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1. 发明申请

US20190290459A1 ANTI-MIGRATION MICROPATTERNED STENT COATING 审中-公开
公开(公告)号：US20190290459A1
公开(公告)日：2019-09-26
申请号：US16439136
申请日：2019-06-12
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： LAURA ELIZABETH FIRSTENBERG , SEAN P. FLEURY
IPC分类号： A61F2/848 , A61F2/04 , A61F2/06 , A61F2/07 , A61F2/00
摘要： An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

2. 发明公开

US20230380998A1 ANTI-MIGRATION MICROPATTERNED STENT COATING 审中-公开
公开(公告)号：US20230380998A1
公开(公告)日：2023-11-30
申请号：US18366973
申请日：2023-08-08
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： LAURA ELIZABETH FIRSTENBERG , SEAN P. FLEURY
IPC分类号： A61F2/848 , A61F2/06 , A61F2/07 , A61F2/00 , A61F2/04
CPC分类号： A61F2/848 , A61F2/064 , A61F2/06 , A61F2/07 , A61F2/0077 , A61F2/04 , Y10T156/10 , A61F2002/075 , A61F2002/072 , A61F2002/077 , A61F2002/0081 , A61F2220/0008 , A61F2250/0063 , A61F2002/044 , A61F2002/8483 , A61F2220/0016
摘要： An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

3. 发明申请

US20220142763A1 ANTI-MIGRATION MICROPATTERNED STENT COATING 有权
公开(公告)号：US20220142763A1
公开(公告)日：2022-05-12
申请号：US17583670
申请日：2022-01-25
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： LAURA ELIZABETH FIRSTENBERG , SEAN P. FLEURY
IPC分类号： A61F2/00
摘要： An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.

4. 发明申请

US20200146803A1 ANTI-MIGRATION MICROPATTERNED STENT COATING 审中-公开
公开(公告)号：US20200146803A1
公开(公告)日：2020-05-14
申请号：US16738326
申请日：2020-01-09
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： WILLIAM BERTOLINO , LAURA ELIZABETH FIRSTENBERG , CLAIRE M. MCLEOD , ANDREA LAI , SANDRA LAM , SHANNON TAYLOR
IPC分类号： A61F2/04 , A61F2/848 , A61F2/90 , B29C65/48 , B29C65/00 , A61F2/07 , B29C45/37
摘要： An endoprosthesis has an expanded state and a contracted state, the endoprosthesis includes a stent having an inner surface defining a lumen, having an outer surface, and defining a plurality of apertures through the outer surface, wherein the apertures are arranged in a micropattern; and a coating (e.g., polymeric coating) attached to the outer surface of the stent. The coating includes a base and a tissue engagement portion including a second surface facing outwardly from the stent, the tissue engagement portion including a structure that defines a plurality of holes extending inwardly from the second surface toward the base. The holes are arranged in a micropattern. When the endoprosthesis is expanded to the expanded state in a lumen defined by a vessel wall, the structure applies a force that may reduce stent migration by creating an interlock between the vessel wall and the endoprosthesis.

5. 发明申请

US20170065398A1 ANTI-MIGRATION MICROPATTERNED STENT COATING 审中-公开
标题翻译：防移动微电脑涂层
公开(公告)号：US20170065398A1
公开(公告)日：2017-03-09
申请号：US15355529
申请日：2016-11-18
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： WILLIAM BERTOLINO , LAURA ELIZABETH FIRSTENBERG , CLAIRE M. MCLEOD , ANDREA LAI , SANDRA LAM , SHANNON TAYLOR
IPC分类号： A61F2/04 , B29C65/00 , B29C65/48 , B29C45/37 , A61F2/90 , A61F2/848
摘要： An endoprosthesis has an expanded state and a contracted state, the endoprosthesis includes a stent having an inner surface defining a lumen, having an outer surface, and defining a plurality of apertures through the outer surface, wherein the apertures are arranged in a micropattern; and a coating (e.g., polymeric coating) attached to the outer surface of the stent. The coating includes a base and a tissue engagement portion including a second surface facing outwardly from the stent, the tissue engagement portion including a structure that defines a plurality of holes extending inwardly from the second surface toward the base. The holes are arranged in a micropattern. When the endoprosthesis is expanded to the expanded state in a lumen defined by a vessel wall, the structure applies a force that may reduce stent migration by creating an interlock between the vessel wall and the endoprosthesis.
摘要翻译：内假体具有扩张状态和收缩状态，内假体包括具有限定内腔的内表面的支架，具有外表面，并且通过外表面限定多个孔，其中所述孔布置在微图案中; 以及附着到支架的外表面的涂层（例如，聚合物涂层）。涂层包括基部和组织接合部分，其包括从支架向外的第二表面，所述组织接合部分包括限定从第二表面朝向基部向内延伸的多个孔的结构。孔布置在微图案中。当在由血管壁限定的内腔中将内假体扩张到扩张状态时，该结构施加可以通过在血管壁和内用假体之间产生互锁来减少支架迁移的力。

6. 发明公开

US20230149190A1 ANTI-MIGRATION MICROPATTERNED STENT COATING 审中-公开
公开(公告)号：US20230149190A1
公开(公告)日：2023-05-18
申请号：US18156699
申请日：2023-01-19
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： WILLIAM BERTOLINO , LAURA ELIZABETH FIRSTENBERG , CLAIRE M. MCLEOD , ANDREA LAI , SANDRA LAM , SHANNON TAYLOR
IPC分类号： A61F2/90 , A61F2/848 , A61F2/91 , A61F2/86
CPC分类号： A61F2/90 , A61F2/848 , A61F2/91 , A61F2/86 , B29C65/48
摘要： An endoprosthesis has an expanded state and a contracted state, the endoprosthesis includes a stent having an inner surface defining a lumen, having an outer surface, and defining a plurality of apertures through the outer surface, wherein the apertures are arranged in a micropattern; and a coating (e.g., polymeric coating) attached to the outer surface of the stent. The coating includes a base and a tissue engagement portion including a second surface facing outwardly from the stent, the tissue engagement portion including a structure that defines a plurality of holes extending inwardly from the second surface toward the base. The holes are arranged in a micropattern. When the endoprosthesis is expanded to the expanded state in a lumen defined by a vessel wall, the structure applies a force that may reduce stent migration by creating an interlock between the vessel wall and the endoprosthesis.

7. 发明申请

US20170340782A1 Superhydrophobic Coating For Airway Mucus Plugging Prevention 审中-公开
公开(公告)号：US20170340782A1
公开(公告)日：2017-11-30
申请号：US15679756
申请日：2017-08-17
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： SEAN P. FLEURY , MARK D. WOOD , DANE T. SEDDON , LAURA ELIZABETH FIRSTENBERG , PAUL SMITH , GARY J. LEANNA , CLAUDE O. CLERC , JAMES WELDON , STEVEN E. WALAK
IPC分类号： A61L31/14 , A61F2/82 , A61L31/10 , A61F2/07 , A61F2/00 , A61F2/86 , A61F2/04
CPC分类号： A61L31/14 , A61F2/0077 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2002/043 , A61F2230/0067 , A61F2230/0091 , A61F2250/0026 , A61F2250/0039 , A61F2250/0051 , A61F2250/0056 , A61L31/10 , A61L2400/12 , A61L2400/18 , C08L27/18 , C08L23/12
摘要： A method for reducing mucus accumulation in an airway including disposing an implantable device within an airway, wherein the implantable device has a first end, a second end, and an inner surface defining a lumen extending from the first end to the second end; wherein at least a portion of the inner surface has a hydrophobic polymer coating thereon, wherein a polymer coating surface has dynamic water contact angles of 145 degrees or greater; and wherein the implantable device is constructed and arranged to maintain patency of the airway; wherein accumulation of mucus is reduced as compared to a similar implantable device without the hydrophobic portion of the inner surface. An implantable medical device having a superhydrophobic surface and a method of making an implantable medical device having a superhydrophobic surface are also provided. An implantable medical device having a micropatterned surface with enhanced adhesion to tissue, optionally in combination with other region(s) having a superhydrophobic surface and a method of making such a device. Methods and devices for prevention of bacterial adhesion to implanted medical devices.

8. 发明申请

US20170056213A1 ANTI-MIGRATION MICROPATTERNED STENT COATING 审中-公开
标题翻译：防移动微电脑涂层
公开(公告)号：US20170056213A1
公开(公告)日：2017-03-02
申请号：US15340465
申请日：2016-11-01
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： LAURA ELIZABETH FIRSTENBERG , SEAN P. FLEURY
IPC分类号： A61F2/848 , A61F2/04 , A61F2/00
CPC分类号： A61F2/848 , A61F2/0077 , A61F2/04 , A61F2/06 , A61F2/064 , A61F2/07 , A61F2002/0081 , A61F2002/044 , A61F2002/072 , A61F2002/075 , A61F2002/077 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2250/0063 , Y10T156/10
摘要： An endoprosthesis has an expanded state and an unexpanded state, the endoprosthesis includes a stent, wherein the stent has a first end, a second end, an inner surface defining a lumen, an outer surface, and a thickness defined between the inner surface and the outer surface; and a stent end covering disposed at one of the first and second ends, the stent end covering including a polymeric coating that includes a base and a plurality of protrusions, the base including a first major surface facing the outer surface of the stent, the base further including a second major surface from which each of the plurality of protrusions extends outwardly, the first major surface opposing the second major surface, wherein the protrusions are arranged in a micropattern. Methods of making and using an endoprosthesis are provided.
摘要翻译：内假体具有扩张状态和未展开状态，内假体包括支架，其中支架具有第一端，第二端，限定内腔的内表面，外表面和限定在内表面和内表面之间的厚度外表面以及设置在所述第一和第二端中的一个上的支架端盖，所述支架端盖包括聚合物涂层，所述聚合物涂层包括基部和多个突起，所述基部包括面向所述支架的外表面的第一主表面，还包括第二主表面，所述多个突起中的每一个从所述第二主表面向外延伸，所述第一主表面与所述第二主表面相对，其中所述突起被布置在微图案中。提供制造和使用内置假体的方法。

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