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1. 发明申请

US20140179802A1 FIBER COMPRISING A BIODEGRADABLE POLYMER 审中-公开
标题翻译：包含可生物降解聚合物的纤维
公开(公告)号：US20140179802A1
公开(公告)日：2014-06-26
申请号：US14115146
申请日：2012-05-02
申请人： Astrid Franken , George Mihov , Jens Christoph Thies
发明人： Astrid Franken , George Mihov , Jens Christoph Thies
IPC分类号： A61K9/00 , A61K47/34
CPC分类号： A61K9/0051 , A61K9/0019 , A61K9/70 , A61K47/34 , C08G69/44 , D01F1/10 , D01F6/625 , D01F6/82 , D10B2331/02 , D10B2331/041 , D10B2401/12
摘要： The present invention relates to a fiber comprising a biodegradable polymer which undergoes dimensional change upon injection in the human or animal body wherein the dimensional change is a reduction of the surface area to volume ratio of a factor 2 to 10. The fiber is sized for injection via a pharmaceutical syringe needle having a bore of at least 25 Gauge. The biodegradable polymer is an amorphous biodegradable polymer selected from the group of poly-hexamethylene carbonates or polyesteramides. The amorphous biodegradable polymer is a preferably a polyesteramide comprising alpha-amino acids, diols and dicarboxylic acids as building blocks. The invention further relates to the use of the fiber for the manufacturing of a medicament for the treatment of ophthalmic diseases. The invention also relates to a process for the manufacturing of the fiber comprising the following process steps; a. extruding a biodegradable polymer into a fiber fitting in a needle of at least 25 Gauge b. which while under tension is cooled below its glass transition temperature such that the resultant fiber is amorphous.
摘要翻译：本发明涉及一种包含生物可降解聚合物的纤维，其在人或动物体内注射时经历尺寸变化，其中尺寸变化是因子2至10的表面积与体积比的降低。纤维的尺寸用于注射通过具有至少25度的孔的制药注射器针头。可生物降解的聚合物是选自聚六亚甲基碳酸酯或聚酯酰胺的无定形可生物降解的聚合物。无定形可生物降解聚合物优选为包含α-氨基酸，二醇和二羧酸作为结构单元的聚酯酰胺。本发明还涉及该纤维在制备用于治疗眼科疾病的药物中的用途。本发明还涉及一种用于制造纤维的方法，包括以下工艺步骤; 一个。将可生物降解的聚合物挤出到至少25巴的针中的纤维配合物中。其在张力下被冷却到其玻璃化转变温度以下，使得所得纤维是无定形的。

2. 发明申请

US20140105957A1 BIS-(ALPHA-AMINO-DIOL-DIESTER) CONTAINING POLYESTERAMIDE FOR OPHTAMOLOGY 审中-公开
标题翻译：含有聚酰胺酰胺的BIS-（ALPHA-AMINO-DIOL-DIESTER）
公开(公告)号：US20140105957A1
公开(公告)日：2014-04-17
申请号：US14113521
申请日：2012-05-02
申请人： Astrid Franken , George Mihov , Jens Christoph Thies
发明人： Astrid Franken , George Mihov , Jens Christoph Thies
IPC分类号： A61K47/34 , A61K9/00
CPC分类号： A61K47/34 , A61K9/0048 , A61K9/0051 , A61K31/4535 , A61K31/5575
摘要： The present invention relates to an ocular polymer delivery composition comprising at least one ophthalmologic agent dispersed in at least one biodegradable polymer, wherein the polymer comprises at least one of a poly (ester amide) (PEA) having a chemical formula described by structural formula (I).
摘要翻译：本发明涉及一种眼部聚合物递送组合物，其包含分散在至少一种可生物降解的聚合物中的至少一种眼科剂，其中所述聚合物包含具有结构式（Q）所描述的化学式的聚（酯酰胺）（PEA）一世）。

3. 发明授权

US09855219B2 Core-shell nanoparticles 有权
公开(公告)号：US09855219B2
公开(公告)日：2018-01-02
申请号：US12438596
申请日：2007-09-05
申请人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
发明人： Nanning Joerg Arfsten , Steven Armes , Pascal Jozef Paul Buskens , Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven
IPC分类号： G02B1/10 , C08K9/02 , A61K9/50 , C08K3/36 , C08K9/00 , C09D7/12 , G02B1/111 , C08L53/00
CPC分类号： A61K9/5089 , A61K9/501 , C08K3/36 , C08K9/00 , C08K9/02 , C08K9/10 , C08K9/12 , C08K2201/011 , C08K2201/013 , C08L53/00 , C08L2207/53 , C09D7/70 , G02B1/111 , Y10T428/254 , Y10T428/2998
摘要： The present invention relates to a composition suitable for forming an optical coating, the composition comprising core-shell nanoparticles, wherein said nanoparticles comprise: (a) core material comprising polymer; and (b) shell material comprising metal oxide.

4. 发明申请

US20090215913A1 Highly porous polymeric materials comprising biologically active molecules via covalent grafting 审中-公开
标题翻译：通过共价接枝包含生物活性分子的高度多孔的聚合物材料
公开(公告)号：US20090215913A1
公开(公告)日：2009-08-27
申请号：US11918777
申请日：2006-04-21
申请人： Jens Christoph Thies , Sebastien Pierre , Neil Ronald Cameron
发明人： Jens Christoph Thies , Sebastien Pierre , Neil Ronald Cameron
IPC分类号： C08J9/36 , C08J9/00
CPC分类号： C12N11/06 , C12N11/08
摘要： The present invention relates to highly porous polymeric materials comprising covalently grafted biologically active species. The invention also relates to a process for the preparation of highly porous materials comprising functional monomers capable of grafting to a biologically active molecular species comprising the steps of: (a) preparing an emulsion composition comprising a droplet phase and a continuous phase and containing monomers, (b) curing the emulsion and (c) optionally removing the water/droplet phase. The invention further relates to a process for grafting biologically active species to such a highly porous polymeric material comprising the steps of: (i) exposing the highly porous material to a solution of the biologically active species in a suitable solvent medium, (ii) optionally adding an activating agent, (iii) optionally heating, and (iv) rinsing the porous material with solvent medium to remove non-grafted species. The highly porous polymeric materials comprising covalently grafted biologically active species can be used e.g. as a heterogeneous catalyst, in biosensors, for chromatography, in biomedical devices and in implants.
摘要翻译：本发明涉及包含共价接枝的生物活性物质的高度多孔的聚合物材料。本发明还涉及一种制备包含能够接枝到生物活性分子物质的官能单体的高度多孔材料的方法，包括以下步骤：（a）制备包含液滴相和连续相并含有单体的乳液组合物，（b）固化乳液和（c）任选地除去水/液滴相。本发明还涉及将生物活性物质接枝到这种高度多孔的聚合物材料的方法，包括以下步骤：（i）将高度多孔的材料暴露于生物活性物质在合适的溶剂介质中的溶液，（ii）任选地加入活化剂，（iii）任选地加热，和（iv）用溶剂介质漂洗多孔材料以除去未接枝的物质。包含共价接枝的生物活性物质的高度多孔的聚合物材料可以例如使用。作为非均相催化剂，生物传感器，色谱法，生物医学装置和植入物。

5. 发明授权

US09545161B2 Articles comprising porous coatings 有权
标题翻译：包含多孔涂层的制品
公开(公告)号：US09545161B2
公开(公告)日：2017-01-17
申请号：US12160644
申请日：2007-02-12
申请人： Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven , Hermanus Adrianus Langermans
发明人： Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven , Hermanus Adrianus Langermans
IPC分类号： B05D5/06 , A47G1/06 , G02B1/10 , G02B1/11 , C03C17/00 , B82Y20/00 , G02B1/111
CPC分类号： G02B1/11 , A47G1/06 , B82Y20/00 , C03C17/007 , C03C2217/425 , C03C2217/45 , C03C2217/475 , C03C2217/732 , G02B1/10 , G02B1/111 , G02B1/118 , G02B2207/101 , Y10T428/24355 , Y10T428/24942 , Y10T428/249978 , Y10T428/24998 , Y10T428/25 , Y10T428/265 , Y10T428/31504 , Y10T428/31507 , Y10T428/31786 , Y10T428/31935
摘要： The invention relates to an article comprising a substrate and a nano-porous coating, wherein the reflectivity of the article is less then 2%, and whereby the amount of sodium measured in the coating by XPS is less then 1 wt %, and further to a method of making the article.
摘要翻译：本发明涉及一种包含基材和纳米多孔涂层的制品，其中制品的反射率小于2％，并且由此通过XPS在涂层中测量的钠的量小于1重量％，进而至制作文章的方法。

6. 发明申请

US20130256230A1 MEMBRANE SUITABLE FOR BLOOD FILTRATION 审中-公开
标题翻译：膜适用于血液过滤
公开(公告)号：US20130256230A1
公开(公告)日：2013-10-03
申请号：US13701321
申请日：2011-05-31
申请人： Konraad Albert Louise Hector Dullaert , Marko Dorschu , Jun Qiu , Jens Christoph Thies
发明人： Konraad Albert Louise Hector Dullaert , Marko Dorschu , Jun Qiu , Jens Christoph Thies
IPC分类号： B01D71/56 , G01N33/49
CPC分类号： B01D71/56 , B01D65/08 , B01D67/0088 , B01D69/12 , B01D71/26 , B01D2239/025 , B01D2239/1233 , B01D2321/28 , B01D2323/39 , B01D2325/36 , D01F6/60 , D01F6/80 , D01F6/90 , D04H1/728 , G01N33/491
摘要： The invention relates to a membrane construction comprising multiple layers wherein at least one of the layers is a nanoweb made of polymeric nanofibers, wherein the mean flow pore size of the nanoweb is in the range from 50 nm to 5 μm, wherein the number average diameter of the nanofibers is in the range from 100 to 600 nm, wherein the basis weight of the nanoweb is in the range from 1 to 20 g/m2, wherein the porosity of the nanoweb is in the range from 60 to 95%, wherein at least one of the layers is a support layer and wherein the nanoweb is hydrophilic.
摘要翻译：本发明涉及包括多个层的膜结构，其中至少一个层是由聚合物纳米纤维制成的纳米纤维网，其中纳米纤维网的平均流动孔径在50nm至5um的范围内，其中数均直径的纳米纤维的范围在100至600nm的范围内，其中纳米纤维网的基重在1至20g / m 2的范围内，其中纳米纤维网的孔隙率在60至95％的范围内，其中在层中的至少一层是支撑层，其中纳米网是亲水性的。

7. 发明申请

US20120135149A1 IMPROVED ANTI-BIOFOULING COATING 审中-公开
标题翻译：改进抗生素涂料
公开(公告)号：US20120135149A1
公开(公告)日：2012-05-31
申请号：US13257850
申请日：2010-03-25
申请人： Pascal Josef Paul Buskens , Jacobus Adriaan Antonius Vermeulen , Ronnie de Rijk , Jens Christoph Thies , Jun Qiu
发明人： Pascal Josef Paul Buskens , Jacobus Adriaan Antonius Vermeulen , Ronnie de Rijk , Jens Christoph Thies , Jun Qiu
IPC分类号： B05D5/00 , C09D5/16
CPC分类号： C08F283/12 , C08F291/00 , C08J7/047 , C08L51/003 , C08L51/085 , C09D5/1637 , C09D151/003 , C09D151/085 , C09D201/005 , C08L2666/02
摘要： The invention relates to a coating material suitable for providing a substrate with an anti-biofouling coating, the coating material comprising a macromolecule comprising: (A) a macromolecular scaffold comprising a reactive group capable of undergoing a Michael type reaction between a Michael type acceptor group and a Michael type donor group, (B) at least one functional moiety attached to the macromolecular scaffold, said at least one functional moiety comprising a hydrophilic moiety, wherein the functional moiety is derivable from a Michael type reaction, involving the reactive group on the macromolecular scaffold and a reactive hydrophilic moiety and (C) at least one moiety capable of crosslinking the coating material.
摘要翻译：本发明涉及一种适用于提供具有抗生物污损涂层的基材的涂层材料，所述涂层材料包含大分子，其包含：（A）大分子支架，其包含能够在迈克尔型受体基团之间经历迈克尔型反应的反应性基团和（B）至少一个与大分子支架连接的功能部分，所述至少一个功能部分包含亲水部分，其中所述功能部分可衍生自迈克尔型反应，涉及所述反应性基团大分子支架和反应性亲水部分和（C）能够交联涂层材料的至少一个部分。

8. 发明申请

US20110263011A1 ANTIFOULING COATING COMPOSITION COMPRISING FUNCTIONALIZED NANOPARTICLES 审中-公开
标题翻译：包含官能化纳米粒子的抗磨涂料组合物
公开(公告)号：US20110263011A1
公开(公告)日：2011-10-27
申请号：US13127104
申请日：2009-10-30
申请人： Jun Qiu , Ronnie B.M. de Rijk , Jens Christoph Thies
发明人： Jun Qiu , Ronnie B.M. de Rijk , Jens Christoph Thies
IPC分类号： C12M1/40 , C12M3/00 , B01L3/00 , B05D3/02 , B05D3/06 , B32B15/04 , B32B27/36 , B32B27/30 , B32B27/06 , B32B27/34 , B32B25/20 , B32B17/06 , C09D5/16 , B32B27/32
CPC分类号： C09C1/3081 , B82Y30/00 , C01G23/047 , C01P2004/64 , C01P2004/84 , C09C1/043 , C09C1/3684 , C09C1/40 , C09C3/12 , C09D5/1637 , C09D5/1687 , Y10T428/31507 , Y10T428/31544 , Y10T428/31663 , Y10T428/31678 , Y10T428/31721 , Y10T428/31739 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938
摘要： Method for providing a substrate with an anti-biofouling coating the method comprising: a. obtaining a coating composition comprising nanoparticles being grafted with reactive groups and hydrophilic polymer chains and a solvent; b. applying the coating composition to the substrate; and c. optionally curing the coating composition herein the surface tension of the coating composition at 25° C. is below 40 mN/m.
摘要翻译：用于向基材提供抗生物污损涂层的方法，所述方法包括：a。获得包含用反应性基团和亲水性聚合物链和溶剂接枝的纳米颗粒的涂料组合物; b。将涂料组合物施加到基材上; 和c。任选地在此处固化涂料组合物，涂料组合物在25℃下的表面张力低于40mN / m。

9. 发明申请

US20100230351A1 Hydrophilic Membrane 审中-公开
标题翻译：亲水膜
公开(公告)号：US20100230351A1
公开(公告)日：2010-09-16
申请号：US12670113
申请日：2008-07-24
申请人： Hendrik Derk Hoving , Jun Qiu , Jens Christoph Thies , Gijsbertus Hendrikus Maria Calis , Johannes Leonardus Maria Op Den Kamp
发明人： Hendrik Derk Hoving , Jun Qiu , Jens Christoph Thies , Gijsbertus Hendrikus Maria Calis , Johannes Leonardus Maria Op Den Kamp
IPC分类号： B01D67/00 , B01D61/00 , B01D61/36 , B01D61/42 , B01D61/02 , B01D61/14 , B01D71/70 , B01D71/52 , B01D71/02 , B05D3/06
CPC分类号： B01D69/02 , B01D71/024 , B01D71/025 , B01D71/027 , B01D71/52 , B01D71/70 , B01D2323/345 , B01D2325/36
摘要： The invention relates to an hydrophilic membrane comprising a membrane carrier and a hydrophilic coating with good properties. The coating may comprise covalently bound inorganic-organic hybrid material; or the coating may comprise ring-opening polymerized components like epoxy resins. The coating composition preferably is applied in a solvent, the solvent is evaporated, and the coating is cured with UV radiation. The hydrophilic membrane is very useful in water purification, and in other applications.
摘要翻译：本发明涉及包含膜载体和具有良好性能的亲水涂层的亲水膜。涂层可以包括共价结合的无机 - 有机杂化材料; 或涂层可以包括开环聚合的组分如环氧树脂。涂料组合物优选在溶剂中进行，蒸发溶剂，并用UV辐射固化涂层。亲水膜在水净化和其他应用中非常有用。

10. 发明申请

US20100167009A1 ARTICLES COMPRISING POROUS COATINGS 有权
标题翻译：包含多孔涂层的文章
公开(公告)号：US20100167009A1
公开(公告)日：2010-07-01
申请号：US12160644
申请日：2007-02-12
申请人： Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven , Hermanus Adrianus Langermans
发明人： Jens Christoph Thies , Patrick Wilhelmus Antonius Vrijaldenhoven , Hermanus Adrianus Langermans
IPC分类号： B32B3/26 , B05D3/02 , B32B3/00 , B05D3/00
CPC分类号： G02B1/11 , A47G1/06 , B82Y20/00 , C03C17/007 , C03C2217/425 , C03C2217/45 , C03C2217/475 , C03C2217/732 , G02B1/10 , G02B1/111 , G02B1/118 , G02B2207/101 , Y10T428/24355 , Y10T428/24942 , Y10T428/249978 , Y10T428/24998 , Y10T428/25 , Y10T428/265 , Y10T428/31504 , Y10T428/31507 , Y10T428/31786 , Y10T428/31935
摘要： The invention relates to an article comprising a substrate and a nano-porous coating, wherein the reflectivity of the article is less then 2%, and whereby the amount of sodium measured in the coating by XPS is less then 1 wt %, and further to a method of making the article.
摘要翻译：本发明涉及一种包含基材和纳米多孔涂层的制品，其中制品的反射率小于2％，并且由此通过XPS在涂层中测量的钠的量小于1重量％，进而至制作文章的方法。

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