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1. 发明授权

US5681561A Compositions and methods for improving autologous fat grafting 失效
标题翻译：用于改善自体脂肪移植的组合物和方法
公开(公告)号：US5681561A
公开(公告)日：1997-10-28
申请号：US475543
申请日：1995-06-07
申请人： Bernard Hirshowitz , Ella Lindenbaum , Yaron Har-Shai
发明人： Bernard Hirshowitz , Ella Lindenbaum , Yaron Har-Shai
IPC分类号： A61K35/12 , A61K35/35 , C12N5/077
CPC分类号： C12N5/0653 , A61K31/00 , A61K35/12 , A61K35/35 , A61K38/1808 , A61K38/1841 , A61K38/1858 , A61K38/28 , A61K38/30 , A61K45/06
摘要： The present invention relates to compositions and methods for enhancing the success of autologous fat grafting in a patient. The compositions according to the present invention are useful for enhancing autologous fat grafting by improving the survival rate of lipocytes which are injected into a patient as part of a fat grafting procedure. These compositions comprise a fat grafting effective amount of autologous lipocytes in combination with a lipocyte growth effective amount of a non-steroidal anabolic hormone selected from insulin, triiodothyronine/thyroxine (T.sub.3 or T.sub.4), mixtures thereof, and optionally, growth hormone, most preferably a mixture of all three hormones because of the favorable effect these three hormones exhibit in combination to promote autologous fat grafting, the hormones being further combined with a lipocyte growth effective amount of a nutrient medium, preferably a serum free nutrient medium as at least a minimum essential medium.
摘要翻译：本发明涉及增加患者自体脂肪移植成功的组合物和方法。根据本发明的组合物可用于通过提高作为脂肪移植过程的一部分而注入患者的脂肪细胞的存活率来增强自体脂肪移植。这些组合物包含脂肪移植有效量的自体脂肪细胞与脂肪细胞生长有效量的非甾体合成代谢激素组合选自胰岛素，三碘甲状腺原氨酸/甲状腺素（T3或T4），其混合物和任选的生长激素，最优选所有三种激素的混合物，因为这三种激素组合显示出促进自体脂肪移植的有利作用，激素进一步与脂肪细胞生长有效量的营养培养基，优选无血清营养培养基组合，至少为最小值必不可少的媒介。

2. 发明授权

US5895656A Gas or gel-filled silicone cushion for treatment of keloid and hypertrophic scars 失效
标题翻译：气体或凝胶填充硅胶垫，用于治疗瘢痕疙瘩和肥厚性瘢痕
公开(公告)号：US5895656A
公开(公告)日：1999-04-20
申请号：US733235
申请日：1996-10-18
申请人： Bernard Hirshowitz , Ella Lindenbaum , Yaron Har-Shai
发明人： Bernard Hirshowitz , Ella Lindenbaum , Yaron Har-Shai
IPC分类号： A61F13/00 , A61F13/02 , A61K31/695 , A61L15/00 , A61L15/26 , A01N25/34 , A61L15/16
CPC分类号： A61K31/695 , A61F13/023 , A61L15/26
摘要： The present invention relates to the treatment of keloid and hypertrophic scars by covering the scar with a gas-or gel-filled cushion made of smooth or textured silicone sheeting. It relates particularly to a cushion in the form of a hollow bag filled with completely dry air, inert gel or an inert gas. The invention also relates to a silicone sheeting cushion enclosing silicone beads, polymeric pieces or bodies made of polyfluoroethylene sheeting or a related polymer which produces a negative static charge or, preferably, a silicone sponge or hydrophobic gel, most preferably silicone gel.
摘要翻译：本发明涉及通过用由光滑或纹理的硅胶片制成的气体或凝胶填充的垫覆盖瘢痕和治疗瘢痕疙瘩。特别涉及填充有完全干燥空气，惰性凝胶或惰性气体的中空袋形式的衬垫。本发明还涉及一种包封聚硅氧烷颗粒，由聚氟乙烯薄片制成的聚合物片或主体或产生负静电荷的相关聚合物的硅氧烷薄片垫，或优选硅氧烷海绵或疏水性凝胶，最优选有机硅凝胶。

3. 外观设计

USD360463S Surgical contractor for the closure of skin defects 失效
公开(公告)号：USD360463S
公开(公告)日：1995-07-18
申请号：US11749
申请日：1993-08-13
申请人： Mark T. Steiner , Jeffrey A. Stein , Bernard Hirshowitz
设计人： Mark T. Steiner , Jeffrey A. Stein , Bernard Hirshowitz

4. 发明授权

US5759193A Single needle skin stretching device 失效
标题翻译：单针皮肤拉伸装置
公开(公告)号：US5759193A
公开(公告)日：1998-06-02
申请号：US664623
申请日：1996-06-18
申请人： John E. Burbank , Charles L. Putnam , Bernard Hirshowitz
发明人： John E. Burbank , Charles L. Putnam , Bernard Hirshowitz
IPC分类号： A61B17/03 , A61B17/08 , A61B17/28 , A61B19/00
CPC分类号： A61B17/08 , A61B2017/081 , A61B2017/2837 , A61B2017/2943 , A61B2090/034 , A61B90/02 , A61B90/03 , A61B90/06
摘要： One or more devices for stretching skin to close a wide skin defect may be used with two long interdermal needles which are inserted underneath the skin along margins of the wound. The skin stretching device may include a pair of needle shafts each having a hook or needle at a distal end for engaging one of the interdermal needles, and a contracting mechanism provided for drawing the opposing needle hooks toward one another, thereby approximating the opposing margins of the wound. The skin stretching device may also include a control knob for limiting the amount of force applied by the device, and a tension indicator for indicating the amount of force applied by the device. Each elongated shafts may also exhibit a retaining member about which a swivel platform rotates, and to which two or more needles are attached. The skin stretching device may further include elongated shafts which, at their distal ends, angle away from the body of the shafts, each exhibiting a single needle. Finally, the skin stretching device may include curved shafts which exhibit one or more needles at their distal ends.
摘要翻译：用于拉伸皮肤以闭合宽皮肤缺陷的一种或多种装置可以与两根长的皮肤内针头一起使用，这些针头沿着伤口的边缘插入皮肤下方。皮肤拉伸装置可以包括一对针轴，每个针轴在远端具有钩或针，用于接合其中一个内皮针;以及收缩机构，用于将相对的针钩相互拉向，从而近似相对的边缘伤口。皮肤拉伸装置还可以包括用于限制由装置施加的力的量的控制旋钮，以及用于指示由装置施加的力的张力的张力指示器。每个细长轴还可以具有保持构件，旋转平台围绕该保持构件旋转，并且连接有两个或更多个针。皮肤拉伸装置还可以包括细长轴，其在其远端处远离轴的主体，每个轴呈现单个针。最后，皮肤拉伸装置可以包括在其远端展现一个或多个针的弯曲轴。

5. 发明授权

US5486196A Apparatus for the closure of wide skin defects by stretching of skin 失效
标题翻译：用于通过拉伸皮肤来关闭宽皮肤缺陷的装置
公开(公告)号：US5486196A
公开(公告)日：1996-01-23
申请号：US55413
申请日：1993-05-03
申请人： Bernard Hirshowitz , Amnon Levy , Alexander R. Gilat , Eitan Rogel , Jeffrey Stein , Julian Borgia
发明人： Bernard Hirshowitz , Amnon Levy , Alexander R. Gilat , Eitan Rogel , Jeffrey Stein , Julian Borgia
IPC分类号： A61B17/06 , A61B17/08 , A61B19/00 , A61B17/00
CPC分类号： A61B17/08 , A61B17/06066 , A61B2017/081 , A61B2090/032 , A61B2090/0801 , A61B90/02
摘要： An apparatus for closing wide skin defects may be used with two long interdermal needles configured for insertion underneath skin close to margins of a skin defect. The skin closing apparatus may include two U-shaped retaining members configured as a flange connecting two legs and forming a U-shaped profile. Each of the legs may include a sharp hook at the end of the leg adapted for piercing the skin and engaging one of the long interdermal needles. Each retaining member may include a pivoting platform that pivots up to 20.degree. from an initial position indicated by a detent mechanism. A contracting mechanism such as a screw may connect the retaining members and approximate the interdermal needles, while bringing the skin margins together until final closure of the skin defect results. The skin closing apparatus may also include a clutch mechanism configured to disengage the screw from a knob or handle, when a predetermined force is met or exceeded. A visual or auditory element may also be provided to indicate the amount of force applied to the skin. A retractor may be packaged with the skin closing apparatus and long interdermal needles in a presterilized kit. The retractor may exhibit atraumatic ends having curved edges. The retractor may also exhibit english and metric measuring scales to aid in placing the skin closing apparatus and long interdermal needles about the skin defect. The device may be configured as a single use device utilized with gamma sterilization. In the event the device is configured for multiple uses, any conventional sterilization method may be utilized.
摘要翻译：可以使用用于闭合宽皮肤缺陷的装置，其中两个长的腹膜针被配置用于插入皮肤缺陷边缘附近的皮肤下面。皮肤关闭装置可以包括两个U形保持构件，其构造成连接两个腿并形成U形轮廓的凸缘。每个腿部可以包括在腿部末端处的尖锐的钩子，其适于刺穿皮肤并且接合长的经皮针中的一个。每个保持构件可以包括枢转平台，其从由止动机构指示的初始位置枢转高达20°。诸如螺钉的收缩机构可以将保持构件连接并且近似于透皮针，同时使皮肤边缘在一起，直到皮肤缺陷的最终闭合。皮肤关闭装置还可以包括离合器机构，其被配置为当达到或超过预定力时使螺钉与旋钮或手柄脱离。还可以提供视觉或听觉元件以指示施加到皮肤的力的量。收缩器可以与皮肤闭合装置和长的经皮针包装在预先灭活的试剂盒中。牵开器可能表现为具有弯曲边缘的无创伤端。牵开器还可以展示英制和公制测量秤，以帮助将皮肤关闭装置和长的皮肤针放置在皮肤缺陷周围。该装置可以被配置为与伽马灭菌一起使用的单一使用装置。在设备被配置为多用途的情况下，可以使用任何常规的灭菌方法。

6. 发明授权

US4896680A Method of extending a flap of skin 失效
标题翻译：延长皮肤皮瓣的方法
公开(公告)号：US4896680A
公开(公告)日：1990-01-30
申请号：US150673
申请日：1988-02-01
申请人： Bernard Hirshowitz
发明人： Bernard Hirshowitz
IPC分类号： A61B17/02 , A61B17/03 , A61B17/08 , A61B19/00
CPC分类号： A61B17/08 , A61B17/02 , A61B90/02
摘要： A method of applying force to the skin such as to for use in stretching the skin by load cycling, or for use as a surgical retractor, utilizes an apparatus that comprises two pins or hooks that are joined together by a flexible nylon strap. The strap has rectangular apertures separated by lateral bars. One end of the strap is riveted to one pin while the other end of the strap is passed through a ratchet locking device mounted on the other pin. In use, one pin is fastened to a loose flap of skin and the other pin is fastened to another site on the skin surface. The free end of the strap is then pulled through the locking device, which holds it against movement in the opposite direction, until the desired tension is applied, the skin under tension is allowed to creep and extend in length, and the free end of the strap is then pulled further through the locking device to reapply tension to the skin.

7. 发明授权

US10589091B2 Static electricity generator and methods thereof 有权
公开(公告)号：US10589091B2
公开(公告)日：2020-03-17
申请号：US15128976
申请日：2015-03-25
申请人： ELIACHAR TECHNOLOGIES DEVELOPMENT LTD , Bernard Hirshowitz
发明人： Bernard Hirshowitz , Nir Lilach , Eliahu Eliachar
IPC分类号： A61N1/00 , A61N1/10 , H02N1/04
摘要： The present invention provides a portable handheld static-electricity generator and a method thereof for alleviating pain in at least one portion of patient's body, comprising: a movable brush, a polymer assembly comprising a rubbing-surface portion upon which the brush rubs and an automatically-operated mechanical unit. The polymer assembly having affinity to a defined charge such that when the movable brush rubs the rubbing-surface of the polymer assembly for a predefined time a static electricity is generated.

8. 发明授权

US5893879A Apparatus for the closure of wide skin defects by stretching of skin 失效
公开(公告)号：US5893879A
公开(公告)日：1999-04-13
申请号：US367136
申请日：1995-07-12
申请人： Bernard Hirshowitz , Amnon Levy , Alexander R. Gilat, deceased , Eitan Rogel , Jeffrey Stein , Julian Borgia, deceased , Charles L. Putnam , Paul DiCesare , Daniel Rodak , Thomas Whitlock
发明人： Bernard Hirshowitz , Amnon Levy , Alexander R. Gilat, deceased , Eitan Rogel , Jeffrey Stein , Julian Borgia, deceased , Charles L. Putnam , Paul DiCesare , Daniel Rodak , Thomas Whitlock
IPC分类号： A61B17/03 , A61B17/06 , A61B17/08 , A61B19/00 , A61B17/04
CPC分类号： A61B17/08 , A61B17/06066 , A61B2017/081 , A61B2090/032 , A61B2090/0801 , A61B90/02
摘要： An apparatus for closing wide skin defects may be used with two long interdermal needles configured for insertion underneath skin close to margins of a skin defect. The skin closing apparatus may include two retaining members (70, 71) configured as a flange connecting two legs (20) and forming a U-shaped profile. Each of the legs may include either a sharp book (23) or a blunt skin insertion element at the end of the leg adapted for percing the skin and engaging one of the long interdermal needles. Alternatively, the retaining members may include topical engagement elements for engaging portions of the interdermal needles which are located above the skin surface. A contracting mechanism such as a screw (82) may connect the retaining members and approximate the interdermal needles, while bringing the skin margins together until final closure of the skin defect results. One of the retaining members may be fixed to the screw shaft while the other may be releasably connected to the screw shaft by an intergral locking mechanism (85). The skin closing apparatus may also include a clutch mechanism (110) configured to disengage the screw from a knob (81) or handle, when a predetermined force is met or exceeded. Each retaining member of the skin stretching device may include a base segment connected to a pivotal needle carrier by a flexible pivot segment (132). Each retaining member may also include a base segment, which carries the skin insertion needles, removably connected to the body of the skin stretching device. Each base segment may further include a male and/or female connector (143, 144) for engaging a connector (146, 148) on an opposing base member. The retaining members of the skin stretching device may also include skin insertion needles which may be adjustably positioned. The apparatus may further include a device for shielding (176) the sharp points of the skin insertion needles.

9. 外观设计

USD352356S Surgical contractor for the closure of wide skin defects 失效
公开(公告)号：USD352356S
公开(公告)日：1994-11-08
申请号：US3751
申请日：1992-12-03
申请人： Bernard Hirshowitz , Amnon Levy
设计人： Bernard Hirshowitz , Amnon Levy

10. 发明授权

US5263971A Apparatus for the closure of wide skin defects by stretching of skin 失效
标题翻译：用于通过拉伸皮肤来关闭宽皮肤缺陷的装置
公开(公告)号：US5263971A
公开(公告)日：1993-11-23
申请号：US835636
申请日：1992-02-13
申请人： Bernard Hirshowitz , Amnon Levy
发明人： Bernard Hirshowitz , Amnon Levy
IPC分类号： A61B17/03 , A61B17/04 , A61B17/08 , A61B17/00
CPC分类号： A61B17/08 , A61B17/0466 , A61B2017/081
摘要： An apparatus for closing wide skin defects may include two long pins for insertion underneath the skin close to the margins of the defect. Two U-shaped members may also be provided. Each U-shaped member may include a sharp hook at the end of each leg adapted to pierce the skin and to engage one pin each in two places. A contracting screw may connect the two members and approximate the pins and the skin margins until final closure of the defect. A parallel alignment mechanism may also be provided to maintain the U-shaped members in parallel alignment.
摘要翻译：用于闭合宽皮肤缺陷的装置可以包括两个长的插针，用于插入靠近缺损边缘的皮肤下方。还可以提供两个U形构件。每个U形构件可以包括在每个腿的端部处的适于刺穿皮肤并且在两个位置接合一个销的尖锐钩。收缩螺钉可以连接两个构件并且近似销和皮肤边缘直到缺陷的最终闭合。还可以提供平行对准机构以将U形构件保持平行对准。

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