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1. 发明授权

US08303915B2 Thin film apparatus and method 有权
标题翻译：薄膜装置及方法
公开(公告)号：US08303915B2
公开(公告)日：2012-11-06
申请号：US11926590
申请日：2007-10-29
申请人： Brian H. Kram , Vincent R. Rizzo , Ryan Reeser , David Chafin
发明人： Brian H. Kram , Vincent R. Rizzo , Ryan Reeser , David Chafin
IPC分类号： G01N1/31 , G01N35/02 , B05C5/02
CPC分类号： G01N1/2813 , G01N1/312 , G01N35/1002 , G01N35/1065 , G01N35/1081 , G01N2035/00039 , G01N2035/00138
摘要： A platen for contacting a liquid to a surface of a substantially flat substrate is disclosed. The platen includes a liquid application station and a stripping element at an end of the liquid application station, wherein the stripping element includes an intersecting gap and an air barrier. Also disclosed are an apparatus including the platen and a method of using the platen to contact a substrate with a liquid.
摘要翻译：公开了一种用于将液体接触到基本上平坦的基板的表面的压板。压板包括液体施加站和在液体施加站的端部处的剥离元件，其中剥离元件包括相交间隙和空气屏障。还公开了一种包括压板的装置和使用压板以与液体接触衬底的方法。

2. 发明申请

US20090170152A1 Tissue Conditioning Protocols 审中-公开
标题翻译：组织调理方案
公开(公告)号：US20090170152A1
公开(公告)日：2009-07-02
申请号：US12344564
申请日：2008-12-28
申请人： Ryan Reeser , Brian H. Kram , Vincent R. Rizzo , David Chafin , Jerome W. Kosmeder , Christopher Bieniarz
发明人： Ryan Reeser , Brian H. Kram , Vincent R. Rizzo , David Chafin , Jerome W. Kosmeder , Christopher Bieniarz
IPC分类号： G01N1/28
CPC分类号： G01N1/30 , G01N1/312 , G01N1/36
摘要： Solutions exhibiting little or no evaporative loss at elevated temperatures, i.e., in excess of 100° C., are employed in place of conventional aqueous-based antigen retrieval solutions.
摘要翻译：使用在高温下（即超过100℃）几乎没有或没有蒸发损失的溶液代替常规的水性抗原检索溶液。

3. 发明申请

US20080102006A1 THIN FILM APPARATUS AND METHOD 有权
标题翻译：薄膜装置和方法
公开(公告)号：US20080102006A1
公开(公告)日：2008-05-01
申请号：US11926590
申请日：2007-10-29
申请人： Brian H. Kram , Vincent R. Rizzo , Ryan Reeser , David Chafin
发明人： Brian H. Kram , Vincent R. Rizzo , Ryan Reeser , David Chafin
IPC分类号： B01J19/00
CPC分类号： G01N1/2813 , G01N1/312 , G01N35/1002 , G01N35/1065 , G01N35/1081 , G01N2035/00039 , G01N2035/00138
摘要： A platen for contacting a liquid to a surface of a substantially flat substrate is disclosed. The platen includes a liquid application station and a stripping element at an end of the liquid application station, wherein the stripping element includes an intersecting gap and an air barrier. Also disclosed are an apparatus including the platen and a method of using the platen to contact a substrate with a liquid.
摘要翻译：公开了一种用于将液体接触到基本上平坦的基板的表面的压板。压板包括液体施加站和在液体施加站的端部处的剥离元件，其中剥离元件包括相交间隙和空气屏障。还公开了一种包括压板的装置和使用压板以与液体接触衬底的方法。

4. 发明授权

US10126216B2 Method for tissue sample fixation 有权
公开(公告)号：US10126216B2
公开(公告)日：2018-11-13
申请号：US13372040
申请日：2012-02-13
申请人： David Chafin , Abbey Pierson Theiss , Michael Otter , Esteban Roberts
发明人： David Chafin , Abbey Pierson Theiss , Michael Otter , Esteban Roberts
IPC分类号： G01N1/30 , G01N1/31
摘要： An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.

5. 发明申请

US20120214195A1 METHOD FOR TISSUE SAMPLE FIXATION 审中-公开
标题翻译：组织样本定位方法
公开(公告)号：US20120214195A1
公开(公告)日：2012-08-23
申请号：US13372040
申请日：2012-02-13
申请人： David Chafin , Abbey Pierson Theiss , Michael Otter , Esteban Roberts
发明人： David Chafin , Abbey Pierson Theiss , Michael Otter , Esteban Roberts
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , G01N1/31
摘要： An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.
摘要翻译：导致第一温度的醛固定溶液第一次接触组织样品，另外使醛固定液在高于第一温度的第二温度下接触组织样品持续第二时间段。第一时间段通常为约15分钟至约4小时，第一温度通常为大于0℃至至少15℃。第二温度通常为大于约22℃至约55℃，第二时间段为约1小时至约4小时。使用这个过程，改进的组织形态和IHC染色以及翻译后修饰信号的优异保存已经在大约4小时内完成，与室温方案相比，24小时，并且观察到更均匀的形态和抗原保存。

6. 发明授权

US10267769B2 Processing system for processing specimens using acoustic energy 有权
公开(公告)号：US10267769B2
公开(公告)日：2019-04-23
申请号：US13582705
申请日：2011-03-04
申请人： Michael Otter , David Chafin , Abbey Pierson , Jefferson Curtis Taft
发明人： Michael Otter , David Chafin , Abbey Pierson , Jefferson Curtis Taft
IPC分类号： G01N29/44 , G01N29/024
摘要： A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver.

7. 发明申请

US20120329088A1 PROCESSING SYSTEM FOR PROCESSING SPECIMENS USING ACOUSTIC ENERGY 审中-公开
标题翻译：使用声学能量处理样品的处理系统
公开(公告)号：US20120329088A1
公开(公告)日：2012-12-27
申请号：US13582705
申请日：2011-03-04
申请人： Michael Otter , David Chafin , Abbey Pierson , Jefferson Curtis Taft
发明人： Michael Otter , David Chafin , Abbey Pierson , Jefferson Curtis Taft
IPC分类号： G01N1/30 , C12M1/42 , G01N29/44 , G01N29/024 , G01N29/07 , G01N29/12
CPC分类号： G01N29/024 , G01N29/4427 , G01N2291/02466 , G01N2291/02475
摘要： A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver.
摘要翻译：用于固定生物样品的方法包括在固定生物样品的同时通过已经从受试者中除去的生物样品递送能量。评估通过生物样品传播的能量的速度变化，以监测固定的进展。用于执行该方法的系统可以包括输出能量的发射机和被配置为检测发射能量的接收机。计算设备可以基于来自接收器的信号来评估能量的速度。

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