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1. 发明授权

US08262714B2 Techniques for selecting signal delivery sites and other parameters for treating depression and other neurological disorders, and associated systems and methods 有权
标题翻译：用于选择信号传递部位的技术和用于治疗抑郁症和其他神经障碍的其它参数，以及相关的系统和方法
公开(公告)号：US08262714B2
公开(公告)日：2012-09-11
申请号：US12395257
申请日：2009-02-27
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N5/055 , A61N1/36
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍以及相关系统和方法的信号传递部位和其他信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法还包括获得对应于患者大脑第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。然后至少部分地基于第二成像信息来选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

2. 发明申请

US20130066391A1 TECHNIQUES FOR SELECTING SIGNAL DELIVERY SITES AND OTHER PARAMETERS FOR TREATING DEPRESSION AND OTHER NEUROLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于选择信号传递站点和其他参数用于治疗衰竭和其他神经疾病的技术及相关系统和方法
公开(公告)号：US20130066391A1
公开(公告)日：2013-03-14
申请号：US13606906
申请日：2012-09-07
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N1/36
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is selected based in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍的信号递送部位和其它信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法包括获得对应于患者大脑第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。部分基于第二成像信息选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

3. 发明申请

US20100036453A1 TECHNIQUES FOR SELECTING SIGNAL DELIVERY SITES AND OTHER PARAMETERS FOR TREATING DEPRESSION AND OTHER NEUROLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：用于选择信号传递站点的技术和用于治疗衰竭和其他神经疾病的其他参数以及相关系统和方法
公开(公告)号：US20100036453A1
公开(公告)日：2010-02-11
申请号：US12395257
申请日：2009-02-27
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N1/36 , A61B5/055
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍以及相关系统和方法的信号传递部位和其他信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法还包括获得对应于患者大脑的第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。然后至少部分地基于第二成像信息来选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

4. 发明授权

US08538537B2 Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders 有权
标题翻译：用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神障碍和神经病理障碍）的系统和方法
公开(公告)号：US08538537B2
公开(公告)日：2013-09-17
申请号：US12330437
申请日：2008-12-08
申请人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
发明人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
IPC分类号： A61N1/00
CPC分类号： A61N1/36082
摘要： Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropsychiatric and neuropsychological disorders are disclosed. A method for treating a patient's neurological disorder in accordance with a particular embodiment includes, in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient's skull cavity, and outside a cortical surface of the patient's brain. The electrode is implanted at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned at the precentral sulcus and at the patient's middle frontal gyrus. The method can further include treating the patient's disorder by applying electrical stimulation to the patient via the at least one stimulation electrode.
摘要翻译：公开了用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神和神经心理障碍）的系统和方法。根据特定实施方案的用于治疗患者神经障碍的方法包括在被鉴定为具有神经心理障碍和神经精神障碍中的至少一种的患者中，将至少一个刺激电极植入患者的颅骨腔内，皮质外患者脑部表面。将电极植入在位于中心龈沟处和患者中额叶回的前中央龈下参考点前方约15mm至约35mm范围内的位置处。该方法还可以包括通过经由至少一个刺激电极向患者施加电刺激来治疗患者的病症。

5. 发明申请

US20090149898A1 Systems and Methods for Providing Targeted Neural Stimulation Therapy to Address Neurological Disorders, Including Neuropyschiatric and Neuropyschological Disorders 有权
标题翻译：提供靶向神经刺激治疗解决神经障碍，包括神经精神和神经病理障碍的系统和方法
公开(公告)号：US20090149898A1
公开(公告)日：2009-06-11
申请号：US12330437
申请日：2008-12-08
申请人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
发明人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropsychiatric and neuropsychological disorders are disclosed. A method for treating a patient's neurological disorder in accordance with a particular embodiment includes, in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient's skull cavity, and outside a cortical surface of the patient's brain. The electrode is implanted at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned at the precentral sulcus and at the patient's middle frontal gyrus. The method can further include treating the patient's disorder by applying electrical stimulation to the patient via the at least one stimulation electrode.
摘要翻译：公开了用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神和神经心理障碍）的系统和方法。根据特定实施方案的用于治疗患者神经障碍的方法包括在被鉴定为具有神经心理障碍和神经精神障碍中的至少一种的患者中，将至少一个刺激电极植入患者的颅骨腔内，皮质外患者脑部表面。将电极植入在位于中心龈沟处和患者中额叶回的前中央龈下参考点前方约15mm至约35mm范围内的位置处。该方法还可以包括通过经由至少一个刺激电极向患者施加电刺激来治疗患者的病症。

6. 发明申请

US20050033386A1 System and method for remote programming of a medical device 审中-公开
标题翻译：用于远程编程医疗设备的系统和方法
公开(公告)号：US20050033386A1
公开(公告)日：2005-02-10
申请号：US10941318
申请日：2004-09-15
申请人： Brett Osborn , Brian Kopell
发明人： Brett Osborn , Brian Kopell
IPC分类号： A61N1/08 , A61N1/372
CPC分类号： A61N1/37282 , A61N1/08
摘要： A system and method allows a physician to remotely change the settings of a medical device that is implanted in a patient who is physically separated from the patient. The physician uses a computer to remotely access the patient's computer and programs new settings for the medical device that is conveyed to an emulator which in turn conveys the settings to the medical device. Patients who have neurostimulators implanted in them are particularly suited to receive the benefits of the present invention.
摘要翻译：一种系统和方法允许医生远程地改变植入物理上与病人分离的病人的医疗设备的设置。医生使用计算机远程访问病人的计算机，并为传送给仿真器的医疗设备编程新的设置，该设备又将设置传送到医疗设备。植入神经刺激器的患者特别适合于接受本发明的益处。

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