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1. 发明申请

US20070122832A1 Process for Preparing L-amino Acids 审中-公开
标题翻译： L-氨基酸的制备方法
公开(公告)号：US20070122832A1
公开(公告)日：2007-05-31
申请号：US11615860
申请日：2006-12-22
申请人： Bettina Mockel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
发明人： Bettina Mockel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
IPC分类号： C12Q1/68 , C07H21/04 , C12P13/08 , C12N9/10 , C12N15/74 , C12N1/21
CPC分类号： C12N9/1205 , C07K14/34 , C12N9/10 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： The invention relates to isolated polynucleotides comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the citA gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）多核苷酸，其与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同至少70％ b）编码多肽的多核苷酸，其包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列，c）与a）的多核苷酸互补的多核苷酸，或b），和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少有citA基因以减毒形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。

2. 发明申请

US20050266534A1 Nucleotide sequences which code for the cstA gene 审中-公开
标题翻译：编码cstA基因的核苷酸序列
公开(公告)号：US20050266534A1
公开(公告)日：2005-12-01
申请号：US11147238
申请日：2005-06-08
申请人： Bettina Mockel , Achim Marx , Walter Pfefferle , Mike Farwick , Thomas Hermann
发明人： Bettina Mockel , Achim Marx , Walter Pfefferle , Mike Farwick , Thomas Hermann
IPC分类号： C07K14/34 , C12N1/21 , C12N15/12 , C12N15/31 , C12P13/08 , C07H21/04 , C12N9/10 , C12N15/74 , C12P13/04
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the cstA gene, and a host-vector system having a coryneform host bacterium in which the cstA gene is present in attenuated form and a vector which carries at least the cstA gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码cstA基因的多核苷酸序列的分离的多核苷酸，以及具有cstA基因以减毒形式存在的棒状细胞宿主细菌的宿主载体系和至少携带cstA基因的载体至SEQ ID No 1，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

3. 发明授权

US07205144B2 Nucleotide sequences encoding a sensor kinase, citA, from Corynebacterium glutamicum 有权
标题翻译：编码来自谷氨酸棒杆菌的传感器激酶citA的核苷酸序列
公开(公告)号：US07205144B2
公开(公告)日：2007-04-17
申请号：US10977474
申请日：2004-11-01
申请人： Bettina Mockel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
发明人： Bettina Mockel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
IPC分类号： C12N15/00 , C12N1/20 , C12N5/00 , C07H21/02 , C07H21/04 , C12N9/12 , C12P21/06 , C12Q1/48 , C07K1/00
CPC分类号： C12N9/1205 , C07K14/34 , C12N9/10 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： The invention related to an isolated nucleic acid consisting of a fragment of the polynucleotide of Corynebacterium glutamicum citA gene or a fragment of the full complement of the polynucleotide of the C. glutamicum citA gene wherein said fragment is at least 30 consecutive nucleotide in length, and the vector and host cell harboring these nucleic acids.
摘要翻译：本发明涉及由谷氨酸棒杆菌citA基因的多核苷酸的片段或谷氨酸棒杆菌citA基因的多核苷酸的全补体的片段组成的分离的核酸，其中所述片段长度为至少30个连续的核苷酸，以及携带这些核酸的载体和宿主细胞。

4. 发明申请

US20050112664A1 Nucleotide sequences coding for the citA gene 有权
标题翻译：编码citA基因的核苷酸序列
公开(公告)号：US20050112664A1
公开(公告)日：2005-05-26
申请号：US10977474
申请日：2004-11-01
申请人： Bettina Mockel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
发明人： Bettina Mockel , Mike Farwick , Thomas Hermann , Achim Marx , Walter Pfefferle
IPC分类号： A61K38/48 , C07K14/34 , C12N9/12 , C12P13/08 , C12Q1/68 , C07H21/04 , C12N1/21 , C12N9/10 , C12N15/74
CPC分类号： C12N9/1205 , C07K14/34 , C12N9/10 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： The invention relates to isolated polynucleotides comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which. comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the citA gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）多核苷酸，其与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同至少70％，b）编码多肽的多核苷酸。包括与SEQ ID No.2的氨基酸序列至少70％的程度相同的氨基酸序列，c）与a）或b）的多核苷酸互补的多核苷酸，和d）包含在 a），b）或c）的多核苷酸序列的至少15个连续核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少citA基因以减毒形式存在，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

5. 发明申请

US20050221450A1 Methods of making L-amino acids in coryneform bacteria using the sigE gene 审中-公开
标题翻译：使用sigE基因在棒状细菌中制备L-氨基酸的方法
公开(公告)号：US20050221450A1
公开(公告)日：2005-10-06
申请号：US11137504
申请日：2005-05-26
申请人： Bettina Mockel , Thoams Hermann , Mike Farwick , Michael Binder , Walter Pfefferle
发明人： Bettina Mockel , Thoams Hermann , Mike Farwick , Michael Binder , Walter Pfefferle
IPC分类号： C07K14/34 , C12P13/08 , C12P13/04 , C07H21/04 , C12N9/10 , C12N9/12 , C12N15/74
CPC分类号： C12R1/15 , C07K14/34 , C12P13/08
摘要： The present invention relates to an isolated polynucleotide from Corynebacterium glutamicum comprising a polynucleotide sequence chosen from the group consisting of (a) a polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO: 2; (b) a polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO: 2; (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b); and (d) a polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the sigE gene is present in enhanced form, and the use of polynucleotides which comprise the sequence according to the invention as hybridization probes.
摘要翻译：本发明涉及来自谷氨酸棒杆菌的分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自（a）与编码包含氨基酸的多肽的多核苷酸的至少70％的程度相同的多核苷酸 SEQ ID NO：2的序列; （b）编码多肽的多核苷酸，其包含与SEQ ID NO：2的氨基酸序列至少70％的程度相同的氨基酸序列; （c）与（a）或（b）的多核苷酸互补的多核苷酸; 和（d）包含（a），（b）或（c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少 sigE基因以增强形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。

6. 发明授权

US06818432B2 Nucleotide sequences encoding the ptsH gene 有权
标题翻译：编码ptsH基因的核苷酸序列
公开(公告)号：US06818432B2
公开(公告)日：2004-11-16
申请号：US09819930
申请日：2001-03-29
申请人： Mike Farwick , Bettina Mockel , Walter Pfefferle
发明人： Mike Farwick , Bettina Mockel , Walter Pfefferle
IPC分类号： C12N120
CPC分类号： C12N9/1205 , C12P13/04 , C12P13/08
摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising a) polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide containing the amino acid sequence of SEQ ID no. 2, b) polynucleotide which codes for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID no.2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative production of L-amino acids with enhancement of the ptsH gene coding for component H of the phosphotransferase system, and the use of the above polynucleotides as primer or hybridisation probe.
摘要翻译：本发明涉及含有多核苷酸序列的分离的多核苷酸，所述多核苷酸序列选自包含a）多核苷酸的多核苷酸，所述多核苷酸与编码含有SEQ ID NO：1的氨基酸序列的多肽的多核苷酸具有至少70％的同一性。 2，b）编码含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽的多核苷酸，c）与a）或b）的多核苷酸互补的多核苷酸，和d）多核苷酸，其包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸，以及用于增强编码磷酸转移酶系统的组分H的ptsH基因的L-氨基酸的发酵生产的方法，以及使用上述多核苷酸作为引物或杂交探针。

7. 发明申请

US20050009143A1 Nucleotide sequences encoding the ptsH gene 有权
标题翻译：编码ptsH基因的核苷酸序列
公开(公告)号：US20050009143A1
公开(公告)日：2005-01-13
申请号：US10916437
申请日：2004-08-12
申请人： Mike Farwick , Bettina Mockel , Walter Pfefferle
发明人： Mike Farwick , Bettina Mockel , Walter Pfefferle
IPC分类号： C12N1/21 , C12N9/12 , C12P13/04 , C12P13/08 , C07H21/04 , C12N1/20 , C12N9/10
CPC分类号： C12N9/1205 , C12P13/04 , C12P13/08
摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising a) polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide containing the amino acid sequence of SEQ ID no. 2, b) polynucleotide which codes for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID no.2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative production of L-amino acids with enhancement of the ptsH gene coding for component H of the phosphotransferase system, and the use of the above polynucleotides as primer or hybridisation probe.
摘要翻译：本发明涉及含有多核苷酸序列的分离的多核苷酸序列，所述多核苷酸序列选自以下组：a）多核苷酸，其与编码含有SEQ ID NO：1的氨基酸序列的多肽的多核苷酸具有至少70％的相同性。 2，b）编码含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽的多核苷酸，c）与a）或b）的多核苷酸互补的多核苷酸，和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及用于增加编码磷酸转移酶系统的组分H的ptsH基因的L-氨基酸的发酵生产的方法，以及使用上述多核苷酸作为引物或杂交探针。

8. 发明授权

US06355454B1 Process for the fermentative production of L-amino acids using coryneform bacteria 有权
标题翻译：使用棒状细菌发酵生产L-氨基酸的方法
公开(公告)号：US06355454B1
公开(公告)日：2002-03-12
申请号：US09324940
申请日：1999-06-03
申请人： Achim Marx , Bettina Mockel , Walter Pfefferle , Hermann Sahm , Albert De Graaf , Lothar Eggeling
发明人： Achim Marx , Bettina Mockel , Walter Pfefferle , Hermann Sahm , Albert De Graaf , Lothar Eggeling
IPC分类号： C12P1304
CPC分类号： C12Y104/01002 , C12N9/0016 , C12P13/06 , C12P13/08 , C12P13/227 , C12P13/24
摘要： This invention relates to a process for the production of L-amino acids using coryneform bacteria, in which the glutamate dehydrogenase gene is amplified.
摘要翻译：本发明涉及使用棒状细菌生产L-氨基酸的方法，其中谷氨酸脱氢酶基因被扩增。

9. 发明申请

US20060205046A1 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE ZWA1 GENE 失效
标题翻译：编号为ZWA1基因的核苷酸序列
公开(公告)号：US20060205046A1
公开(公告)日：2006-09-14
申请号：US11419529
申请日：2006-05-22
申请人： Bettina Mockel , Walter Pfefferle , Achim Marx , Jorn Kalinowski , Brigitte Bathe , Alfred Puhler
发明人： Bettina Mockel , Walter Pfefferle , Achim Marx , Jorn Kalinowski , Brigitte Bathe , Alfred Puhler
IPC分类号： C12P13/08 , C12N15/74 , C12N1/21
CPC分类号： C07K14/34 , C12N9/00 , C12P13/08
摘要： Disclosed herein is an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO:2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO:2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.
摘要翻译：本文公开了一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID NO：2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸 b）编码多肽的多核苷酸，其包含与SEQ ID NO：2的氨基酸序列至少70％相同程度的氨基酸序列c）与a）和 b）和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及在所用棒状细菌中扩增zwa1基因的L-氨基酸的发酵制剂的方法。

10. 发明授权

US06759218B2 Nucleotide sequences coding for the glbO gene 有权
标题翻译：编码glbO基因的核苷酸序列
公开(公告)号：US06759218B2
公开(公告)日：2004-07-06
申请号：US10139520
申请日：2002-05-07
申请人： Bettina Mockel , Achim Marx , Walter Pfefferle
发明人： Bettina Mockel , Achim Marx , Walter Pfefferle
IPC分类号： C12P1304
CPC分类号： C12P13/04 , C07K14/34 , C07K14/805 , C12P13/08
摘要： The present invention provides an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide which is at least 70% identical to a polynucleotide which codes for a polypeptide containing the amino acid sequence of SEQ ID no. 2, b) polynucleotide which codes for a polypeptide which contains an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID no. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative production of L-amino acids with enhancement of the glbO gene which codes for the haemoglobin-like protein and the use of the above polynucleotides as a primer or hybridization probe.
摘要翻译：本发明提供了一种分离的多核苷酸，其含有多核苷酸序列，所述多核苷酸序列选自与编码含有SEQ ID NO：1的氨基酸序列的多肽的多核苷酸至少70％同一的组a）多核苷酸。 2，b）编码多肽的多核苷酸，其含有与SEQ ID No：1的氨基酸序列至少70％相同的氨基酸序列。 2）c）与a）或b）的多核苷酸互补的多核苷酸，和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及发酵产生L 氨基酸，其增强编码血红蛋白样蛋白质的glbO基因，以及使用上述多核苷酸作为引物或杂交探针。

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