专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050070971A1 Apparatus and methods for applying neural stimulation to a patient 失效
标题翻译：将神经刺激应用于患者的装置和方法
公开(公告)号：US20050070971A1
公开(公告)日：2005-03-31
申请号：US10910775
申请日：2004-08-02
申请人： Brad Fowler , Bradford Gliner
发明人： Brad Fowler , Bradford Gliner
IPC分类号： A61N20060101 , A61N1/05 , A61N1/18 , A61N1/36
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0539
摘要： Systems and methods for neural stimulation may include a stimulus unit; a first electrode assembly having a first set of contacts; and a second set of contacts. The stimulus unit can be an implantable pulse generator including a first terminal that can be biased at a first signal polarity and a second terminal that can be biased at a second signal polarity. The first electrode assembly includes a support member configured to be placed at the stimulation site, the first set of contacts carried by the support member, and a first lead configured to be attached to the first terminal of the implantable pulse generator for biasing the surface contacts at the first polarity. The second set of contacts is detached from the surface electrode assembly. The second set of contacts can be one or more conductive elements fixed to or forming portions of the implantable pulse generator, or a separate electrode array.
摘要翻译：用于神经刺激的系统和方法可以包括刺激单元; 具有第一组触点的第一电极组件; 和第二组联系人。刺激单元可以是可植入脉冲发生器，其包括可以以第一信号极性偏置的第一端子和可以以第二信号极性偏置的第二端子。第一电极组件包括被配置为放置在刺激部位的支撑构件，由支撑构件承载的第一组触点，以及构造成附接到可植入脉冲发生器的第一端子的第一引线，用于偏置表面触点在第一极性。第二组触点与表面电极组件脱离。第二组触点可以是固定到可植入脉冲发生器的一部分或形成部分的一个或多个导电元件，或单独的电极阵列。

2. 发明申请

US20080103548A1 METHODS FOR TREATING NEUROLOGICAL DISORDERS, INCLUDING NEUROPSYCHIATRIC AND NEUROPSYCHOLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS 审中-公开
标题翻译：治疗神经病变的方法，包括神经病学和神经病学疾病及相关系统
公开(公告)号：US20080103548A1
公开(公告)日：2008-05-01
申请号：US11833217
申请日：2007-08-02
申请人： Brad Fowler , Bradford Gliner , W. Sheffield , Leif Sloan
发明人： Brad Fowler , Bradford Gliner , W. Sheffield , Leif Sloan
IPC分类号： A61N1/05
CPC分类号： A61N1/36082
摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient-specific measure and the target measure.
摘要翻译：公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者目标措施。该方法可以进一步包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。

3. 发明申请

US20080039895A1 ELECTROMAGNETIC SIGNAL DELIVERY FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS, AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：由神经元功能丧失，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递
公开(公告)号：US20080039895A1
公开(公告)日：2008-02-14
申请号：US11697694
申请日：2007-04-06
申请人： Brad Fowler , Bradford Gliner , David Himes
发明人： Brad Fowler , Bradford Gliner , David Himes
IPC分类号： A61N1/00
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译：公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。信号可以在亚阈值水平应用于皮层和/或皮质下区域。

4. 发明申请

US20080046035A1 ELECTRODE CONFIGURATIONS FOR REDUCING INVASIVENESS AND/OR ENHANCING NEURAL STIMULATION EFFICACY, AND ASSOCIATED METHODS 审中-公开
公开(公告)号：US20080046035A1
公开(公告)日：2008-02-21
申请号：US11845006
申请日：2007-08-24
申请人： Brad Fowler , Bradford Gliner
发明人： Brad Fowler , Bradford Gliner
IPC分类号： A61N1/36
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/36017 , A61N1/36082
摘要： Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient's skull and implanting an electrode device within the patient's skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient's brain.

5. 发明申请

US20080033503A1 ELECTRODE CONFIGURATIONS FOR REDUCING INVASIVENESS AND/OR ENHANCING NEURAL STIMULATION EFFICACY, AND ASSOCIATED METHODS 审中-公开
标题翻译：用于减少入侵和/或增强神经刺激效能的电极配置及相关方法
公开(公告)号：US20080033503A1
公开(公告)日：2008-02-07
申请号：US11845005
申请日：2007-08-24
申请人： Brad Fowler , Bradford Gliner
发明人： Brad Fowler , Bradford Gliner
IPC分类号： A61N1/04
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/36017 , A61N1/36082
摘要： Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient's skull and implanting an electrode device within the patient's skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient's brain.
摘要翻译：公开了用于降低侵入性和/或增强神经刺激功效的电极配置及相关方法。根据用于治疗脑疾病的本发明的一个实施例的方法包括识别患者颅骨内的目标神经结构并且在患者的颅骨内植入电极装置，使得通常垂直于颅骨的轴线靠近电极装置并且通过电极装置的至少一个电接触偏离目标神经结构。该方法还包括通过向至少一个电触点施加电信号来刺激目标神经结构。在特定实施例中，电极装置可以位于患者大脑的裂缝，凹槽，凹槽和/或血管结构之间，沿着，横过或相邻。

6. 发明申请

US20060190056A1 Apparatus and methods for applying neural stimulation to a patient 审中-公开
标题翻译：将神经刺激应用于患者的装置和方法
公开(公告)号：US20060190056A1
公开(公告)日：2006-08-24
申请号：US11376258
申请日：2006-03-15
申请人： Brad Fowler , Bradford Gliner
发明人： Brad Fowler , Bradford Gliner
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0539
摘要： Systems and methods for neural stimulation may include a stimulus unit; a first electrode assembly having a first set of contacts; and a second set of contacts. The stimulus unit can be an implantable pulse generator including a first terminal that can be biased at a first signal polarity and a second terminal that can be biased at a second signal polarity. The first electrode assembly includes a support member configured to be placed at the stimulation site, the first set of contacts carried by the support member, and a first lead configured to be attached to the first terminal of the implantable pulse generator for biasing the surface contacts at the first polarity. The second set of contacts is detached from the surface electrode assembly. The second set of contacts can be one or more conductive elements fixed to or forming portions of the implantable pulse generator, or a separate electrode array.
摘要翻译：用于神经刺激的系统和方法可以包括刺激单元; 具有第一组触点的第一电极组件; 和第二组联系人。刺激单元可以是可植入脉冲发生器，其包括可以以第一信号极性偏置的第一端子和可以以第二信号极性偏置的第二端子。第一电极组件包括被配置为放置在刺激部位的支撑构件，由支撑构件承载的第一组触点，以及构造成附接到可植入脉冲发生器的第一端子的第一引线，用于偏置表面触点在第一极性。第二组触点与表面电极组件脱离。第二组触点可以是固定到可植入脉冲发生器的一部分或形成部分的一个或多个导电元件，或单独的电极阵列。

7. 发明申请

US20060106430A1 Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods 审中-公开
标题翻译：用于降低侵袭力和/或增强神经刺激功效的电极配置及相关方法
公开(公告)号：US20060106430A1
公开(公告)日：2006-05-18
申请号：US10987118
申请日：2004-11-12
申请人： Brad Fowler , Bradford Gliner
发明人： Brad Fowler , Bradford Gliner
IPC分类号： A61N1/32
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/36017 , A61N1/36082
摘要： Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient's skull and implanting an electrode device within the patient's skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient's brain.
摘要翻译：公开了用于降低侵入性和/或增强神经刺激功效的电极配置及相关方法。根据用于治疗脑疾病的本发明的一个实施例的方法包括识别患者颅骨内的目标神经结构并且在患者的颅骨内植入电极装置，使得通常垂直于颅骨的轴线靠近电极装置并且通过电极装置的至少一个电接触偏离目标神经结构。该方法还包括通过向至少一个电触点施加电信号来刺激目标神经结构。在特定实施例中，电极装置可以位于患者大脑的裂缝，凹槽，凹槽和/或血管结构之间，沿着，横过或相邻。

8. 发明申请

US20070179558A1 Systems and methods for varying electromagnetic and adjunctive neural therapies 审中-公开
标题翻译：用于改变电磁和辅助神经疗法的系统和方法
公开(公告)号：US20070179558A1
公开(公告)日：2007-08-02
申请号：US11344453
申请日：2006-01-30
申请人： Bradford Gliner , Jeffrey Balzer , Brad Fowler , Leif Sloan
发明人： Bradford Gliner , Jeffrey Balzer , Brad Fowler , Leif Sloan
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/37247
摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.
摘要翻译：公开了用于改变电磁和辅助神经疗法的系统和方法。根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号非植入设备）。该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。根据其他实施例的系统可以支持多个信号传递装置。

9. 发明申请

US20060015153A1 Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
公开(公告)号：US20060015153A1
公开(公告)日：2006-01-19
申请号：US11182713
申请日：2005-07-15
申请人： Bradford Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif Sloan
发明人： Bradford Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif Sloan
IPC分类号： A61N1/18
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

10. 发明申请

US20120041498A1 SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 有权
标题翻译：用于增强或影响神经刺激效能和/或效率的系统和方法
公开(公告)号：US20120041498A1
公开(公告)日：2012-02-16
申请号：US13179133
申请日：2011-07-08
申请人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
发明人： Bradford Evan Gliner , Allen Wyler , Brad Fowler , W. Douglas Sheffield , Richard Kuntz , Kent Leyde , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： H04L67/2842 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36135 , A61N1/36146 , A61N1/37252 , G06F13/385 , H04L49/90 , H04L49/901 , H04L67/2823
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。第一和第二时域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发频率以及规则和/或变化的腹内刺激参数的突发模式。在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式