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1. 发明申请

US20170232265A1 Monitoring Electrode Voltages In An Implantable Medical Device System Having Daisy-Chained Electrode-Driver Integrated Circuits 审中-公开
公开(公告)号：US20170232265A1
公开(公告)日：2017-08-17
申请号：US15588423
申请日：2017-05-05
申请人： Boston Scientific Neuromodulation Corporation
发明人： Jordi Parramon , Jess W. Shi , Emanuel Feldman
IPC分类号： A61N1/372 , A61N1/36 , A61N1/05 , A61N1/08 , A61N1/02
CPC分类号： A61N1/37241 , A61N1/025 , A61N1/05 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36125 , A61N1/36153
摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.

2. 发明授权

US09643016B2 Monitoring electrode voltages in an implantable medical device system having daisy-chained electrode-driver integrated circuits 有权
公开(公告)号：US09643016B2
公开(公告)日：2017-05-09
申请号：US15091938
申请日：2016-04-06
申请人： Boston Scientific Neuromodulation Corporation
发明人： Jordi Parramon , Jess W. Shi , Emanuel Feldman
IPC分类号： A61N1/372 , A61N1/36 , A61N1/05 , A61N1/02
CPC分类号： A61N1/37241 , A61N1/025 , A61N1/05 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36125 , A61N1/36153
摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.

3. 发明授权

US09314638B2 Monitoring electrode voltages in an implantable medical device system having daisy-chained electrode-driver integrated circuits 有权
公开(公告)号：US09314638B2
公开(公告)日：2016-04-19
申请号：US14817941
申请日：2015-08-04
申请人： Boston Scientific Neuromodulation Corporation
发明人： Jordi Parramon , Jess W. Shi , Emanuel Feldman
IPC分类号： A61N1/372 , A61N1/02 , A61N1/36 , A61N1/05
CPC分类号： A61N1/37241 , A61N1/025 , A61N1/05 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36125 , A61N1/36153
摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.

4. 发明申请

US20160082260A1 Architectures for an Implantable Medical Device System 审中-公开
标题翻译：可植入医疗器械系统的架构
公开(公告)号：US20160082260A1
公开(公告)日：2016-03-24
申请号：US14961649
申请日：2015-12-07
申请人： Boston Scientific Neuromodulation Corporation
发明人： Paul J. Griffith , Jordi Parramon , Goran Marnfeldt , Daniel Aghassian , Kiran Nimmagadda , Emanuel Feldman , Jess W. Shi
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/0551 , A61N1/0553 , A61N1/36071
摘要： An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicates with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG.
摘要翻译：公开了一种用于植入式医疗装置（例如植入式脉冲发生器（IPG））的改进的架构。在一个实施例中，用于IPG的各种功能块被并入到信号集成电路（IC）中。每个功能块通过由通信协议管理的集中式总线彼此通信，并且如果需要，与其他片外设备通信。为了与总线进行通信并遵守协议，每个电路块包括与该协议相关的总线接口电路。由于每个块符合协议，任何给定的块都可以轻松修改或升级，而不影响其他块的设计，便于IPG电路的调试和升级。此外，由于集中式总线可以从集成电路中取出，所以额外的电路可以很容易地从芯片上添加到IPG中来修改或添加功能。

5. 发明申请

US20140018883A1 Techniques for Sensing and Adjusting a Compliance Voltage in an Implantable Stimulator Device 有权
公开(公告)号：US20140018883A1
公开(公告)日：2014-01-16
申请号：US13971685
申请日：2013-08-20
申请人： Boston Scientific Neuromodulation Corporation
发明人： Jess W. Shi , Yuping He , Que T. Doan , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36125 , A61N1/36071 , A61N1/37
摘要： Disclosed herein are methods and circuitry for monitoring and adjusting a compliance voltage in an implantable stimulator devices to an optimal value that is sufficiently high to allow for proper circuit performance (i.e., sufficient current output), but low enough that power is not needlessly wasted via excessive voltage drops across the current output circuitry. The algorithm measures output voltages across the current source and sink circuitry during at least periods of actual stimulation when both the current sources and sinks are operable, and adjusts the compliance voltage so as to reduce these output voltages to within guard band values preferably indicative for operation in transistor saturation. The output voltages can additionally be monitored during periods between stimulation pulses to improve the accuracy of the measurement, and is further beneficial in that such additional measurements are not perceptible to the patient.

6. 发明授权

US08781598B2 Techniques for sensing and adjusting a compliance voltage in an implantable stimulator device 有权
标题翻译：用于感测和调整植入式刺激器装置中的顺从电压的技术
公开(公告)号：US08781598B2
公开(公告)日：2014-07-15
申请号：US13971685
申请日：2013-08-20
申请人： Boston Scientific Neuromodulation Corporation
发明人： Jess W. Shi , Yuping He , Que T. Doan , David K. L. Peterson
IPC分类号： A61N1/05
CPC分类号： A61N1/36125 , A61N1/36071 , A61N1/37
摘要： Disclosed herein are methods and circuitry for monitoring and adjusting a compliance voltage in an implantable stimulator devices to an optimal value that is sufficiently high to allow for proper circuit performance (i.e., sufficient current output), but low enough that power is not needlessly wasted via excessive voltage drops across the current output circuitry. The algorithm measures output voltages across the current source and sink circuitry during at least periods of actual stimulation when both the current sources and sinks are operable, and adjusts the compliance voltage so as to reduce these output voltages to within guard band values preferably indicative for operation in transistor saturation. The output voltages can additionally be monitored during periods between stimulation pulses to improve the accuracy of the measurement, and is further beneficial in that such additional measurements are not perceptible to the patient.
摘要翻译：本文公开了用于监测和调整可植入式刺激器装置中的顺应性电压的方法和电路，以达到足够高以允许适当的电路性能（即，足够的电流输出）的最佳值，但是足够低以使得功率不会被无用地浪费通过电流输出电路上的电压过大。当电流源和接收器都可操作时，该算法在至少实际刺激期间测量电流源和接收电路两端的输出电压，并且调整顺从电压，以便将这些输出电压降低到优选地指示操作的保护带值内晶体管饱和。在刺激脉冲之间的周期期间可以另外监视输出电压，以提高测量的准确度，并且进一步有益的是，这种附加测量对于患者是不可察觉的。

7. 发明申请

US20170143970A1 Sample and Hold Circuitry for Monitoring Voltages in an Implantable Neurostimulator 审中-公开
公开(公告)号：US20170143970A1
公开(公告)日：2017-05-25
申请号：US15424274
申请日：2017-02-03
申请人： Boston Scientific Neuromodulation Corporation
发明人： Jess W. Shi , Emanuel Feldman , Jordi Parramon
IPC分类号： A61N1/36 , A61N1/08 , A61N1/378 , A61N1/02
CPC分类号： A61N1/36125 , A61B5/04001 , A61N1/025 , A61N1/08 , A61N1/378 , A61N1/3937
摘要： Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing.

8. 发明申请

US20150290456A1 Sample and Hold Circuitry for Monitoring Voltages in an Implantable Neurostimulator 审中-公开
标题翻译：用于监测植入式神经刺激器中的电压的采样和保持电路
公开(公告)号：US20150290456A1
公开(公告)日：2015-10-15
申请号：US14747380
申请日：2015-06-23
申请人： Boston Scientific Neuromodulation Corporation
发明人： Jess W. Shi , Emanuel Feldman , Jordi Parramon
IPC分类号： A61N1/08 , A61N1/378
CPC分类号： A61N1/36125 , A61B5/04001 , A61N1/025 , A61N1/08 , A61N1/378 , A61N1/3937
摘要： Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing.
摘要翻译：公开了用于在可植入神经刺激器中监测电极和其它电压的采样和保持电路。在一个实施例中，采样和保持电路包含多个选择的合适电压，并在两个不同的测量阶段期间将其传送到两个存储电容器。电容器串联连接以增加存储在电容器上的两个电压，然后将存在于串行连接顶部和底部的电压输入到差分放大器以计算其差值。采样和保持电路在计算两个电极之间的电阻时特别有用，当使用双相脉冲测量电阻时，采样和保持电路特别有用。采样和保持电路是灵活的，并且可以用于在双相或单相脉冲期间测量感兴趣的其他电压。

9. 发明授权

US09061152B2 Techniques for sensing and adjusting a compliance voltage in an implantable stimulator device 有权
标题翻译：用于感测和调整植入式刺激器装置中的顺从电压的技术
公开(公告)号：US09061152B2
公开(公告)日：2015-06-23
申请号：US14324438
申请日：2014-07-07
申请人： Boston Scientific Neuromodulation Corporation
发明人： Jess W. Shi , Yuping He , Que T. Doan , David K. L. Peterson
IPC分类号： A61N1/36 , A61N1/37
CPC分类号： A61N1/36125 , A61N1/36071 , A61N1/37
摘要： Disclosed herein are methods and circuitry for monitoring and adjusting a compliance voltage in an implantable stimulator devices to an optimal value that is sufficiently high to allow for proper circuit performance (i.e., sufficient current output), but low enough that power is not needlessly wasted via excessive voltage drops across the current output circuitry. The algorithm measures output voltages across the current source and sink circuitry during at least periods of actual stimulation when both the current sources and sinks are operable, and adjusts the compliance voltage so as to reduce these output voltages to within guard band values preferably indicative for operation in transistor saturation. The output voltages can additionally be monitored during periods between stimulation pulses to improve the accuracy of the measurement, and is further beneficial in that such additional measurements are not perceptible to the patient.
摘要翻译：本文公开了用于监测和调整可植入式刺激器装置中的顺应性电压的方法和电路，以达到足够高以允许适当的电路性能（即，足够的电流输出）的最佳值，但是足够低以使得功率不会被无用地浪费通过电流输出电路上的电压过大。当电流源和接收器都可操作时，该算法在至少实际刺激期间测量电流源和接收电路两端的输出电压，并且调整顺从电压，以便将这些输出电压降低到优选地指示操作的保护带值内晶体管饱和。在刺激脉冲之间的周期期间可以另外监视输出电压，以提高测量的准确度，并且进一步有益的是，这种附加测量对于患者是不可察觉的。

10. 发明授权

US09962551B2 Monitoring electrode voltages in an implantable medical device system having daisy-chained electrode-driver integrated circuits 有权
公开(公告)号：US09962551B2
公开(公告)日：2018-05-08
申请号：US15588423
申请日：2017-05-05
申请人： Boston Scientific Neuromodulation Corporation
发明人： Jordi Parramon , Jess W. Shi , Emanuel Feldman
IPC分类号： A61N1/372 , A61N1/36 , A61N1/05 , A61N1/08 , A61N1/02
CPC分类号： A61N1/37241 , A61N1/025 , A61N1/05 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36125 , A61N1/36153
摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.

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