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1. 发明申请

US20210045471A1 Appendage Protection Assembly 有权
公开(公告)号：US20210045471A1
公开(公告)日：2021-02-18
申请号：US16539672
申请日：2019-08-13
申请人： Brielle Benedict , James Benedict
发明人： Brielle Benedict , James Benedict
IPC分类号： A41D13/08 , A41D13/06
摘要： An appendage protection assembly for an infant includes a set of sleeves. Each sleeve has first end that is open so that the first end is configured to insert a respective appendage of the infant into the sleeve. The sleeve is configured to insulate the respective appendage and to shield the respective appendage from contact with a device that is coupled to the respective appendage. Each of a set of slits is positioned in a second end of a respective sleeve and extends into opposing sides of the respective sleeve to define a pair of flaps. The pair of flaps is configured to be separated to allow access to digits of the respective appendage that is positioned in the respective sleeve. Each of a set of closures that is coupled to a respective sleeve proximate to an associated slit is positioned to selectively close the associated slit.

2. 发明申请

US20050010547A1 Method and apparatus for managing identity information on a network 审中-公开
标题翻译：用于管理网络上的身份信息的方法和装置
公开(公告)号：US20050010547A1
公开(公告)日：2005-01-13
申请号：US10616561
申请日：2003-07-10
申请人： Rocco Carinci , James Benedict , Keith Trudell , Joseph Waddington
发明人： Rocco Carinci , James Benedict , Keith Trudell , Joseph Waddington
IPC分类号： G06F7/00 , H04L29/06
CPC分类号： H04L63/08
摘要： A centralized identity management service includes a dynamically configured client interface that communication with a directory assess daemon. The data access daemon processes and fulfils requests by communicating with third party databases. A data access layer is interposed between the data access daemon and databases to allow the directories to be modified without affecting the data access daemon. Providing a self-configuring user interface facilitates rapid creation of network services and allows the services to be modified without manually reconfiguring the user interface. Common data format schemas facilitates deployment of new services on the network by allowing services to be defined to take advantage of the features provided by the identity management infrastructure.
摘要翻译：集中式身份管理服务包括动态配置的与目录评估守护进程通信的客户端界面。数据访问守护进程通过与第三方数据库通信来处理和满足请求。在数据访问守护进程和数据库之间插入数据访问层，以允许修改目录而不影响数据访问守护程序。提供自配置用户界面有助于快速创建网络服务，并允许修改服务，而无需手动重新配置用户界面。通用数据格式模式有助于通过允许定义服务来利用身份管理基础设施提供的功能来在网络上部署新服务。

3. 外观设计

USD947476S1 Laundry hamper 有权
公开(公告)号：USD947476S1
公开(公告)日：2022-03-29
申请号：US29735502
申请日：2020-05-21
申请人： James Benedict , Shawn Benedict
设计人： James Benedict , Shawn Benedict

4. 发明申请

US20080031970A1 Method of Promoting Natural Bypass 审中-公开
标题翻译：促进自然绕道的方法
公开(公告)号：US20080031970A1
公开(公告)日：2008-02-07
申请号：US11843797
申请日：2007-08-23
申请人： James Benedict , John Ranieri , Marsha Whitney , Rama Akella
发明人： James Benedict , John Ranieri , Marsha Whitney , Rama Akella
IPC分类号： A61K35/32 , A61K38/18 , A61K38/30 , A61K47/32 , A61P9/10
CPC分类号： A61K38/1808 , A61K9/0019 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/30 , A61K47/32 , A61K2300/00
摘要： An angiogenic factor comprising a mixture of proteins derived from bone. The angiogenic protein mixture is produced by a series of steps that allow the proteins to be kept in solution. The angiogenic mixture of bone proteins is produced by a multi-step process that includes at least one ultrafiltration step, an anion exchange chromatography step, a cation exchange chromatography step and a high performance liquid chromatography (HPLC) purification step.
摘要翻译：包含衍生自骨的蛋白质混合物的血管生成因子。血管生成蛋白质混合物通过允许蛋白质保持在溶液中的一系列步骤产生。通过包括至少一个超滤步骤，阴离子交换层析步骤，阳离子交换层析步骤和高效液相色谱（HPLC）纯化步骤的多步法生产骨蛋白的血管生成混合物。

5. 发明申请

US20070141103A1 Pliable medical device and method of use 有权
标题翻译：柔韧的医疗器械及使用方法
公开(公告)号：US20070141103A1
公开(公告)日：2007-06-21
申请号：US11305715
申请日：2005-12-16
申请人： James Benedict , Greg Brewster , Donald Freeman
发明人： James Benedict , Greg Brewster , Donald Freeman
IPC分类号： A61F2/02 , A61K38/22 , A61K38/29
CPC分类号： A61L27/3608 , A61L27/20 , A61L27/28 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2430/02 , C08L1/28
摘要： A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and “blow-out” of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.
摘要翻译：用作骨移植物替代物或骨移植物延长剂的牢固但柔韧的医疗装置保持其形状，而不需要诸如注射器的容纳装置。因为该装置是固体，所以很容易在体内定位或定位，并且在身体的潮湿环境中，其将保持良好的形状，长时间。因为冻干的柔韧的医疗装置是多孔的，因此与没有被冻干的类似的腻子相比，它吸收含有体液如骨髓的血液和其它有益细胞，有助于其优异的骨修复功效。此外，这些冻干的柔韧的医疗设备比类似的油灰更容易终止蒸汽消毒，因为不存在水分以便将容器（注射器）煮沸和“吹出”。存在于制剂中的甘油具有柔韧性但具有低蒸气压。

6. 发明申请

US20060216325A1 Composition and device for in vivo cartilagerepair 审中-公开
标题翻译：用于体内软骨修复的组合物和装置
公开(公告)号：US20060216325A1
公开(公告)日：2006-09-28
申请号：US11433968
申请日：2006-05-15
申请人： Brent Atkinson , Pedro Bittman , James Benedict , John Ranieri , Marsha Whitney , Donald Chickering
发明人： Brent Atkinson , Pedro Bittman , James Benedict , John Ranieri , Marsha Whitney , Donald Chickering
IPC分类号： A61F2/28
CPC分类号： A61K9/5153 , A61B17/06166 , A61F2/30756 , A61F2002/2817 , A61F2002/30036 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2250/0035 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/26 , A61L27/48 , A61L27/50 , A61L27/54 , A61L2300/252 , A61L2300/30 , A61L2300/624 , A61L2400/12 , A61L2430/06 , B82Y5/00 , Y10S977/91 , Y10S977/914 , C08L89/06 , C08L5/08
摘要： The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)-lactic acid/glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device comprising any biodegradable matrix in which the nanospheres loaded with the factor combination is contained.
摘要翻译：所述的组合物用于体内软骨修复。其基本上由天然衍生的成骨诱导和/或软骨诱导的因子（例如衍生自骨）的混合物或与纳米球递送系统组合的这种混合物的合成模拟物组成。因素的优选混合物是从骨分离的因子（称为BP）并由Poser和Benedict（WO 95/13767）描述的组合。纳米球传递系统由纳米球定义为直径小于1000nm的聚合物颗粒（其中大多数颗粒的范围优选在200-400nm之间），其中纳米球包封因子的组合。纳米球以重量比为0.001至17％（w / w），优选1至4％（w / w）的因子混合物加载，并具有释放曲线，初始爆发为10至20％至少在接下来的七天内，前24小时的总负荷和每天至少0.1次的长时间释放。纳米球由例如，（（D，L） - 乳酸/乙醇酸） - 共聚物（PLGA）。负载的纳米球是例如。通过相位反演。组合物有利地用作包含其中包含加载因子组合的纳米球的任何可生物降解的基质的装置。

7. 发明申请

US20060194729A1 Method of promoting natural bypass 审中-公开
公开(公告)号：US20060194729A1
公开(公告)日：2006-08-31
申请号：US11359102
申请日：2006-02-22
申请人： James Benedict , John Ranieri , Marsha Whitney , Rama Akella
发明人： James Benedict , John Ranieri , Marsha Whitney , Rama Akella
IPC分类号： A61K38/18 , A61K38/17 , A61K38/30
CPC分类号： A61K38/1808 , A61K9/0019 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/30 , A61K47/32 , A61K2300/00
摘要： An angiogenic factor comprising a mixture of proteins derived from bone. The angiogenic protein mixture is produced by a series of steps that allow the proteins to be kept in solution. The angiogenic mixture of bone proteins is produced by a multi-step process that includes at least one ultrafiltration step, an anion exchange chromatography step, a cation exchange chromatography step and a high performance liquid chromatography (HPLC) purification step.

8. 发明申请

US20050026867A1 Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain 审中-公开
标题翻译：透明质酸相关超氧化物歧化酶模拟及其在治疗关节疼痛中的应用
公开(公告)号：US20050026867A1
公开(公告)日：2005-02-03
申请号：US10916108
申请日：2004-08-11
申请人： James Benedict
发明人： James Benedict
IPC分类号： A61K31/555 , A61K31/728 , A61K47/48 , A61P19/02
CPC分类号： A61K31/728 , A61K31/555 , A61K47/61 , A61K2300/00
摘要： Herein is disclosed a composition, comprising a superoxide dismutase mimic (SODm) associated with hyaluronic acid (HA), wherein the composition is a liquid at about 37° C. The composition is useful in a method of treating pain or inflammation in a joint of a mammal, comprising (i) providing the composition and (ii) injecting the composition into or close to the joint.
摘要翻译：本文公开了一种组合物，其包含与透明质酸（HA）相关联的超氧化物歧化酶模拟物（SODm），其中所述组合物在约37℃下是液体。所述组合物可用于治疗疼痛或炎症的方法，哺乳动物，其包括（i）提供所述组合物和（ii）将所述组合物注入或接近所述关节。

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