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1. 发明授权

US5620477A Pulse generator with case that can be active or inactive 失效
标题翻译：脉冲发生器，可以处于活动或非活动状态
公开(公告)号：US5620477A
公开(公告)日：1997-04-15
申请号：US455824
申请日：1995-05-31
申请人： Benjamin D. Pless , Steven M. Mitchell , M. Elizabeth Bush
发明人： Benjamin D. Pless , Steven M. Mitchell , M. Elizabeth Bush
IPC分类号： A61N1/375
CPC分类号： A61N1/3752
摘要： A pulse generator having a housing for enclosing and containing pulse generator defibrillation circuitry, particularly adapted to allow for ease of manufacture and use, is disclosed. At least one surface of the housing is electrically conductive and connected to the pulse generator circuitry for delivering defibrillating energy to the heart. The defibrillator is provided with a case activating lead connector cavity having two connector blocks. By plugging in a lead with a pin long enough to contact the only first connector block, the lead becomes active. Using a plug with a longer pin to contact both blocks activates the can. To use neither a lead in the case activating port, nor an active can, a plug with a short or nonconductive pin may be used to plug the cavity without activating the can. By using this system, various electrode configurations can be used as required to provide the optimum system for a given patient. The pulse generator housing is preferably implanted in the left pectoral region proximate the heart with the conductive surface facing the heart. Other implantable electrodes are discharged against the pulse generator housing electrode.
摘要翻译：公开了一种脉冲发生器，其具有用于封闭和容纳脉冲发生器除颤电路的壳体，特别适于容易制造和使用。壳体的至少一个表面是导电的并且连接到脉冲发生器电路，用于将去纤维化能量递送到心脏。除颤器设置有具有两个连接器块的壳体启动引线连接器腔。通过插入一根引脚，引脚长度足以接触唯一的第一个连接器块，引线将变为活动状态。使用较长针脚的插头接触两个块可激活罐头。为了在启动端口的情况下既不使用引线，也不使用活动端子，可以使用具有短导体或非导通插头的插头来插入腔体而不激活罐体。通过使用该系统，可以根据需要使用各种电极配置来为给定的患者提供最佳的系统。脉冲发生器壳体优选地植入靠近心脏的左胸部区域，导电表面面向心脏。其他可植入电极被排出脉冲发生器壳体电极。

2. 发明授权

US5456706A Cardiac defibrillation lead having defibrillation and atrial sensing electrodes 失效
标题翻译：心脏除颤导联具有除颤和心房感应电极
公开(公告)号：US5456706A
公开(公告)日：1995-10-10
申请号：US177293
申请日：1994-01-04
申请人： Benjamin D. Pless , Drew A. Hoffmann , Michael B. Sweeney , M. Elizabeth Bush , Steven M. Mitchell
发明人： Benjamin D. Pless , Drew A. Hoffmann , Michael B. Sweeney , M. Elizabeth Bush , Steven M. Mitchell
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/0563 , A61N1/3956
摘要： A lead for use with an implantable cardioverter/defibrillator system is disclosed. In the preferred embodiment, the lead combines a right ventricular endocardial electrode, a superior vena cava electrode and one or more atrial sensing electrodes on a single catheter lead. The distal end of the lead is transvenously implanted, typically through an incision in the cephalic or subclavian vein. The proximal end of the lead is then tunneled below the fascia to the location of the pulse generator. Ventricular sensing and/or pacing electrode(s) may also be included at the distal end of the combined lead to provide ventricular intracardiac electrogram sensing and bradycardia pacing.
摘要翻译：公开了一种用于植入式心律转复/除颤器系统的引导件。在优选实施例中，引线将单个导管引线上的右心室心内膜电极，上腔静脉电极和一个或多个心房感测电极组合。导管的远端经常植入，通常通过头部或锁骨下静脉中的切口。引线的近端然后在筋膜下方隧道穿过脉冲发生器的位置。心室感应和/或起搏电极也可以包括在组合导联的远端，以提供心室心电图检测和心动过缓起搏。

3. 发明授权

US5683447A Lead with septal defibrillation and pacing electrodes 失效
标题翻译：带隔膜除颤和起搏电极
公开(公告)号：US5683447A
公开(公告)日：1997-11-04
申请号：US574802
申请日：1995-12-19
申请人： M. Elizabeth Bush , Eric S. Fain , Drew A. Hoffmann , Benjamin D. Pless
发明人： M. Elizabeth Bush , Eric S. Fain , Drew A. Hoffmann , Benjamin D. Pless
IPC分类号： A61N1/04 , A61N1/05
CPC分类号： A61N1/0573 , A61N1/056 , A61N1/0563
摘要： A lead system for use with an implantable pacemaker/cardioverter/defibrillator. The lead system includes a securable pace/sense electrode positioned between the distal tip of the lead and the tricuspid valve. The distal tip of the lead is positioned at the apex of the right ventricle and may or may not be secured there by a second fixation means such as a screw tip or tines. The securable pace/sense electrode allows the defibrillation electrode to be accurately positioned by the patient's surgeon and maintained in intimate contact with the septum wall of the patient's heart, thereby reducing defibrillation thresholds; it provides a sense signal from the region of the His bundle or AV node, which can be used with other electrodes to distinguish between various arrhythmias; and it provides more physiologic pacing leading to greater cardiac output.
摘要翻译：用于植入式心脏起搏器/心律转复除颤器的牵引系统。引导系统包括位于引线的远端和三尖瓣之间的可固定速度/感测电极。引线的远端位于右心室的顶点处，并且可以通过第二固定装置（例如螺钉尖端或尖齿）固定或不固定。可靠的速度/感测电极允许除颤电极由患者的外科医生精确定位，并与患者心脏的隔膜壁保持紧密接触，从而减少除颤阈值; 它从His束或AV节点的区域提供感测信号，其可以与其他电极一起使用以区分各种心律失常; 并且它提供更多的生理起搏导致更大的心输出量。

4. 发明授权

US5542173A Method of making flexible defibrillation electrode 失效
标题翻译：制作柔性除颤电极的方法
公开(公告)号：US5542173A
公开(公告)日：1996-08-06
申请号：US388766
申请日：1995-02-15
申请人： Craig E. Mar , Benjamin D. Pless , M. Elizabeth Bush
发明人： Craig E. Mar , Benjamin D. Pless , M. Elizabeth Bush
IPC分类号： A61N1/04 , A61N1/05 , H01R43/00
CPC分类号： A61N1/0563 , Y10T29/49117
摘要： An implantable defibrillator lead comprises a flexible core onto which is wound helically wound coils to form an electrode. These electrode coils are partially encapsulated by a flexible matrix which holds them in their wrapped position around the core. Due to its coiled coil structure, this electrode provides improved flexibility, and can be used endocardially, intravascularly, epicardially, or subcutaneously. The electrode may function alternately as a defibrillation electrode and as a sensing electrode in a lead with a separate pacing electrode.
摘要翻译：可植入除颤器引线包括柔性芯，绕线圈缠绕在其上以形成电极。这些电极线圈被柔性矩阵部分封装，将它们保持在围绕芯的缠绕位置。由于其螺旋线圈结构，该电极提供改善的柔性，并且可以在心内膜，血管内，心外膜或皮下使用。电极可以作为除颤电极交替地起作用，并且作为具有单独的起搏电极的引线中的感测电极。

5. 发明授权

US5439485A Flexible defibrillation electrode of improved construction 失效
标题翻译：柔性除颤电极结构改善
公开(公告)号：US5439485A
公开(公告)日：1995-08-08
申请号：US126619
申请日：1993-09-24
申请人： Craig E. Mar , Benjamin D. Pless , M. Elizabeth Bush
发明人： Craig E. Mar , Benjamin D. Pless , M. Elizabeth Bush
IPC分类号： A61N1/04 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0563 , Y10T29/49117
摘要： An implantable defibrillator lead comprises a flexible core onto which is wound helically wound coils to form an electrode. These electrode coils are partially encapsulated by a flexible matrix which holds them in their wrapped position around the core. Due to its coiled coil structure, this electrode provides improved flexibility, and can be used endocardially, intravascularly, epicardially, or subcutaneously. The electrode may function alternately as a defibrillation electrode and as a sensing electrode in a lead with a separate pacing electrode.
摘要翻译：可植入除颤器引线包括柔性芯，绕线圈缠绕在其上以形成电极。这些电极线圈被柔性矩阵部分封装，将它们保持在围绕芯的缠绕位置。由于其螺旋线圈结构，该电极提供改善的柔性，并且可以在心内膜，血管内，心外膜或皮下使用。电极可以作为除颤电极交替地起作用，并且作为具有单独的起搏电极的引线中的感测电极。

6. 发明授权

US5411544A Defibrillation lead with improved mechanical and electrical characteristics 失效
标题翻译：除颤引线具有改善的机械和电气特性
公开(公告)号：US5411544A
公开(公告)日：1995-05-02
申请号：US145839
申请日：1993-11-02
申请人： Craig E. Mar , M. Elizabeth Bush , Benjamin D. Pless
发明人： Craig E. Mar , M. Elizabeth Bush , Benjamin D. Pless
IPC分类号： A61N1/04 , A61N1/05
CPC分类号： A61N1/0563
摘要： An implantable cardiac defibrillation lead is provided in which surface modification and deposition techniques are utilized to provide improved electrical and mechanical characteristics. The surface of an electrode can thereby be matched to the heart tissue for biocompatibility while at the same time providing for the appropriate electrical and mechanical characteristics of the electrode material.
摘要翻译：提供了可植入的心脏除颤引线，其中使用表面改性和沉积技术来提供改善的电气和机械特性。因此，电极的表面可以与心脏组织匹配以用于生物相容性，同时提供电极材料的适当的电气和机械特性。

7. 发明授权

US08543208B2 Systems and methods for interacting with an implantable medical device 有权
公开(公告)号：US08543208B2
公开(公告)日：2013-09-24
申请号：US12554959
申请日：2009-09-07
申请人： Benjamin D. Pless , David R. Fischell , Barbara Gibb , Lisa Guzzo , Adrian R. M. Upton
发明人： Benjamin D. Pless , David R. Fischell , Barbara Gibb , Lisa Guzzo , Adrian R. M. Upton
IPC分类号： A61N1/00
CPC分类号： A61B5/076 , A61B5/0006 , A61B5/0031 , A61B5/0478 , A61B5/0482 , A61B5/4094 , A61B5/686 , A61B5/742 , A61B5/7475 , A61N1/36064 , A61N1/36135 , A61N1/37252 , A61N1/37258 , A61N1/37282 , G06F19/00
摘要： An interactive implantable medical device system includes an implantable medical device and a network-enabled external device capable of bi-directional communication and interaction with the implantable medical device. The external device is programmed to interact with other similarly-enabled devices. The system facilitates improved patient care by eliminating unnecessary geographic limitations on implantable medical device interrogation and programming, and by allowing patients, physicians, and other users to access medical records, history, and information and to receive status and care-related alerts and messages anywhere there is access to a communications network.

8. 发明申请

US20120253417A1 DIFFERENTIAL NEUROSTIMULATION THERAPY DRIVEN BY PHYSIOLOGICAL THERAPY 有权
标题翻译：通过生理治疗驱动的差异性神经病学治疗
公开(公告)号：US20120253417A1
公开(公告)日：2012-10-04
申请号：US13523855
申请日：2012-06-14
申请人： Benjamin D. Pless , Thomas K. Tcheng
发明人： Benjamin D. Pless , Thomas K. Tcheng
IPC分类号： A61N1/36 , A61F7/00 , A61M37/00
CPC分类号： A61N1/36135 , A61B5/0006 , A61B5/0022 , A61B5/0031 , A61B5/021 , A61B5/026 , A61B5/04012 , A61B5/0476 , A61B5/0488 , A61B5/076 , A61B5/14542 , A61B5/14546 , A61B5/4812 , A61B5/4836 , A61B5/686 , A61B5/743 , A61M5/14276 , A61N1/0529 , A61N1/0531 , A61N1/0539 , A61N1/36064 , A61N1/36067 , A61N1/36078 , A61N1/36139
摘要： An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
摘要翻译：适用于为各种神经障碍提供治疗的可植入神经刺激器系统能够基于要递送治疗的上下文（生理或其他）改变治疗递送策略。根据各种传感器测量，计算，推断和设备状态（包括经过时间和时间），在这种情况下提供适当的治疗方案，响应和预定的治疗方法可以不同。

9. 发明申请

US20100328679A1 Method and System for Device Identification 审中-公开
标题翻译：设备识别方法与系统
公开(公告)号：US20100328679A1
公开(公告)日：2010-12-30
申请号：US12876528
申请日：2010-09-07
申请人： Benjamin D. Pless
发明人： Benjamin D. Pless
IPC分类号： G01B11/24
CPC分类号： G06K9/2036 , G06K9/00577
摘要： Disclosed is a medical device susceptible of identification using interference patterns. A source signal may be directed from an energy source towards the surface of a device for reflection therefrom. An interference pattern may be detected from the surface of the device, such as by a sensor. A determination as to whether a match exists between the representation of the interference pattern and a stored representation of an interference pattern may be performed. If a match exists, the device may be identified based on the stored representation of the interference pattern. Otherwise, a representation of the interference pattern may be stored and a unique identifier may be assigned to the stored representation of the interference pattern.
摘要翻译：公开了一种易受干扰图案识别的医疗器械。源信号可以从能量源朝向装置的表面引导以从其反射。可以从设备的表面（例如通过传感器）检测干涉图案。可以执行关于在干涉图案的表示和存储的干涉图案的表示之间是否存在匹配的确定。如果存在匹配，则可以基于存储的干涉图案的表示来识别该设备。否则，可以存储干扰图案的表示，并且可以将唯一标识符分配给所存储的干涉图案的表示。

10. 发明授权

US07136695B2 Patient-specific template development for neurological event detection 有权
公开(公告)号：US07136695B2
公开(公告)日：2006-11-14
申请号：US09977052
申请日：2001-10-12
申请人： Benjamin D. Pless , Thomas K. Tcheng , Eyad Kishawi , Barbara Gibb , Javier Echauz , Rosana Esteller
发明人： Benjamin D. Pless , Thomas K. Tcheng , Eyad Kishawi , Barbara Gibb , Javier Echauz , Rosana Esteller
IPC分类号： A61B5/0476 , A61N1/18
CPC分类号： G06F19/3418 , A61B5/0476 , A61B5/4094 , A61B5/7217 , G06F19/00
摘要： An epileptiform activity patient-specific template creation system permits a user to efficiently develop an optimized set of patient-specific parameters for epileptiform activity detection algorithms. The epileptiform activity patient template creation system is primarily directed for use with an implantable neurostimulator system having EEG storage capability, in conjunction with a computer software program operating within a computer workstation having a processor, disk storage and input/output facilities for storing, processing and displaying patient EEG signals. The implantable neurostimulator is operative to store records of EEG data when neurological events are detected, when it receives external commands to record, or at preset or random times. The computer workstation operates on stored and uploaded records of EEG data to derive the patient-specific templates.

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