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1. 发明申请

US20060108521A1 Daughter ion spectra with time-of-flight mass spectrometers 有权
标题翻译：带飞行时间质谱仪的子离子谱
公开(公告)号：US20060108521A1
公开(公告)日：2006-05-25
申请号：US11229047
申请日：2005-09-16
申请人： Armin Holle , Michael Schubert
发明人： Armin Holle , Michael Schubert
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/0045 , H01J49/403 , H01J49/4215
摘要： The invention relates to methods and devices for measuring daughter ion spectra (also called fragment ion spectra or MS/MS spectra) in time-of-flight mass spectrometers with orthogonal injection of the ions. The invention filters the parent ions selected to be fragmented by a mass filter before they are injected into the time-of-flight mass spectrometer, fragments the selected ions in a first stage of the time-of-flight mass spectrometer within a collision cell filled with collision gas at collision energies between one and five kiloelectron-volts, further accelerates the fragment ions and measures the fragment ions in a second stage of the time-of-flight mass spectrometer.
摘要翻译：本发明涉及通过正交注射离子来测量飞行时间质谱仪中的子离子谱（也称为碎片离子谱或MS / MS谱）的方法和装置。本发明在被注入飞行时间质谱仪之前过滤选择被质量过滤器分段的亲本离子，在飞行时间质谱仪的第一阶段将所选择的离子碎片在填充的碰撞池内碰撞气体在一个和五千伏电压之间的碰撞能量下，进一步加速碎片离子并在飞行时间质谱仪的第二阶段测量碎片离子。

2. 发明授权

US07301145B2 Daughter ion spectra with time-of-flight mass spectrometers 有权
标题翻译：带飞行时间质谱仪的子离子谱
公开(公告)号：US07301145B2
公开(公告)日：2007-11-27
申请号：US11229047
申请日：2005-09-16
申请人： Armin Holle , Michael Schubert
发明人： Armin Holle , Michael Schubert
IPC分类号： H01J49/44
CPC分类号： H01J49/0031 , H01J49/0045 , H01J49/403 , H01J49/4215
摘要： The invention relates to methods and devices for measuring daughter ion spectra (also called fragment ion spectra or MS/MS spectra) in time-of-flight mass spectrometers with orthogonal injection of the ions. The invention filters the parent ions selected to be fragmented by a mass filter before they are injected into the time-of-flight mass spectrometer, fragments the selected ions in a first stage of the time-of-flight mass spectrometer within a collision cell filled with collision gas at collision energies between one and five kiloelectron-volts, further accelerates the fragment ions and measures the fragment ions in a second stage of the time-of-flight mass spectrometer.
摘要翻译：本发明涉及通过正交注射离子来测量飞行时间质谱仪中的子离子谱（也称为碎片离子谱或MS / MS谱）的方法和装置。本发明在被注入飞行时间质谱仪之前过滤选择被质量过滤器分段的亲本离子，在飞行时间质谱仪的第一阶段将所选择的离子碎片在填充的碰撞池内碰撞气体在一个和五千伏电压之间的碰撞能量下，进一步加速碎片离子并在飞行时间质谱仪的第二阶段测量碎片离子。

3. 发明授权

US07541597B2 Automatic cleaning of ion sources 有权
标题翻译：自动清洗离子源
公开(公告)号：US07541597B2
公开(公告)日：2009-06-02
申请号：US11559086
申请日：2006-11-13
申请人： Armin Holle , Gregor Przybyla
发明人： Armin Holle , Gregor Przybyla
IPC分类号： H01J27/00 , H01J37/08 , G21K5/10
CPC分类号： H01J49/10 , H01J37/32862
摘要： The invention relates to the automatic cleaning of ion sources inside mass spectrometers, especially the cleaning of ion sources where the ions are generated by matrix-assisted laser desorption (MALDI).The invention consists in cleaning the electrodes of the ion source, which are contaminated with organic material, in the mass spectrometer itself by etching with reactive ions produced by an electrically generated gas discharge in a specially admitted reactant gas.
摘要翻译：本发明涉及质谱仪内离子源的自动清洗，特别是通过基质辅助激光解吸（MALDI）产生离子的离子源的清洗。本发明通过在特别允许的反应气体中通过用电气产生的气体放电产生的活性离子进行蚀刻来清洁质谱仪本身中被有机材料污染的离子源的电极。

4. 发明申请

US20090095903A1 CLEANED DAUGHTER ION SPECTRA FROM MALDI IONIZATION 有权
标题翻译：从MALDI离子中清除大豆离子光谱
公开(公告)号：US20090095903A1
公开(公告)日：2009-04-16
申请号：US12237167
申请日：2008-09-24
申请人： Armin Holle
发明人： Armin Holle
IPC分类号： H01J49/40 , B01D59/44
CPC分类号： G01N27/62 , H01J49/0045
摘要： In a mass spectrometer having an ion source in which analyte substances are ionized by matrix assisted laser desorption and form an ion beam that travels to a parent ion selector for selecting ions to form daughter ions, the ion beam is reflected in at least one reflector prior to the parent ion selector so that only ions that have both the mass of the parent ions and their kinetic energy are allowed to pass to the parent ion selector. By taking this measure, the mass resolution in the daughter ion spectra is also increased; the improved mass resolution and improved signal-to-noise ratio produce higher sensitivity, even though fewer ions are admitted for analysis in the daughter ion spectrum.
摘要翻译：在具有离子源的质谱仪中，分析物质通过基质辅助激光解吸离子化并形成离子束，该离子束行进到母离子选择器以选择离子形成子离子，离子束在至少一个反射器中被反射到母体离子选择器，使得只有具有母体离子的质量和它们的动能的离子才允许传递到母体离子选择器。通过采取这种措施，子离子光谱中的质量分辨率也增加了; 改进的质量分辨率和改善的信噪比产生更高的灵敏度，即使在子离子谱中分析较少的离子也被允许。

5. 发明授权

US07408152B2 Ion source using matrix-assisted laser desorption/ionization 有权
标题翻译：离子源使用矩阵辅助激光解吸/电离
公开(公告)号：US07408152B2
公开(公告)日：2008-08-05
申请号：US11314966
申请日：2005-12-21
申请人： Armin Holle , Jens Höhndorf , Andreas Haase , Markus Kayser
发明人： Armin Holle , Jens Höhndorf , Andreas Haase , Markus Kayser
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01S3/09415 , H01J49/164 , H01S3/005 , H01S3/1118 , H01S3/115 , H01S3/1611 , H01S3/1638 , H01S5/041 , H01S5/14 , H01S5/183
摘要： An ion source generating ions by matrix-assisted laser desorption/ionization (MALDI) comprising a MALDI sample support and a solid-state the laser system generating a pulsed laser beam, which has a wavelength in the range between 332 and 342 nanometers and is spatially shaped in the solid-state laser system such that the spatial intensity distribution of the laser beam on the MALDI sample support exhibits more than one intensity peak.
摘要翻译：通过基质辅助激光解吸/电离（MALDI）产生离子的离子源包括MALDI样品支持体和固态激光系统，其产生脉冲激光束，其波长在332和342纳米之间并且在空间上在固体激光系统中成形，使得激光束在MALDI样品支架上的空间强度分布呈现多于一个强度峰值。

6. 发明申请

US20060169914A1 Ion source using matrix-assisted laser desorption/ionization 有权
标题翻译：离子源使用矩阵辅助激光解吸/电离
公开(公告)号：US20060169914A1
公开(公告)日：2006-08-03
申请号：US11314966
申请日：2005-12-21
申请人： Armin Holle , Jens Hohndorf , Andreas Haase , Markus Kayser
发明人： Armin Holle , Jens Hohndorf , Andreas Haase , Markus Kayser
IPC分类号： H01J27/24
CPC分类号： H01S3/09415 , H01J49/164 , H01S3/005 , H01S3/1118 , H01S3/115 , H01S3/1611 , H01S3/1638 , H01S5/041 , H01S5/14 , H01S5/183
摘要： An ion source generating ions by matrix-assisted laser desorption/ionization (MALDI) comprising a MALDI sample support and a solid-state the laser system generating a pulsed laser beam, which has a wavelength in the range between 332 and 342 nanometers and is spatially shaped in the solid-state laser system such that the spatial intensity distribution of the laser beam on the MALDI sample support exhibits more than one intensity peak.
摘要翻译：通过基质辅助激光解吸/电离（MALDI）产生离子的离子源包括MALDI样品支持体和固态激光系统，其产生脉冲激光束，其波长在332和342纳米之间并且在空间上在固体激光系统中成形，使得激光束在MALDI样品支架上的空间强度分布呈现多于一个强度峰值。

7. 发明授权

US07989759B2 Cleaned daughter ion spectra from maldi ionization 有权
标题翻译：来自马氏电离的清除的子离子光谱
公开(公告)号：US07989759B2
公开(公告)日：2011-08-02
申请号：US12237167
申请日：2008-09-24
申请人： Armin Holle
发明人： Armin Holle
IPC分类号： H01J49/40
CPC分类号： G01N27/62 , H01J49/0045
摘要： In a mass spectrometer having an ion source in which analyte substances are ionized by matrix assisted laser desorption and form an ion beam that travels to a parent ion selector for selecting ions to form daughter ions, the ion beam is reflected in at least one reflector prior to the parent ion selector so that only ions that have both the mass of the parent ions and their kinetic energy are allowed to pass to the parent ion selector. By taking this measure, the mass resolution in the daughter ion spectra is also increased; the improved mass resolution and improved signal-to-noise ratio produce higher sensitivity, even though fewer ions are admitted for analysis in the daughter ion spectrum.
摘要翻译：在具有离子源的质谱仪中，分析物质通过基质辅助激光解吸离子化并形成离子束，该离子束行进到母离子选择器以选择离子形成子离子，离子束在至少一个反射器中被反射到母体离子选择器，使得只有具有母体离子的质量和它们的动能的离子才允许传递到母体离子选择器。通过采取这种措施，子离子光谱中的质量分辨率也增加了; 改进的质量分辨率和改善的信噪比产生更高的灵敏度，即使在子离子谱中分析较少的离子也被允许。

8. 发明申请

US20090206247A1 ADJUSTING THE DETECTOR AMPLIFICATION IN MASS SPECTROMETERS 有权
标题翻译：调整大量光谱仪中的探测器放大
公开(公告)号：US20090206247A1
公开(公告)日：2009-08-20
申请号：US12389766
申请日：2009-02-20
申请人： Armin Holle
发明人： Armin Holle
IPC分类号： B01D59/44
CPC分类号： H01J49/025 , H01J49/0009
摘要： The amplification of secondary-electron multipliers in mass spectrometers is automatically adjusted by generating mass spectra with single ion signals, determining the average value of the peak heights of these single ion signals, and setting the amplification so that the average peak height assumes a desired nominal value. The amplification may be set via the supply voltage of the secondary-electron multiplier and can be increased or decreased by a desired factor using the known characteristic of the secondary-electron multiplier.
摘要翻译：通过用单一离子信号产生质谱来确定质谱仪中的二次电子倍增器的放大率，确定这些单个离子信号的峰值高度的平均值，并设置放大倍数，使平均峰值高度达到所需的标称值值。可以通过二次电子倍增器的电源电压来设置放大，并且可以使用二次电子倍增器的已知特性来增加或减少期望的因子。

9. 发明授权

US07297942B2 Method and device for cleaning desorption ion sources 有权
标题翻译：解吸离子源清洗方法及装置
公开(公告)号：US07297942B2
公开(公告)日：2007-11-20
申请号：US10757686
申请日：2004-01-14
申请人： Armin Holle , Jochen Franzen
发明人： Armin Holle , Jochen Franzen
IPC分类号： B01D59/44
CPC分类号： H01J49/0409 , B08B1/00 , B08B3/024 , Y10T436/25
摘要： The invention relates to the cleaning of contaminated accelerating or guiding electrodes of ion sources used for ion generation by desorption. A cleaning plate is used that has an outer contour similar to that of a standard sample support plate, and may be equipped with cleaning scrubbers that can be moved out when necessary to contact the electrodes. The scrubbers may include soft covers, and can carry out the cleaning by dry rubbing or with the help of high-boiling solvents for the matrix substances. The moving out of the cleaning scrubbers can be controlled by external light pulses from a laser or video camera spot light. Alternatively, the cleaning plate may be equipped with spray nozzles connected to a reservoir of cleaning fluid which is sprayed onto the electrodes, and the evacuation of the ventilated ion source chamber may be used to initiate the spraying.
摘要翻译：本发明涉及用于通过解吸产生离子源的离子源污染的加速或引导电极的清洁。使用具有类似于标准样品支撑板的外轮廓的清洁板，并且可以配备有可以在必要时移出以与电极接触的清洁洗涤器。洗涤器可以包括软盖，并且可以通过干摩擦或借助高沸点溶剂进行基质物质的清洁。清洁洗涤器的移出可以通过激光或摄像机点光源的外部光脉冲来控制。或者，清洁板可以配备有连接到喷射到电极上的清洁流体的储存器的喷嘴，并且通风离子源室的抽真空可以用于开始喷雾。

10. 发明申请

US20060071160A1 Laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis 有权
标题翻译：激光系统用于通过基质辅助激光解吸在质谱分析中电离样品
公开(公告)号：US20060071160A1
公开(公告)日：2006-04-06
申请号：US11226855
申请日：2005-09-14
申请人： Andreas Haase , Markus Kayser , Jens Hohndorf , Armin Holle
发明人： Andreas Haase , Markus Kayser , Jens Hohndorf , Armin Holle
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01S3/005 , H01S3/08022
摘要： The invention relates to a laser system for the ionization of a sample by matrix-assisted laser desorption in mass spectrometric analysis. The invention consists in providing a laser system which generates a spatially modulated intensity distribution with intensity spots on the sample, which significantly improves the quality and the robustness of the mass spectrometric analysis compared with a spatially homogeneous intensity distribution and, in particular, improves the ionization efficiency and, for a time-of-flight mass spectrometer with axial injection, the mass resolution and the signal-to-noise ratio.
摘要翻译：本发明涉及一种用于在质谱分析中通过基质辅助激光解吸电离样品的激光系统。本发明提供一种激光系统，其产生具有样品上强度斑点的空间调制强度分布，与空间均匀的强度分布相比，显着提高了质谱分析的质量和鲁棒性，并且特别地提高了电离效率，对于具有轴向注射的飞行时间质谱仪，质量分辨率和信噪比。

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