S）玻璃与稀土元素掺杂而形成，并且还含有0.1〜10原子％的卤素元素基于Ge-Ga-S玻璃。通过使用光纤，即使添加的Pr + 3的浓度高，也可以抑制镨（Pr + 3）离子的聚集，从而提高光放大效率。

3. 发明授权

US07933019B2 Surface plasmon resonance sensor using rotating mirror 失效
标题翻译：表面等离子体共振传感器采用旋转镜
公开(公告)号：US07933019B2
公开(公告)日：2011-04-26
申请号：US12671841
申请日：2008-08-13
申请人： Bong-Hyun Chung , Yong-Beom Shin
发明人： Bong-Hyun Chung , Yong-Beom Shin
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/7743 , G01N2201/0636 , G01N2201/105 , G02B5/008
摘要： Disclosed is a surface plasmon resonance sensor having a rotating mirror, including (a) an incident light source unit for oscillating a laser as incident light; (b) a polarizer for polarizing the incident light; (c) a rotating mirror having cylindrical or planar shapes for reflecting the polarized incident light to radiate disk-shaped light; (d) a light shielding film for allowing part of the disk-shaped light to pass therethrough and located adjacent to the central axis of the rotating mirror; (e) a cylinder lens for focusing the light passed through the light shielding film thereon; (f) a metal thin film for receiving the light focused on the cylinder lens to generate surface plasmon resonance; (g) a dielectric medium provided under the metal thin film; and (h) a detector for detecting the light reflected from the metal thin film. This surface plasmon resonance sensor can solve conventional interference problems of a laser being used as a light source to obtain an image for measurement of angle and two-dimensional reflected light intensity, including the deterioration of the quality of the image and the variation in the intensity of light source depending on the position of incidence.
摘要翻译：公开了一种具有旋转镜的表面等离子体共振传感器，包括：（a）用于使激光振荡的入射光源单元作为入射光; （b）用于偏振入射光的偏振器; （c）具有用于反射偏振的入射光以辐射盘形光的圆柱形或平面形状的旋转镜; （d）遮光膜，用于允许所述盘状光的一部分通过并位于所述旋转镜的中心轴线附近; （e）用于将通过遮光膜的光聚焦在其上的柱面透镜; （f）用于接收聚焦在圆柱透镜上的光以产生表面等离子体共振的金属薄膜; （g）设置在金属薄膜下方的电介质; 和（h）用于检测从金属薄膜反射的光的检测器。该表面等离子体共振传感器可以解决用作光源的激光的常规干扰问题，以获得用于测量角度和二维反射光强度的图像，包括图像质量的劣化和强度变化的光源取决于发生的位置。

4. 发明申请

US20100231914A1 SURFACE PLASMON RESONANCE SENSOR USING ROTATING MIRROR 失效
标题翻译：使用旋转镜的表面等离子体共振传感器
公开(公告)号：US20100231914A1
公开(公告)日：2010-09-16
申请号：US12671841
申请日：2008-08-13
申请人： Bong-Hyun Chung , Yong-Beom Shin
发明人： Bong-Hyun Chung , Yong-Beom Shin
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/7743 , G01N2201/0636 , G01N2201/105 , G02B5/008
摘要： Disclosed is a surface plasmon resonance sensor having a rotating mirror, including (a) an incident light source unit for oscillating a laser as incident light; (b) a polarizer for polarizing the incident light; (c) a rotating mirror having cylindrical or planar shapes for reflecting the polarized incident light to radiate disk-shaped light; (d) a light shielding film for allowing part of the disk-shaped light to pass therethrough and located adjacent to the central axis of the rotating mirror; (e) a cylinder lens for focusing the light passed through the light shielding film thereon; (f) a metal thin film for receiving the light focused on the cylinder lens to generate surface plasmon resonance; (g) a dielectric medium provided under the metal thin film; and (h) a detector for detecting the light reflected from the metal thin film. This surface plasmon resonance sensor can solve conventional interference problems of a laser being used as a light source to obtain an image for measurement of angle and two-dimensional reflected light intensity, including the deterioration of the quality of the image and the variation in the intensity of light source depending on the position of incidence.
摘要翻译：公开了一种具有旋转镜的表面等离子体共振传感器，包括：（a）用于使激光振荡的入射光源单元作为入射光; （b）用于偏振入射光的偏振器; （c）具有用于反射偏振的入射光以辐射盘形光的圆柱形或平面形状的旋转镜; （d）遮光膜，用于允许所述盘状光的一部分通过并位于所述旋转镜的中心轴线附近; （e）用于将通过遮光膜的光聚焦在其上的柱面透镜; （f）用于接收聚焦在圆柱透镜上的光以产生表面等离子体共振的金属薄膜; （g）设置在金属薄膜下方的电介质; 和（h）用于检测从金属薄膜反射的光的检测器。该表面等离子体共振传感器可以解决用作光源的激光的常规干扰问题，以获得用于测量角度和二维反射光强度的图像，包括图像质量的劣化和强度变化的光源取决于发生的位置。

5. 发明授权

US06480663B1 Optical fiber for optical amplifier 有权
标题翻译：光放大器用光纤
公开(公告)号：US06480663B1
公开(公告)日：2002-11-12
申请号：US09482917
申请日：2000-01-14
申请人： Jong Heo , Yong-Beom Shin , Sun-Tae Jung , Hyoun-Soo Kim
发明人： Jong Heo , Yong-Beom Shin , Sun-Tae Jung , Hyoun-Soo Kim
IPC分类号： G02B600
CPC分类号： C03C13/044 , H01S3/06716
摘要： An optical fiber for an optical amplifier, which contains dysprosium ion (Dy3+) with an improved light amplification efficiency at the 1.31 &mgr;m band. The optical fiber includes a germanium-gallium-sulfide (Ge—Ga—S) glass, an alkali metal halide, and Dy as a rare earth element. In the optical fiber, the interaction of electrons of Dy3+ and phonons in the glass lattice can be minimized, so that the multiphonon relaxation of Dy3+0 from 4F11/2 and 6H9/2 to 6H11/2 is slowed down, and thus the fluorescence lifetime at 1.31 &mgr;m is elongated, further improving the fluorescence efficiency of the optical fiber.
摘要翻译：一种用于光放大器的光纤，其包含在1.31mum带处具有改善的光放大效率的镝离子（Dy3 +）。光纤包括锗 - 硫化镓（Ge-Ga-S）玻璃，碱金属卤化物和作为稀土元素的Dy。在光纤中，可以使Dy3 +和玻璃晶格中的声子之间的相互作用最小化，使得从4F11 / 2和6H9 / 2到6H11 / 2的Dy3 + 0的多谐音弛豫变慢，因此荧光 1.31μm的寿命延长，进一步提高了光纤的荧光效率。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式