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    • 3. 发明授权
    • Miniature lenses, systems and methods of making the same
    • 微型镜头,系统和制作方法
    • US08587881B2
    • 2013-11-19
    • US13176565
    • 2011-07-05
    • Ashutosh SharmaAnkur Verma
    • Ashutosh SharmaAnkur Verma
    • G02B3/00
    • B29D11/00298B32B27/06B32B2457/12G02B3/0018Y10T428/24802
    • Techniques related to miniature lenses and lens arrays are generally described herein. The described techniques may be embodied in apparatuses, systems, methods and/or processes for making and using such lenses. In some examples, the various techniques may be utilized for miniature lenses such as nanometer to micron sized spherical lenses or lens arrays. An example process may include dewetting polymer films to form such lenses. The resulting lens-size may be tunable from about 200 nm to a few tens of microns, and more particularly in a range from about 200 nm to about 10 μm with spherical shapes of contact angles ranging from about 30° to about 150°. The resulting lenses may be tunable polymeric structures formed generally by self-organized room temperature dewetting of ultrathin polymer films by reducing the surface tension.
    • 本文通常描述与微型镜片和透镜阵列相关的技术。 所描述的技术可以体现在用于制造和使用这种透镜的装置,系统,方法和/或过程中。 在一些示例中,各种技术可以用于微型透镜,例如纳米至微米尺寸的球面透镜或透镜阵列。 示例性方法可以包括将聚合物膜去除以形成这种透镜。 所得到的镜片尺寸可以从约200nm调节到几十微米,更特别地在约200nm至约10μm的范围内,球形接触角范围为约30°至约150°。 所得到的透镜可以是可调节的聚合物结构,通常通过降低表面张力通过自组织室温去除超薄聚合物膜而形成。
    • 8. 发明申请
    • Multianalyte assay method
    • 多分析方法
    • US20050287680A1
    • 2005-12-29
    • US10876405
    • 2004-06-25
    • Srivatsa VenkatasubbaraoAshutosh Sharma
    • Srivatsa VenkatasubbaraoAshutosh Sharma
    • C12Q1/68G01N33/543G01N33/551G01N33/58
    • G01N33/587
    • A plurality of groups of colorimetrically distinguishable metal nanoparticles are prepared to label specific analytes whose presence in a sample is under investigation, each group for specific analytes. After being mixed with the sample so that labeling can occur if the analyte or analytes are present, the sample is exposed to a sensor having probes for the analytes under investigation. Binding of any of the analytes present will carry the metal nanoparticle as well, which then enables colorimetric detection of each label to determine which if any of the analytes is present in the sample. In an alternative method the probes can be labeled with calorimetrically distinguishable metal nanoparticle labels and any binding events can be detected calorimetrically.
    • 制备多组可比分辨的金属纳米颗粒,以标记其在样品中的存在正在研究中的特定分析物,每组用于特定分析物。 在与样品混合后,如果存在分析物或分析物,就可能发生标记,将样品暴露于具有被研究分析物的探针的传感器。 存在的任何分析物的结合也将携带金属纳米颗粒,其然后使得能够对每个标记进行比色检测,以确定样品中是否存在任何分析物。 在替代方法中,探针可以用量热分辨的金属纳米颗粒标记进行标记,并且可以用量热法检测任何结合事件。