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1. 发明申请

US20120282280A1 BI-SPECIFIC DIGOXIGENIN BINDING ANTIBODIES 有权
标题翻译：双特异性抗体结合抗体
公开(公告)号：US20120282280A1
公开(公告)日：2012-11-08
申请号：US13382505
申请日：2010-06-30
申请人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffman , Ludger Markus Ickenstein , Kerstin Jahn-Hofman , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffman , Ludger Markus Ickenstein , Kerstin Jahn-Hofman , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： A61K39/44 , C07K16/30 , A61P35/00 , G01N21/64
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical 5 compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对靶蛋白和半抗原的双特异性抗体和抗体片段，其中半抗原是PEG或生物素，最优选地高辛，其制备方法，它们作为治疗或诊断剂的递送平台的用途，含有所述抗体及其用途。

2. 发明授权

US09050375B2 Bi-specific digoxigenin binding antibodies 有权
标题翻译：双特异性地高辛结合抗体
公开(公告)号：US09050375B2
公开(公告)日：2015-06-09
申请号：US13382505
申请日：2010-06-30
申请人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： C07K16/46 , A61K49/00 , A61K49/16 , A61K47/48 , A61K31/704 , A61K39/395 , B82Y5/00 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C12N15/11 , C12N15/113 , A61K39/00
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对靶蛋白和半抗原的双特异性抗体和抗体片段，其中半抗原为PEG或生物素，最优选为地高辛，其制备方法，用作治疗或诊断试剂的递送平台，含有所述抗体及其用途。

3. 发明授权

US09036880B2 High-resolution three-dimensional medical imaging with dynamic real-time information 有权
标题翻译：高分辨率三维医学影像与动态实时信息
公开(公告)号：US09036880B2
公开(公告)日：2015-05-19
申请号：US12797759
申请日：2010-06-10
申请人： Ulrich Hartung , Matthias John
发明人： Ulrich Hartung , Matthias John
IPC分类号： G06K9/00 , A61B6/03 , A61B6/00 , A61B8/08 , A61B5/00 , A61B6/12 , A61B8/00 , A61B19/00 , G01R33/48 , G01R33/563
CPC分类号： A61B6/032 , A61B5/7285 , A61B6/12 , A61B6/4441 , A61B6/466 , A61B6/503 , A61B6/504 , A61B6/5247 , A61B6/541 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/483 , A61B8/5238 , A61B8/543 , A61B2090/364 , G01R33/4808 , G01R33/56308
摘要： A computer-implemented method, a device, a system and a computer program are disclosed for three-dimensional displaying of medical body structures within the framework of a medical procedure, in particular cardiac surgery, wherein movement information is derived from a dynamic image of a body structure to be examined. In at least one embodiment, movement information is derived from vector analysis. After acquiring a static image of the respective body structure, vector analysis is applied to the static image to derive a modified static image with movement information of the body structure. The static image can then be displayed after it has moved.
摘要翻译：公开了一种计算机实现的方法，装置，系统和计算机程序，用于在医疗程序，特别是心脏手术的框架内的医疗体结构的三维显示，其中运动信息是从动态图像身体结构要检查。在至少一个实施例中，从矢量分析导出运动信息。在获取相应身体结构的静态图像之后，将矢量分析应用于静态图像，以获得具有身体结构的运动信息的修改的静态图像。静态图像可以在移动后显示。

4. 发明授权

US09014423B2 Method and system for catheter tracking in fluoroscopic images using adaptive discriminant learning and measurement fusion 有权
标题翻译：使用自适应判别学习和测量融合的荧光镜图像中导管跟踪的方法和系统
公开(公告)号：US09014423B2
公开(公告)日：2015-04-21
申请号：US13412882
申请日：2012-03-06
申请人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
发明人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
IPC分类号： G06K9/00 , A61B6/00 , A61B6/12 , G06T7/20
CPC分类号： A61B6/487 , A61B6/12 , A61B6/503 , G06T7/246 , G06T2207/10016 , G06T2207/10064 , G06T2207/20076 , G06T2207/20081 , G06T2207/30021 , G06T2207/30048
摘要： A method and system for adaptive discriminant learning and measurement fusion for image based catheter tracking is disclosed. An adaptive discriminant model is trained online based on a tracked object, such as a pigtail catheter tip, in at least one previous frame of a fluoroscopic image sequence. The object is tracked in the current frame of the fluoroscopic image sequence based at least on the adaptive discriminant model trained online. The object may be tracked in the current frame based on a fusion of three types of measurement models including the adaptive discriminant model trained online, an object detection model trained offline, and an online appearance model.
摘要翻译：公开了一种用于基于图像的导管跟踪的自适应判别学习和测量融合的方法和系统。在荧光镜像图像序列的至少一个先前帧中，基于跟踪对象（例如尾纤导管尖端）在线训练自适应判别模型。至少基于在线训练的自适应判别模型，在透视图像序列的当前帧中跟踪对象。基于三种类型的测量模型的融合，可以在当前帧中跟踪对象，包括在线训练的自适应判别模型，离线训练的对象检测模型和在线外观模型。

5. 发明申请

US20120296202A1 Method and System for Registration of Ultrasound and Physiological Models to X-ray Fluoroscopic Images 有权
标题翻译：超声和生理模型注射X射线荧光镜图像的方法和系统
公开(公告)号：US20120296202A1
公开(公告)日：2012-11-22
申请号：US13475048
申请日：2012-05-18
申请人： Peter Mountney , Markus Kaiser , Ingmar Voigt , Matthias John , Razvan Ioan Ionasec , Jan Boese , Dorin Comaniciu
发明人： Peter Mountney , Markus Kaiser , Ingmar Voigt , Matthias John , Razvan Ioan Ionasec , Jan Boese , Dorin Comaniciu
IPC分类号： A61B6/02 , A61B8/12
CPC分类号： A61B6/12 , A61B6/4417 , A61B6/4441 , A61B6/487 , A61B6/503 , A61B6/5247 , A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/4245 , A61B8/4416 , A61B8/5261
摘要： A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.
摘要翻译：公开了一种用于将超声图像和生理模型记录到X射线透视图像的方法和系统。接收透视图像和超声图像，如经食道超声心动图（TEE）图像。在透视图像中检测超声探头的2D位置。基于在荧光镜图像中检测到的超声波探头的2D位置来估计超声探头的3D姿态。超声图像被映射到用于根据超声探头的估计3D姿势获取荧光镜图像的荧光镜图像采集装置的3D坐标系。然后可以使用与透视图像相关联的投影矩阵将超声图像投影到透视图像中。可以在超声图像中检测患者特异性生理模型并将其投影到透视图像中。

6. 发明授权

US08273870B2 Compositions and methods for inhibiting expression of a mutant gene 有权
标题翻译：用于抑制突变基因表达的组合物和方法
公开(公告)号：US08273870B2
公开(公告)日：2012-09-25
申请号：US13177316
申请日：2011-07-06
申请人： Roland Kreutzer , Stefan Limmer , Matthias John
发明人： Roland Kreutzer , Stefan Limmer , Matthias John
IPC分类号： C07H21/04
CPC分类号： C12N15/1131 , C12N15/111 , C12N2310/14 , C12N2310/53 , C12N2320/50
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a first strand that has a complementary region that is complementary to at least a portion of an RNA transcript of at least part of the mutant target gene and a second strand of the dsRNA complementary or substantially complementary to the first strand. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
摘要翻译：本发明涉及用于抑制突变基因表达的双链核糖核酸（dsRNA），其包含第一链，该第一链具有与至少部分至少部分的RNA转录物的至少一部分互补的互补区突变靶基因和与第一链互补或基本上互补的dsRNA的第二链。本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。药物组合物可用于抑制靶突变基因的表达，以及用于治疗由靶基因表达引起的疾病。本发明还涉及抑制靶突变基因表达的方法，以及用于治疗由靶基因表达引起的疾病的方法。

7. 发明申请

US20120123250A1 Method and System for Pigtail Catheter Motion Prediction 有权
标题翻译：猪尾导管运动预测方法与系统
公开(公告)号：US20120123250A1
公开(公告)日：2012-05-17
申请号：US13297373
申请日：2011-11-16
申请人： Yu Pang , Yefeng Zheng , Matthias John , Jan Boese , Dorin Comaniciu
发明人： Yu Pang , Yefeng Zheng , Matthias John , Jan Boese , Dorin Comaniciu
IPC分类号： A61B6/00
CPC分类号： A61B6/487 , A61B6/12 , A61B6/5264 , G06T7/246 , G06T7/277 , G06T2207/10121 , G06T2207/30021
摘要： A method and system for autoregressive model based pigtail catheter motion prediction in a fluoroscopic image sequence is disclosed. Parameters of an autoregressive model are estimated based on observed pigtail catheter tip positions in a plurality of previous frames of a fluoroscopic image sequence. A pigtail catheter tip position in a current frame of the fluoroscopic image sequence is predicted using the fitted autoregressive model. The predicted pigtail catheter tip position can be used to constrain pigtail catheter tip detection in the current frame. The predicted pigtail catheter tip position may also be used to predict abnormal motion in the fluoroscopic image sequence.
摘要翻译：公开了一种在透视图像序列中基于自回归模型的尾纤导管运动预测的方法和系统。基于在透视图像序列的多个先前帧中的观察到的尾纤导管尖端位置来估计自回归模型的参数。使用拟合的自回归模型预测荧光镜图像序列的当前帧中的尾纤导管尖端位置。预测的猪尾导管尖端位置可用于限制当前帧中的尾纤导管尖端检测。预测的猪尾导管尖端位置也可以用于预测荧光镜像图像序列中的异常运动。

8. 发明授权

US08077940B2 Method for reconstructing a three-dimensional target volume in realtime and displaying it 有权
标题翻译：实时重建三维目标体积并进行显示的方法
公开(公告)号：US08077940B2
公开(公告)日：2011-12-13
申请号：US11725830
申请日：2007-03-20
申请人： Matthias John , Norbert Rahn
发明人： Matthias John , Norbert Rahn
IPC分类号： G06K9/00
CPC分类号： A61B8/12 , A61B5/0066 , A61B5/0456 , A61B8/543 , G06T11/005 , G06T2211/428
摘要： The invention relates to a method for reconstructing a three-dimensional target volume, particularly within the human body, in realtime and displaying it, with a three-dimensional reconstruction volume being determined from a basic set comprising a minimum number of two-dimensional images obtained from an image recording device located within the target volume, wherein, when a new image is included in the basic set, locally limited updating at least of the reconstruction volume's partial areas covered by the new image will under a predefined condition be performed and the updated reconstruction volume will be displayed.
摘要翻译：本发明涉及一种用于重建三维目标体积，特别是在人体内实时地显示三维目标体积的方法，并且显示三维目标体积，其中三维重建体积是从包括最小数目的二维图像获得的基本集合确定的从位于所述目标体积内的图像记录装置，其中，当在所述基本组中包括新图像时，在执行所述新图像所覆盖的至少所述重建体积的部分区域内的局部限制更新将被执行，并且所述更新重建体积将被显示。

9. 发明申请

US20110046725A1 METHOD OF IMAGING FOR HEART VALVE IMPLANT PROCEDURE 失效
标题翻译：心瓣植入手术成像方法
公开(公告)号：US20110046725A1
公开(公告)日：2011-02-24
申请号：US12545435
申请日：2009-08-21
申请人： Alois Noettling , Jan Boese , Matthias John , Volkmar Falk , Thomas Walther
发明人： Alois Noettling , Jan Boese , Matthias John , Volkmar Falk , Thomas Walther
IPC分类号： A61F2/24 , A61B6/03 , A61B6/00 , G01N23/04 , H05G1/60 , G06K9/00 , G09G5/00
CPC分类号： A61B6/032 , A61B6/503 , A61B8/0883 , A61F2/24
摘要： A method as a workflow for imaging for a heart valve implant procedure includes positioning the patient and an articulated imaging apparatus relative to one another, inducing rapid ventricular pacing in the patient, and imaging a region of the patient's heart to obtain image date for a three-dimensional image. The three-dimensional data is used to construct a three-dimensional image of the region of the patient's heart an the three-dimensional image is displayed for use in the implanting of the replacement heart valve. Optional steps may include obtaining a real time two-dimensional image of the patient's heart and superimposing the real time two-dimensional image with the constructed three dimensional image. The replacement valve is moved into position in the patient's heart during rapid ventricular pacing and breath hold using the superimposed two-dimensional and three-dimensional image information.
摘要翻译：作为用于心脏瓣膜植入程序的成像工作流程的方法包括相对于彼此定位患者和关节成像装置，在患者体内引起快速心室起搏，以及对患者心脏的区域进行成像以获得三维图像的图像日期维度图像。三维数据用于构建患者心脏区域的三维图像，显示三维图像以用于置换心脏瓣膜的植入。可选步骤可以包括获得患者心脏的实时二维图像，并且用构建的三维图像叠加实时二维图像。使用重叠的二维和三维图像信息，在快速心室起搏和呼吸保持期间将置换瓣膜移动到患者心脏中的位置。

10. 发明申请

US20100290685A1 FUSION OF 3D VOLUMES WITH CT RECONSTRUCTION 有权
标题翻译：融合CT重建3D体积
公开(公告)号：US20100290685A1
公开(公告)日：2010-11-18
申请号：US12769789
申请日：2010-04-29
申请人： Wolfgang Wein , Estelle Camus , Matthias John , Ali Kamen , Christophe Duong , Chenyang Xu
发明人： Wolfgang Wein , Estelle Camus , Matthias John , Ali Kamen , Christophe Duong , Chenyang Xu
IPC分类号： G06K9/62
CPC分类号： G06T7/33 , G06T2207/10081 , G06T2207/10136 , G06T2207/20221 , G06T2207/30048
摘要： A method for registration of ultrasound device in three dimensions to a C-arm scan, the method including acquiring a baseline volume, acquiring images in which the ultrasound device is disposed, locating the device within the images, registering the location of the device to the baseline volume, acquiring an ultrasound volume from the ultrasound device, registering the ultrasound volume to the baseline volume, and performing fusion imaging to display a view of the ultrasound device in the baseline volume.
摘要翻译：一种用于将三维超声装置注册到C臂扫描的方法，所述方法包括获取基线体积，获取其中设置超声装置的图像，将装置定位在图像内，将装置的位置登记到基线体积，从超声装置获取超声波体积，将超声波体积记录到基线体积，以及执行融合成像以在基线体积中显示超声装置的视图。

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