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1. 发明授权

US06656678B1 Method for examination of a surface layer 失效
标题翻译：表层检查方法
公开(公告)号：US06656678B1
公开(公告)日：2003-12-02
申请号：US09585146
申请日：2000-06-01
申请人： Bernhard Wolf , Hans-Jürgen Gahle , Günter Igel , Werner Baumann , Ralf Ehret , Mirko Lehmann
发明人： Bernhard Wolf , Hans-Jürgen Gahle , Günter Igel , Werner Baumann , Ralf Ehret , Mirko Lehmann
IPC分类号： C12Q100
CPC分类号： H01L22/24 , G01B11/30 , G01N21/94
摘要： In a method for examination of the surface of an object for a topographic and/or a chemical property, the object-surface is impinged with surface-structure selective biocomponents for examination of a topographic property and/or with chemoselective biocomponents for the examination of a chemical property, together with a nutrient medium and/or an osmotic protective medium for the biocomponents. The biocomponents contained in the nutrient medium and/or the osmotic protective medium are in contact with the object-surface or are spaced from the object surface by less than the detection range of the biocomponents. The object surface is then examined with the biocomponents contained in the nutrient medium and/or the osmotic protective medium by determining at least one examination measurement value. The examination measurement value is compared with a reference measurement value, and conclusions can be drawn about the topographic and/or chemical properties of the object from the result of the comparison. Using the method, an object surface can be examined for a topographic and/or chemical property in a simple manner with a high measuring sensitivity.
摘要翻译：在用于检查地形和/或化学性质的物体的表面的方法中，物体表面与表面结构选择性生物组分碰撞以检查地形性质和/或化学选择性生物成分用于检查化学性质，以及生物组分的营养培养基和/或渗透保护介质。包含在营养培养基和/或渗透保护介质中的生物成分与物体表面接触或与物体表面间隔小于生物成分的检测范围。然后通过确定至少一个检查测量值用包含在营养培养基和/或渗透保护介质中的生物组分检查物体表面。将检查测量值与参考测量值进行比较，并从比较结果中得出关于物体的地形和/或化学性质的结论。使用该方法，可以以高测量灵敏度的简单方式检查物体表面的地形和/或化学特性。

2. 发明授权

US06368851B1 Method and apparatus for measuring a state variable 有权
标题翻译：用于测量状态变量的方法和装置
公开(公告)号：US06368851B1
公开(公告)日：2002-04-09
申请号：US09321458
申请日：1999-05-27
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12M142
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.
摘要翻译：提供了一种用于测量位于营养介质（2）中并被支撑并附着到支撑区域（5）上的生物体（3）的状态变量的方法。在电池（3）的支撑区域（5）内并且距离支撑区域边缘一定距离处，在电池（3）的膜中形成开口。围绕开口并附着到支撑区域（5）的细胞膜的边缘将从细胞（3）内发现的液体与营养培养基（2）密封。通过打开状态变量（2）进行测量。还提供了一种用于执行该方法的装置。

3. 发明授权

US06288440B1 Chip arrangement 失效
标题翻译：芯片布置
公开(公告)号：US06288440B1
公开(公告)日：2001-09-11
申请号：US09342697
申请日：1999-06-29
申请人： Ulrich Sieben , Günter Igel , Mirko Lehmann , Hans-Jürgen Gahle , Bernhard Wolf , Werner Baumann , Ralf Ehret
发明人： Ulrich Sieben , Günter Igel , Mirko Lehmann , Hans-Jürgen Gahle , Bernhard Wolf , Werner Baumann , Ralf Ehret
IPC分类号： H01L23495
CPC分类号： H01L23/5385 , A61B5/14532 , A61B5/1473 , G01N33/48707 , H01L2924/0002 , H01L2924/00
摘要： A chip arrangement (1) has a substrate board (2) with an opening (3), into which a carrier chip (4) is inserted, which has an electrical or electronic structural component (5). At least one conductor path (7) is integrated into the carrier chip (4), which connects the structural component (5) to the electrical connection contact (8). The carrier chip (4) is inserted into the opening (3) in such a way that its ends project beyond the opposite-facing, flat-sided surfaces (9, 9′) of the substrate board (2), and thereby form overhangs (10, 10′). Here, the structural component is arranged on the overhang (10) projecting beyond the one surface (9), and the connection contact (8) is arranged on the overhang (10′) projecting beyond the other surface (9′), and the conductor path (7) connecting the structural component (5) and the connection contact (8) passes through the opening (3). A seal is arranged between the substrate board (2) and the carrier chip (4).
摘要翻译：芯片装置（1）具有带有开口（3）的基板（2），其中插入有载体芯片（4），其具有电或电子结构部件（5）。至少一个导体路径（7）集成到载体芯片（4）中，其将结构部件（5）连接到电连接触点（8）。载体芯片（4）以这样的方式插入到开口（3）中，使得其端部突出超过衬底板（2）的相对面对的平坦表面（9,9'），从而形成突出部（10,10'）。这里，结构部件布置在突出超过一个表面（9）的伸出部（10）上，并且连接触点（8）布置在突出超过另一个表面（9'）的伸出部（10'）上，并且连接结构部件（5）和连接触点（8）的导体路径（7）穿过开口（3）。在基板（2）和载体芯片（4）之间设置密封件。

4. 发明授权

US06475760B1 Method for intracellular manipulation of a biological cell 有权
标题翻译：细胞内操作生物细胞的方法
公开(公告)号：US06475760B1
公开(公告)日：2002-11-05
申请号：US09321051
申请日：1999-05-27
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12N1300
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.
摘要翻译：提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封并使细胞液体抵抗培养物中等（2）。电池（3）的内部通过开口被操纵。还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。

5. 发明授权

US07501276B2 Apparatus for intracellular manipulation of a biological cell 失效
标题翻译：用于细胞内操作生物细胞的装置
公开(公告)号：US07501276B2
公开(公告)日：2009-03-10
申请号：US10202419
申请日：2002-07-23
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12M1/42 , C12N15/87
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.
摘要翻译：提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封在一起，并使细胞液体抵抗培养物中等（2）。电池（3）的内部通过开口被操纵。还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。

6. 发明授权

US06638743B2 Method for measuring a state variable 失效
公开(公告)号：US06638743B2
公开(公告)日：2003-10-28
申请号：US10119354
申请日：2002-04-09
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jörg Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jörg Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12N1300
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.

7. 发明授权

US06191489B1 Micromechanical layer stack arrangement particularly for flip chip or similar connections 有权
标题翻译：微机械层堆叠布置，特别适用于倒装芯片或类似连接
公开(公告)号：US06191489B1
公开(公告)日：2001-02-20
申请号：US09506634
申请日：2000-02-18
申请人： Günter Igel , Hans-Jürgen Gahle , Mirko Lehmann
发明人： Günter Igel , Hans-Jürgen Gahle , Mirko Lehmann
IPC分类号： H01L2348
CPC分类号： H01L24/12 , H01L23/3192 , H01L24/11 , H01L2224/13018 , H01L2224/13022 , H01L2224/13099 , H01L2224/13144 , H01L2224/13147 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01022 , H01L2924/01029 , H01L2924/01033 , H01L2924/01046 , H01L2924/01047 , H01L2924/01049 , H01L2924/01074 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/19043 , H01L2924/351 , H01L2924/00
摘要： A process is provided for manufacturing a layer arrangement (1) having a bump for a flip chip or similar connection. The layer arrangement has a plurality of layers (2, 3, 4, 5, 6, 7, 11) made of solid material and stacked into a layer stack (8). A recess (10) that extends over several layers (2, 3, 4, 5, 6, 7, 11) is made in the layer stack (8) transverse to the coating planes of the layers (2, 3, 4, 5, 6, 7, 11). A bump material (14) is placed in the recess (10). A profiling is created on the lateral boundary wall of the recess (10) by removal of layer material of different layers (2, 3, 4, 5, 6, 7, 11) of the layer stack (8). The profiling, starting from the surface (9) of the layer stack (8) and progressing in layers to the inside of the recess (10), has at least two indentations (12) and at least one projection (13) located between them. After the production of the profiling, a bump material (14) is brought into the recess (10) in such a way that it grasps behind the indentations (12).
摘要翻译：提供了一种用于制造具有用于倒装芯片或类似连接的凸块的层布置（1）的工艺。层布置具有由固体材料制成并堆叠成层堆叠（8）的多个层（2,3,4,5,6,7,11）。在层叠体（8）中横跨多层（2,3,4,5,6,7,11）的层（2,3,4,5,11）的涂层平面（2,3,4,5），6,7,11）。凸起材料（14）放置在凹部（10）中。通过去除层叠（8）的不同层（2,3,4,5,6,7,11）的层材料，在凹槽（10）的侧边界壁上形成轮廓。从层叠体（8）的表面（9）开始并且分层进入凹部（10）的内部的成型具有至少两个凹口（12）和位于它们之间的至少一个突起（13）。在生产轮廓之后，将凸块材料（14）以这样一种方式被带到凹槽（10）中，使得它抓住压痕（12）的后面。

8. 发明授权

US06471838B1 Measuring device and process for its manufacture 失效
标题翻译：测量装置及其制造工艺
公开(公告)号：US06471838B1
公开(公告)日：2002-10-29
申请号：US09506646
申请日：2000-02-18
申请人： Günter Igel , Hans-Jürgen Gahle , Mirko Lehmann
发明人： Günter Igel , Hans-Jürgen Gahle , Mirko Lehmann
IPC分类号： G01N27327
CPC分类号： G01N27/226 , G01N21/03 , G01N27/07
摘要： A measuring device (1), for examining a medium (2) that is liquid or free-flowing, has at least two electrically and/or optically conducting layers or layer areas (5a, 5b, 5c, 6a, 6b, 7a, 7b) located on a substrate layer (3), wherein these layers or layer areas are electrically and/or optically insulated from each other. At least one of these layers or layer areas (5a, 5b, 5c, 6a, 6b, 7a, 7b) is part of a layer stack (4), which has several layers arranged on top of each other on the substrate layer (3). The layer stack has, on its side facing away from the substrate layer (3), a recess that adjoins the electrically and/or optically conducting layers or layer areas (5a, 5b, 6a, 6b, 7a, 7b). At least one electrically and/or optically conducting layer or layer area (5a, 5b, 6a, 6b, 7a, 7b) located in the layer stack (4) is spaced at a distance from the bottom (11) of the recess (10).
摘要翻译：用于检查液体或自由流动的介质（2）的测量装置（1）具有至少两个电和/或光导电层或层区（5a，5b，5c，6a，6b，7a，7b）），其中这些层或层区域彼此电隔离和/或光学绝缘。这些层或层区域（5a，5b，5c，6a，6b，7a，7b）中的至少一个是层叠体（4）的一部分，其在基底层（3）上彼此顶部布置有多个层）。层叠体在其背离衬底层（3）的一侧具有邻接电和/或光传导层或层区（5a，5b，6a，6b，7a，7b）的凹部。位于层叠体（4）中的至少一个电和/或光传导层或层区（5a，5b，6a，6b，7a，7b）与凹部（10）的底部（11））。

9. 发明申请

US20060154379A1 Process for structuring a surface layer 审中-公开
标题翻译：用于构造表面层的方法
公开(公告)号：US20060154379A1
公开(公告)日：2006-07-13
申请号：US11371617
申请日：2006-03-09
申请人： Bernhard Wolf , Hans-Jurgen Gahle , Giinter Igel , Werner Baumann , Ralf Ehret , Mirko Lehmann
发明人： Bernhard Wolf , Hans-Jurgen Gahle , Giinter Igel , Werner Baumann , Ralf Ehret , Mirko Lehmann
IPC分类号： G01N33/543 , B05D3/02
CPC分类号： H01L22/24 , G01B11/30 , G01N21/94
摘要： A process for structuring a surface layer of an object includes applying bio-components to the surface of the object that carry away surface material. The bio-components are contained in at least one of a nutrient and osmotic protective medium. The at least one of a nutrient and osmotic protective medium having the bio-components contained therein is removed after the surface material is carried away from the object surface.
摘要翻译：用于构造物体的表面层的方法包括将生物组分应用于携带表面材料的物体表面。生物成分包含在营养和渗透保护介质中的至少一种中。在将表面材料从物体表面带走之后，除去其中含有生物成分的营养物和渗透保护介质中的至少一种。

10. 发明授权

US06346675B1 Coupling and method for its manufacture 失效
标题翻译：联轴器及其制造方法
公开(公告)号：US06346675B1
公开(公告)日：2002-02-12
申请号：US09506635
申请日：2000-02-18
申请人： Günter Igel , Hans-Jürgen Gahle , Mirko Lehmann
发明人： Günter Igel , Hans-Jürgen Gahle , Mirko Lehmann
IPC分类号： H02G318
CPC分类号： F16B21/088 , Y10T16/05
摘要： A coupling (1) has a coupling receiver (2) and a coupling counterpart (3) connectable with it, which in the coupling position is held in a receiver depression (6) of the coupling receiver. The receiver depression (6) is arranged in a layer stack (4) with at least two layers (5a, 5b, 5c, 5d, 5e). Proceeding from the flat surface of the layer stack (4) bordering upon the recess depression (6) to the interior of the receiver depression (6), the lateral boundary wall of the recess depression (6) has at least one cutback, which is formed by a receding layer (5a, 5c) or a receding layer area. The coupling counterpart (3) has at least one lateral guide and/or locking projection (9a, 9b), which engages into a cutback (8a, 8b) of the component (2) in the coupling position.
摘要翻译：耦合器（1）具有耦合接收器（2）和可与其连接的耦合对应器（3），其在耦合位置被保持在耦合接收器的接收器凹部（6）中。接收器凹部（6）布置在具有至少两层（5a，5b，5c，5d，5e）的层叠体（4）中。从凹陷（6）与接收器凹部（6）的内部接合的层叠体（4）的平坦表面开始，凹陷凹部（6）的侧边界壁具有至少一个切口由后退层（5a，5c）或后退层区域形成。耦合对应物（3）具有至少一个横向引导和/或锁定突起（9a，9b），其在联接位置处接合到部件（2）的切口（8a，8b）中。

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