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1. 发明申请

US20080293590A1 Multianalyte assay method 审中-公开
标题翻译：多分析方法
公开(公告)号：US20080293590A1
公开(公告)日：2008-11-27
申请号：US12185732
申请日：2008-08-04
申请人： Srivatsa Venkatasubbarao , Ashutosh Sharma
发明人： Srivatsa Venkatasubbarao , Ashutosh Sharma
IPC分类号： C40B30/04 , C40B40/00
CPC分类号： G01N33/587
摘要： A plurality of groups of colorimetrically distinguishable metal nanoparticles are prepared to label specific analytes whose presence in a sample is under investigation, each group for specific analytes. After being mixed with the sample so that labeling can occur if the analyte or analytes are present, the sample is exposed to a sensor having probes for the analytes under investigation. Binding of any of the analytes present will carry the metal nanoparticle as well, which then enables colorimetric detection of each label to determine which if any of the analytes is present in the sample. In an alternative method the probes can be labeled with colorimetrically distinguishable metal nanoparticle labels and any binding events can be detected colorimetrically.
摘要翻译：制备多组可比分辨的金属纳米颗粒，以标记其在样品中的存在正在研究中的特定分析物，每组用于特定分析物。在与样品混合后，如果存在分析物或分析物，就可能发生标记，将样品暴露于具有被研究分析物的探针的传感器。存在的任何分析物的结合也将携带金属纳米颗粒，其然后使得能够对每个标记进行比色检测，以确定样品中是否存在任何分析物。在替代方法中，探针可以用比色可区分的金属纳米颗粒标记进行标记，并且可以比色地检测任何结合事件。

2. 发明申请

US20050287680A1 Multianalyte assay method 审中-公开
标题翻译：多分析方法
公开(公告)号：US20050287680A1
公开(公告)日：2005-12-29
申请号：US10876405
申请日：2004-06-25
申请人： Srivatsa Venkatasubbarao , Ashutosh Sharma
发明人： Srivatsa Venkatasubbarao , Ashutosh Sharma
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/551 , G01N33/58
CPC分类号： G01N33/587
摘要： A plurality of groups of colorimetrically distinguishable metal nanoparticles are prepared to label specific analytes whose presence in a sample is under investigation, each group for specific analytes. After being mixed with the sample so that labeling can occur if the analyte or analytes are present, the sample is exposed to a sensor having probes for the analytes under investigation. Binding of any of the analytes present will carry the metal nanoparticle as well, which then enables colorimetric detection of each label to determine which if any of the analytes is present in the sample. In an alternative method the probes can be labeled with calorimetrically distinguishable metal nanoparticle labels and any binding events can be detected calorimetrically.
摘要翻译：制备多组可比分辨的金属纳米颗粒，以标记其在样品中的存在正在研究中的特定分析物，每组用于特定分析物。在与样品混合后，如果存在分析物或分析物，就可能发生标记，将样品暴露于具有被研究分析物的探针的传感器。存在的任何分析物的结合也将携带金属纳米颗粒，其然后使得能够对每个标记进行比色检测，以确定样品中是否存在任何分析物。在替代方法中，探针可以用量热分辨的金属纳米颗粒标记进行标记，并且可以用量热法检测任何结合事件。

3. 发明授权

US07023547B2 Apparatus including a biochip for imaging of biological samples and method 有权
公开(公告)号：US07023547B2
公开(公告)日：2006-04-04
申请号：US09838700
申请日：2001-04-19
申请人： Srivatsa Venkatasubbarao , Lothar U. Kempen
发明人： Srivatsa Venkatasubbarao , Lothar U. Kempen
IPC分类号： G01J4/00 , G01N33/557
CPC分类号： G01N21/21 , G01N21/253 , G01N21/552 , Y10S436/805
摘要： Imaging apparatus which images the changes in height of reactive spots on the surface of a slide requires the surface roughness of the slide to be small enough to distinguish the changes in height from the roughness features of the slide.

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