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1. 发明申请

US20050149155A1 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：刺激肺动脉压力感受器的刺激
公开(公告)号：US20050149155A1
公开(公告)日：2005-07-07
申请号：US10746852
申请日：2003-12-24
申请人： Avram Scheiner , Ronald Heil , Peter Kelley
发明人： Avram Scheiner , Ronald Heil , Peter Kelley
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, the distal end having a biased portion having an outer diameter dimensioned to abut a wall of a pulmonary artery, an electrode coupled proximate the distal end, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线体，所述远端具有偏压部分，所述偏压部分的外径尺寸设计成邻接肺动脉壁，邻近远端连接的电极和可植入脉冲发电机电耦合到电极。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

2. 发明申请

US20070067008A1 Leads for pacing and/or sensing the heart from within the coronary veins 审中-公开
标题翻译：引导在冠状静脉内起搏和/或感测心脏
公开(公告)号：US20070067008A1
公开(公告)日：2007-03-22
申请号：US11600807
申请日：2006-11-16
申请人： Avram Scheiner , Ronald Heil , Peter Kelley , Bruce Tockman , Randy Westlund , Jay Warren
发明人： Avram Scheiner , Ronald Heil , Peter Kelley , Bruce Tockman , Randy Westlund , Jay Warren
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead for monitoring or stimulating cardiac activity is provided. The lead is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator. The lead body has one or more electrodes associated therewith. The lead is constructed and arranged so that when it is implanted, the electrodes are housed in the coronary vasculature and urged into intimate contact a vessel wall.
摘要翻译：提供监测或刺激心脏活动的潜在客户。引线适于植入在冠状脉管系统内部或其周围的心脏上，并用于连接到信号发生器。引线体具有与其相关联的一个或多个电极。导线被构造和布置成使得当其被植入时，电极被容纳在冠状脉管系统中并被促使与血管壁紧密接触。

3. 发明申请

US20050149128A1 Barorflex stimulation system to reduce hypertension 有权
标题翻译： Barorflex刺激系统降低高血压
公开(公告)号：US20050149128A1
公开(公告)日：2005-07-07
申请号：US10746134
申请日：2003-12-24
申请人： Ronald Heil , Avram Scheiner , Imad Libbus
发明人： Ronald Heil , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/36 , A61N1/362 , A61N1/365
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

4. 发明申请

US20050149156A1 Lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：用于刺激肺动脉中的压力感受器的铅
公开(公告)号：US20050149156A1
公开(公告)日：2005-07-07
申请号：US10746861
申请日：2003-12-24
申请人： Imad Libbus , Ronald Heil , Avram Scheiner
发明人： Imad Libbus , Ronald Heil , Avram Scheiner
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0476 , A61N1/05 , A61N1/056 , A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线主体，靠近远端连接的可扩张电极，所述可扩张电极具有尺寸设计成邻接肺动脉壁的扩张直径，以及电耦合的可植入脉冲发生器到可膨胀电极。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

5. 发明申请

US20050137674A1 Distal or proximal fixation of over-the-tether myocardial leads 有权
标题翻译：远端或近端固定超过系绳心肌引线
公开(公告)号：US20050137674A1
公开(公告)日：2005-06-23
申请号：US10972298
申请日：2004-10-22
申请人： M. Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme
发明人： M. Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N2001/0578
摘要： The present invention is a myocardial lead attachment system for securing a lead within the myocardium. The attachment system includes an anchor configured to engage the heart, a tether coupled to the anchor and a lead body. The lead body has a proximal end, a distal end, a lumen for accepting the tether and a lock housing in the lumen. A lock structure is on the tether and mates with the lock housing and restrains motion of the lead with respect to the tether in either of a proximal or a distal direction.
摘要翻译：本发明是用于将铅固定在心肌内的心肌引导附着系统。附接系统包括构造成接合心脏的锚，连接到锚固体的系绳和引导体。引线体具有近端，远端，用于接纳系绳的内腔和在内腔中的锁定壳体。锁定结构位于系绳上并且与锁定壳体配合并且在近端或远端方向中抑制引线相对于系绳的运动。

6. 发明申请

US20050119718A1 Absorbable myocardial lead fixation system 有权
标题翻译：可吸收心肌引导固定系统
公开(公告)号：US20050119718A1
公开(公告)日：2005-06-02
申请号：US10971577
申请日：2004-10-22
申请人： M. Sean Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme
发明人： M. Sean Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme
IPC分类号： A61B5/0492 , A61B17/04 , A61B17/06 , A61N1/05
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： A myocardial lead attachment system for securing a distal end of a lead within a myocardium of a patient's heart. The system includes a lead body, an anchor mechanism formed of a bioabsorbable or biodegradable polymer for engaging a surface of the patient's heart and a surface feature formed on a portion of the lead body for promoting formation of scar tissue around said portion of the lead body.
摘要翻译：用于将铅的远端固定在患者心脏的心肌内的心肌引线附着系统。该系统包括引线体，由生物可吸收或可生物降解的聚合物形成的锚固机构，用于接合患者心脏的表面，以及形成在引线体的一部分上的表面特征，用于促进在引线体的所述部分周围形成瘢痕组织。

7. 发明申请

US20050113901A1 Myocardial lead attachment system 审中-公开
标题翻译：心肌引导附件系统
公开(公告)号：US20050113901A1
公开(公告)日：2005-05-26
申请号：US10971551
申请日：2004-10-22
申请人： M. Sean Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme , Charles Gresl
发明人： M. Sean Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme , Charles Gresl
IPC分类号： A61B5/0492 , A61B17/04 , A61B17/06 , A61N1/05
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： The present invention is a myocardial lead attachment system for securing a distal end of a lead within a myocardium of a patient's heart. The system includes an anchor, a tether coupled to the anchor, and a delivery instrument for receiving and advancing the anchor through a tract in the heart from a proximal entrance site to a distal exit site in such a manner that the tether extends proximally from the anchor through the tract. The delivery instrument includes a needle having a distal tip and a nest. The nest is positioned proximal to the distal tip and is sized to receive the anchor. The delivery instrument further includes an ejection mechanism for ejecting the anchor from the nest.
摘要翻译：本发明是用于将铅的远端固定在患者心脏的心肌内的心肌引导附着系统。所述系统包括锚固件，联接到所述锚固件的系绳和用于接收并推进所述锚固件穿过所述心脏中的管道从近侧入口部位到远端出口部位的方式的系统，所述系绳以从所述锚固件的方式向近侧延伸锚通过道。递送器械包括具有远端和窝的针。巢定位在远侧末端附近，并且其尺寸被设计成接收锚。输送仪器还包括用于从座中弹出锚固件的弹出机构。

8. 发明申请

US20050137672A1 Myocardial lead 审中-公开
标题翻译：心肌铅
公开(公告)号：US20050137672A1
公开(公告)日：2005-06-23
申请号：US10972049
申请日：2004-10-22
申请人： M. Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme , David Yingling
发明人： M. Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme , David Yingling
IPC分类号： A61B5/0492 , A61B17/04 , A61B17/06 , A61N1/05
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： The present invention is a lead for use in connection with a myocardial lead attachment system of the type having an anchor for engaging the heart and a tether extending from the anchor. The lead includes a lead body having a proximal end, a distal end and a lumen for accepting the tether. A tapered tip is separate from the lead and positioned adjacent the distal end of the lead. The tip has a longitudinal through-hole for accepting the tether.
摘要翻译：本发明是一种用于与具有用于接合心脏的锚固件和从锚固件延伸的系绳的类型的心肌引线附接系统相关联的引线。引线包括具有近端，远端和用于接收系绳的内腔的引线体。锥形尖端与引线分离并且位于铅的远端附近。尖端具有用于接受系绳的纵向通孔。

9. 发明申请

US20050113900A1 Myocardial lead with fixation mechanism 有权
标题翻译：心肌导联与固定机制
公开(公告)号：US20050113900A1
公开(公告)日：2005-05-26
申请号：US10971549
申请日：2004-10-22
申请人： Jason Shiroff , Ronald Heil , Peter Kelley , M. Coe , Randy Westlund , Donald Palme , David Yingling
发明人： Jason Shiroff , Ronald Heil , Peter Kelley , M. Coe , Randy Westlund , Donald Palme , David Yingling
IPC分类号： A61B5/0492 , A61B17/04 , A61B17/06 , A61N1/05
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： The present invention is a myocardial lead attachment system and method for securing a distal end of a lead within the myocardium of a patient's heart. The system includes an anchor, a tether coupled at a distal end to the anchor and a lead body. The lead body has a proximal end, a distal end, and a lumen extending therethrough for receiving the tether. A fixation mechanism is at the distal end of the lead body, and is adapted to collapse to a first configuration during implantation and deploy to a second configuration after implantation.
摘要翻译：本发明是用于将铅的远端固定在患者心脏的心肌内的心肌引导附着系统和方法。该系统包括锚固件，在远端连接到锚固件的系绳和引线主体。引线本体具有近端，远端和延伸穿过其中的内腔，用于接收系绳。固定机构位于引线主体的远端，并且适于在植入期间折叠成第一构型并且在植入之后部署到第二构造。

10. 发明申请

US20070191921A1 SENSORS HAVING PROTECTIVE ELUTING COATING AND METHOD THEREFOR 有权
标题翻译：具有保护性涂层涂层的传感器及其方法
公开(公告)号：US20070191921A1
公开(公告)日：2007-08-16
申请号：US11738251
申请日：2007-04-20
申请人： Qingsheng Zhu , Ronald Heil , Mudit Jain
发明人： Qingsheng Zhu , Ronald Heil , Mudit Jain
IPC分类号： A61N1/05
CPC分类号： A61B5/14546 , A61B5/14532 , A61N1/0568
摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.
摘要翻译：一种装置包括可植入装置，例如具有装置主体的长期可植入装置。一个或多个化学传感器与装置本体结合。药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

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