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1. 发明授权

US06520034B1 High air volume to low liquid volume aerosol collector 失效
标题翻译：高空气体积到低液体体积的气溶胶收集器
公开(公告)号：US06520034B1
公开(公告)日：2003-02-18
申请号：US10116375
申请日：2002-04-03
申请人： Donald A. Masquelier , Fred P. Milanovich , Klaus Willeke
发明人： Donald A. Masquelier , Fred P. Milanovich , Klaus Willeke
IPC分类号： G01N140
CPC分类号： G01N1/2273 , G01N1/2202 , G01N1/24 , G01N1/40 , G01N2001/1018 , G01N2001/2223 , G01N2001/2276 , G01N2015/0088
摘要： A high air volume to low liquid volume aerosol collector. A high volume flow of aerosol particles is drawn into an annular, centripetal slot in a collector which directs the aerosol flow into a small volume of liquid pool contained is a lower center section of the collector. The annular jet of air impinges into the liquid, imbedding initially airborne particles in the liquid. The liquid in the pool continuously circulates in the lower section of the collector by moving to the center line, then upwardly, and through assistance by a rotating deflector plate passes back into the liquid at the outer area adjacent the impinging air jet which passes upwardly through the liquid pool and through a hollow center of the collector, and is discharged via a side outlet opening. Any liquid droplets escaping with the effluent air are captured by a rotating mist eliminator and moved back toward the liquid pool. The collector includes a sensor assembly for determining, controlling, and maintaining the level of the liquid pool, and includes a lower centrally located valve assembly connected to a liquid reservoir and to an analyzer for analyzing the particles which are impinged into the liquid pool.
摘要翻译：高空气体积到低液体体积的气溶胶收集器。气溶胶颗粒的大体积流动被吸入收集器中的环形向心槽中，其将气溶胶流引导到容纳的小容积的液体池中，该容器是收集器的下部中心部分。环形空气射流冲击液体，最初嵌入液体中的空气中的颗粒。池中的液体通过移动到中心线，然后向上而在收集器的下部部分中连续地循环，并且通过旋转偏转板的辅助在靠近冲击空气射流的外部区域返回到液体中，该冲击空气射流向上通过液池并通过收集器的中空中心，并通过侧出口开口排出。用流出的空气排出的任何液滴都被旋转除雾器捕获并向液体池移回。收集器包括用于确定，控制和维持液池的液位的传感器组件，并且包括连接到液体储存器的下部中心定位的阀组件和用于分析撞击到液体池中的颗粒的分析器。

2. 发明授权

US06905885B2 Portable pathogen detection system 失效
标题翻译：便携式病原体检测系统
公开(公告)号：US06905885B2
公开(公告)日：2005-06-14
申请号：US09880515
申请日：2001-06-12
申请人： Billy W. Colston , Matthew Everett , Fred P. Milanovich , Steve B. Brown , Kodumudi Vendateswaran , Jonathan N. Simon
发明人： Billy W. Colston , Matthew Everett , Fred P. Milanovich , Steve B. Brown , Kodumudi Vendateswaran , Jonathan N. Simon
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/54313
摘要： A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.
摘要翻译：便携式病原体检测系统，实现了生物样品中靶标的现场多重检测。该系统包括：微珠特异性试剂，孵育/混合室，一次性微珠捕获底物和光学测量和解码装置。该系统的基础是高度灵活的液体阵列，其利用光学编码的微珠作为生物测定的模板。目标生物样品被光学标记并捕获在微珠上，微珠又依次在有序阵列或无序阵列一次性捕获基底上捕获，然后光学读取。

3. 发明授权

US4771006A Optrode for sensing hydrocarbons 失效
标题翻译：用于感测碳氢化合物的反应
公开(公告)号：US4771006A
公开(公告)日：1988-09-13
申请号：US14703
申请日：1987-02-13
申请人： Holly Miller , Fred P. Milanovich , Tomas B. Hirschfeld , Fred S. Miller
发明人： Holly Miller , Fred P. Milanovich , Tomas B. Hirschfeld , Fred S. Miller
IPC分类号： G01N21/64
CPC分类号： G01N21/643 , G01N2021/6434 , G01N2021/772 , G01N2021/7786 , Y10T436/196666
摘要： A two-phase system employing the Fujiwara reaction is provided for the fluorometric detection of halogenated hydrocarbons. A fiber optic is utilized to illuminate a column of pyridine trapped in a capillary tube coaxially attached at one end to the illuminating end of the fiber optic. A strongly alkaline condition necessary for the reaction is maintained by providing a reservoir of alkali in contact with the column of pyridine, the surface of contact being adjacent to the illuminating end of the fiber optic. A semipermeable membrane caps the other end of the capillary tube, the membrane being preferentially permeable to the halogenated hydrocarbon and but preferentially impermeable to water and pyridine. As the halogenated hydrocarbon diffuses through the membrane and into the column of pyridine, fluorescent reaction products are formed. Light propagated by the fiber optic from a light source, excites the fluorescent products. Light from the fluorescence emission is also collected by the same fiber optic and transmitted to a detector. The intensity of the fluorescence gives a measure of the concentration of the halogenated hydrocarbons.
摘要翻译：提供了使用藤原反应的两相体系用于卤代烃的荧光检测。光纤被用于照亮被捕获在毛细管中的吡啶柱，所述毛细管同轴地连接到光纤的照明端。通过提供与吡啶列接触的碱性储存器来保持反应所需的强碱性条件，接触表面与光纤的照明端相邻。半透膜覆盖毛细管的另一端，膜优先对卤代烃是可渗透的，但优先对水和吡啶不渗透。当卤代烃扩散通过膜并进入吡啶柱时，形成荧光反应产物。由光纤从光源传播的光激发荧光产品。来自荧光发射的光也被相同的光纤收集并传输到检测器。荧光强度可测量卤代烃的浓度。

4. 发明授权

US09052255B2 System for autonomous monitoring of bioagents 有权
标题翻译：生物制剂自主监测系统
公开(公告)号：US09052255B2
公开(公告)日：2015-06-09
申请号：US12786248
申请日：2010-05-24
申请人： Richard G. Langlois , Fred P. Milanovich , Billy W. Colston, Jr. , Steve B. Brown , Don A. Masquelier , Raymond P. Mariella, Jr. , Kodomudi Venkateswaran
发明人： Richard G. Langlois , Fred P. Milanovich , Billy W. Colston, Jr. , Steve B. Brown , Don A. Masquelier , Raymond P. Mariella, Jr. , Kodomudi Venkateswaran
IPC分类号： G01N33/543 , G01N30/96 , G01N33/00 , G01N1/22 , G01N35/08 , G01N15/14
CPC分类号： G01N1/2202 , G01N1/2211 , G01N15/1459 , G01N35/08 , G01N2001/2217 , G06F19/00 , Y02A90/26
摘要： An autonomous monitoring system for monitoring for bioagents. A collector gathers the air, water, soil, or substance being monitored. A sample preparation means for preparing a sample is operatively connected to the collector. A detector for detecting the bioagents in the sample is operatively connected to the sample preparation means. One embodiment of the present invention includes confirmation means for confirming the bioagents in the sample.
摘要翻译：一个用于监测生物标签的自主监测系统。收集者收集被监测的空气，水，土壤或物质。用于制备样品的样品制备装置可操作地连接到收集器。用于检测样品中的生物试剂的检测器可操作地连接到样品制备装置。本发明的一个实施方案包括用于确认样品中的生物试剂的确认装置。

5. 发明授权

US5122224A Direct flow crystal growth system 失效
标题翻译：直流晶体生长系统
公开(公告)号：US5122224A
公开(公告)日：1992-06-16
申请号：US428538
申请日：1989-10-30
申请人： Kenneth E. Montgomery , Fred P. Milanovich
发明人： Kenneth E. Montgomery , Fred P. Milanovich
IPC分类号： C30B7/00
CPC分类号： C30B7/00 , C30B29/14 , Y10S117/90 , Y10T117/1024 , Y10T117/1096
摘要： A crystal is grown in a constantly filtered solution which is flowed directly into the growing face of a crystal. In a continuous flow system, solution at its saturation temperature is removed from a crystal growth tank, heated above its saturation temperature, filtered, cooled back to its saturation temperature, and returned to the tank.
摘要翻译：将晶体生长在不断过滤的溶液中，该溶液直接流入晶体的生长面。在连续流动系统中，将其饱和温度的溶液从晶体生长槽中除去，在其饱和温度以上加热，过滤，冷却至饱和温度，并返回到罐中。

6. 发明授权

US4913519A Optical sensor for the detection of ice formation and other chemical species 失效
标题翻译：用于检测冰层和其他化学物质的光学传感器
公开(公告)号：US4913519A
公开(公告)日：1990-04-03
申请号：US164172
申请日：1988-03-04
申请人： Stanley M. Klainer , Fred P. Milanovich
发明人： Stanley M. Klainer , Fred P. Milanovich
IPC分类号： G01N21/41 , C03C13/00 , G01N21/43 , G02B6/02
CPC分类号： G01N21/431 , C03C13/008 , G02B6/02
摘要： An ice sensor for the remote rapid indication of ice formation or the presence of ice is a fiber optic "switch", activated by ice but not by water, and based on the difference in optical properties between water and ice. The approach is to construct a "fiber optic" which itself is the ice sensor. The fiber optic sensor (FOS) is designed so that no light is transmitted when water is present but as soon as ice begins to form, light is relayed. Thus ice switches on the light- In addition, limited quantitative information can be made available on the rate of ice formation. Alternatively the sensor can be formed of another type optical waveguide instead of an optical fiber. The ice sensor is formed by placing spaced stripes of a clad material on a fiber optic core, or other waveguide structure, where the clad has a refractive index close to ice and the core has an index greater than the clad but less than water. It is best to index match the core to the clad for optimal transmission when ice forms in the gaps between the clad stripes. The advantages of the ice sensor include: specific, sensitive, real-time response, small, light weight, inexpensive, requires no line-of-sight, EMI immune, rugged and flexible. The instrumentation needed to operate the ice FOS is simple, small, light weight, inexpensive, easy to operate, battery powered - optional, rugged, reliable and amenable to telemetry of information.
摘要翻译：用于远程快速指示冰层或存在冰的冰传感器是由冰而不是水激活的光纤“开关”，并且基于水和冰之间的光学性质的差异。该方法是构造一个本身是冰传感器的“光纤”。光纤传感器（FOS）被设计成当存在水时不发射光，但一旦冰开始形成，光被中继。因此，在冰上开启冰。此外，可以根据冰的形成速率提供有限的定量信息。或者，传感器可以由另一种类型的光波导代替光纤形成。冰传感器通过将包覆材料的间隔条纹放置在光纤芯或其它波导结构上而形成，其中包层的折射率接近于冰，并且芯的折射率大于包层但小于水。当包层条纹之间的间隙中形成冰时，最好将核心与包层匹配，以获得最佳传播。冰传感器的优点包括：具体，灵敏，实时响应小，重量轻，价格便宜，无需视距，EMI免疫，坚固耐用，灵活。操作冰FOS所需的仪器简单，体积小，重量轻，价格低廉，易于操作，电池供电 - 可选，坚固耐用，可靠，易于遥测信息。

7. 发明授权

US4666672A Optrode for sensing hydrocarbons 失效
公开(公告)号：US4666672A
公开(公告)日：1987-05-19
申请号：US721150
申请日：1985-04-08
申请人： Holly Miller , Fred P. Milanovich , Tomas B. Hirschfeld , Fred S. Miller
发明人： Holly Miller , Fred P. Milanovich , Tomas B. Hirschfeld , Fred S. Miller
IPC分类号： G01N21/64
CPC分类号： G01N21/643 , G01N2021/6434 , G01N2021/772 , G01N2021/7786 , Y10T436/196666 , Y10T436/255
摘要： A two-phase system employing the Fujiwara reaction is provided for the fluorometric detection of halogenated hydrocarbons. A fiber optic is utilized to illuminate a column of pyridine trapped in a capillary tube coaxially attached at one end to the illuminating end of the fiber optic. A strongly alkaline condition necessary for the reaction is maintained by providing a reservoir of alkali in contact with the column of pyridine, the surface of contact being adjacent to the illuminating end of the fiber optic. A semipermeable membrane caps the other end of the capillary tube, the membrane being preferentially permeable to the halogenated hydrocarbon and but preferentially impermeable to water and pyridine. As the halogenated hydrocarbon diffuses through the membrane and into the column of pyridine, fluorescent reaction products are formed. Light propagated by the fiber optic from a light source, excites the fluorescent products. Light from the fluorescence emission is also collected by the same fiber optic and transmitted to a detector. The intensity of the fluorescence gives a measure of the concentration of the halogenated hydrocarbons.

8. 发明授权

US07993266B2 Early detection of contagious diseases 有权
标题翻译：早期发现传染病
公开(公告)号：US07993266B2
公开(公告)日：2011-08-09
申请号：US10375273
申请日：2003-02-26
申请人： Billy W. Colston, Jr. , Fred P. Milanovich , Pedro Estacio , John Chang
发明人： Billy W. Colston, Jr. , Fred P. Milanovich , Pedro Estacio , John Chang
IPC分类号： A61B5/00
CPC分类号： A61B5/002 , G06F19/00 , G06F19/3418 , G16H50/80 , Y10S128/903 , Y10S128/92
摘要： This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.
摘要翻译：本发明提供了使用这种用于警告暴露于传染性疾病的个体的装置的电子邻近装置和监视方法。当一个人变得有症状并且被诊断为对于特定传染性代理人是积极的，最近维持与感染个体的阈值接近度的个人被通知并被建议立即寻求医疗照顾。在感染的早期阶段（症状前）的个体治疗显着降低了首先暴露于传染性疾病的受感染人群的传染性，从而防止了疾病在整个普通人群中的传播。

9. 发明授权

US06586233B2 Convectively driven PCR thermal-cycling 失效
公开(公告)号：US06586233B2
公开(公告)日：2003-07-01
申请号：US09802549
申请日：2001-03-09
申请人： William J. Benett , James B. Richards , Fred P. Milanovich
发明人： William J. Benett , James B. Richards , Fred P. Milanovich
IPC分类号： C12M136
CPC分类号： B01L7/52 , B01L2400/0445
摘要： A polymerase chain reaction system provides an upper temperature zone and a lower temperature zone in a fluid sample. Channels set up convection cells in the fluid sample and move the fluid sample repeatedly through the upper and lower temperature zone creating thermal cycling.

10. 发明申请

US20110027781A1 System for Autonomous Monitoring of Bioagents 有权
标题翻译：生物制剂自主监测系统
公开(公告)号：US20110027781A1
公开(公告)日：2011-02-03
申请号：US12786248
申请日：2010-05-24
申请人： Richard G. Langlois , Fred P. Milanovich , Billy W. Colston, JR. , Steve B. Brown , Don A. Masquelier , Ray P. Mariella , Kodomudi Venkateswaran
发明人： Richard G. Langlois , Fred P. Milanovich , Billy W. Colston, JR. , Steve B. Brown , Don A. Masquelier , Ray P. Mariella , Kodomudi Venkateswaran
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N1/2202 , G01N1/2211 , G01N15/1459 , G01N35/08 , G01N2001/2217 , G06F19/00 , Y02A90/26
摘要： An autonomous monitoring system for monitoring for bioagents. A collector gathers the air, water, soil, or substance being monitored. A sample preparation means for preparing a sample is operatively connected to the collector. A detector for detecting the bioagents in the sample is operatively connected to the sample preparation means. One embodiment of the present invention includes confirmation means for confirming the bioagents in the sample.
摘要翻译：一个用于监测生物标签的自主监测系统。收集者收集被监测的空气，水，土壤或物质。用于制备样品的样品制备装置可操作地连接到收集器。用于检测样品中的生物试剂的检测器可操作地连接到样品制备装置。本发明的一个实施方案包括用于确认样品中的生物试剂的确认装置。

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