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    • 4. 发明申请
    • Insulin mimetic amino acid sequences
    • 胰岛素模拟氨基酸序列
    • US20050089969A1
    • 2005-04-28
    • US10476184
    • 2002-10-07
    • Josef WisslerGilda GeorgiGunther Boehm
    • Josef WisslerGilda GeorgiGunther Boehm
    • C07K14/62A61K38/00A61K38/28A61K38/30A61P5/48C07K14/415C07K14/47C07K14/475C12N15/17C07H21/04
    • C07K14/415A61K38/00C07K14/4732
    • The invention relates to exsulins or insulin mimetic amino acid sequences with a molecular weight of up to 55,000 daltons and with 1 to 50 basic units of following Formula (1): [−] L,V,I,A]-X1—X2-[L,V,I,A]-[D,E]-[N,Q,M]-X3—[C,H]—X4 [−], whereby; [L,V,I,A], [D,E], [N,Q,M], [C,H] and X1 to 4 represent peptidically linked amino acids; [L,V,I,A] represents leucine (L), valine (V), isoleucine (I) or alanine (A); [D,E] represents asparaginic acid (D) or glutamic acid (E); [N,Q,M] represents asparagine (N), glutamine (Q) or methionine (M); [C,H] represents cysteine (C) or histidine (H); both groups [L,V,I,A] in a basic unit can be identical or different; X1, X2, X3 and X4 represent any type of amino acid and the four amino acids X1 to 4 in a basic unit can be identical or different. The inventive exsulins can be used in dietetic and pharmaceutical agents, and to be precise, can be used for mimicking the properties and functions of members of the family of endogenous insulin and IGF proteohormones/mediators and for preventing, treating and influencing hormonal states and disturbances as well as various degenerative diseases of the body of mammals including various forms of hormonal metabolic disturbances, hormonal resistances, hormonal deficiencies, hyperinsulinemia, diabetes mellitus and autoimmune diseases as well as neurodegenerative and secondary diseases.
    • 本发明涉及分子量高达55,000道尔顿的exsulins或胰岛素模拟氨基酸序列,以及具有1至50个下式(1)的基本单位:[ - ] L,V,I,A] -X < 1 2 - [L,V,I,A] - [D,E] - [N,Q,M] -X 3 - [C,H] -X 4 - [ - ],由此; [L,V,I,A],[D,E],[N,Q,M],[C,H]和X 1〜4代表肽连接的氨基酸; [L,V,I,A]表示亮氨酸(L),缬氨酸(V),异亮氨酸(I)或丙氨酸(A) [D,E]表示天冬氨酸(D)或谷氨酸(E); [N,Q,M]表示天冬酰胺(N),谷氨酰胺(Q)或甲硫氨酸(M); [C,H]表示半胱氨酸(C)或组氨酸(H); 基本单元中的两组[L,V,I,A]可以相同或不同; X 1,X 2,X 3和X 4代表任何类型的氨基酸,并且四个氨基酸 基本单元中的X 1〜4可以相同或不同。 本发明的exsulins可以用于饮食和药物,并且精确地可以用于模拟内源胰岛素和IGF蛋白激素/介体家族成员的性质和功能,并用于预防,治疗和影响荷尔蒙状态和干扰 以及哺乳动物身体的各种退行性疾病,包括各种形式的激素代谢紊乱,激素抵抗,激素缺乏症,高胰岛素血症,糖尿病和自身免疫疾病以及神经变性和继发性疾病。
    • 5. 发明授权
    • Oligosaccharide mixture
    • 寡糖混合物
    • US07939118B2
    • 2011-05-10
    • US10148193
    • 2000-12-07
    • Bernd StahlGünther BöhmBerndt FinkeGilda GeorgiJürgen JelinekJoachim J. Schmitt
    • Bernd StahlGünther BöhmBerndt FinkeGilda GeorgiJürgen JelinekJoachim J. Schmitt
    • C13K1/06
    • A61K45/06A23L5/00A23L29/30A23L33/10A23L33/125A23V2002/00A61K31/702A61K35/20A61K2300/00A23V2250/28
    • An oligosaccharide mixture based on oligosaccharides from one or several animal milks composed of two or more monosaccharide units. The oligosaccharide mixture comprises at least two oligosaccharide fractions which are each composed of at least two different oligosaccharides. Lactose does not pertain thereto and the total spectrum of the oligosaccharides in the oligosaccharide mixture differs from those present in animal milk or animal milks, wherefrom the oligosaccharide fractions are extracted and that a) if the oligosaccharides are extracted from only one animal milk, the proportion of neutral oligosaccharides to acidic oligosaccharides is 90-60:10-40 weight %, or b) if the oligosaccharides are extracted from at least two animal milks, the oligosaccharides extracted from two different animal milks each make up 10 weight % of the total amount of oligosaccharides present in the oligosaccharide mixture. The oligosaccharide mixture approximates human milk with respect to its positive properties.
    • 基于由两个或更多个单糖单元组成的一个或几个动物奶的寡糖的寡糖混合物。 寡糖混合物包含至少两种各自由至少两种不同寡糖组成的寡糖部分。 乳糖与其无关,低聚糖混合物中寡糖的总光谱与动物乳或动物奶中存在的低聚糖的总光谱不同,其中提取寡糖部分,并且a)如果寡糖仅从一种动物乳提取,则比例 的中性寡糖与酸性寡糖的比例为90-60:10-40重量%,或b)如果从至少两只动物奶中提取低聚糖,则从两种不同动物奶中提取的寡糖各自占总量的10重量% 的寡糖混合物中存在的寡糖。 寡糖混合物相对于其正性质接近人乳。
    • 10. 发明授权
    • Protein component for dietetic food
    • 饮食食品的蛋白质成分
    • US06355297B1
    • 2002-03-12
    • US09774189
    • 2001-02-06
    • Günther SawatzkiGilda GeorgiGünther Böhm
    • Günther SawatzkiGilda GeorgiGünther Böhm
    • A23J310
    • A23J3/344A23J3/10A23L33/19Y10S426/801
    • The invention relates to the use of a protein component based on conventional proteins used for the production of foods, at least 20 wt-% thereof having a phosphate residue, which is covalently bound to the protein, whereby 50 to 100 wt-% of the proteins including at least one covalently bound phosphate residue, are subjected to a dephosphorylation reaction wherein 20 to 100% of the covalently bound phosphate residues were removed, for a treatment of adult and adolescent patients, as well as of babies and small children suffering from a disturbed gastrointestinal motility and of reflux-predisposed patients. The use of said protein component not only allows for a sufficient protein supply but it also passes rapidly through the stomach and prevents the stomach contents from flowing back into the oesophagus.
    • 本发明涉及基于用于生产食品的常规蛋白质的蛋白质组分的用途,其至少20重量%具有与蛋白质共价结合的磷酸盐残基,由此将50至100重量% 蛋白质包括至少一个共价结合的磷酸盐残基,进行去磷酸化反应,其中除去20-100%共价结合的磷酸盐残留物,用于治疗成年和青少年患者以及患有 紊乱的胃肠蠕动和反流易感患者。 所述蛋白质组分的使用不仅允许足够的蛋白质供应,而且还快速通过胃并防止胃内容物流回食道。