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1. 发明申请

US20050222080A1 Cycloglycans suitable to inhibit mammalian infection 审中-公开
标题翻译：适合抑制哺乳动物感染的抗生素
公开(公告)号：US20050222080A1
公开(公告)日：2005-10-06
申请号：US10502059
申请日：2003-01-20
申请人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis , Gunther Boehm
发明人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis , Gunther Boehm
IPC分类号： A61K31/715 , A61K31/724
CPC分类号： A61K31/715 , Y02A50/473
摘要： Described is the use of in particular homopolymer cycloglycans having a ring-shaped base structure of 2 to 40 monosaccharides in the ring, for preventing the invasion and infection of mammal cells by pathogens, and for combating diseases caused by such pathogens, and food compositions, dietetic compositions and pharmaceutical compositions containing these cycloglycans.
摘要翻译：描述了特别是在环中具有2至40个单糖的环状基本结构的均聚物环糊精的用途，用于防止病原体侵染和感染哺乳动物细胞，以及用于防治由这种病原体引起的疾病，以及食物组合物，饮食组合物和含有这些循环体的药物组合物。

2. 发明申请

US20050004070A1 Anti-infectious carbohydrates 失效
标题翻译：抗感染性碳水化合物
公开(公告)号：US20050004070A1
公开(公告)日：2005-01-06
申请号：US10490102
申请日：2002-09-25
申请人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis
发明人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis
IPC分类号： A61K31/702 , A61K31/715 , A61P31/00 , A61K31/739 , C08B37/00
CPC分类号： A61K31/702 , A61K31/715
摘要： Neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens are disclosed. Food, dietetic products and pharmaceutical agents containing oligosaccharides consist of a base unit of formula (I), and between 0 and 19 other units of formula (II), which are linked directly or indirectly to the base unit. Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc rpresents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); R independently represent a β 1-3 or β 1-6 glycosidic link to HexNAc monosaccharide of the next [Gal-HexNAc] unit (II), and on a terminal [Gal-HexNAc] unit, or R are not present; and a terminal [Gal-HexNAc] unit, wherein R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.
摘要翻译：公开了用于防止病原体侵染和感染哺乳动物细胞并用于与这种病原体引起的疾病的中性直链或支链寡糖。含有寡糖的食品，饮食产品和药剂由式（I）的基本单元和0至19个式（II）的其它单元直接或间接连接到基础单元组成。 Gal代表半乳糖单糖单位; Glc表示葡萄糖单糖单元; HexNAc表示N-乙酰化的半乳糖胺或葡糖胺单糖单元（GalNAc或GlcNAc）; R独立地表示与下一个[Gal-HexNAc]单元（II）的HexNAc单糖的β1-3或β1-6糖基连接，并且在末端[Gal-HexNAc]单元上，或R不存在; 和末端[Gal-HexNAc]单元，其中R表示脱氧己糖基团，可以在HexNAc单糖单元上具有另一脱氧己糖基团。

3. 发明授权

US07858595B2 Anti-infectious carbohydrates 失效
标题翻译：抗感染性碳水化合物
公开(公告)号：US07858595B2
公开(公告)日：2010-12-28
申请号：US10490102
申请日：2002-09-25
申请人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jörg Slaghuis
发明人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jörg Slaghuis
IPC分类号： A61K31/715 , A61K31/70 , C07H5/06 , C07H1/00 , A23G3/00
CPC分类号： A61K31/702 , A61K31/715
摘要： Neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens are disclosed. Food, dietetic products and pharmaceutical agents containing oligosaccharides consist of a base unit of formula (I), and between 0 and 19 other units of formula (II), which are linked directly or indirectly to the base unit. Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc rpresents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); R independently represent a β 1-3 or β 1-6 glycosidic link to HexNAc monosaccharide of the next [Gal-HexNAc] unit (II), and on a terminal [Gal-HexNAc] unit, or R are not present; and a terminal [Gal-HexNAc] unit, wherein R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.
摘要翻译：公开了用于防止病原体侵染和感染哺乳动物细胞并用于与这种病原体引起的疾病的中性直链或支链寡糖。含有寡糖的食品，饮食产品和药剂由式（I）的基本单元和0至19个式（II）的其它单元直接或间接连接到基础单元组成。 Gal代表半乳糖单糖单位; Glc表示葡萄糖单糖单元; HexNAc表示N-乙酰化的半乳糖胺或葡糖胺单糖单元（GalNAc或GlcNAc）; R独立地代表一个 1-3或＆bgr; 1-6糖苷键连接到下一个[Gal-HexNAc]单元（II）的HexNAc单糖和末端[Gal-HexNAc]单元或R不存在; 和末端[Gal-HexNAc]单元，其中R表示脱氧己糖基团，可以在HexNAc单糖单元上具有另一脱氧己糖基团。

4. 发明申请

US20050070464A1 Sialic carbohydrates 审中-公开
标题翻译：唾液碳水化合物
公开(公告)号：US20050070464A1
公开(公告)日：2005-03-31
申请号：US10502049
申请日：2003-01-31
申请人： Bernd Stahl , Sorge Kelm , Gunther Boehm , Berndt Finke , Joachim Schmitt
发明人： Bernd Stahl , Sorge Kelm , Gunther Boehm , Berndt Finke , Joachim Schmitt
IPC分类号： A23C9/20 , A23F3/30 , A23L1/09 , A23L1/29 , A61P37/00 , C07H7/027 , C07H17/04 , A61K38/16 , A61K31/739
CPC分类号： C07H17/04 , A23C9/20 , A23F3/30 , A23L29/30 , A23L33/125 , A23L33/40 , A23V2002/00 , A23V2250/5438 , C07H7/027 , A23V2250/156 , A23V2250/70 , A23V2250/0644
摘要： The invention relates to the use of sialic carbohydrates of general formula (I), containing at least one carbohydrate unit of general formula (II) for the immune modulation, immune suppression and in the prevention and treatment of infections in humans and animals. In said formula (II), Sia represents a sialic acid or a sialic acid derivative in an α2-3 bond, Gal represents a galactose-monosaccharide-unit, HexNac represents an N-acetylated galactosamine or glucosamine-monosaccharide-unit (GalNAc or GlcNAc), Hex represents a galactose- or glucose-monosaccharide-unit (Gal or Glc), C represents HexNac or Hex or is absent, n represents 1-50, V represents OH, a carbohydrate radical or a connecting point on a support T, with the proviso that if V represents OH, n represents 1, and if V represents a carbohydrate radical or a support T, n represents the number of carbohydrate unites of general formula (II) directly connected to said carbohydrate radical or support, X represents a sialic acid or a sialic acid derivative, wherein a second sialic acid or a sialic acid derivative or more sialic acid or sialic acid derivatives can be connected to an α2-8 bond, a phosphate, a sulphate, or carboxyl-group or a monosaccharide having a phosphate, sulphate, or carboxyl group and only one of the radicals X is present.
摘要翻译：本发明涉及含有至少一种通式（II）的碳水化合物单元的通式（I）的唾液酸碳水化合物用于免疫调节，免疫抑制和预防和治疗人和动物感染的用途。在所述式（II）中，Sia表示α2-3键中的唾液酸或唾液酸衍生物，Gal表示半乳糖 - 单糖单元，HexNac表示N-乙酰化的半乳糖胺或葡糖胺单糖单元（GalNAc或GlcNAc ），Hex表示半乳糖或葡萄糖单糖单元（Gal或Glc），C表示HexNac或Hex或不存在，n表示1-50，V表示OH，碳水化合物基团或载体T上的连接点，条件是如果V表示OH，n表示1，并且如果V表示碳水化合物基团或载体T，则n表示与所述碳水化合物基团或载体直接连接的通式（II）的碳水化合物单元的数目，X表示唾液酸或唾液酸衍生物，其中第二唾液酸或唾液酸衍生物或更多的唾液酸或唾液酸衍生物可以连接到α2-8键，磷酸盐，硫酸盐或羧基或单糖上，其具有磷酸盐，硫酸盐，或羧基，并且仅存在基团X中的一个。

5. 发明申请

US20080096794A1 Peptide Mixture From Peptides Having A Molecular Weight Of from 1000 To 5000 Dalton 审中-公开
标题翻译：具有分子量为1000至5000道尔顿的肽的肽混合物
公开(公告)号：US20080096794A1
公开(公告)日：2008-04-24
申请号：US11660595
申请日：2005-08-12
申请人： Gunther Boehm , Christopher Beermann , Bernd Stahl , Gilda Georgi , Joachim Schmitt , Nadine Bock , Sorge Kelm
发明人： Gunther Boehm , Christopher Beermann , Bernd Stahl , Gilda Georgi , Joachim Schmitt , Nadine Bock , Sorge Kelm
IPC分类号： A61K38/00 , A23C9/00 , A23J3/08 , A61P43/00 , C07K16/00 , A23J3/10 , A23L1/305
CPC分类号： A23J3/346 , A23J3/344 , A23L33/18 , A23L33/40 , A61K35/20 , A61K36/06 , A61K36/31 , A61K36/48 , A61K36/88 , A61K38/168 , A61K38/1709 , A61K2300/00
摘要： The invention relates to the use of a peptide mixture comprising peptides with a molecular weight from 1000 to 5000 Daltons for the prevention and/or treatment of tumour diseases, of diseases which are associated with a development disorder of the immune system, of diseases of the immune system, of autoimmune reactions, of allergies and of inflammation in man, a protein component which contains such a peptide mixture and a formula food containing this peptide mixture. The peptides are preferably obtained from non-human proteins suitable for nutritional purposes, in particular by the enzymatic or hydrolytic cleavage of these proteins.
摘要翻译：本发明涉及包含分子量为1000至5000道尔顿的肽的肽混合物在预防和/或治疗与免疫系统发育障碍相关的疾病的肿瘤疾病中的用途，免疫系统，自身免疫反应，过敏和人类炎症，含有这种肽混合物的蛋白质组分和含有该肽混合物的配方食品。肽优选地从适合于营养目的的非人蛋白质获得，特别是通过这些蛋白质的酶促或水解切割。

6. 发明授权

US08715769B2 Preventing diseases in infants delivered via caesarean section 有权
标题翻译：预防通过剖宫产分娩的婴儿的疾病
公开(公告)号：US08715769B2
公开(公告)日：2014-05-06
申请号：US12091011
申请日：2006-10-06
申请人： Joachim Schmitt , Bernd Stahl , Jan Knol
发明人： Joachim Schmitt , Bernd Stahl , Jan Knol
IPC分类号： A23L1/29
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention provides the use of a composition comprising non-digestible oligosaccharide for the manufacture of a composition for enteral administration to an infant delivered via caesarean section.
摘要翻译：本发明提供包含不消化的寡糖的组合物在通过剖宫产递送的婴儿制造用于肠内给药的组合物中的用途。

7. 发明申请

US20110150851A1 NUTRITIONAL COMPOSITION FOR INFANTS DELIVERED VIA CAESAREAN SECTION 审中-公开
标题翻译：通过CAESAREAN部分提供的婴儿的营养成分
公开(公告)号：US20110150851A1
公开(公告)日：2011-06-23
申请号：US13001991
申请日：2009-06-19
申请人： Joachim Schmitt , Francis Lecroix , Pierre Jesenne , Bernd Stahl , Günther Boehm , Emmanuel Perrin
发明人： Joachim Schmitt , Francis Lecroix , Pierre Jesenne , Bernd Stahl , Günther Boehm , Emmanuel Perrin
IPC分类号： A61K35/74 , A61P31/04
CPC分类号： A23C9/1234 , A23C9/1236 , A23C21/026 , A23L29/30 , A23L33/135 , A23L33/21 , A23L33/40 , A23V2002/00 , A61K35/744 , A61K35/745 , A61K35/747 , A23V2200/3204 , A23V2200/3202 , A23V2250/28 , A23V2200/32
摘要： The present invention relates to compositions to be administered to infants delivered via caesarean section and in particular to a product comprising inactivated cells and/or bacterial cell fragments of Gram-negative bacteria and of optionally inactivated Gram-positive bacteria. Thereby it is possible to stimulate a fast colonisation of the intestinal microbiota of said infants.
摘要翻译：本发明涉及给予通过剖宫产递送的婴儿的组合物，特别涉及包含革兰氏阴性细菌的灭活细胞和/或细菌细胞片段以及任选灭活的革兰氏阳性细菌的产品。因此，可以刺激所述婴儿的肠道微生物群的快速定植。

8. 发明授权

US07655784B2 Trans-sialidases obtained from Trypanosoma congolense 失效
标题翻译：来自锥虫的转唾液酸酶
公开(公告)号：US07655784B2
公开(公告)日：2010-02-02
申请号：US10538840
申请日：2003-12-11
申请人： Joachim Schmitt , Gunter Boehm , Bernd Stahl , Roland Schauer , Evelin Tiralongo , Silke Schrader
发明人： Joachim Schmitt , Gunter Boehm , Bernd Stahl , Roland Schauer , Evelin Tiralongo , Silke Schrader
IPC分类号： C07H21/02 , C07H21/04 , A61K39/00
CPC分类号： C12N9/1081
摘要： The invention relates to novel enzymes, which transfer sialic acid from a donor molecule onto an acceptor molecule (trans-sialidases). The enzymes are isolated from the protozoan Trypanosoma congolense. The invention also relates to functional equivalents of said enzymes, to the nucleic acid sequences and amino acid sequences that code for the enzymes and their functional equivalents, to expression constructs and vectors that contain said sequences, to recombinant microorganisms that carry the inventive coding nucleic-acid sequences, to a method for the recombinant production of the inventive enzymes, to a method for isolating said enzyme from Trypanosoma congolense, to a method for the enzymatic sialization of acceptor molecules using the inventive enzymes, to effectors of the inventive trans-sialidases, to the use of the nucleic acid sequences, amino acid sequences, enzymes, effectors or sialization products for producing vaccines, medicaments, foodstuffs or food additives, in addition to the latter products obtained by the inventive method.
摘要翻译：本发明涉及将唾液酸从供体分子转移到受体分子（反唾液酸酶）上的新型酶。这些酶是从原生动物锥虫中分离的。本发明还涉及所述酶的功能等同物，编码酶及其功能等同物的核酸序列和氨基酸序列，含有所述序列的表达构建体和载体，携带本发明编码核酸的重组微生物，酸序列，重组生产本发明酶的方法，用于将所述酶与锥虫属分离的方法，使用本发明酶将受体分子酶促唾液酸化的方法用于本发明的反唾液酸酶的实施者，使用除了通过本发明方法获得的后一种产品之外的核酸序列，氨基酸序列，酶，效应物或用于生产疫苗，药物，食品或食品添加剂的唾液化产品。

9. 发明申请

US20110117077A1 NUTRITIONAL COMPOSITION FOR INFANTS DELIVERED VIA CAESAREAN SECTION 审中-公开
标题翻译：通过CAESAREAN部分提供的婴儿的营养成分
公开(公告)号：US20110117077A1
公开(公告)日：2011-05-19
申请号：US12997537
申请日：2009-06-12
申请人： Joachim Schmitt , Emmanuel Perrin , Bernd Stahl , Günther Boehm
发明人： Joachim Schmitt , Emmanuel Perrin , Bernd Stahl , Günther Boehm
IPC分类号： A61K35/20 , A61P37/08 , A61P17/00 , A61P11/06 , A61P31/00 , A61P1/12 , A61P1/14
CPC分类号： A61K31/702 , A23L33/135 , A23L33/40 , A23V2002/00 , A61K31/733 , A61K35/744 , A61K35/745 , A61K38/017 , A61K38/018 , A61K2300/00 , A23V2200/324 , A23V2200/3202 , A23V2200/3204 , A23V2250/28
摘要： The present invention relates to methods for feeding of infants delivered via caesarean section and to compositions to be administered to infants delivered via caesarean section and in particular to the use of a product obtained by fermentation of milk, whey, whey protein, whey protein hydrolysate, casein, casein hydrolysate and/or lactose by lactic acid producing bacteria. Thereby it is possible to stimulate a fast colonisation of the intestinal microbiota of said infants.
摘要翻译：本发明涉及通过剖宫产输送的婴儿的喂养方法和通过剖宫产输送的婴儿施用的组合物，特别涉及使用通过发酵乳，乳清，乳清蛋白，乳清蛋白水解物，酪蛋白，酪蛋白水解物和/或乳糖。因此，可以刺激所述婴儿的肠道微生物群的快速定植。

10. 发明申请

US20090220639A1 PREVENTING DISEASES IN INFANTS DELIVERED VIA CAESAREAN SECTION 有权
标题翻译：通过CAESAREAN部分预防哺乳动物疾病
公开(公告)号：US20090220639A1
公开(公告)日：2009-09-03
申请号：US12091011
申请日：2006-10-06
申请人： Joachim Schmitt , Bernd Stahl , Jan Knol
发明人： Joachim Schmitt , Bernd Stahl , Jan Knol
IPC分类号： A23L1/29 , A23C9/127 , A23K1/18 , A23L1/308
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention provides the use of a composition comprising non-digestible oligosaccharide for the manufacture of a composition for enteral administration to an infant delivered via caesarean section.
摘要翻译：本发明提供包含不消化的寡糖的组合物在通过剖宫产递送的婴儿制造用于肠内给药的组合物中的用途。

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