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1. 发明申请

US20060127275A1 Liquid analysis cartridge 有权
标题翻译：液体分析盒
公开(公告)号：US20060127275A1
公开(公告)日：2006-06-15
申请号：US11195328
申请日：2005-08-02
申请人： Mark Holl , Floyd Edwards , Robert Morff , Gerald Klein
发明人： Mark Holl , Floyd Edwards , Robert Morff , Gerald Klein
IPC分类号： G01N33/00
CPC分类号： B01L3/502707 , B01F5/0646 , B01F5/0647 , B01F5/0648 , B01F13/0059 , B01L3/502715 , B01L3/502738 , B01L3/502746 , B01L3/502776 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2400/0487 , B01L2400/0655 , G01N15/14 , Y10T156/1064 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management. The analysis cartridge can be a self-contained disposable cartridge having an integral waste storage container. This invention further provides a sheath flow assembly. The sheath flow assembly includes a sample channel and first and second sheath fluid channels positioned on either side of and converging with the sample channel. The assembly also includes upper and lower sheath fluid chambers positioned above and below and converging with the sample channel. The flow cartridges of this invention can be formed by molding, machining or etching. In a preferred embodiment they are laminated. This invention further provides a method of fabricating a laminated microfluidic flow device. In the method, flow elements are formed in rigid sheets and abutting surfaces of the sheets are bonded together.
摘要翻译：本发明提供一种用于储存含颗粒的液体的装置和方法。存储装置包括具有多个颗粒捕获区域的微流体回旋流动通道。存储通道优选地是各向同性的空间周期性通道。沉淀的颗粒可以在储存后重新悬浮。本发明还提供一种其中具有回旋存储通道的微流体分析盒。样品分析可以使用光学，电气，压力敏感或流量敏感检测。多个分析通道可以包括在单个盒中。分析通道可以连接到用于稀释剂，指示剂或裂解剂的试剂入口。混合通道可以位于试剂入口和分析区域之间，以允许试剂混合和反应。墨盒可以包括用于流量管理的附加阀和泵。分析盒可以是具有一体式废物储存容器的独立的一次性盒。本发明还提供一种鞘流组件。护套流动组件包括样品通道和位于样品通道两侧并与样品通道收敛的第一和第二鞘液通道。组件还包括位于上方和下方的上部和下部鞘液室，并与样品通道会聚。本发明的流动筒可以通过模制，机加工或蚀刻来形成。在优选实施例中，它们被层压。本发明还提供一种制造层压微流体流动装置的方法。在该方法中，流动元件形成为刚性片，并且片材的邻接表面粘合在一起。

2. 发明授权

US06712925B1 Method of making a liquid analysis cartridge 有权
标题翻译：制作液体分析盒的方法
公开(公告)号：US06712925B1
公开(公告)日：2004-03-30
申请号：US09428804
申请日：1999-10-28
申请人： Mark R. Holl , Floyd Edwards , Robert Morff , Gerald L. Klein
发明人： Mark R. Holl , Floyd Edwards , Robert Morff , Gerald L. Klein
IPC分类号： B32B3104
CPC分类号： B01L3/502707 , B01F5/0646 , B01F5/0647 , B01F5/0648 , B01F13/0059 , B01L3/502715 , B01L3/502738 , B01L3/502746 , B01L3/502776 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2400/0487 , B01L2400/0655 , G01N15/14 , Y10T156/1064 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management. The analysis cartridge can be a self-contained disposable cartridge having an integral waste storage container. This invention further provides a sheath flow assembly. The sheath flow assembly includes a sample channel and first and second sheath fluid channels positioned on either side of and converging with the sample channel. The assembly also includes upper and lower sheath fluid chambers positioned above and below and converging with the sample channel. The flow cartridges of this invention can be formed by molding, machining or etching. In a preferred embodiment they are laminated. This invention further provides a method of fabricating a laminated microfluidic flow device. In the method, flow elements are formed in rigid sheets and abutting surfaces of the sheets are bonded together.
摘要翻译：本发明提供一种用于储存含颗粒的液体的装置和方法。存储装置包括具有多个颗粒捕获区域的微流体回旋流动通道。存储通道优选地是各向同性的空间周期性通道。沉淀的颗粒可以在储存后重新悬浮。本发明还提供一种其中具有回旋存储通道的微流体分析盒。样品分析可以使用光学，电气，压力敏感或流量敏感检测。多个分析通道可以包括在单个盒中。分析通道可以连接到用于稀释剂，指示剂或裂解剂的试剂入口。混合通道可以位于试剂入口和分析区域之间，以允许试剂混合和反应。墨盒可以包括用于流量管理的附加阀和泵。分析盒可以是具有一体式废物储存容器的独立的一次性盒。本发明还提供一种鞘流组件。护套流动组件包括样品通道和位于样品通道两侧并与样品通道收敛的第一和第二鞘液通道。组件还包括位于上方和下方的上部和下部鞘液室，并与样品通道会聚。本发明的流动筒可以通过模制，机加工或蚀刻来形成。在优选实施例中，它们被层压。本发明还提供一种制造层压微流体流动装置的方法。在该方法中，流动元件形成为刚性片材，并且片材的邻接表面粘合在一起。

3. 发明授权

US06656431B2 Sample analysis instrument 有权
标题翻译：样品分析仪
公开(公告)号：US06656431B2
公开(公告)日：2003-12-02
申请号：US09428839
申请日：1999-10-28
申请人： Mark R. Holl , Floyd Edwards , Robert Morff , Gerald L. Klein
发明人： Mark R. Holl , Floyd Edwards , Robert Morff , Gerald L. Klein
IPC分类号： G01N2100
CPC分类号： B01L3/502707 , B01F5/0646 , B01F5/0647 , B01F5/0648 , B01F13/0059 , B01L3/502715 , B01L3/502738 , B01L3/502746 , B01L3/502776 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2400/0487 , B01L2400/0655 , G01N15/14 , Y10T156/1064 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management. The analysis cartridge can be a self-contained disposable cartridge having an integral waste storage container. This invention further provides a sheath flow assembly. The sheath flow assembly includes a sample channel and first and second sheath fluid channels positioned on either side of and converging with the sample channel. The assembly also includes upper and lower sheath fluid chambers positioned above and below and converging with the sample channel. The flow cartridges of this invention can be formed by molding, machining or etching. In a preferred embodiment they are laminated. This invention further provides a method of fabricating a laminated microfluidic flow device. In the method, flow elements are formed in rigid sheets and abutting surfaces of the sheets are bonded together.
摘要翻译：本发明提供一种用于储存含颗粒的液体的装置和方法。存储装置包括具有多个颗粒捕获区域的微流体回旋流动通道。存储通道优选地是各向同性的空间周期性通道。沉淀的颗粒可以在储存后重新悬浮。本发明还提供一种其中具有回旋存储通道的微流体分析盒。样品分析可以使用光学，电气，压力敏感或流量敏感检测。多个分析通道可以包括在单个盒中。分析通道可以连接到用于稀释剂，指示剂或裂解剂的试剂入口。混合通道可以位于试剂入口和分析区域之间，以允许试剂混合和反应。墨盒可以包括用于流量管理的附加阀和泵。分析盒可以是具有一体式废物储存容器的独立的一次性盒。本发明还提供一种鞘流组件。护套流动组件包括样品通道和位于样品通道两侧并与样品通道收敛的第一和第二鞘液通道。组件还包括位于上方和下方的上部和下部鞘液室，并与样品通道会聚。本发明的流动筒可以通过模制，机加工或蚀刻来形成。在优选实施例中，它们被层压。本发明还提供一种制造层压微流体流动装置的方法。在该方法中，流动元件形成为刚性片材，并且片材的邻接表面粘合在一起。

4. 发明授权

US06830729B1 Sample analysis instrument 有权
标题翻译：样品分析仪
公开(公告)号：US06830729B1
公开(公告)日：2004-12-14
申请号：US09723823
申请日：2000-11-28
申请人： Mark R. Holl , Floyd Edwards , Robert Morff , Gerald L. Klein
发明人： Mark R. Holl , Floyd Edwards , Robert Morff , Gerald L. Klein
IPC分类号： G01N2100
CPC分类号： B01L3/502707 , B01F13/0059 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2200/0636 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2400/0487 , B01L2400/0655 , G01N15/14
摘要： The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management. The analysis cartridge can be a self-contained disposable cartridge having an integral waste storage container. This invention further provides a sheath flow assembly. The sheath flow assembly includes a sample channel and first and second sheath fluid channels positioned on either side of and converging with the sample channel. The assembly also includes upper and lower sheath fluid chambers positioned above and below and converging with the sample channel. The flow cartridges of this invention can be formed by molding, machining or etching. In a preferred embodiment they are laminated. This invention further provides a method of fabricating a laminated microfluidic flow device. In the method, flow elements are formed in rigid sheets and abutting surfaces of the sheets are bonded together.
摘要翻译：本发明提供一种用于储存含颗粒的液体的装置和方法。存储装置包括具有多个颗粒捕获区域的微流体回旋流动通道。存储通道优选地是各向同性的空间周期性通道。沉淀的颗粒可以在储存后重新悬浮。本发明还提供一种其中具有回旋存储通道的微流体分析盒。样品分析可以使用光学，电气，压力敏感或流量敏感检测。多个分析通道可以包括在单个盒中。分析通道可以连接到用于稀释剂，指示剂或裂解剂的试剂入口。混合通道可以位于试剂入口和分析区域之间，以允许试剂混合和反应。墨盒可以包括用于流量管理的附加阀和泵。分析盒可以是具有一体式废物储存容器的独立的一次性盒。本发明还提供一种鞘流组件。护套流动组件包括样品通道和位于样品通道两侧并与样品通道收敛的第一和第二鞘液通道。组件还包括位于上方和下方的上部和下部鞘液室，并与样品通道会聚。本发明的流动筒可以通过模制，机加工或蚀刻来形成。在优选实施例中，它们被层压。本发明还提供一种制造层压微流体流动装置的方法。在该方法中，流动元件形成为刚性片材，并且片材的邻接表面粘合在一起。

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