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1. 发明授权

US09326940B2 Asymmetric liposomes for the highly efficient encapsulation of nucleic acids and hydrophilic anionic compounds, and method for preparing same 有权
标题翻译：用于高效包封核酸和亲水性阴离子化合物的不对称脂质体及其制备方法
公开(公告)号：US09326940B2
公开(公告)日：2016-05-03
申请号：US13697705
申请日：2010-11-12
申请人： Myung Kyu Lee , Abbas Mokhtarieh Amir , Bong Hyun Chung , Jong Min Choi
发明人： Myung Kyu Lee , Abbas Mokhtarieh Amir , Bong Hyun Chung , Jong Min Choi
IPC分类号： A61K9/127 , A61K31/122 , A61K31/70 , A61K31/713
CPC分类号： A61K9/1272 , A61K9/1271 , A61K9/1277 , A61K31/122 , A61K31/70 , A61K31/713
摘要： The present invention relates to asymmetric liposomes for high encapsulation efficiency of nucleic acids and hydrophilic anionic compounds, and to a method for preparing same, and specifically, to asymmetric liposomes consisting of a cationic lipid having a small head group as an internal lipid and a neutral or PEGylated lipid having a big head group as an external lipid, wherein nucleic acids and/or anionic compounds are encapsulated in the internal lipid. According to the present invention, asymmetric liposomes, in which nucleic acids and hydrophilic anionic compounds are encapsulated with high efficiency, may be prepared, and thus the same may be used for various purposes, such as gene therapy, and the delivery of hydrophilic anionic drugs which are difficult to prepare as prodrugs, and drug delivery, imaging, etc. can be carried out by encapsulating a fluorescent contrast agent in the liposome.
摘要翻译：本发明涉及用于核酸和亲水性阴离子化合物的高包封效率的不对称脂质体及其制备方法，具体涉及由具有小头基团作为内部脂质和中性的阳离子脂质组成的不对称脂质体或具有大头基的聚乙二醇化脂质作为外部脂质，其中核酸和/或阴离子化合物包封在内部脂质中。根据本发明，可以制备其中核酸和亲水性阴离子化合物以高效率包封的不对称脂质体，因此可以用于各种目的，例如基因治疗和递送亲水性阴离子药物其难以作为前药制备，并且药物递送，成像等可以通过将荧光对比剂包封在脂质体中来进行。

2. 发明授权

US08557567B2 Method for fabricating nanogap and nanogap sensor 有权
标题翻译：纳米胶和纳米胶片传感器的制造方法
公开(公告)号：US08557567B2
公开(公告)日：2013-10-15
申请号：US11887978
申请日：2006-09-05
申请人： Bong hyun Chung , Sang kyu Kim , Hye jung Park
发明人： Bong hyun Chung , Sang kyu Kim , Hye jung Park
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/5438 , B82Y15/00 , C30B29/06 , C30B33/10
摘要： The present invention relates to a method of fabricating a nanogap and a nanogap sensor, and to a nanogap and a nanogap sensor fabricated using the method. The present invention relates to a method of fabricating a nanogap and a nanogap sensor, which can be realized by an anisotropic etching using a semiconductor manufacturing process. According to the method of present invention, the nanogap and nanogap sensor can be simply and cheaply produced in large quantities.
摘要翻译：本发明涉及制造纳米隙和纳米隙传感器的方法，以及使用该方法制造的纳米隙和纳米隙传感器。本发明涉及一种可以通过使用半导体制造工艺的各向异性蚀刻来实现的纳米隙和纳米隙传感器的制造方法。根据本发明的方法，可以大量地简单且廉价地生产纳米隙和纳米隙传感器。

3. 发明授权

US08236509B2 Method for preparing antibody monolayers which have controlled orientation using peptide hybrid 有权
标题翻译：使用肽杂交制备具有受控取向的抗体单层的方法
公开(公告)号：US08236509B2
公开(公告)日：2012-08-07
申请号：US12679982
申请日：2007-10-18
申请人： Sang Jeon Chung , Bong Hyun Chung , Yongwon Jung , Hyo Jin Kang , Jeong Min Lee
发明人： Sang Jeon Chung , Bong Hyun Chung , Yongwon Jung , Hyo Jin Kang , Jeong Min Lee
IPC分类号： G01N33/53
CPC分类号： C07K17/00 , C07K7/02 , C07K7/08 , G01N33/54353 , G01N33/54393
摘要： The present invention relates to a method for preparing an protein monolayer using a peptide hybrid for protein immobilization, more precisely a peptide hybrid for protein immobilization which has improved solubility by introducing a PEG linker and a proper reaction group to the oligopeptide having specific affinity to selected types of proteins and is designed to provide enough space between solid substrates and proteins immobilized, whereby various solid substrates treated by the hybrid catch specific proteins effectively on. The peptide hybrid for protein immobilization of the present invention facilitates the control of orientation of an antibody on various solid surfaces and immobilization of various antibodies of different origins or having different isotypes with different affinity. Therefore, the surface treatment technique using the peptide hybrid of the invention can be effectively used for the production of various immunosensors and immune chips.
摘要翻译：本发明涉及一种使用肽杂交体制备蛋白质单层的方法，更准确地说，用于蛋白质固定的肽杂交体，其通过将PEG接头和适当的反应基团引入具有对所选择的特异性亲和力的寡肽而具有改善的溶解性蛋白质类型被设计为在固体底物和固定的蛋白质之间提供足够的空间，由此通过混合物处理的各种固体底物有效捕获特异性蛋白质。用于本发明的蛋白质固定化的肽杂合物有助于控制抗体在各种固体表面上的取向并且固定不同来源的各种抗体或具有不同亲和力的不同同种型。因此，使用本发明的肽杂交体的表面处理技术可以有效地用于生产各种免疫传感器和免疫芯片。

4. 发明申请

US20120059326A1 Microneedle Unit Capable of Controlling Fluid Delivery 有权
标题翻译：能够控制流体输送的微针单元
公开(公告)号：US20120059326A1
公开(公告)日：2012-03-08
申请号：US13263306
申请日：2010-04-08
申请人： Bong Hyun Chung , Nyeon Sik Eum
发明人： Bong Hyun Chung , Nyeon Sik Eum
IPC分类号： A61M5/32 , A61M5/00
CPC分类号： A61M37/0015 , A61M5/178 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061
摘要： Provided is a microneedle unit comprising a case having a space accommodating a fluid and a fluid channel through which the fluid is discharged, a microneedle coupled to a lower portion of the case, a base cover disposed at the lower portion of the case, having a hole through which the microneedle passes, and being vertically movable, a guide pin coupled to the base cover and configured to open and close the fluid channel, and an elastic member configured to impart a restoring force such that the base cover is moved upward by an external pressure and then returns downward again. Therefore, the microneedle unit, which is provided to deliver a fluid into the skin with no pain and no scar, can control injection of the fluid using the guide pin, and repeatedly and conveniently control injection of the fluid using the elastic member.
摘要翻译：提供了一种微针单元，其包括具有容纳流体的空间和流体被排出的流体通道的壳体，连接到壳体的下部的微针，设置在壳体的下部的底盖，具有所述微针通过所述孔并且可垂直移动;引导销，其联接到所述基座盖并且构造成打开和关闭所述流体通道;以及弹性构件，其构造成赋予恢复力，使得所述底盖向上移动一个外部压力再次向下返回。因此，提供用于将流体输送到皮肤中而没有疼痛和无疤痕的微针单元可以使用导销来控制流体的注入，并且使用弹性构件重复且方便地控制流体的注入。

5. 发明申请

US20110171269A1 METHOD FOR MANUFACTURING UNIFORM SIZE POLYMERIC NANOPARTICLES CONTAINING POORLY SOLUBLE DRUGS 有权
标题翻译：制造含有不溶性药物的均匀聚合物纳米颗粒的方法
公开(公告)号：US20110171269A1
公开(公告)日：2011-07-14
申请号：US12990540
申请日：2009-04-30
申请人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
IPC分类号： A61K9/00 , A61K31/235 , A61P1/16 , B82Y40/00 , B82Y5/00
CPC分类号： A61K9/1652 , A61K9/5153 , A61K31/235 , A61K31/343 , A61K31/513 , A61K31/519 , A61K31/5415 , A61K31/573 , A61K31/585 , A61K31/704 , A61K31/7048 , B01D65/00 , C08J3/03 , Y10S516/929
摘要： The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring. The polymeric nanoparticles of the present invention is capable of manufacturing nano-sized small and uniform polymeric nanoparticles through a simple method of employing a non-volatile polar solvent, especially a solvent having a polarity similar to that of water, as a solvent for a mixture solution of biodegradable polymer and poorly soluble materials, and using a low mechanical energy condition and batch-adding of dispersion in an emulsifying process. The polymeric nanoparticles of the present invention are advantageous in that the dissolution rate of the poorly soluble drugs contained in polymeric particles is dramatically improved, and the poorly soluble drugs are gradually and steadily released and maintained at a constant density over a long period of time.
摘要翻译：本发明涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，更具体地说，涉及一种制备均匀尺寸的含有难溶性药物的聚合物纳米颗粒的方法，包括将可生物降解聚合物溶解在非挥发性物质中的第一步骤极性有机溶剂，向水中添加难溶性药物和生物降解性聚合物溶液以产生分散体的第二步骤，以及在低机械能级搅拌的条件下将分散体分批加入到乳化剂溶液中的第三步骤。本发明的聚合物纳米颗粒能够通过使用非挥发性极性溶剂，特别是极性类似于水的溶剂的简单方法作为混合物的溶剂来制造纳米尺寸的小而均匀的聚合物纳米颗粒可生物降解聚合物和难溶性物质的溶液，并且使用低机械能条件和在乳化过程中分批添加分散体。本发明的聚合物纳米颗粒的优点在于，包含在聚合物颗粒中的难溶性药物的溶解速度显着提高，并且难溶性药物在长时间内逐渐且稳定地释放并保持在恒定的密度。

6. 发明授权

US07933019B2 Surface plasmon resonance sensor using rotating mirror 失效
标题翻译：表面等离子体共振传感器采用旋转镜
公开(公告)号：US07933019B2
公开(公告)日：2011-04-26
申请号：US12671841
申请日：2008-08-13
申请人： Bong-Hyun Chung , Yong-Beom Shin
发明人： Bong-Hyun Chung , Yong-Beom Shin
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/7743 , G01N2201/0636 , G01N2201/105 , G02B5/008
摘要： Disclosed is a surface plasmon resonance sensor having a rotating mirror, including (a) an incident light source unit for oscillating a laser as incident light; (b) a polarizer for polarizing the incident light; (c) a rotating mirror having cylindrical or planar shapes for reflecting the polarized incident light to radiate disk-shaped light; (d) a light shielding film for allowing part of the disk-shaped light to pass therethrough and located adjacent to the central axis of the rotating mirror; (e) a cylinder lens for focusing the light passed through the light shielding film thereon; (f) a metal thin film for receiving the light focused on the cylinder lens to generate surface plasmon resonance; (g) a dielectric medium provided under the metal thin film; and (h) a detector for detecting the light reflected from the metal thin film. This surface plasmon resonance sensor can solve conventional interference problems of a laser being used as a light source to obtain an image for measurement of angle and two-dimensional reflected light intensity, including the deterioration of the quality of the image and the variation in the intensity of light source depending on the position of incidence.
摘要翻译：公开了一种具有旋转镜的表面等离子体共振传感器，包括：（a）用于使激光振荡的入射光源单元作为入射光; （b）用于偏振入射光的偏振器; （c）具有用于反射偏振的入射光以辐射盘形光的圆柱形或平面形状的旋转镜; （d）遮光膜，用于允许所述盘状光的一部分通过并位于所述旋转镜的中心轴线附近; （e）用于将通过遮光膜的光聚焦在其上的柱面透镜; （f）用于接收聚焦在圆柱透镜上的光以产生表面等离子体共振的金属薄膜; （g）设置在金属薄膜下方的电介质; 和（h）用于检测从金属薄膜反射的光的检测器。该表面等离子体共振传感器可以解决用作光源的激光的常规干扰问题，以获得用于测量角度和二维反射光强度的图像，包括图像质量的劣化和强度变化的光源取决于发生的位置。

7. 发明申请

US20110020225A1 POROUS POLYMER PARTICLES IMMOBILIZED WITH CHARGED MOLECULES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：用充电分子固定的多孔聚合物颗粒及其制备方法
公开(公告)号：US20110020225A1
公开(公告)日：2011-01-27
申请号：US12672517
申请日：2008-08-05
申请人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
发明人： Bong Hyun Chung , Yong Taik Lim , Jung Hyun Han
IPC分类号： A61K49/00 , A61K9/14 , A61P31/00
CPC分类号： A61K9/5031 , A61K49/0034 , A61K49/0054 , A61K49/0056 , A61K49/0089 , C08J3/12 , C08J2367/04
摘要： The present invention relates to porous polymer particles containing a charged molecule immobilized therein and a method for preparing the same. According to the disclosed invention, porous particles can be prepared using a biocompatible polymer and, at the same time, a charged molecule can be immobilized in the pores of the porous particles, such that various charged molecules can be loaded in the porous particles. In addition, various kinds of drugs or functional materials can be loaded into the porous particles of the present invention by electrostatic attraction and absorption or adsorption by a capillary phenomenon occurring due to porous properties.
摘要翻译：本发明涉及含有固定在其中的带电分子的多孔聚合物颗粒及其制备方法。根据所公开的发明，可以使用生物相容性聚合物制备多孔颗粒，并且同时可以将带电分子固定在多孔颗粒的孔中，使得各种带电分子可以负载在多孔颗粒中。此外，通过由于多孔性质而发生的毛细管现象的静电吸引和吸收，可以将各种药物或功能材料装载到本发明的多孔颗粒中。

8. 发明申请

US20100256397A1 WATER SOLUBLE PHOTOCHROMIC COMPOUNDS FOR LABELING OF BIOMOLECULES AND METHOD FOR DETECTING BIOMOLECULES USING THE SAME 有权
标题翻译：用于生物分子标记的水溶性光致变色化合物和使用该分析物检测生物分子的方法
公开(公告)号：US20100256397A1
公开(公告)日：2010-10-07
申请号：US12739601
申请日：2008-08-21
申请人： Bong Hyun Chung , Sang Jeon Chung , Suh Hyun Lee , Im Sik Chung , Hyun Kyu Park , Chang Soo Lee
发明人： Bong Hyun Chung , Sang Jeon Chung , Suh Hyun Lee , Im Sik Chung , Hyun Kyu Park , Chang Soo Lee
IPC分类号： C07D409/06
CPC分类号： G01N33/533 , A61K49/0021 , A61K49/006 , C09B11/24
摘要： The present invention relates to water-soluble photochromic compounds for labeling biomolecules and a method of detecting biomolecules using the same. More specifically, relates to water-soluble photochromic compounds for labeling biomolecules, in which a functional group rendering photochromic molecules water-soluble is linked to a functional group capable of binding to biomolecules, and a method of detecting biomolecules using the same. Because the disclosed water-soluble photochromic compounds exhibit the color corresponding to the wavelength of visible light range, they allow signals to be easily detected not only with an UV-VIS spectrophotometer but also visually. Accordingly, the photochromic compounds can be advantageously used in sensors for diagnosing diseases.
摘要翻译：本发明涉及用于标记生物分子的水溶性光致变色化合物和使用其的生物分子的检测方法。更具体地，涉及用于标记生物分子的水溶性光致变色化合物，其中使可溶于水的光致变色分子的官能团与能够结合生物分子的官能团连接，以及使用该生物分子检测生物分子的方法。由于所公开的水溶性光致变色化合物表现出与可见光范围波长相对应的颜色，所以它们不仅可以用UV-VIS分光光度计而且可视地容易地检测信号。因此，光致变色化合物可有利地用于诊断疾病的传感器中。

9. 发明申请

US20100231914A1 SURFACE PLASMON RESONANCE SENSOR USING ROTATING MIRROR 失效
标题翻译：使用旋转镜的表面等离子体共振传感器
公开(公告)号：US20100231914A1
公开(公告)日：2010-09-16
申请号：US12671841
申请日：2008-08-13
申请人： Bong-Hyun Chung , Yong-Beom Shin
发明人： Bong-Hyun Chung , Yong-Beom Shin
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/7743 , G01N2201/0636 , G01N2201/105 , G02B5/008
摘要： Disclosed is a surface plasmon resonance sensor having a rotating mirror, including (a) an incident light source unit for oscillating a laser as incident light; (b) a polarizer for polarizing the incident light; (c) a rotating mirror having cylindrical or planar shapes for reflecting the polarized incident light to radiate disk-shaped light; (d) a light shielding film for allowing part of the disk-shaped light to pass therethrough and located adjacent to the central axis of the rotating mirror; (e) a cylinder lens for focusing the light passed through the light shielding film thereon; (f) a metal thin film for receiving the light focused on the cylinder lens to generate surface plasmon resonance; (g) a dielectric medium provided under the metal thin film; and (h) a detector for detecting the light reflected from the metal thin film. This surface plasmon resonance sensor can solve conventional interference problems of a laser being used as a light source to obtain an image for measurement of angle and two-dimensional reflected light intensity, including the deterioration of the quality of the image and the variation in the intensity of light source depending on the position of incidence.
摘要翻译：公开了一种具有旋转镜的表面等离子体共振传感器，包括：（a）用于使激光振荡的入射光源单元作为入射光; （b）用于偏振入射光的偏振器; （c）具有用于反射偏振的入射光以辐射盘形光的圆柱形或平面形状的旋转镜; （d）遮光膜，用于允许所述盘状光的一部分通过并位于所述旋转镜的中心轴线附近; （e）用于将通过遮光膜的光聚焦在其上的柱面透镜; （f）用于接收聚焦在圆柱透镜上的光以产生表面等离子体共振的金属薄膜; （g）设置在金属薄膜下方的电介质; 和（h）用于检测从金属薄膜反射的光的检测器。该表面等离子体共振传感器可以解决用作光源的激光的常规干扰问题，以获得用于测量角度和二维反射光强度的图像，包括图像质量的劣化和强度变化的光源取决于发生的位置。

10. 发明申请

US20100228237A1 GOLD NANOCAGES CONTAINING MAGNETIC NANOPARTICLES 审中-公开
标题翻译：包含磁性纳米粒子的金纳米颗粒
公开(公告)号：US20100228237A1
公开(公告)日：2010-09-09
申请号：US12376792
申请日：2007-07-30
申请人： Bong Hyun Chung , Yong Taik Lim , Jin Kyeong Kim
发明人： Bong Hyun Chung , Yong Taik Lim , Jin Kyeong Kim
IPC分类号： A61B18/20 , B05D5/12 , B05D7/00 , B82B3/00 , C22C5/02 , B32B1/00
CPC分类号： G01N33/5434 , B82Y25/00 , H01F1/0054 , Y10T428/2913 , Y10T428/2982 , Y10T428/2991
摘要： The present invention relates to gold nanocages containing magnetic nanoparticles and a preparation method thereof. More specifically, relates to hollow-type gold nanocage particles, which contain iron oxide nanoparticles having a magnetic property and have an optical property of strongly absorbing or scattering light in the near-infrared (NIR) region, as well as a preparation method thereof. Due to their optical property and magnetic property, the magnetic nanoparticle-containing gold nanocages can be used in various applications, including analysis in a turbid medium with light, cancer therapy or biomolecular manipulation using light, contrast agents for magnetic resonance imaging, magnetic hyperthermia treatment and drug delivery guide, etc.
摘要翻译：本发明涉及含有磁性纳米颗粒的金纳米颗粒及其制备方法。更具体地说，涉及含有具有磁性能并具有在近红外（NIR）区域中强吸收或散射光的光学性质的氧化铁纳米粒子的中空型金纳米颗粒及其制备方法。由于磁性纳米颗粒的光学性质和磁性，可以在各种应用中使用含有磁性纳米颗粒的金纳米颗粒，包括在具有光的混浊介质，癌症治疗或使用光的生物分子操作，磁共振成像造影剂，磁疗热疗药物传递指南等

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