专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09856466B2 Compositions and methods comprising serine protease variants 有权
公开(公告)号：US09856466B2
公开(公告)日：2018-01-02
申请号：US14115801
申请日：2012-05-04
申请人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, Jr. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
发明人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, Jr. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
IPC分类号： C12N9/54 , C11D3/386
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.

2. 发明申请

US20140154782A1 Compositions and Methods Comprising Serine Protease Variants 有权
标题翻译：包含丝氨酸蛋白酶变体的组成和方法
公开(公告)号：US20140154782A1
公开(公告)日：2014-06-05
申请号：US14115801
申请日：2012-05-04
申请人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, JR. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
发明人： Neelam S. Amin , Katherine Augustyn , Joshua R. Basler , Luis G. Cascao-Pereira , Katherine D. Collier , Edward M. Concar , David A. Estell , James T. Kellis, JR. , Euan John Magennis , Alexander Pisarchik , Ayrookaran J. Poulose , Philip Frank Souter , Glenn Steven Ward , Jian Yao
IPC分类号： C12N9/54 , C11D3/386
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides serine protease variants, more specifically subtilisin variants produced there from. Specifically, the present invention provides serine protease variants, more specifically subtilisin variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants, more specifically subtilisin variants. In some embodiments, the present invention provides cleaning compositions comprising at least one of these serine protease variants, more specifically subtilisin variants.
摘要翻译：本发明提供丝氨酸蛋白酶变体，更具体地是从其产生的枯草杆菌蛋白酶变体。具体而言，与参考丝氨酸蛋白酶相比，本发明提供丝氨酸蛋白酶变体，更具体地具有一个或多个取代的枯草杆菌蛋白酶变体。此外，本发明提供包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体的组合物。在一些实施方案中，本发明提供了包含这些丝氨酸蛋白酶变体，更具体地枯草杆菌蛋白酶变体中的至少一种的清洁组合物。

3. 发明授权

US08785171B2 Fabric and home care products comprising cold water proteases 有权
标题翻译：包含冷水蛋白酶的面料和家庭护理产品
公开(公告)号：US08785171B2
公开(公告)日：2014-07-22
申请号：US12963681
申请日：2010-12-09
申请人： Philip Frank Souter , Glenn Steven Ward , Viktor Yuryevich Alekseyev , Joshua Roy Basler , Luis Gustavo Cascão-Pereira , David A. Estell , Ayrookaran J. Poulose , James T. Kellis, Jr. , Alexander Pisarchik , Daniel Esteban Torres-Pazmino
发明人： Philip Frank Souter , Glenn Steven Ward , Viktor Yuryevich Alekseyev , Joshua Roy Basler , Luis Gustavo Cascão-Pereira , David A. Estell , Ayrookaran J. Poulose , James T. Kellis, Jr. , Alexander Pisarchik , Daniel Esteban Torres-Pazmino
IPC分类号： C12N9/48
CPC分类号： C11D3/38618 , C11D3/38609 , C11D3/38681 , C12N9/50
摘要： This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness. Such cold water proteases may be derived from parent enzymes, including BPN′ subtilisin and subtilisin derived from Bacillus lentus, by substitution, insertion and/or deletion of one or more of the parent enzymes' amino acids.
摘要翻译：本发明涉及包含一种或多种冷水蛋白酶的织物和家庭护理产品以及用于制造和使用这些产品的方法。这样的组合物提供改善的清洁和新鲜度。这样的冷水蛋白酶可以通过取代，插入和/或缺失一种或多种亲本氨基酸从母体酶衍生，包括BPN'枯草杆菌蛋白酶和源自迟缓芽孢杆菌的枯草杆菌蛋白酶。

4. 发明申请

US20110237487A1 FABRIC AND HOME CARE PRODUCTS 有权
标题翻译：织物和家庭护理产品
公开(公告)号：US20110237487A1
公开(公告)日：2011-09-29
申请号：US12963681
申请日：2010-12-09
申请人： Philip Frank Souter , Glenn Steven Ward , Viktor Yuryevich Alekseyev , Joshua Roy Basler , Luis Gustavo Cascão-Pereira , David A. Estell , Ayrookaran J. Poulose , James T. Kellis, JR. , Alexander Pisarchik , Daniel Esteban Torres-Pazmino
发明人： Philip Frank Souter , Glenn Steven Ward , Viktor Yuryevich Alekseyev , Joshua Roy Basler , Luis Gustavo Cascão-Pereira , David A. Estell , Ayrookaran J. Poulose , James T. Kellis, JR. , Alexander Pisarchik , Daniel Esteban Torres-Pazmino
IPC分类号： C11D3/60 , C11D3/386 , C11D7/60 , D06L1/16 , B08B3/00
CPC分类号： C11D3/38618 , C11D3/38609 , C11D3/38681 , C12N9/50
摘要： This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness. Such cold water proteases may be derived from parent enzymes, including BPN′ subtilisin and subtilisin derived from Bacillus lentus, by substitution, insertion and/or deletion of one or more of the parent enzymes' amino acids.
摘要翻译：本发明涉及包含一种或多种冷水蛋白酶的织物和家庭护理产品以及用于制造和使用这些产品的方法。这样的组合物提供改善的清洁和新鲜度。这样的冷水蛋白酶可以通过取代，插入和/或缺失一种或多种亲本氨基酸从母体酶衍生，包括BPN'枯草杆菌蛋白酶和源自迟缓芽孢杆菌的枯草杆菌蛋白酶。

5. 发明授权

US08728790B2 Compositions and methods comprising protease variants 有权
标题翻译：包含蛋白酶变体的组合物和方法
公开(公告)号：US08728790B2
公开(公告)日：2014-05-20
申请号：US12963930
申请日：2010-12-09
申请人： Joshua R Basler , Luis G Cascão-Pereira , David A Estell , James T Kellis, Jr. , Alexander Pisarchik , Ayrookaran J. Poulose , Daniel E. Torres Pazmino
发明人： Joshua R Basler , Luis G Cascão-Pereira , David A Estell , James T Kellis, Jr. , Alexander Pisarchik , Ayrookaran J. Poulose , Daniel E. Torres Pazmino
IPC分类号： C12N9/64
CPC分类号： C12N9/54 , C11D3/386 , C12N9/52 , C12N9/64 , C12Y304/21062
摘要： The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions.
摘要翻译：本发明提供了蛋白酶变体，包含蛋白酶变体的组合物，以及使用这种蛋白酶变体和组合物的方法。

6. 发明申请

US20110262999A1 Compositions and Methods Comprising Protease Variants 有权
标题翻译：包含蛋白酶变体的组成和方法
公开(公告)号：US20110262999A1
公开(公告)日：2011-10-27
申请号：US12963930
申请日：2010-12-09
申请人： Joshua R. Basler , Luis G. Cascão-Pereira , David A. Estell , James T. Kellis, JR. , Alexander Pisarchik , Ayrookaran J. Poulose , Daniel Torres Pazmino
发明人： Joshua R. Basler , Luis G. Cascão-Pereira , David A. Estell , James T. Kellis, JR. , Alexander Pisarchik , Ayrookaran J. Poulose , Daniel Torres Pazmino
IPC分类号： C12N9/54 , C12N5/10 , C12N1/00 , C07H21/04 , C12N15/63 , C12S9/00
CPC分类号： C12N9/54 , C11D3/386 , C12N9/52 , C12N9/64 , C12Y304/21062
摘要： The present invention provides protease variants, compositions comprising protease variants, and methods of using such protease variants and compositions.
摘要翻译：本发明提供了蛋白酶变体，包含蛋白酶变体的组合物，以及使用这种蛋白酶变体和组合物的方法。

7. 发明申请

US20110256610A1 Compositions And Methods Comprising Variant Microbial Proteases 审中-公开
标题翻译：包含变异微生物蛋白酶的组成和方法
公开(公告)号：US20110256610A1
公开(公告)日：2011-10-20
申请号：US12996576
申请日：2009-06-03
申请人： Viktor Yuryevich Alekseyev , Luis G. Cascao-Pereira , James T. Kellis, JR. , Alexander Pisarchik
发明人： Viktor Yuryevich Alekseyev , Luis G. Cascao-Pereira , James T. Kellis, JR. , Alexander Pisarchik
IPC分类号： C12N9/56 , B08B1/00 , D06L1/00 , C12S11/00 , C11D3/60
CPC分类号： C12N9/54 , A23K20/189 , C11D3/386 , C11D3/38681 , C11D11/0017 , C12N9/52 , C12Y304/21062
摘要： The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant proteases suitable for laundry cleaning applications.
摘要翻译：本发明提供了变体枯草杆菌蛋白酶和包含本文所述的至少一种变体枯草杆菌蛋白酶的组合物，以及使用这些变体和组合物的方法。在一些实施方案中，本发明提供适用于衣物洗涤应用的变体蛋白酶。

8. 发明申请

US20060141576A1 Variants of corticotropin releasing hormone receptor type 1 and uses thereof 审中-公开
公开(公告)号：US20060141576A1
公开(公告)日：2006-06-29
申请号：US11358841
申请日：2006-02-21
申请人： Alexander Pisarchik , Andrzej Slominski
发明人： Alexander Pisarchik , Andrzej Slominski
IPC分类号： C12P21/06 , C07H21/04 , C07K14/72 , C07K16/28
CPC分类号： C07K14/72 , A61K38/00 , C07K14/723
摘要： The present invention identifies four new isoforms of human corticotropin releasing hormone receptor type 1 (CRH-R1e, 1f, 1g and 1h) and three new isoforms of mouse corticotropin releasing hormone receptor type 1 (mCRH-R1c, 1e and 1f). The data indicate that polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, external stress (UV), and that cAMP dependent pathways and TPA may regulate CRH-R1.

9. 发明申请

US20070059711A1 Microarray for evaluation of stress-related genes in skin 审中-公开
标题翻译：用于评估皮肤中应激相关基因的微阵列
公开(公告)号：US20070059711A1
公开(公告)日：2007-03-15
申请号：US11193801
申请日：2005-07-29
申请人： Andrzej Slominski , Alexander Pisarchik
发明人： Andrzej Slominski , Alexander Pisarchik
IPC分类号： C12Q1/68 , G06F19/00 , C12P19/34 , C12M1/34
CPC分类号： C12Q1/6888 , C12Q1/6837 , C12Q1/6883 , C12Q2600/158 , G16B25/00
摘要： The present invention provides a novel DNA microarray chip that can be used for simultaneous testing of transcriptional responses to cutaneous stressors in the context of neuro-endocrine-immune functions of the skin. The transcriptional responses to ultraviolet radiation in epidermal keratinocytes were tested using such microarray chip containing more than 700 neuro-endocrine-immune related genes. The gene expression pattern was non-random and time dependent; it included increased expression of genes involved in water and salt balance, prostaglandin synthesis, keratinocyte differentiation as well as genes coding for stress effectors, cytokines and metalloproteinases. In contrast, expression was decreased for genes coding for growth factors and their receptors, and for elements of extracellular matrix. This stochastic pattern suggests that transcriptional responses are coordinated and aimed at preservation of epidermal barrier function, prevention of early carcinogenic events and remodeling of extracellular matrix.
摘要翻译：本发明提供了一种新颖的DNA微阵列芯片，其可用于在皮肤神经 - 内分泌 - 免疫功能的背景下同时测试对皮肤应激物的转录反应。使用含有700多种神经 - 内分泌 - 免疫相关基因的微阵列芯片测试表皮角化细胞中对紫外线辐射的转录反应。基因表达模式是非随机和时间依赖性的; 它包括参与水和盐平衡的基因的表达增加，前列腺素合成，角质形成细胞分化以及编码应激作用子，细胞因子和金属蛋白酶的基因。相比之下，编码生长因子及其受体的基因和细胞外基质的元件的表达降低。这种随机模式表明转录反应是协调的，旨在保护表皮屏障功能，预防早期致癌事件和细胞外基质的重塑。

10. 发明公开

US20240060986A1 METHOD FOR SELECTING PEPTIDE INHIBITORS BASED ON PROTEIN CYTOTOXICITY 审中-公开
公开(公告)号：US20240060986A1
公开(公告)日：2024-02-22
申请号：US18236189
申请日：2023-08-21
申请人： Alexander Pisarchik
发明人： Alexander Pisarchik
IPC分类号： G01N33/68
CPC分类号： G01N33/6845
摘要： A Method for selecting peptide inhibitors based on protein cytotoxicity by inserting a cytotoxic target protein and a library of peptide variants in a host cell, expressing the cytotoxic protein and peptide variants in the host cell, and identifying the peptide variants that block the cytotoxic target protein. The cytotoxic target protein is formed by synthesizing a cytotoxic protein gene and cloning the cytotoxic protein gene with an expression vector in a host cell. The library of peptide variants is formed by synthesizing a peptide library or building a peptide library using degenerate oligos and by cloning the peptide library with an expression vector in the host cell. Peptide variants are identified by identifying growing clones through growth on solid media or in a liquid culture. Both cyclic and linear peptides are produced. Intracellular biasing libraries of peptide variants produce inhibitor peptides with lower toxicity and higher stability compared to current methods.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式