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1. 发明申请

US20090011489A1 MULTIPLY-SUBSTITUTED PROTEASE VARIANTS 审中-公开
标题翻译：多选取代蛋白质变体
公开(公告)号：US20090011489A1
公开(公告)日：2009-01-08
申请号：US11929929
申请日：2007-10-30
申请人： Ayrookaran J. Poulose , David A. Estell , James T. Kellis, JR. , Richard R. Bott
发明人： Ayrookaran J. Poulose , David A. Estell , James T. Kellis, JR. , Richard R. Bott
IPC分类号： C12N9/56 , C12N15/11 , C12N15/00 , C12N1/20
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C12Y304/21062
摘要： Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease, Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substitution at a position selected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.
摘要翻译：公开了包含衍生自天然或重组非人蛋白酶的DNA序列的蛋白酶变体的新型酶变体。变体蛋白酶一般通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中多个氨基酸残基的取代。这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。取代的氨基酸残基对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置27,45,170,181,251和271。还描述了包含在解淀粉芽孢杆菌枯草杆菌蛋白酶的1,4,14,69,61,87,100,102,118,128,204和258的位置上的至少一个另外的取代的其它变体。

2. 发明申请

US20110091959A1 Multiply-Substituted Protease Variants 审中-公开
公开(公告)号：US20110091959A1
公开(公告)日：2011-04-21
申请号：US12776940
申请日：2010-05-10
申请人： Ayrookaran J. Poulose , David A. Estell , James T. Kellis, JR. , Richard R. Bott
发明人： Ayrookaran J. Poulose , David A. Estell , James T. Kellis, JR. , Richard R. Bott
IPC分类号： C12N9/48 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C12Y304/21062
摘要： Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substitution at a position selected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.

3. 发明申请

US20110086412A1 Multiply-Substituted Protease Variants 审中-公开
标题翻译：多重取代的蛋白酶变体
公开(公告)号：US20110086412A1
公开(公告)日：2011-04-14
申请号：US12776932
申请日：2010-05-10
申请人： Ayrookaran J. Poulose , David A. Estell , James T. Kellis, JR. , Richard R. Bott
发明人： Ayrookaran J. Poulose , David A. Estell , James T. Kellis, JR. , Richard R. Bott
IPC分类号： C12N9/50 , C12N15/57 , C12N15/63 , C12N1/00
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C12Y304/21062
摘要： Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substitution at a position selected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.
摘要翻译：公开了包含衍生自天然或重组非人蛋白酶的DNA序列的蛋白酶变体的新型酶变体。一般来说，变体蛋白酶通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中的多个氨基酸残基的取代。这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。取代的氨基酸残基对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置27,45,170,181,251和271。还描述了包含在解淀粉芽孢杆菌枯草杆菌蛋白酶的1,4,14,69,61,87,100,102,118,128,204和258的位置上的至少一个另外的取代的其它变体。

4. 发明授权

US07306937B2 Multiply-substituted protease variants 有权
标题翻译：多重取代的蛋白酶变体
公开(公告)号：US07306937B2
公开(公告)日：2007-12-11
申请号：US10500943
申请日：2003-01-16
申请人： Ayrookaran J. Poulose , David A Estell , James T Kellis, Jr. , Richard R. Bott
发明人： Ayrookaran J. Poulose , David A Estell , James T Kellis, Jr. , Richard R. Bott
IPC分类号： C12N9/52 , C12N9/54 , C12N15/57 , C12N15/74 , C11D3/386
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C12Y304/21062
摘要： Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or re-combinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substitution at a position selected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.
摘要翻译：公开了包含衍生自天然存在或重组非人蛋白酶的DNA序列的蛋白酶变体的新型酶变体。一般来说，变体蛋白酶通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中的多个氨基酸残基的取代。这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。取代的氨基酸残基对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置27,45,170,181,251和271。还描述了包含在解淀粉芽孢杆菌枯草杆菌蛋白酶的1,4,14,69,61,87,100,102,118,128,204和258的位置上的至少一个另外的取代的其它变体。

5. 发明授权

US08728790B2 Compositions and methods comprising protease variants 有权
标题翻译：包含蛋白酶变体的组合物和方法
公开(公告)号：US08728790B2
公开(公告)日：2014-05-20
申请号：US12963930
申请日：2010-12-09
申请人： Joshua R Basler , Luis G Cascão-Pereira , David A Estell , James T Kellis, Jr. , Alexander Pisarchik , Ayrookaran J. Poulose , Daniel E. Torres Pazmino
发明人： Joshua R Basler , Luis G Cascão-Pereira , David A Estell , James T Kellis, Jr. , Alexander Pisarchik , Ayrookaran J. Poulose , Daniel E. Torres Pazmino
IPC分类号： C12N9/64
CPC分类号： C12N9/54 , C11D3/386 , C12N9/52 , C12N9/64 , C12Y304/21062
摘要： The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions.
摘要翻译：本发明提供了蛋白酶变体，包含蛋白酶变体的组合物，以及使用这种蛋白酶变体和组合物的方法。

6. 发明授权

US09856466B2 Compositions and methods comprising serine protease variants 有权
公开(公告)号：US09856466B2
公开(公告)日：2018-01-02
申请号：US14115801
申请日：2012-05-04
申请人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, Jr. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
发明人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, Jr. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
IPC分类号： C12N9/54 , C11D3/386
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.

7. 发明申请

US20130260438A1 COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS (AS AMENDED) 审中-公开
标题翻译：包含丝氨酸蛋白酶变体（如修订）的组合物和方法
公开(公告)号：US20130260438A1
公开(公告)日：2013-10-03
申请号：US13696512
申请日：2011-05-05
申请人： Viktor Yuryevich Alekseyev , Neelam A Amin , Katherine Auguslyn , Luis Gustavo Cascao-Pereira , Katherine D. Collier , David A. Estell , James T. Kellis, JR. , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
发明人： Viktor Yuryevich Alekseyev , Neelam A Amin , Katherine Auguslyn , Luis Gustavo Cascao-Pereira , Katherine D. Collier , David A. Estell , James T. Kellis, JR. , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： The present invention provides serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
摘要翻译：本发明提供了丝氨酸蛋白酶变体。具体地，本发明提供了与参考丝氨酸蛋白酶相比具有一个或多个取代的丝氨酸蛋白酶变体。此外，本发明提供包含这些丝氨酸蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体中的至少一种的清洁组合物。

8. 发明申请

US20100192985A1 COMPOSITIONS AND METHODS COMPRISING SERINE PROTEASE VARIANTS 审中-公开
标题翻译：包含丝氨酸蛋白酶变体的组合物和方法
公开(公告)号：US20100192985A1
公开(公告)日：2010-08-05
申请号：US12616097
申请日：2009-11-10
申请人： Wolfgang Aehle , Luis G. Cascao-Pereira , David A. Estell , Frits Goedegebuur , James T. Kellis, JR. , Ayrookaran J. Poulose , Brian F. Schmidt
发明人： Wolfgang Aehle , Luis G. Cascao-Pereira , David A. Estell , Frits Goedegebuur , James T. Kellis, JR. , Ayrookaran J. Poulose , Brian F. Schmidt
IPC分类号： C12N9/56 , C07H21/00 , C12N15/74 , C12N1/21 , C11D3/386 , B08B3/00
CPC分类号： C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38636 , C11D3/38645 , C11D3/38654 , C12N9/50 , C12N9/54 , C12Y304/21062
摘要： The present invention provides methods for protein engineering and serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants.
摘要翻译：本发明提供蛋白质工程方法和丝氨酸蛋白酶变体。具体地，本发明提供了与参考丝氨酸蛋白酶相比具有一个或多个取代的丝氨酸蛋白酶变体。此外，本发明提供包含这些丝氨酸蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体中的至少一种的清洁组合物。

9. 发明申请

US20140154782A1 Compositions and Methods Comprising Serine Protease Variants 有权
标题翻译：包含丝氨酸蛋白酶变体的组成和方法
公开(公告)号：US20140154782A1
公开(公告)日：2014-06-05
申请号：US14115801
申请日：2012-05-04
申请人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, JR. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
发明人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, JR. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
IPC分类号： C12N9/54 , C11D3/386
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
摘要翻译：本发明提供丝氨酸蛋白酶变体，更具体地是从其产生的枯草杆菌蛋白酶变体。具体而言，与参考丝氨酸蛋白酶相比，本发明提供丝氨酸蛋白酶变体，更具体地具有一个或多个取代的枯草杆菌蛋白酶变体。此外，本发明提供包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体中的至少一种的清洁组合物。

10. 发明申请

US20110237487A1 FABRIC AND HOME CARE PRODUCTS 有权
标题翻译：织物和家庭护理产品
公开(公告)号：US20110237487A1
公开(公告)日：2011-09-29
申请号：US12963681
申请日：2010-12-09
申请人： Philip Frank Souter , Glenn Steven Ward , Viktor Yuryevich Alekseyev , Joshua Roy Basler , Luis Gustavo Cascão-Pereira , David A. Estell , Ayrookaran J. Poulose , James T. Kellis, JR. , Alexander Pisarchik , Daniel Esteban Torres-Pazmino
发明人： Philip Frank Souter , Glenn Steven Ward , Viktor Yuryevich Alekseyev , Joshua Roy Basler , Luis Gustavo Cascão-Pereira , David A. Estell , Ayrookaran J. Poulose , James T. Kellis, JR. , Alexander Pisarchik , Daniel Esteban Torres-Pazmino
IPC分类号： C11D3/60 , C11D3/386 , C11D7/60 , D06L1/16 , B08B3/00
CPC分类号： C11D3/38618 , C11D3/38609 , C11D3/38681 , C12N9/50
摘要： This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness. Such cold water proteases may be derived from parent enzymes, including BPN′ subtilisin and subtilisin derived from Bacillus lentus, by substitution, insertion and/or deletion of one or more of the parent enzymes' amino acids.
摘要翻译：本发明涉及包含一种或多种冷水蛋白酶的织物和家庭护理产品以及用于制造和使用这些产品的方法。这样的组合物提供改善的清洁和新鲜度。这样的冷水蛋白酶可以通过取代，插入和/或缺失一种或多种亲本氨基酸从母体酶衍生，包括BPN'枯草杆菌蛋白酶和源自迟缓芽孢杆菌的枯草杆菌蛋白酶。

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