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1. 发明授权

US06200318B1 Kit for sternum fixation in chest surgery 失效
标题翻译：胸外固定术套件
公开(公告)号：US06200318B1
公开(公告)日：2001-03-13
申请号：US09403064
申请日：2000-04-17
申请人： Yaron Har-Shai , Roni Ammar , Pertti Tormala
发明人： Yaron Har-Shai , Roni Ammar , Pertti Tormala
IPC分类号： A61B1782
CPC分类号： A61B17/8861 , A61B17/823 , A61B17/8866 , A61B17/8869
摘要： A tool kit for use in the inducement of the reconstitution and healing of the sternum after an operation on a patient in the chest region in which during the operation the sternum is cut into two hemisterna. The kit serves for the post-operational approximation and fixation of the hemisterna in a position which enables their spontaneous growing together. The kit includes an approximation tool for the application of a selected force to the hemisterna to brig them into reconstituted configuration, and a set of clamping apparatus for firmly locking the hemisterna in the reconstituted configuration. The clamping apparatus is made of a non-immunogenic polymeric material that is readily degraded in the patient's body to yield degradation products readily absorbed by the patient's body.
摘要翻译：一种工具箱，用于在胸部区域的患者手术后诱导胸骨的重建和愈合，其中在手术期间将胸骨切割成两个半胸骨。该试剂盒用于术后近似和固定半胸肌，使其能够一起自发生长。该套件包括一个近似工具，用于将所选择的力应用于半胸围以将其重新构造成重构构型，以及一组夹紧装置，用于将半胸骨牢固地锁定在重构构型中。夹持装置由非免疫原性聚合物材料制成，其在患者体内易于降解，以产生容易被患者身体吸收的降解产物。

2. 发明授权

US5895656A Gas or gel-filled silicone cushion for treatment of keloid and hypertrophic scars 失效
标题翻译：气体或凝胶填充硅胶垫，用于治疗瘢痕疙瘩和肥厚性瘢痕
公开(公告)号：US5895656A
公开(公告)日：1999-04-20
申请号：US733235
申请日：1996-10-18
申请人： Bernard Hirshowitz , Ella Lindenbaum , Yaron Har-Shai
发明人： Bernard Hirshowitz , Ella Lindenbaum , Yaron Har-Shai
IPC分类号： A61F13/00 , A61F13/02 , A61K31/695 , A61L15/00 , A61L15/26 , A01N25/34 , A61L15/16
CPC分类号： A61K31/695 , A61F13/023 , A61L15/26
摘要： The present invention relates to the treatment of keloid and hypertrophic scars by covering the scar with a gas-or gel-filled cushion made of smooth or textured silicone sheeting. It relates particularly to a cushion in the form of a hollow bag filled with completely dry air, inert gel or an inert gas. The invention also relates to a silicone sheeting cushion enclosing silicone beads, polymeric pieces or bodies made of polyfluoroethylene sheeting or a related polymer which produces a negative static charge or, preferably, a silicone sponge or hydrophobic gel, most preferably silicone gel.
摘要翻译：本发明涉及通过用由光滑或纹理的硅胶片制成的气体或凝胶填充的垫覆盖瘢痕和治疗瘢痕疙瘩。特别涉及填充有完全干燥空气，惰性凝胶或惰性气体的中空袋形式的衬垫。本发明还涉及一种包封聚硅氧烷颗粒，由聚氟乙烯薄片制成的聚合物片或主体或产生负静电荷的相关聚合物的硅氧烷薄片垫，或优选硅氧烷海绵或疏水性凝胶，最优选有机硅凝胶。

3. 发明授权

US06503246B1 Cryoprobe and method of treating scars 失效
标题翻译：冷冻剂和治疗疤痕的方法
公开(公告)号：US06503246B1
公开(公告)日：2003-01-07
申请号：US09610488
申请日：2000-07-05
申请人： Yaron Har-Shai , Micha Amar
发明人： Yaron Har-Shai , Micha Amar
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00747 , A61B2018/0262 , A61B2018/0293
摘要： An intralesional method for treating a hypertrophic scar or keloid using a cryoprobe. The method comprises: (a) inserting the cryoprobe into the hypertrophic scar or keloid so that the cryoprobe is positioned within the hypertrophic scar or keloid; and (b) introducing a cryogen into the cryoprobe thereby freezing the hypertrophic scar or keloid. The cryoprobe has a sealed distal end comprising a cutting tip. Also disclosed is a cryoprobe comprising an elongated, uninsulated housing having a sealed distal end and a proximal end. The housing comprises therein a cryogen inlet tube. The cryoprobe further comprises a cutting tip at the distal end of the housing and a cryogen vent adjacent to the proximal end and in fluid communication with the interior of the housing.
摘要翻译：使用冷冻探针治疗肥大性瘢痕或瘢痕疙瘩的病灶内方法。该方法包括：（a）将冷冻探针插入增生性瘢痕或瘢痕疙瘩中，使冷冻探针置于肥大性瘢痕或瘢痕疙瘩内; 和（b）将冷冻剂引入冷冻探针，从而冷冻肥大性瘢痕或瘢痕疙瘩。冷冻探针具有包括切割尖端的密封远端。还公开了一种冷冻探头，其包括具有密封的远端和近端的细长的非绝缘壳体。壳体中包括冷冻剂入口管。冷冻探针还包括在壳体的远端处的切割尖端和邻近近端并与壳体的内部流体连通的冷冻剂通气。

4. 发明授权

US5681561A Compositions and methods for improving autologous fat grafting 失效
标题翻译：用于改善自体脂肪移植的组合物和方法
公开(公告)号：US5681561A
公开(公告)日：1997-10-28
申请号：US475543
申请日：1995-06-07
申请人： Bernard Hirshowitz , Ella Lindenbaum , Yaron Har-Shai
发明人： Bernard Hirshowitz , Ella Lindenbaum , Yaron Har-Shai
IPC分类号： A61K35/12 , A61K35/35 , C12N5/077
CPC分类号： C12N5/0653 , A61K31/00 , A61K35/12 , A61K35/35 , A61K38/1808 , A61K38/1841 , A61K38/1858 , A61K38/28 , A61K38/30 , A61K45/06
摘要： The present invention relates to compositions and methods for enhancing the success of autologous fat grafting in a patient. The compositions according to the present invention are useful for enhancing autologous fat grafting by improving the survival rate of lipocytes which are injected into a patient as part of a fat grafting procedure. These compositions comprise a fat grafting effective amount of autologous lipocytes in combination with a lipocyte growth effective amount of a non-steroidal anabolic hormone selected from insulin, triiodothyronine/thyroxine (T.sub.3 or T.sub.4), mixtures thereof, and optionally, growth hormone, most preferably a mixture of all three hormones because of the favorable effect these three hormones exhibit in combination to promote autologous fat grafting, the hormones being further combined with a lipocyte growth effective amount of a nutrient medium, preferably a serum free nutrient medium as at least a minimum essential medium.
摘要翻译：本发明涉及增加患者自体脂肪移植成功的组合物和方法。根据本发明的组合物可用于通过提高作为脂肪移植过程的一部分而注入患者的脂肪细胞的存活率来增强自体脂肪移植。这些组合物包含脂肪移植有效量的自体脂肪细胞与脂肪细胞生长有效量的非甾体合成代谢激素组合选自胰岛素，三碘甲状腺原氨酸/甲状腺素（T3或T4），其混合物和任选的生长激素，最优选所有三种激素的混合物，因为这三种激素组合显示出促进自体脂肪移植的有利作用，激素进一步与脂肪细胞生长有效量的营养培养基，优选无血清营养培养基组合，至少为最小值必不可少的媒介。

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