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1. 发明授权

US09426999B2 Method for culturing lactic acid bacterium and method for producing fermented milk 有权
标题翻译：培养乳酸菌的方法及发酵乳的制造方法
公开(公告)号：US09426999B2
公开(公告)日：2016-08-30
申请号：US13260249
申请日：2010-03-26
申请人： Masayuki Kamijo
发明人： Masayuki Kamijo
IPC分类号： C12P7/56 , C12N1/20 , A23C9/123
CPC分类号： A23C9/1234 , A23Y2220/00 , A23Y2220/37 , A23Y2300/41 , C12N1/20
摘要： First, prepared is a whey degradation medium to which a protease, yeast extract, and the like are added. Further, polyoxyethylene sorbitan monooleate or propylene glycol monooleate is added to the whey degradation medium. The whey degradation medium is inoculated with bacteriocin-producing lactic acid bacterium and the lactic acid bacterium is cultured while the whey degradation medium is maintained at pH of 4 to 5. After the completion of the culture, the whey degradation medium (culture solution) is centrifuged to thereby separate therefrom a concentrated cell suspension containing the lactic acid bacterium in a concentrated form. The concentrated cell suspension has very low antibacterial activity (several tens AU or less). Then, by adding the concentrated cell suspension to a yogurt mix and fermenting the same, it is possible to produce yogurt containing the bacteriocin-producing lactic acid bacterium without any delay in the fermentation.
摘要翻译：首先，制备添加有蛋白酶，酵母提取物等的乳清分解培养基。此外，将聚氧乙烯山梨糖醇酐单油酸酯或丙二醇单油酸酯加入到乳清降解介质中。用乳杆菌产生乳酸菌接种乳清分解培养基，培养乳酸菌，同时将乳清分解培养基保持在pH4〜5。培养结束后，将乳清分解培养基（培养液）离心，从而将含有浓缩形式的乳酸菌的浓缩细胞悬浮液分离。浓缩的细胞悬浮液具有非常低的抗菌活性（几十AU或更少）。然后，通过将浓缩的细胞悬浮液加入到酸奶混合物中并发酵，可以在发酵中没有任何延迟地生产含有产生细菌素的乳酸菌的酸奶。

2. 发明授权

US09107438B2 Preventing diseases in infants delivered via caesarean section 有权
标题翻译：预防通过剖宫产分娩的婴儿的疾病
公开(公告)号：US09107438B2
公开(公告)日：2015-08-18
申请号：US14135171
申请日：2013-12-19
申请人： N.V. Nutricia
发明人： Joachim Schmitt , Bernd Stahl , Jan Knol
IPC分类号： A23L1/29 , A23C9/123 , A23C9/20 , A23L1/03 , A23L1/30 , A23L1/308 , A61K31/202 , A61K31/702 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/745 , A61K35/747 , A61K35/74 , A61K47/36
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention provides the use of a composition comprising non-digestible oligosaccharide for the manufacture of a composition for enteral administration to an infant delivered via caesarean section.
摘要翻译：本发明提供包含不消化的寡糖的组合物在通过剖宫产递送的婴儿制造用于肠内给药的组合物中的用途。

3. 发明申请

US20120015073A1 METHOD FOR CULTURING LACTIC ACID BACTERIUM AND METHOD FOR PRODUCING FERMENTED MILK 有权
标题翻译：培养乳酸菌的方法和生产发酵乳的方法
公开(公告)号：US20120015073A1
公开(公告)日：2012-01-19
申请号：US13260249
申请日：2010-03-26
申请人： Masayuki Kamijo
发明人： Masayuki Kamijo
IPC分类号： A23C9/123 , C12N1/20
CPC分类号： A23C9/1234 , A23Y2220/00 , A23Y2220/37 , A23Y2300/41 , C12N1/20
摘要： First, prepared is a whey degradation medium to which a protease, yeast extract, and the like are added. Further, polyoxyethylene sorbitan monooleate or propylene glycol monooleate is added to the whey degradation medium. The whey degradation medium is inoculated with bacteriocin-producing lactic acid bacterium and the lactic acid bacterium is cultured while the whey degradation medium is maintained at pH of 4 to 5. After the completion of the culture, the whey degradation medium (culture solution) is centrifuged to thereby separate therefrom a concentrated cell suspension containing the lactic acid bacterium in a concentrated form. The concentrated cell suspension has very low antibacterial activity (several tens AU or less). Then, by adding the concentrated cell suspension to a yogurt mix and fermenting the same, it is possible to produce yogurt containing the bacteriocin-producing lactic acid bacterium without any delay in the fermentation.
摘要翻译：首先，制备添加有蛋白酶，酵母提取物等的乳清分解培养基。此外，将聚氧乙烯山梨糖醇酐单油酸酯或丙二醇单油酸酯加入到乳清降解介质中。用乳杆菌产生乳酸菌接种乳清分解培养基，培养乳酸菌，同时将乳清分解培养基保持在pH4〜5。培养结束后，将乳清分解培养基（培养液）离心，从而将含有浓缩形式的乳酸菌的浓缩细胞悬浮液分离。浓缩的细胞悬浮液具有非常低的抗菌活性（几十AU或更少）。然后，通过将浓缩的细胞悬浮液加入到酸奶混合物中并发酵，可以在发酵中没有任何延迟地生产含有产生细菌素的乳酸菌的酸奶。

4. 发明申请

US20140105865A1 PREVENTING DISEASES IN INFANTS DELIVERED VIA CAESAREAN SECTION 审中-公开
标题翻译：通过CAESAREAN部分预防哺乳动物疾病
公开(公告)号：US20140105865A1
公开(公告)日：2014-04-17
申请号：US14135171
申请日：2013-12-19
申请人： N.V. Nutricia
发明人： Joachim SCHMITT , Bernd Stahl , Jan Knol
IPC分类号： A23L1/29 , A61K35/74 , A61K47/36
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention provides the use of a composition comprising non-digestible oligosaccharide for the manufacture of a composition for enteral administration to an infant delivered via caesarean section.
摘要翻译：本发明提供包含不消化的寡糖的组合物在通过剖宫产递送的婴儿制造用于肠内给药的组合物中的用途。

5. 发明申请

US20090220639A1 PREVENTING DISEASES IN INFANTS DELIVERED VIA CAESAREAN SECTION 有权
标题翻译：通过CAESAREAN部分预防哺乳动物疾病
公开(公告)号：US20090220639A1
公开(公告)日：2009-09-03
申请号：US12091011
申请日：2006-10-06
申请人： Joachim Schmitt , Bernd Stahl , Jan Knol
发明人： Joachim Schmitt , Bernd Stahl , Jan Knol
IPC分类号： A23L1/29 , A23C9/127 , A23K1/18 , A23L1/308
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention provides the use of a composition comprising non-digestible oligosaccharide for the manufacture of a composition for enteral administration to an infant delivered via caesarean section.
摘要翻译：本发明提供包含不消化的寡糖的组合物在通过剖宫产递送的婴儿制造用于肠内给药的组合物中的用途。

6. 发明申请

US20090162323A1 Method for Stimulating the Intestinal Flora 审中-公开
标题翻译：刺激肠道植物的方法
公开(公告)号：US20090162323A1
公开(公告)日：2009-06-25
申请号：US12083612
申请日：2006-10-20
申请人： Günther Boehm , Bernd Stahl , Jan Knol
发明人： Günther Boehm , Bernd Stahl , Jan Knol
IPC分类号： A61K45/00 , A61P1/00
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention relates to methods for feeding and to compositions to be administered to infants delivered via caesarian section and in particular to the use of a) at least two different microorganisms; or b) at least one microorganism and at least one indigestible oligosaccharide; or c) at least two different Bifidobacteria species, subspecies or strains for the manufacture of a composition for enteral administration to an infant delivered via caesarean section. Thereby it is possible to stimulate the healthy development of the intestinal flora of said infants.
摘要翻译：本发明涉及用于喂养和组合物的方法，所述组合物施用于通过经肠切片递送的婴儿，特别涉及使用a）至少两种不同的微生物; 或b）至少一种微生物和至少一种难消化的寡糖; 或c）至少两种不同的双歧杆菌物种，亚种或菌株，用于制造用于通过剖宫产输送的婴儿用于肠内给药的组合物。因此，可以刺激所述婴儿的肠道菌群的健康发育。

7. 发明授权

US09596876B2 Method for stimulating the intestinal flora 有权
公开(公告)号：US09596876B2
公开(公告)日：2017-03-21
申请号：US14973166
申请日：2015-12-17
申请人： N.V. Nutricia
发明人： Günther Boehm , Bernd Stahl , Jan Knol
IPC分类号： A23L1/30 , A61K31/7016 , A23C9/123 , A23C9/20 , A61K31/202 , A61K31/702 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/745 , A61K35/747 , A61K35/74 , A61K47/36 , A61K31/7064
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention relates to methods for feeding and to compositions to be administered to infants delivered via caesarian section and in particular to the use of a) at least two different microorganisms; or b) at least one microorganism and at least one indigestible oligosaccharide; or c)at least two different Bifidobacteria species, subspecies or strains for the manufacture of a composition for enteral administration to an infant delivered via caesarean section. Thereby it is possible to stimulate the healthy development of the intestinal flora of said infants.

8. 发明申请

US20160058806A1 METHOD FOR STIMULATING INTESTINAL BARRIER INTEGRITY AFTER NON-NATURAL BIRTH 审中-公开
标题翻译：非自然生殖后刺激梗阻整合的方法
公开(公告)号：US20160058806A1
公开(公告)日：2016-03-03
申请号：US14846120
申请日：2015-09-04
申请人： N.V. Nutricia
发明人： Joachim SCHMITT , Günther BOEHM , Christopher BEERMANN
IPC分类号： A61K35/745 , A23L1/30 , A61K31/7064 , A23L1/308 , A61K31/702 , A61K31/202 , A23L1/29 , A23L1/305
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention relates to methods for feeding and stimulating the health of infants delivered via caesarean section comprising administering long chain polyunsaturated fatty acids and/or nucleotides.
摘要翻译：本发明涉及用于喂养和刺激通过剖宫产递送的婴儿的健康的方法，其包括施用长链多不饱和脂肪酸和/或核苷酸。

9. 发明申请

US20090263537A1 METHOD FOR STIMULATING INTESTINAL BARRIER INTEGRITY AFTER NON-NATURAL BIRTH 审中-公开
标题翻译：非自然生殖后刺激梗阻整合的方法
公开(公告)号：US20090263537A1
公开(公告)日：2009-10-22
申请号：US12091047
申请日：2006-10-06
申请人： Joachim Schmitt , Gunther Boehm
发明人： Joachim Schmitt , Gunther Boehm
IPC分类号： A23K1/18 , A23C11/02 , A23C11/10 , A23K1/16
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention relates to methods for feeding and stimulating the health of infants delivered via caesarean section comprising administering long chain polyunsaturated fatty acids and/or nucleotides
摘要翻译：本发明涉及用于喂养和刺激通过剖宫产递送的婴儿的健康的方法，包括给予长链多不饱和脂肪酸和/或核苷酸

10. 发明申请

US20090221486A1 METHOD FOR TREATING AND/OR PREVENTING INFECTIONS IN INFANTS DELIVERED VIA CAESAREAN SECTION 审中-公开
标题翻译：用于治疗和/或预防通过CAESAREAN部分递送的婴儿感染的方法
公开(公告)号：US20090221486A1
公开(公告)日：2009-09-03
申请号：US12091050
申请日：2006-10-06
申请人： Joachim Schmitt , Bernd Stahl , Jan Knol
发明人： Joachim Schmitt , Bernd Stahl , Jan Knol
IPC分类号： A61K38/16 , A61K31/702 , A61K31/7088
CPC分类号： A23L33/21 , A23C9/1234 , A23C9/203 , A23C9/206 , A23L29/065 , A23L33/10 , A23L33/12 , A23L33/135 , A23L33/17 , A23L33/40 , A23V2002/00 , A23Y2220/85 , A23Y2300/19 , A23Y2300/21 , A23Y2300/25 , A23Y2300/29 , A23Y2300/31 , A23Y2300/41 , A23Y2300/45 , A23Y2300/49 , A23Y2300/55 , A23Y2300/59 , A23Y2300/65 , A61K31/202 , A61K31/7016 , A61K31/702 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/732 , A61K31/734 , A61K35/74 , A61K35/745 , A61K35/747 , A61K47/36 , Y02A50/473 , Y02A50/475 , A23V2200/32 , A23V2200/3204 , A23V2200/3202 , A23V2200/30 , A23V2200/324 , A23V2250/28 , A61K2300/00
摘要： The present invention provides the use of a composition comprising uronic acid oligosaccharide for the manufacture of a composition for enteral administration to an infant delivered via caesarean section.
摘要翻译：本发明提供包含糖醛酸寡糖的组合物在通过剖宫产递送的婴儿制造用于肠内给药的组合物中的用途。

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