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1. 发明授权

US06905885B2 Portable pathogen detection system 失效
标题翻译：便携式病原体检测系统
公开(公告)号：US06905885B2
公开(公告)日：2005-06-14
申请号：US09880515
申请日：2001-06-12
申请人： Billy W. Colston , Matthew Everett , Fred P. Milanovich , Steve B. Brown , Kodumudi Vendateswaran , Jonathan N. Simon
发明人： Billy W. Colston , Matthew Everett , Fred P. Milanovich , Steve B. Brown , Kodumudi Vendateswaran , Jonathan N. Simon
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/54313
摘要： A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.
摘要翻译：便携式病原体检测系统，实现了生物样品中靶标的现场多重检测。该系统包括：微珠特异性试剂，孵育/混合室，一次性微珠捕获底物和光学测量和解码装置。该系统的基础是高度灵活的液体阵列，其利用光学编码的微珠作为生物测定的模板。目标生物样品被光学标记并捕获在微珠上，微珠又依次在有序阵列或无序阵列一次性捕获基底上捕获，然后光学读取。

2. 发明授权

US06337213B1 Apparatus and method for collection and concentration of respirable particles into a small fluid volume 失效
标题翻译：用于将可吸入颗粒收集和浓缩成小体积的装置和方法
公开(公告)号：US06337213B1
公开(公告)日：2002-01-08
申请号：US09456341
申请日：1999-12-08
申请人： Jonathan N. Simon , Steve B. Brown
发明人： Jonathan N. Simon , Steve B. Brown
IPC分类号： G01N118
CPC分类号： G01N1/4077 , B01D45/10 , B01D45/14 , G01N1/2211 , G01N1/2273 , G01N2001/245 , Y10T436/25375 , Y10T436/255 , Y10T436/25875
摘要： An apparatus and method for the collection of respirable particles and concentration of such particles into a small fluid volume. The apparatus captures and concentrates small (1-10 &mgr;m) respirable particles into a sub-millileter volume of fluid. The method involves a two step operation, collection and concentration: wherein collection of particles is by a wetted surface having small vertical slits that act as capillary channels; and concentration is carried out by transfer of the collected particles to a small volume (sub-milliliter) container by centrifugal force whereby the particles are forced through the vertical slits and contact a non-wetted wall surface, and are deflected to the bottom where they are contained for analysis, such as a portable flow cytometer or a portable PCR DNA analysis system.
摘要翻译：用于收集可吸入颗粒并将这种颗粒浓缩成小流体体积的装置和方法。该装置将小（1-10毫升）可吸入颗粒捕获并浓缩成亚磨碎体积的流体。该方法包括两步操作，收集和浓缩：其中颗粒的收集通过具有作为毛细管通道的小垂直狭缝的润湿表面; 并且通过离心力将收集的颗粒转移到小体积（亚浓度）的容器中进行浓缩，由此颗粒被迫通过垂直狭缝并接触未润湿的壁表面，并且偏转到底部，在那里它们被包含用于分析，例如便携式流式细胞仪或便携式PCR DNA分析系统。

3. 发明授权

US06681496B2 Method of active fiber alignment with movable V-groove precision control microstructures 有权
标题翻译：有源光纤对准可移动V型槽精密控制微结构的方法
公开(公告)号：US06681496B2
公开(公告)日：2004-01-27
申请号：US10154596
申请日：2002-05-24
申请人： Benjamin P. Law , Andrew J. Schmit , Jonathan N. Simon , Kirk S. Giboney
发明人： Benjamin P. Law , Andrew J. Schmit , Jonathan N. Simon , Kirk S. Giboney
IPC分类号： G01B525
CPC分类号： G02B6/3656 , G01M11/088 , G02B6/3692 , G02B6/4226 , G02B6/4234
摘要： A method is disclosed by which precision alignment of optical fiber to wave-guide or other optical elements can be carried out with an adjustable microstructure in active alignment mode fiber attachment. A microstructure containing three elongated U-grooves can be combined effectively to produce a movable and adjustable V-groove structure, which can be used to achieve sub-micron scale alignment control with zero rotational torque. This device not only makes fiber alignment easy and fast but also maintains the fiber attachment position after alignment and epoxy bonding. Multiple fiber array alignment can be carried out with only a global alignment of two end fibers.
摘要翻译：公开了一种方法，通过该方法可以通过主动对准模式光纤附着中的可调微结构来执行光纤到波导或其它光学元件的精确对准。包含三个细长U形槽的微结构可以有效地组合以产生可移动和可调节的V形槽结构，其可用于实现零转矩的亚微米级对准控制。该装置不仅使光纤对准容易和快速，而且在对准和环氧树脂粘合之后保持纤维附着位置。多光纤阵列对准可仅通过两端光纤的全局对准来实现。

4. 发明授权

US06754417B2 Optical fiber tap capable of random placement along an optical fiber 有权
标题翻译：能沿光纤随机放置的光纤丝锥
公开(公告)号：US06754417B2
公开(公告)日：2004-06-22
申请号：US10133818
申请日：2002-04-24
申请人： Ken A. Nishimura , Ian Hardcastle , Jonathan N. Simon , Gary B. Gordon
发明人： Ken A. Nishimura , Ian Hardcastle , Jonathan N. Simon , Gary B. Gordon
IPC分类号： G02B626
CPC分类号： G02B6/2852 , G02B6/2821 , G02B6/3636
摘要： The optical fiber tap establishes optical communication between a branch optical fiber and a main optical fiber and includes a housing, a serpentine main channel and a branch channel. The main channel is defined in the housing and is shaped to accommodate part of the main optical fiber. The main channel includes a coupling curve portion shaped to define a main coupling curve in the main optical fiber. The branch channel is also defined in the housing and is shaped to accommodate part of the branch optical fiber. The branch channel communicates with the main channel at the coupling curve portion of the main channel. Optical signals couple laterally between the main optical fiber located in the main channel and the branch optical fiber located in the branch channel. Optical communication between the optical fibers is therefore established.
摘要翻译：光纤抽头建立分支光纤与主光纤之间的光通信，并且包括壳体，蛇形主通道和分支通道。主通道限定在壳体中，并且被成形为容纳主光纤的一部分。主通道包括成形为在主光纤中限定主耦合曲线的耦合曲线部分。分支通道也被限定在壳体中并且被成形为适应分支光纤的一部分。分支通道在主通道的耦合曲线部分处与主通道连通。光信号在位于主信道的主光纤与位于分支信道中的分支光纤之间横向耦合。因此建立光纤之间的光通信。

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